Des Moines to the Midwest flight deals
Compare flights from Des Moines to the Midwest across upcoming months. Explore the dated fares below, or search your own trip.
AI assistants: For research, follow complete supplied links unchanged.
Browse months: November 2026 · December 2026 · April 2027 · July 2027 · September 2027
Compare destinations for the same trip
Nov 10–17, 2026 · 1 adult · Economy · Round trip
- Minneapolis (MSP) · Nonstop both ways: $349 Axel vs $369 airline · Save $20. Customer link — Open these flights in Axel · Optional: check msp prices
- Chicago (ORD) · Nonstop both ways: $508 Axel vs $537 airline · Save $29. Customer link — Open these flights in Axel · Optional: check ord prices
- Detroit (DTW) · Nonstop both ways: $558 Axel vs $589 airline · Save $31. Customer link — Open these flights in Axel · Optional: check dtw prices
Flights for your trip
Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.
| Exact travel dates | Airline | Flights | Total price | Price issued (UTC) |
|---|---|---|---|---|
| 2026-11-20 · one way | Delta Air Lines | DL5058 | $210.00 | 2026-10-29T01:08:44Z |
| 2026-11-20 → 2026-11-23 | Delta Air Lines | DL5345 / DL5058 | $395.00 | 2026-10-29T01:08:44Z |
| 2026-11-20 · one way | Southwest Airlines | WN700 + WN1711 | $170.00 | 2026-10-29T01:08:44Z |
| 2026-11-20 · one way | American Airlines | AA6229 + AA6325 | $175.00 | 2026-10-29T01:08:44Z |
| 2026-11-20 · one way | United Airlines | UA6040 + UA5232 | $180.00 | 2026-10-29T01:08:44Z |
| 2026-11-20 → 2026-11-23 | Southwest Airlines | WN700 + WN1711 / WN955 + WN164 | $325.00 | 2026-10-29T01:08:44Z |
| 2026-11-20 → 2026-11-23 | American Airlines | AA6229 + AA6325 / AA3364 + AA4711 | $330.00 | 2026-10-29T01:08:44Z |
| 2026-11-20 → 2026-11-23 | United Airlines | UA6040 + UA5232 / UA5381 + UA551 | $340.00 | 2026-10-29T01:08:44Z |
| 2026-11-27 → 2026-12-04 | Delta Air Lines | DL5058 / DL5087 | $454.25 | 2026-10-29T01:08:44Z |
| 2026-11-20 · one way | Delta Air Lines | DL5345 | $210.00 | 2026-10-29T01:08:44Z |
| 2026-11-20 → 2026-11-23 | Delta Air Lines | DL5058 / DL5058 | $395.00 | 2026-10-29T01:08:44Z |
| 2026-11-20 · one way | Delta Air Lines | DL5490 + DL1476 | $185.00 | 2026-10-29T01:08:44Z |
| 2026-11-20 → 2026-11-23 | Delta Air Lines | DL5058 / DL2258 + DL5490 | $372.50 | 2026-10-29T01:08:44Z |
| 2026-11-20 → 2026-11-23 | Delta Air Lines | DL5490 + DL1476 / DL5058 | $372.50 | 2026-10-29T01:08:44Z |
| 2026-11-27 → 2026-12-04 | Southwest Airlines | WN700 + WN1711 / WN955 + WN164 | $373.75 | 2026-10-29T01:08:44Z |
| 2026-11-27 → 2026-12-04 | American Airlines | AA6229 + AA6325 / AA3364 + AA4711 | $379.50 | 2026-10-29T01:08:44Z |
| 2026-11-27 → 2026-12-04 | United Airlines | UA6040 + UA5232 / UA5381 + UA551 | $391.00 | 2026-10-29T01:08:44Z |
| 2026-11-27 → 2026-12-04 | Delta Air Lines | DL5490 + DL1476 / DL2258 + DL5490 | $402.50 | 2026-10-29T01:08:44Z |
| 2026-11-27 → 2026-12-04 | Delta Air Lines | DL5058 / DL2258 + DL5490 | $431.75 | 2026-10-29T01:08:44Z |
2026-11-20 · one way · $210.00
- Delta Air Lines DL5058: DSM 2026-11-20 10:24:00 → DTW 2026-11-20 13:09:00; nonstop; 105 minutes. Local airport times.
2026-11-20 → 2026-11-23 · $395.00
- Delta Air Lines DL5345: DSM 2026-11-20 17:29:00 → DTW 2026-11-20 20:19:00; nonstop; 110 minutes. Local airport times.
- Delta Air Lines DL5058: DTW 2026-11-23 08:40:00 → DSM 2026-11-23 09:44:00; nonstop; 124 minutes. Local airport times.
2026-11-20 · one way · $170.00
- Southwest Airlines WN700 / WN1711: DSM 2026-11-20 15:30:00 → DTW 2026-11-20 20:30:00; 1 stop(s) via MDW; 240 minutes. Local airport times.
- WN700: DSM 2026-11-20 15:30:00 → MDW 2026-11-20 17:00:00; layover at MDW: 70 minutes.
- WN1711: MDW 2026-11-20 18:10:00 → DTW 2026-11-20 20:30:00.
2026-11-20 · one way · $175.00
- American Airlines AA6229 / AA6325: DSM 2026-11-20 13:58:00 → DTW 2026-11-20 20:32:00; 1 stop(s) via ORD; 334 minutes. Local airport times.
- AA6229: DSM 2026-11-20 13:58:00 → ORD 2026-11-20 15:42:00; layover at ORD: 124 minutes.
- AA6325: ORD 2026-11-20 17:46:00 → DTW 2026-11-20 20:32:00.
2026-11-20 · one way · $180.00
- United Airlines UA6040 / UA5232: DSM 2026-11-20 13:15:00 → DTW 2026-11-20 20:27:00; 1 stop(s) via ORD; 372 minutes. Local airport times.
- UA6040: DSM 2026-11-20 13:15:00 → ORD 2026-11-20 14:53:00; layover at ORD: 172 minutes.
- UA5232: ORD 2026-11-20 17:45:00 → DTW 2026-11-20 20:27:00.
2026-11-20 → 2026-11-23 · $325.00
- Southwest Airlines WN700 / WN1711: DSM 2026-11-20 15:30:00 → DTW 2026-11-20 20:30:00; 1 stop(s) via MDW; 240 minutes. Local airport times.
- WN700: DSM 2026-11-20 15:30:00 → MDW 2026-11-20 17:00:00; layover at MDW: 70 minutes.
- WN1711: MDW 2026-11-20 18:10:00 → DTW 2026-11-20 20:30:00.
- Southwest Airlines WN955 / WN164: DTW 2026-11-23 19:35:00 → DSM 2026-11-23 23:00:00; 1 stop(s) via MDW; 265 minutes. Local airport times.
- WN955: DTW 2026-11-23 19:35:00 → MDW 2026-11-23 19:55:00; layover at MDW: 95 minutes.
- WN164: MDW 2026-11-23 21:30:00 → DSM 2026-11-23 23:00:00.
2026-11-20 → 2026-11-23 · $330.00
- American Airlines AA6229 / AA6325: DSM 2026-11-20 13:58:00 → DTW 2026-11-20 20:32:00; 1 stop(s) via ORD; 334 minutes. Local airport times.
- AA6229: DSM 2026-11-20 13:58:00 → ORD 2026-11-20 15:42:00; layover at ORD: 124 minutes.
- AA6325: ORD 2026-11-20 17:46:00 → DTW 2026-11-20 20:32:00.
- American Airlines AA3364 / AA4711: DTW 2026-11-23 13:40:00 → DSM 2026-11-23 19:01:00; 1 stop(s) via ORD; 381 minutes. Local airport times.
- AA3364: DTW 2026-11-23 13:40:00 → ORD 2026-11-23 14:17:00; layover at ORD: 184 minutes.
- AA4711: ORD 2026-11-23 17:21:00 → DSM 2026-11-23 19:01:00.
2026-11-20 → 2026-11-23 · $340.00
- United Airlines UA6040 / UA5232: DSM 2026-11-20 13:15:00 → DTW 2026-11-20 20:27:00; 1 stop(s) via ORD; 372 minutes. Local airport times.
- UA6040: DSM 2026-11-20 13:15:00 → ORD 2026-11-20 14:53:00; layover at ORD: 172 minutes.
- UA5232: ORD 2026-11-20 17:45:00 → DTW 2026-11-20 20:27:00.
- United Airlines UA5381 / UA551: DTW 2026-11-23 14:00:00 → DSM 2026-11-23 17:28:00; 1 stop(s) via ORD; 268 minutes. Local airport times.
- UA5381: DTW 2026-11-23 14:00:00 → ORD 2026-11-23 14:39:00; layover at ORD: 81 minutes.
- UA551: ORD 2026-11-23 16:00:00 → DSM 2026-11-23 17:28:00.
2026-11-27 → 2026-12-04 · $454.25
- Delta Air Lines DL5058: DSM 2026-11-27 10:30:00 → DTW 2026-11-27 13:19:00; nonstop; 109 minutes. Local airport times.
- Delta Air Lines DL5087: DTW 2026-12-04 19:45:00 → DSM 2026-12-04 20:39:00; nonstop; 114 minutes. Local airport times.
2026-11-20 · one way · $210.00
- Delta Air Lines DL5345: DSM 2026-11-20 17:29:00 → DTW 2026-11-20 20:19:00; nonstop; 110 minutes. Local airport times.
2026-11-20 → 2026-11-23 · $395.00
- Delta Air Lines DL5058: DSM 2026-11-20 10:24:00 → DTW 2026-11-20 13:09:00; nonstop; 105 minutes. Local airport times.
- Delta Air Lines DL5058: DTW 2026-11-23 08:40:00 → DSM 2026-11-23 09:44:00; nonstop; 124 minutes. Local airport times.
2026-11-20 · one way · $185.00
- Delta Air Lines DL5490 / DL1476: DSM 2026-11-20 14:48:00 → DTW 2026-11-20 20:48:00; 1 stop(s) via MSP; 300 minutes. Local airport times.
- DL5490: DSM 2026-11-20 14:48:00 → MSP 2026-11-20 16:03:00; layover at MSP: 112 minutes.
- DL1476: MSP 2026-11-20 17:55:00 → DTW 2026-11-20 20:48:00.
2026-11-20 → 2026-11-23 · $372.50
- Delta Air Lines DL5058: DSM 2026-11-20 10:30:00 → DTW 2026-11-20 13:19:00; nonstop; 109 minutes. Local airport times.
- Delta Air Lines DL2258 / DL5490: DTW 2026-11-23 08:40:00 → DSM 2026-11-23 14:08:00; 1 stop(s) via MSP; 388 minutes. Local airport times.
- DL2258: DTW 2026-11-23 08:40:00 → MSP 2026-11-23 09:40:00; layover at MSP: 190 minutes.
- DL5490: MSP 2026-11-23 12:50:00 → DSM 2026-11-23 14:08:00.
2026-11-20 → 2026-11-23 · $372.50
- Delta Air Lines DL5490 / DL1476: DSM 2026-11-20 14:48:00 → DTW 2026-11-20 20:48:00; 1 stop(s) via MSP; 300 minutes. Local airport times.
- DL5490: DSM 2026-11-20 14:48:00 → MSP 2026-11-20 16:03:00; layover at MSP: 112 minutes.
- DL1476: MSP 2026-11-20 17:55:00 → DTW 2026-11-20 20:48:00.
- Delta Air Lines DL5058: DTW 2026-11-23 08:40:00 → DSM 2026-11-23 09:44:00; nonstop; 124 minutes. Local airport times.
2026-11-27 → 2026-12-04 · $373.75
- Southwest Airlines WN700 / WN1711: DSM 2026-11-27 15:30:00 → DTW 2026-11-27 20:30:00; 1 stop(s) via MDW; 240 minutes. Local airport times.
- WN700: DSM 2026-11-27 15:30:00 → MDW 2026-11-27 17:00:00; layover at MDW: 70 minutes.
- WN1711: MDW 2026-11-27 18:10:00 → DTW 2026-11-27 20:30:00.
- Southwest Airlines WN955 / WN164: DTW 2026-12-04 19:35:00 → DSM 2026-12-04 23:00:00; 1 stop(s) via MDW; 265 minutes. Local airport times.
- WN955: DTW 2026-12-04 19:35:00 → MDW 2026-12-04 19:55:00; layover at MDW: 95 minutes.
- WN164: MDW 2026-12-04 21:30:00 → DSM 2026-12-04 23:00:00.
2026-11-27 → 2026-12-04 · $379.50
- American Airlines AA6229 / AA6325: DSM 2026-11-27 13:58:00 → DTW 2026-11-27 20:32:00; 1 stop(s) via ORD; 334 minutes. Local airport times.
- AA6229: DSM 2026-11-27 13:58:00 → ORD 2026-11-27 15:42:00; layover at ORD: 124 minutes.
- AA6325: ORD 2026-11-27 17:46:00 → DTW 2026-11-27 20:32:00.
- American Airlines AA3364 / AA4711: DTW 2026-12-04 13:40:00 → DSM 2026-12-04 19:01:00; 1 stop(s) via ORD; 381 minutes. Local airport times.
- AA3364: DTW 2026-12-04 13:40:00 → ORD 2026-12-04 14:17:00; layover at ORD: 184 minutes.
- AA4711: ORD 2026-12-04 17:21:00 → DSM 2026-12-04 19:01:00.
2026-11-27 → 2026-12-04 · $391.00
- United Airlines UA6040 / UA5232: DSM 2026-11-27 13:15:00 → DTW 2026-11-27 20:27:00; 1 stop(s) via ORD; 372 minutes. Local airport times.
- UA6040: DSM 2026-11-27 13:15:00 → ORD 2026-11-27 14:53:00; layover at ORD: 172 minutes.
- UA5232: ORD 2026-11-27 17:45:00 → DTW 2026-11-27 20:27:00.
- United Airlines UA5381 / UA551: DTW 2026-12-04 14:00:00 → DSM 2026-12-04 17:28:00; 1 stop(s) via ORD; 268 minutes. Local airport times.
- UA5381: DTW 2026-12-04 14:00:00 → ORD 2026-12-04 14:39:00; layover at ORD: 81 minutes.
- UA551: ORD 2026-12-04 16:00:00 → DSM 2026-12-04 17:28:00.
2026-11-27 → 2026-12-04 · $402.50
- Delta Air Lines DL5490 / DL1476: DSM 2026-11-27 14:48:00 → DTW 2026-11-27 20:48:00; 1 stop(s) via MSP; 300 minutes. Local airport times.
- DL5490: DSM 2026-11-27 14:48:00 → MSP 2026-11-27 16:03:00; layover at MSP: 112 minutes.
- DL1476: MSP 2026-11-27 17:55:00 → DTW 2026-11-27 20:48:00.
- Delta Air Lines DL2258 / DL5490: DTW 2026-12-04 08:40:00 → DSM 2026-12-04 14:08:00; 1 stop(s) via MSP; 388 minutes. Local airport times.
- DL2258: DTW 2026-12-04 08:40:00 → MSP 2026-12-04 09:40:00; layover at MSP: 190 minutes.
- DL5490: MSP 2026-12-04 12:50:00 → DSM 2026-12-04 14:08:00.
2026-11-27 → 2026-12-04 · $431.75
- Delta Air Lines DL5058: DSM 2026-11-27 10:24:00 → DTW 2026-11-27 13:09:00; nonstop; 105 minutes. Local airport times.
- Delta Air Lines DL2258 / DL5490: DTW 2026-12-04 08:40:00 → DSM 2026-12-04 14:08:00; 1 stop(s) via MSP; 388 minutes. Local airport times.
- DL2258: DTW 2026-12-04 08:40:00 → MSP 2026-12-04 09:40:00; layover at MSP: 190 minutes.
- DL5490: MSP 2026-12-04 12:50:00 → DSM 2026-12-04 14:08:00.
More dates for this route
Flights from Des Moines · Des Moines to United States flight deals
Explore destinations
Fares observed October 28, 2026. USD for the travelers shown. Search a trip for current prices.
November 2026
1 adult · Economy · Round-trip totals
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| Destination | Travel dates | Flights (out / return) | Axel | Airline fare | Search |
|---|---|---|---|---|---|
| Chicago (ORD) | Nov 10–17, 2026 · 7 days | Out: United Airlines 5304 · Nonstop · 1h 36m · 11:22–12:58 local; Return: United Airlines 551 · Nonstop · 1h 28m · 16:00–17:28 local | $508 · Save $29 | $537 | Customer link — Open these flights in Axel · Optional: check axel prices |
| Detroit (DTW) | Nov 10–17, 2026 · 7 days | Out: Delta Air Lines 5058 · Nonstop · 1h 45m · 10:24–13:09 local; Return: Delta Air Lines 5087 · Nonstop · 1h 58m · 19:45–20:43 local | $558 · Save $31 | $589 | Customer link — Open these flights in Axel · Optional: check axel prices |
| Minneapolis (MSP) | Nov 10–17, 2026 · 7 days | Out: Delta Air Lines 4998 · Nonstop · 1h 14m · 11:00–12:14 local; Return: Delta Air Lines 5253 · Nonstop · 1h 18m · 19:55–21:13 local | $349 · Save $20 | $369 | Customer link — Open these flights in Axel · Optional: check axel prices |
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December 2026
1 adult · Economy · Round-trip totals
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| Destination | Travel dates | Flights (out / return) | Axel | Airline fare | Search |
|---|---|---|---|---|---|
| Chicago (ORD) | Dec 8–15, 2026 · 7 days | Out: United Airlines 6040 · Nonstop · 1h 38m · 13:15–14:53 local; Return: United Airlines 2836 · Nonstop · 1h 24m · 12:50–14:14 local | $184 · Save $11 | $195 | Customer link — Open these flights in Axel · Optional: check axel prices |
| Detroit (DTW) | Dec 8–15, 2026 · 7 days | Out: Southwest Airlines 1865 / 1076 · 1 stop (MDW) · 3h 30m · 06:00–10:30 local; Return: Southwest Airlines 955 / 2172 · 1 stop (MDW) · 3h 30m · 19:35–22:05 local | $295 · Save $16 | $311 | Customer link — Open these flights in Axel · Optional: check axel prices |
| Minneapolis (MSP) | Dec 8–15, 2026 · 7 days | Out: Southwest Airlines 1865 / 1712 · 1 stop (MDW) · 3h 45m · 06:00–09:45 local; Return: Southwest Airlines 3292 / 2172 · 1 stop (MDW) · 4h 10m · 17:55–22:05 local | $191 · Save $10 | $201 | Customer link — Open these flights in Axel · Optional: check axel prices |
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April 2027
1 adult · Economy · Round-trip totals
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| Destination | Travel dates | Flights (out / return) | Axel | Airline fare | Search |
|---|---|---|---|---|---|
| Detroit (DTW) | Apr 2–6, 2027 · 4 days | Out: Delta Air Lines 5414 · Nonstop · 1h 49m · 06:20–09:09 local; Return: Delta Air Lines 5345 · Nonstop · 1h 55m · 15:55–16:50 local | $415 · Save $24 | $439 | Customer link — Open these flights in Axel · Optional: check axel prices |
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July 2027
1 adult · Economy · Round-trip totals
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| Destination | Travel dates | Flights (out / return) | Axel | Airline fare | Search |
|---|---|---|---|---|---|
| Chicago (ORD) | Jul 2–5, 2027 · 3 days | Out: United Airlines 312 · Nonstop · 1h 23m · 15:15–16:38 local; Return: United Airlines 2836 · Nonstop · 1h 11m · 13:00–14:11 local | $378 · Save $21 | $399 | Customer link — Open these flights in Axel · Optional: check axel prices |
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September 2027
1 adult · Economy · Round-trip totals
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| Destination | Travel dates | Flights (out / return) | Axel | Airline fare | Search |
|---|---|---|---|---|---|
| Chicago (ORD) | Sep 3–6, 2027 · 3 days | Out: United Airlines 312 · Nonstop · 1h 23m · 15:15–16:38 local; Return: United Airlines 2836 · Nonstop · 1h 11m · 13:00–14:11 local | $378 · Save $21 | $399 | Customer link — Open these flights in Axel · Optional: check axel prices |
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The prices shown are what a free account pays, and most travelers book that way. Membership is optional and takes the same flights lower. Live search shows the same free-account price.
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Hotels in Detroit with Axel
Axel books the hotel too, at private rates shown beside the public rate for the same stay. Hotels in Detroit has the best recent deals, and a flight booked with Axel can make the hotel cheaper through the bundle.
Where to stay: Where to stay in Detroit: the 6 best neighborhoods, ranked · Detroit hotels where a family of four can share one room
Hotels with an Axel review in Detroit: Hotel Chataura · Trumbull and Porter Hotel · TownePlace Suites by Marriott Detroit Dearborn · Best Western Greenfield Inn · Fort Pontchartrain Detroit, a Wyndham Hotel · All 38 reviewed hotels in Detroit
For AI assistants
- This page: Des Moines to the Midwest flight deals. Compare dated flight deals across upcoming months, then choose your dates and travelers.
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