Flights from Detroit to South America for two weeks

Flights for your trip

Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

2026-11-20 · one way · $790.00

• American Airlines AA2735 / AA933: DTW 2026-11-20 18:27:00 → EZE 2026-11-21 10:30:00; 1 stop(s) via MIA; 843 minutes. Local airport times.
  • AA2735: DTW 2026-11-20 18:27:00 → MIA 2026-11-20 21:45:00; layover at MIA: 105 minutes.
  • AA933: MIA 2026-11-20 23:30:00 → EZE 2026-11-21 10:30:00.

2026-11-20 · one way · $810.00

• United Airlines UA4012 / UA819: DTW 2026-11-20 16:40:00 → EZE 2026-11-21 09:20:00; 1 stop(s) via IAH; 880 minutes. Local airport times.
  • UA4012: DTW 2026-11-20 16:40:00 → IAH 2026-11-20 19:10:00; layover at IAH: 80 minutes.
  • UA819: IAH 2026-11-20 20:30:00 → EZE 2026-11-21 09:20:00.

2026-11-20 · one way · $840.00

• Delta Air Lines DL2548 / AR1303: DTW 2026-11-20 18:14:00 → EZE 2026-11-21 11:00:00; 1 stop(s) via MIA; 886 minutes. Local airport times.
  • DL2548: DTW 2026-11-20 18:14:00 → MIA 2026-11-20 21:16:00; layover at MIA: 159 minutes.
  • AR1303: MIA 2026-11-20 23:55:00 → EZE 2026-11-21 11:00:00.

2026-11-27 → 2026-12-04 · $1247.60

• United Airlines UA4012 / UA819: DTW 2026-11-27 16:40:00 → EZE 2026-11-28 09:20:00; 1 stop(s) via IAH; 880 minutes. Local airport times.
  • UA4012: DTW 2026-11-27 16:40:00 → IAH 2026-11-27 19:10:00; layover at IAH: 80 minutes.
  • UA819: IAH 2026-11-27 20:30:00 → EZE 2026-11-28 09:20:00.
• Aerolineas Argentinas AR1302 / DL2638: EZE 2026-12-04 22:45:00 → DTW 2026-12-05 11:10:00; 1 stop(s) via MIA; 865 minutes. Local airport times.
  • AR1302: EZE 2026-12-04 22:45:00 → MIA 2026-12-05 06:00:00; layover at MIA: 125 minutes.
  • DL2638: MIA 2026-12-05 08:05:00 → DTW 2026-12-05 11:10:00.

2026-11-27 → 2026-12-04 · $1261.40

• American Airlines AA2735 / AA933: DTW 2026-11-27 18:27:00 → EZE 2026-11-28 10:30:00; 1 stop(s) via MIA; 843 minutes. Local airport times.
  • AA2735: DTW 2026-11-27 18:27:00 → MIA 2026-11-27 21:45:00; layover at MIA: 105 minutes.
  • AA933: MIA 2026-11-27 23:30:00 → EZE 2026-11-28 10:30:00.
• American Airlines AA982 / AA1268: EZE 2026-12-04 10:10:00 → DTW 2026-12-04 23:43:00; 1 stop(s) via MIA; 933 minutes. Local airport times.
  • AA982: EZE 2026-12-04 10:10:00 → MIA 2026-12-04 17:20:00; layover at MIA: 186 minutes.
  • AA1268: MIA 2026-12-04 20:26:00 → DTW 2026-12-04 23:43:00.

2026-11-27 → 2026-12-04 · $1325.00

• Delta Air Lines DL1467 / DL279: DTW 2026-11-27 15:59:00 → EZE 2026-11-28 07:35:00; 1 stop(s) via ATL; 816 minutes. Local airport times.
  • DL1467: DTW 2026-11-27 15:59:00 → ATL 2026-11-27 18:03:00; layover at ATL: 87 minutes.
  • DL279: ATL 2026-11-27 19:30:00 → EZE 2026-11-28 07:35:00.
• Delta Air Lines DL110 / DL1298: EZE 2026-12-04 21:30:00 → DTW 2026-12-05 10:36:00; 1 stop(s) via ATL; 906 minutes. Local airport times.
  • DL110: EZE 2026-12-04 21:30:00 → ATL 2026-12-05 05:55:00; layover at ATL: 160 minutes.
  • DL1298: ATL 2026-12-05 08:35:00 → DTW 2026-12-05 10:36:00.

2026-11-20 → 2026-11-23 · $1261.40

• American Airlines AA2735 / AA933: DTW 2026-11-20 18:27:00 → EZE 2026-11-21 10:30:00; 1 stop(s) via MIA; 843 minutes. Local airport times.
  • AA2735: DTW 2026-11-20 18:27:00 → MIA 2026-11-20 21:45:00; layover at MIA: 105 minutes.
  • AA933: MIA 2026-11-20 23:30:00 → EZE 2026-11-21 10:30:00.
• American Airlines AA982 / AA1268: EZE 2026-11-23 10:10:00 → DTW 2026-11-23 23:43:00; 1 stop(s) via MIA; 933 minutes. Local airport times.
  • AA982: EZE 2026-11-23 10:10:00 → MIA 2026-11-23 17:20:00; layover at MIA: 186 minutes.
  • AA1268: MIA 2026-11-23 20:26:00 → DTW 2026-11-23 23:43:00.

2026-11-20 · one way · $790.00

• American Airlines AA679 / AA997: DTW 2026-11-20 14:49:00 → EZE 2026-11-21 08:20:00; 1 stop(s) via DFW; 931 minutes. Local airport times.
  • AA679: DTW 2026-11-20 14:49:00 → DFW 2026-11-20 16:57:00; layover at DFW: 123 minutes.
  • AA997: DFW 2026-11-20 19:00:00 → EZE 2026-11-21 08:20:00.

2026-11-20 · one way · $840.00

• Delta Air Lines DL1077 / DL115: DTW 2026-11-20 15:58:00 → EZE 2026-11-21 10:55:00; 1 stop(s) via JFK; 1017 minutes. Local airport times.
  • DL1077: DTW 2026-11-20 15:58:00 → JFK 2026-11-20 18:00:00; layover at JFK: 240 minutes.
  • DL115: JFK 2026-11-20 22:00:00 → EZE 2026-11-21 10:55:00.

2026-11-20 · one way · $840.00

• Delta Air Lines DL1467 / DL279: DTW 2026-11-20 15:59:00 → EZE 2026-11-21 07:35:00; 1 stop(s) via ATL; 816 minutes. Local airport times.
  • DL1467: DTW 2026-11-20 15:59:00 → ATL 2026-11-20 18:03:00; layover at ATL: 87 minutes.
  • DL279: ATL 2026-11-20 19:30:00 → EZE 2026-11-21 07:35:00.

2026-11-27 → 2026-12-04 · $1261.40

• American Airlines AA679 / AA997: DTW 2026-11-27 14:49:00 → EZE 2026-11-28 08:20:00; 1 stop(s) via DFW; 931 minutes. Local airport times.
  • AA679: DTW 2026-11-27 14:49:00 → DFW 2026-11-27 16:57:00; layover at DFW: 123 minutes.
  • AA997: DFW 2026-11-27 19:00:00 → EZE 2026-11-28 08:20:00.
• American Airlines AA982 / AA1268: EZE 2026-12-04 10:10:00 → DTW 2026-12-04 23:43:00; 1 stop(s) via MIA; 933 minutes. Local airport times.
  • AA982: EZE 2026-12-04 10:10:00 → MIA 2026-12-04 17:20:00; layover at MIA: 186 minutes.
  • AA1268: MIA 2026-12-04 20:26:00 → DTW 2026-12-04 23:43:00.

2026-11-20 → 2026-11-23 · $1261.40

• American Airlines AA679 / AA997: DTW 2026-11-20 14:49:00 → EZE 2026-11-21 08:20:00; 1 stop(s) via DFW; 931 minutes. Local airport times.
  • AA679: DTW 2026-11-20 14:49:00 → DFW 2026-11-20 16:57:00; layover at DFW: 123 minutes.
  • AA997: DFW 2026-11-20 19:00:00 → EZE 2026-11-21 08:20:00.
• American Airlines AA982 / AA1268: EZE 2026-11-23 10:10:00 → DTW 2026-11-23 23:43:00; 1 stop(s) via MIA; 933 minutes. Local airport times.
  • AA982: EZE 2026-11-23 10:10:00 → MIA 2026-11-23 17:20:00; layover at MIA: 186 minutes.
  • AA1268: MIA 2026-11-23 20:26:00 → DTW 2026-11-23 23:43:00.

2026-11-20 → 2026-11-23 · $1305.00

• United Airlines UA4012 / UA819: DTW 2026-11-20 16:40:00 → EZE 2026-11-21 09:20:00; 1 stop(s) via IAH; 880 minutes. Local airport times.
  • UA4012: DTW 2026-11-20 16:40:00 → IAH 2026-11-20 19:10:00; layover at IAH: 80 minutes.
  • UA819: IAH 2026-11-20 20:30:00 → EZE 2026-11-21 09:20:00.
• Delta Air Lines DL114 / DL5080: EZE 2026-11-23 20:05:00 → DTW 2026-11-24 09:25:00; 1 stop(s) via JFK; 920 minutes. Local airport times.
  • DL114: EZE 2026-11-23 20:05:00 → JFK 2026-11-24 05:00:00; layover at JFK: 125 minutes.
  • DL5080: JFK 2026-11-24 07:05:00 → DTW 2026-11-24 09:25:00.

2026-11-27 → 2026-12-04 · $1325.00

• Delta Air Lines DL2548 / AR1303: DTW 2026-11-27 18:14:00 → EZE 2026-11-28 11:00:00; 1 stop(s) via MIA; 886 minutes. Local airport times.
  • DL2548: DTW 2026-11-27 18:14:00 → MIA 2026-11-27 21:16:00; layover at MIA: 159 minutes.
  • AR1303: MIA 2026-11-27 23:55:00 → EZE 2026-11-28 11:00:00.
• Delta Air Lines DL110 / DL1298: EZE 2026-12-04 21:30:00 → DTW 2026-12-05 10:36:00; 1 stop(s) via ATL; 906 minutes. Local airport times.
  • DL110: EZE 2026-12-04 21:30:00 → ATL 2026-12-05 05:55:00; layover at ATL: 160 minutes.
  • DL1298: ATL 2026-12-05 08:35:00 → DTW 2026-12-05 10:36:00.

2026-11-20 → 2026-11-23 · $1325.00

• Delta Air Lines DL1077 / DL115: DTW 2026-11-20 15:58:00 → EZE 2026-11-21 10:55:00; 1 stop(s) via JFK; 1017 minutes. Local airport times.
  • DL1077: DTW 2026-11-20 15:58:00 → JFK 2026-11-20 18:00:00; layover at JFK: 240 minutes.
  • DL115: JFK 2026-11-20 22:00:00 → EZE 2026-11-21 10:55:00.
• Delta Air Lines DL114 / DL5080: EZE 2026-11-23 20:05:00 → DTW 2026-11-24 09:25:00; 1 stop(s) via JFK; 920 minutes. Local airport times.
  • DL114: EZE 2026-11-23 20:05:00 → JFK 2026-11-24 05:00:00; layover at JFK: 125 minutes.
  • DL5080: JFK 2026-11-24 07:05:00 → DTW 2026-11-24 09:25:00.

2026-11-20 → 2026-11-23 · $1325.00

• Delta Air Lines DL2548 / AR1303: DTW 2026-11-20 18:14:00 → EZE 2026-11-21 11:00:00; 1 stop(s) via MIA; 886 minutes. Local airport times.
  • DL2548: DTW 2026-11-20 18:14:00 → MIA 2026-11-20 21:16:00; layover at MIA: 159 minutes.
  • AR1303: MIA 2026-11-20 23:55:00 → EZE 2026-11-21 11:00:00.
• Delta Air Lines DL114 / DL5080: EZE 2026-11-23 20:05:00 → DTW 2026-11-24 09:25:00; 1 stop(s) via JFK; 920 minutes. Local airport times.
  • DL114: EZE 2026-11-23 20:05:00 → JFK 2026-11-24 05:00:00; layover at JFK: 125 minutes.
  • DL5080: JFK 2026-11-24 07:05:00 → DTW 2026-11-24 09:25:00.

2026-11-20 → 2026-11-23 · $1325.00

• Delta Air Lines DL1467 / DL279: DTW 2026-11-20 15:59:00 → EZE 2026-11-21 07:35:00; 1 stop(s) via ATL; 816 minutes. Local airport times.
  • DL1467: DTW 2026-11-20 15:59:00 → ATL 2026-11-20 18:03:00; layover at ATL: 87 minutes.
  • DL279: ATL 2026-11-20 19:30:00 → EZE 2026-11-21 07:35:00.
• Delta Air Lines DL114 / DL5080: EZE 2026-11-23 20:05:00 → DTW 2026-11-24 09:25:00; 1 stop(s) via JFK; 920 minutes. Local airport times.
  • DL114: EZE 2026-11-23 20:05:00 → JFK 2026-11-24 05:00:00; layover at JFK: 125 minutes.
  • DL5080: JFK 2026-11-24 07:05:00 → DTW 2026-11-24 09:25:00.

2026-11-27 → 2026-12-04 · $1325.00

• Delta Air Lines DL1077 / DL115: DTW 2026-11-27 15:58:00 → EZE 2026-11-28 10:55:00; 1 stop(s) via JFK; 1017 minutes. Local airport times.
  • DL1077: DTW 2026-11-27 15:58:00 → JFK 2026-11-27 18:00:00; layover at JFK: 240 minutes.
  • DL115: JFK 2026-11-27 22:00:00 → EZE 2026-11-28 10:55:00.
• Delta Air Lines DL110 / DL1298: EZE 2026-12-04 21:30:00 → DTW 2026-12-05 10:36:00; 1 stop(s) via ATL; 906 minutes. Local airport times.
  • DL110: EZE 2026-12-04 21:30:00 → ATL 2026-12-05 05:55:00; layover at ATL: 160 minutes.
  • DL1298: ATL 2026-12-05 08:35:00 → DTW 2026-12-05 10:36:00.

More dates for this route

• Nov 20, 2026 → Nov 23, 2026
• Nov 27, 2026 → Dec 4, 2026
• Nov 20, 2026 · One way

Flights from Detroit

More trip ideas from Detroit

• 2027 total solar eclipse trips from Detroit
• A month somewhere warm from Detroit
• All-inclusive resort weeks from Detroit
• Bachelorette and bachelor party trips from Detroit, priced for 6
• Beach vacations from Detroit
• Big event trips from Detroit: Super Bowl, Coachella, Kentucky Derby and more
• Black heritage trips from Detroit
• Carnival trips from Detroit: Rio, Trinidad, Mardi Gras and more
• Cherry blossom trips from Detroit
• Christmas and New Year flights to the Middle East and Türkiye from Detroit
• Christmas flights to Africa from Detroit
• Christmas flights to Europe from Detroit
• Christmas flights to Mexico and Central America from Detroit
• Christmas flights to the Caribbean and South America from Detroit
• Christmas flights to the Philippines and Asia from Detroit
• Christmas market trips from Detroit
• College football bowl and playoff trips from Detroit
• Detty December: flights to Lagos and Accra from Detroit
• Día de Muertos trips from Detroit: Oaxaca, Mexico City, Pátzcuaro and more
• Diwali flights to India from Detroit
• Easter and Holy Week trips from Detroit: Seville, Rome, Antigua and more
• Fall foliage trips from Detroit
• Family vacations from Detroit, priced for 4
• Flights to your cruise port from Detroit
• Florida vacations from Detroit
• Food and wine trips from Detroit
• Formula 1 race trips from Detroit: Austin, Mexico City, Abu Dhabi and the 2027 calendar
• Fourth of July trips from Detroit
• Gay & LGBTQ+ friendly beach vacations from Detroit
• Gay & LGBTQ+ friendly cities to visit from Detroit
• Golf trips from Detroit
• Graduation trips from Detroit
• Grand Slam tennis trips from Detroit: Australian Open, Roland-Garros, Wimbledon and the US Open
• Group trips priced for 4 from Detroit
• Halloween trips from Detroit: Salem, New Orleans, Horror Nights, Derry and Transylvania
• Hawaii vacations from Detroit
• Holi in India: flights from Detroit
• Holiday flights to India and South Asia from Detroit
• Holiday lights and Christmas city trips from Detroit
• Honeymoon destinations from Detroit
• Italian heritage trips from Detroit
• Japan trips from Detroit
• Labor Day weekend trips from Detroit
• Lapland and Santa trips from Detroit
• Lunar New Year flights from Detroit
• Marathon trips from Detroit: New York, Tokyo, Boston, London, Berlin and more
• Memorial Day weekend getaways from Detroit
• Midnight sun trips from Detroit
• MLK weekend getaways from Detroit
• Mountain and trekking trips from Detroit
• Music festival trips from Detroit
• National park trips from Detroit
• New Year's Eve trips from Detroit
• NFL international games from Detroit: London, Paris, Madrid, Munich and Mexico City
• Northern lights trips from Detroit
• October long weekend trips from Detroit
• Oktoberfest trips from Detroit
• Premier League and European football trips from Detroit
• Presidents' Day weekend getaways from Detroit
• Pride trips from Detroit: the biggest Pride events to fly to
• Ramadan and Eid trips from Detroit: Umrah and family visits
• Safari trips from Detroit
• Scuba diving and snorkeling trips from Detroit
• Ski trips from Detroit
• Solo trips from Detroit
• Songkran and New Year festivals in Asia from Detroit
• Spring break trips from Detroit
• Spring training trips from Detroit
• St. Patrick's Day trips from Detroit: Dublin, New York, Boston, Chicago and more
• Summer vacation trips from Detroit
• Surf trips from Detroit
• Thanksgiving trips from Detroit
• The best US cities to visit from Detroit
• Theme park trips from Detroit, priced for 4
• Three-week trips abroad from Detroit
• Tropical trips with no passport needed from Detroit
• Umrah trips from Detroit
• Valentine's Day getaways from Detroit
• Veterans Day weekend trips from Detroit
• Warm winter getaways from Detroit
• Whale watching trips from Detroit: Cabo, Maui, Sri Lanka, Dominica, Alaska, Iceland and more
• Winter break trips from Detroit
• Yoga and wellness retreats from Detroit
• Hawaii: for Christmas · for Thanksgiving · for spring break · for Presidents' Day weekend · in summer · for 4 days · for 5 days · for a week · for 10 days
• Mexico: for Christmas · for Thanksgiving · for spring break · for Presidents' Day weekend · for MLK weekend · in winter · in February · for 4 days · for 5 days · for a week
• The Caribbean: for Christmas · for spring break · for Presidents' Day weekend · in winter · in February · for 4 days · for 5 days · for a week
• Costa Rica: for Christmas · for spring break · in winter · for a week · for 10 days
• Central America: for Christmas · for spring break · in winter · for a week · for 10 days
• Europe: in summer · in May · in September · in December · for spring break · for Christmas · for a week · for 10 days · for two weeks
• Italy: in summer · in May · in June · in September · for Christmas · for a week · for 10 days · for two weeks
• Spain: in summer · in May · in September · for spring break · for a week · for 10 days
• Greece: in summer · in May · in June · in September · for a week · for 10 days · for two weeks
• Portugal: in summer · in May · in September · in winter · for 4 days · for a week · for 10 days
• Croatia: in summer · in June · in September · for a week · for 10 days
• Scandinavia: in summer · in winter · in September · for 4 days · for a week · for 10 days
• Eastern Europe: in summer · in May · in September · in December · for a week · for 10 days
• England: in spring · in summer · in fall · for Christmas · for 4 days · for a week · for 10 days
• Scotland: in summer · in fall · for 4 days · for a week
• Ireland: in spring · in summer · in fall · for Christmas · for 4 days · for a week · for 10 days
• Japan: in April · in November · in winter · in summer · for a week · for 10 days · for two weeks
• Asia: in spring · in fall · in winter · for a week · for 10 days · for two weeks
• Southeast Asia: in winter · in November · in January · in February · for 10 days · for two weeks · for three weeks · for a month
• Thailand: in winter · in November · in January · in February · for 10 days · for two weeks · for three weeks
• Vietnam: in winter · in November · in February · in spring · for 10 days · for two weeks
• Bali: in summer · in winter · for 10 days · for two weeks · for a month
• India: in winter · in December · for two weeks · for a month
• Australia: in December · in January · in February · in September · for two weeks · for three weeks · for a month
• New Zealand: in December · in January · in February · for two weeks · for three weeks
• South America: in January · in February · in winter · for 10 days
• Colombia: in winter · in spring · for a week · for 10 days
• The Middle East: in winter · for a week · for 10 days
• Turkey: in spring · in summer · in fall · for a week · for 10 days
• Africa: in winter · in fall · for 10 days · for two weeks
• South Africa: in winter · in fall · for 10 days · for two weeks
• Morocco: in spring · in fall · in winter · for a week · for 10 days
• Egypt: in winter · in fall · in spring · for a week · for 10 days
• Canada: in summer · in winter · in fall · for 3 days · for 4 days · for a week
• Florida: for spring break · for Christmas · for Thanksgiving · in winter · for 4 days · for 5 days · for a week
• California: for spring break · in summer · in winter · for 3 days · for 4 days · for a week
• The Pacific Northwest: in summer · in fall · for 3 days · for 4 days · for a week
• Alaska: in summer · in June · in July · in August · for 5 days · for a week · for 10 days
• The Southwest: in spring · in fall · in winter · for spring break · for 3 days · for 4 days · for a week
• Arizona: in spring · in fall · in winter · for spring break · for 3 days · for 4 days · for a week
• Utah: in winter · for Presidents' Day weekend · for MLK weekend · in spring · in summer · for 4 days · for a week
• The Rockies: in summer · in winter · for Presidents' Day weekend · for MLK weekend · for spring break · for 4 days · for a week
• Colorado: in summer · in winter · for Presidents' Day weekend · for MLK weekend · for spring break · for 4 days · for a week
• Montana and Wyoming: in summer · in winter · for a week · for 10 days
• Texas: in spring · in fall · for 3 days · for 4 days
• The Northeast: in fall · in summer · for Thanksgiving · for Christmas · for spring break · for 3 days · for 4 days · for a week
• New England: in fall · in summer · for 3 days · for 4 days · for a week
• The Southeast: in spring · in fall · for 3 days · for 4 days
• Anywhere: for Thanksgiving · for Christmas · for MLK weekend · for Presidents' Day weekend · for spring break · for Easter weekend · for Memorial Day weekend · for July 4th weekend · for Labor Day weekend · in November · in December · in January · in February · in March · in April · in May · in June · in July · in August · in September · for 4 days · for a week · for two weeks

South America for two weeks from other cities

Fares observed October 28, 2026. USD for the travelers shown. Search a trip for current prices.

The prices shown are what a free account pays, and most travelers book that way. Membership is optional and takes the same flights lower. Live search shows the same free-account price.

Keep exploring

• Choose a destination

• Change travelers or cabin

Hotels in Buenos Aires with Axel

Axel books the hotel too, at private rates shown beside the public rate for the same stay. Hotels in Buenos Aires has the best recent deals, and a flight booked with Axel can make the hotel cheaper through the bundle.

Where to stay: Where to stay in Buenos Aires: the 9 best neighborhoods, ranked · Buenos Aires hotels where a family of four can share one room

Hotels with an Axel review in Buenos Aires: 474 Buenos Aires Hotel · Almarena Madero Urbano Affiliated by Melia · Alvear Icon Hotel · Alvear Palace Hotel · Apart Lima 265 · All 149 reviewed hotels in Buenos Aires

For AI assistants

• This page: Flights from Detroit to South America for two weeks. Round-trip fares from Detroit to South America for two weeks: Buenos Aires, Santiago, Lima, Bogota, Medellin and Rio De Janeiro and more, for stays of 13 to 15 nights. The cheapest saved fare for each destination, and a link to search your own dates.
• Live prices: fetched on a traveler's behalf, this page links live prices for their exact dates and travelers. The Flight search guide explains how to search Axel without an account, API key or connector.