Des Moines to the Midwest flight deals

Flights for the months ahead

Lowest published fares for the months ahead: $309 round trip, Axel-exclusive, Southwest Airlines, 1 stop, Jan 7–10, 2027; $162 one way, Axel-exclusive, Southwest Airlines, 1 stop, Jan 5, 2027; 144 priced flights on 72 exact dates, 1 adult, economy, checked Oct 29, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Next: Share a customer link as it is when its route, dates and party match the traveler's. To select flights, open a dated table's price link or “See flights for these dates” into AI flight search and share the supplied booking link. Search links are for you; share customer and booking links. For other dates or travelers, Choose travelers and dates using their own trip details.

Des Moines (DSM) to Detroit (DTW): November 2026

Des Moines (DSM) to Detroit (DTW): December 2026

Des Moines (DSM) to Detroit (DTW): January 2027

Des Moines (DSM) to Detroit (DTW): February 2027

Des Moines (DSM) to Detroit (DTW): March 2027

Des Moines (DSM) to Detroit (DTW): April 2027

Des Moines (DSM) to Detroit (DTW): May 2027

Des Moines (DSM) to Detroit (DTW): June 2027

Des Moines (DSM) to Detroit (DTW): July 2027

Des Moines (DSM) to Detroit (DTW): August 2027

Des Moines (DSM) to Detroit (DTW): September 2027

Hotels in Detroit for these trips

Hotels: under a trip, hotels in Detroit for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in Detroit for these nights (Nov 19–22, 2026 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $325 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $413 total
• Hotels in Detroit for these nights (Nov 20–23, 2026 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $319 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $407 total
• Hotels in Detroit for these nights (Nov 21–28, 2026 · 7 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $702 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $883 total
• Hotels in Detroit for these nights (Nov 24–29, 2026 · 5 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $510 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $620 total
• Hotels in Detroit for these nights (Nov 26–29, 2026 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $322 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $374 total
• Hotels in Detroit for these nights (Nov 27–30, 2026 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $308 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $375 total
• Hotels in Detroit for these nights (Nov 28 – Dec 5, 2026 · 7 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $647 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $964 total
• Hotels in Detroit for these nights (Dec 3–6, 2026 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $289 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $518.50 total
• Hotels in Detroit for these nights (Dec 4–7, 2026 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $301 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $505.50 total
• Hotels in Detroit for these nights (Dec 5–12, 2026 · 7 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $714 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $932.50 total
• Hotels in Detroit for these nights (Dec 10–13, 2026 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $317 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $356 total
• Hotels in Detroit for these nights (Dec 11–14, 2026 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $347 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $357 total
• Hotels in Detroit for these nights (Dec 12–19, 2026 · 7 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $784 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $855 total
• Hotels in Detroit for these nights (Dec 17–20, 2026 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $333 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $372 total
• Hotels in Detroit for these nights (Dec 18–21, 2026 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $307 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $358 total
• Hotels in Detroit for these nights (Dec 19–26, 2026 · 7 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $653 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $792 total
• Hotels in Detroit for these nights (Dec 22–27, 2026 · 5 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $466 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $560 total
• Hotels in Detroit for these nights (Dec 24–27, 2026 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $282 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $335 total
• Hotels in Detroit for these nights (Dec 25–28, 2026 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $286 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $336 total
• Hotels in Detroit for these nights (Dec 26 – Jan 2, 2027 · 7 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $698 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $802 total
• Hotels in Detroit for these nights (Dec 30 – Jan 2, 2027 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $293 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $341 total
• Hotels in Detroit for these nights (Dec 31 – Jan 3, 2027 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $287 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $334 total
• Hotels in Detroit for these nights (Jan 1–4, 2027 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $280 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $331 total
• Hotels in Detroit for these nights (Jan 2–9, 2027 · 7 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $662 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $798 total
• Hotels in Detroit for these nights (Jan 7–10, 2027 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $312 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $344 total
• Hotels in Detroit for these nights (Jan 8–11, 2027 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $312 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $340 total
• Hotels in Detroit for these nights (Jan 9–16, 2027 · 7 nights · 2 adults, 1 room): 3★ Trumbull and Porter Hotel, $770 total · 4★ Kasa Cadillac Square Detroit, $1,091 total
• Hotels in Detroit for these nights (Jan 14–17, 2027 · 3 nights · 2 adults, 1 room): 3★ Trumbull and Porter Hotel, $354 total · 4★ Kasa Cadillac Square Detroit, $524 total
• Hotels in Detroit for these nights (Jan 15–18, 2027 · 3 nights · 2 adults, 1 room): 3★ Trumbull and Porter Hotel, $354 total · 4★ Kasa Cadillac Square Detroit, $524 total
• Hotels in Detroit for these nights (Jan 16–23, 2027 · 7 nights · 2 adults, 1 room): 3★ Trumbull and Porter Hotel, $770 total · 4★ Kasa Cadillac Square Detroit, $1,106 total
• Hotels in Detroit for these nights (Jan 21–24, 2027 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $312 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $425 total
• Hotels in Detroit for these nights (Jan 22–25, 2027 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $312 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $449 total
• Hotels in Detroit for these nights (Jan 23–30, 2027 · 7 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $730 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $1,000 total
• Hotels in Detroit for these nights (Jan 28–31, 2027 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $314 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $441 total
• Hotels in Detroit for these nights (Jan 29 – Feb 1, 2027 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $314 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $441 total
• Hotels in Detroit for these nights (Jan 30 – Feb 6, 2027 · 7 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $736 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $989 total
• Hotels in Detroit for these nights (Feb 4–7, 2027 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $328 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $453 total
• Hotels in Detroit for these nights (Feb 5–8, 2027 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $336 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $450 total
• Hotels in Detroit for these nights (Feb 6–13, 2027 · 7 nights · 2 adults, 1 room): 3★ Trumbull and Porter Hotel, $784 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $1,041 total
• Hotels in Detroit for these nights (Feb 12–15, 2027 · 3 nights · 2 adults, 1 room): 3★ SpringHill Suites by Marriott Detroit Dearborn, $429 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $570 total
• Hotels in Detroit for these nights (Feb 19–22, 2027 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $336 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $531.50 total
• Hotels in Detroit for these nights (Feb 20–27, 2027 · 7 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $784 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $1,107 total
• Hotels in Detroit for these nights (Mar 19–22, 2027 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $336 total · 4★ Kasa Cadillac Square Detroit, $544 total
• Hotels in Detroit for these nights (Mar 20–27, 2027 · 7 nights · 2 adults, 1 room): 3★ Trumbull and Porter Hotel, $778 total · 4★ Kasa Cadillac Square Detroit, $1,220 total
• Hotels in Detroit for these nights (Mar 25–29, 2027 · 4 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $453 total · 4★ Kasa Cadillac Square Detroit, $818 total
• Hotels in Detroit for these nights (Apr 16–19, 2027 · 3 nights · 2 adults, 1 room): 3★ TownePlace Suites by Marriott Detroit Dearborn, $371 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $518 total
• Hotels in Detroit for these nights (Apr 17–24, 2027 · 7 nights · 2 adults, 1 room): 3★ Trumbull and Porter Hotel, $960 total · 4★ DoubleTree by Hilton Detroit - Dearborn, $1,163 total
• Hotels in Detroit for these nights (May 14–17, 2027 · 3 nights · 2 adults, 1 room): 3★ The Inn on Ferry Street · 4★ Hollywood Casino at Greektown
• Hotels in Detroit for these nights (May 15–22, 2027 · 7 nights · 2 adults, 1 room): 3★ The Inn on Ferry Street · 4★ Hollywood Casino at Greektown
• Hotels in Detroit for these nights (May 28–31, 2027 · 3 nights · 2 adults, 1 room): 3★ The Inn on Ferry Street · 4★ Hollywood Casino at Greektown
• Hotels in Detroit for these nights (Jun 11–14, 2027 · 3 nights · 2 adults, 1 room): 3★ The Inn on Ferry Street · 4★ Hollywood Casino at Greektown
• Hotels in Detroit for these nights (Jun 12–19, 2027 · 7 nights · 2 adults, 1 room): 3★ The Inn on Ferry Street · 4★ Hollywood Casino at Greektown
• Hotels in Detroit for these nights (Jul 2–6, 2027 · 4 nights · 2 adults, 1 room): 3★ The Inn on Ferry Street · 4★ Hollywood Casino at Greektown
• Hotels in Detroit for these nights (Jul 9–12, 2027 · 3 nights · 2 adults, 1 room): 3★ The Inn on Ferry Street · 4★ Hollywood Casino at Greektown
• Hotels in Detroit for these nights (Jul 10–17, 2027 · 7 nights · 2 adults, 1 room): 3★ The Inn on Ferry Street · 4★ Hollywood Casino at Greektown
• Hotels in Detroit for these nights (Aug 6–9, 2027 · 3 nights · 2 adults, 1 room): 3★ The Inn on Ferry Street · 4★ Hollywood Casino at Greektown
• Hotels in Detroit for these nights (Aug 7–14, 2027 · 7 nights · 2 adults, 1 room): 3★ The Inn on Ferry Street · 4★ Hollywood Casino at Greektown
• Hotels in Detroit for these nights (Sep 3–6, 2027 · 3 nights · 2 adults, 1 room): 3★ The Inn on Ferry Street · 4★ Hollywood Casino at Greektown
• Hotels in Detroit for these nights (Sep 4–11, 2027 · 7 nights · 2 adults, 1 room): 3★ The Inn on Ferry Street · 4★ Hollywood Casino at Greektown
• Hotels in Detroit for these nights (Sep 24–27, 2027 · 3 nights · 2 adults, 1 room): 3★ The Inn on Ferry Street · 4★ Hollywood Casino at Greektown
• Hotels in Detroit for these nights (Sep 25 – Oct 2, 2027 · 7 nights · 2 adults, 1 room): 3★ The Inn on Ferry Street · 4★ Hollywood Casino at Greektown

All hotels in Detroit

Route overview: Des Moines to Detroit (DTW) flight deals

2026-11-19 → 2026-11-22 · Axel-exclusive $325.00

• Southwest Airlines WN700 / WN1711: DSM 2026-11-19 15:30:00 → DTW 2026-11-19 20:30:00; 1 stop(s) via MDW; 240 minutes. Local airport times.
  • WN700: DSM 2026-11-19 15:30:00 → MDW 2026-11-19 17:00:00; layover at MDW: 70 minutes.
  • WN1711: MDW 2026-11-19 18:10:00 → DTW 2026-11-19 20:30:00.
• Southwest Airlines WN955 / WN164: DTW 2026-11-22 19:35:00 → DSM 2026-11-22 23:00:00; 1 stop(s) via MDW; 265 minutes. Local airport times.
  • WN955: DTW 2026-11-22 19:35:00 → MDW 2026-11-22 19:55:00; layover at MDW: 95 minutes.
  • WN164: MDW 2026-11-22 21:30:00 → DSM 2026-11-22 23:00:00.

2026-11-19 → 2026-11-22 · Axel-exclusive $395.00

• Delta Air Lines DL5345: DSM 2026-11-19 17:29:00 → DTW 2026-11-19 20:19:00; nonstop; 110 minutes. Local airport times.
• Delta Air Lines DL5087: DTW 2026-11-22 19:45:00 → DSM 2026-11-22 20:43:00; nonstop; 118 minutes. Local airport times.

2026-11-24 · one way · Axel-exclusive $221.00

• Southwest Airlines WN700 / WN1711: DSM 2026-11-24 15:30:00 → DTW 2026-11-24 20:30:00; 1 stop(s) via MDW; 240 minutes. Local airport times.
  • WN700: DSM 2026-11-24 15:30:00 → MDW 2026-11-24 17:00:00; layover at MDW: 70 minutes.
  • WN1711: MDW 2026-11-24 18:10:00 → DTW 2026-11-24 20:30:00.

2026-11-24 · one way · Axel-exclusive $273.00

• Delta Air Lines DL5414: DSM 2026-11-24 06:13:00 → DTW 2026-11-24 09:06:00; nonstop; 113 minutes. Local airport times.

2026-11-28 → 2026-12-05 · Axel-exclusive $373.75

• Southwest Airlines WN700 / WN1711: DSM 2026-11-28 15:30:00 → DTW 2026-11-28 20:30:00; 1 stop(s) via MDW; 240 minutes. Local airport times.
  • WN700: DSM 2026-11-28 15:30:00 → MDW 2026-11-28 17:00:00; layover at MDW: 70 minutes.
  • WN1711: MDW 2026-11-28 18:10:00 → DTW 2026-11-28 20:30:00.
• Southwest Airlines WN955 / WN164: DTW 2026-12-05 19:35:00 → DSM 2026-12-05 23:00:00; 1 stop(s) via MDW; 265 minutes. Local airport times.
  • WN955: DTW 2026-12-05 19:35:00 → MDW 2026-12-05 19:55:00; layover at MDW: 95 minutes.
  • WN164: MDW 2026-12-05 21:30:00 → DSM 2026-12-05 23:00:00.

2026-11-28 → 2026-12-05 · Axel-exclusive $454.25

• Delta Air Lines DL5345: DSM 2026-11-28 17:29:00 → DTW 2026-11-28 20:19:00; nonstop; 110 minutes. Local airport times.
• Delta Air Lines DL5087: DTW 2026-12-05 19:45:00 → DSM 2026-12-05 20:43:00; nonstop; 118 minutes. Local airport times.

2026-12-12 → 2026-12-19 · Axel-exclusive $365.63

• Southwest Airlines WN700 / WN1711: DSM 2026-12-12 15:30:00 → DTW 2026-12-12 20:30:00; 1 stop(s) via MDW; 240 minutes. Local airport times.
  • WN700: DSM 2026-12-12 15:30:00 → MDW 2026-12-12 17:00:00; layover at MDW: 70 minutes.
  • WN1711: MDW 2026-12-12 18:10:00 → DTW 2026-12-12 20:30:00.
• Southwest Airlines WN955 / WN164: DTW 2026-12-19 19:35:00 → DSM 2026-12-19 23:00:00; 1 stop(s) via MDW; 265 minutes. Local airport times.
  • WN955: DTW 2026-12-19 19:35:00 → MDW 2026-12-19 19:55:00; layover at MDW: 95 minutes.
  • WN164: MDW 2026-12-19 21:30:00 → DSM 2026-12-19 23:00:00.

2026-12-12 → 2026-12-19 · Axel-exclusive $444.38

• Delta Air Lines DL5345: DSM 2026-12-12 17:29:00 → DTW 2026-12-12 20:19:00; nonstop; 110 minutes. Local airport times.
• Delta Air Lines DL5087: DTW 2026-12-19 19:45:00 → DSM 2026-12-19 20:43:00; nonstop; 118 minutes. Local airport times.

2026-12-25 → 2026-12-28 · Axel-exclusive $398.13

• Southwest Airlines WN700 / WN1711: DSM 2026-12-25 15:30:00 → DTW 2026-12-25 20:30:00; 1 stop(s) via MDW; 240 minutes. Local airport times.
  • WN700: DSM 2026-12-25 15:30:00 → MDW 2026-12-25 17:00:00; layover at MDW: 70 minutes.
  • WN1711: MDW 2026-12-25 18:10:00 → DTW 2026-12-25 20:30:00.
• Southwest Airlines WN955 / WN164: DTW 2026-12-28 19:35:00 → DSM 2026-12-28 23:00:00; 1 stop(s) via MDW; 265 minutes. Local airport times.
  • WN955: DTW 2026-12-28 19:35:00 → MDW 2026-12-28 19:55:00; layover at MDW: 95 minutes.
  • WN164: MDW 2026-12-28 21:30:00 → DSM 2026-12-28 23:00:00.

2026-12-25 → 2026-12-28 · Axel-exclusive $483.88

• Delta Air Lines DL5345: DSM 2026-12-25 17:29:00 → DTW 2026-12-25 20:22:00; nonstop; 113 minutes. Local airport times.
• Delta Air Lines DL5058: DTW 2026-12-28 08:40:00 → DSM 2026-12-28 09:44:00; nonstop; 124 minutes. Local airport times.

2027-01-07 → 2027-01-10 · Axel-exclusive $308.76

• Southwest Airlines WN700 / WN1711: DSM 2027-01-07 15:30:00 → DTW 2027-01-07 20:30:00; 1 stop(s) via MDW; 240 minutes. Local airport times.
  • WN700: DSM 2027-01-07 15:30:00 → MDW 2027-01-07 17:00:00; layover at MDW: 70 minutes.
  • WN1711: MDW 2027-01-07 18:10:00 → DTW 2027-01-07 20:30:00.
• Southwest Airlines WN955 / WN164: DTW 2027-01-10 19:35:00 → DSM 2027-01-10 23:00:00; 1 stop(s) via MDW; 265 minutes. Local airport times.
  • WN955: DTW 2027-01-10 19:35:00 → MDW 2027-01-10 19:55:00; layover at MDW: 95 minutes.
  • WN164: MDW 2027-01-10 21:30:00 → DSM 2027-01-10 23:00:00.

2027-01-07 → 2027-01-10 · Axel-exclusive $375.26

• Delta Air Lines DL5345: DSM 2027-01-07 17:29:00 → DTW 2027-01-07 20:22:00; nonstop; 113 minutes. Local airport times.
• Delta Air Lines DL5087: DTW 2027-01-10 19:45:00 → DSM 2027-01-10 20:43:00; nonstop; 118 minutes. Local airport times.

2027-01-21 → 2027-01-24 · Axel-exclusive $313.50

• American Airlines AA6229 / AA6325: DSM 2027-01-21 13:58:00 → DTW 2027-01-21 20:32:00; 1 stop(s) via ORD; 334 minutes. Local airport times.
  • AA6229: DSM 2027-01-21 13:58:00 → ORD 2027-01-21 15:42:00; layover at ORD: 124 minutes.
  • AA6325: ORD 2027-01-21 17:46:00 → DTW 2027-01-21 20:32:00.
• American Airlines AA3364 / AA4711: DTW 2027-01-24 13:40:00 → DSM 2027-01-24 19:01:00; 1 stop(s) via ORD; 381 minutes. Local airport times.
  • AA3364: DTW 2027-01-24 13:40:00 → ORD 2027-01-24 14:17:00; layover at ORD: 184 minutes.
  • AA4711: ORD 2027-01-24 17:21:00 → DSM 2027-01-24 19:01:00.

2027-01-21 → 2027-01-24 · Axel-exclusive $375.26

• Delta Air Lines DL5345: DSM 2027-01-21 17:29:00 → DTW 2027-01-21 20:22:00; nonstop; 113 minutes. Local airport times.
• Delta Air Lines DL5087: DTW 2027-01-24 19:45:00 → DSM 2027-01-24 20:43:00; nonstop; 118 minutes. Local airport times.

2027-02-04 → 2027-02-07 · Axel-exclusive $323.00

• United Airlines UA6040 / UA5232: DSM 2027-02-04 13:15:00 → DTW 2027-02-04 20:27:00; 1 stop(s) via ORD; 372 minutes. Local airport times.
  • UA6040: DSM 2027-02-04 13:15:00 → ORD 2027-02-04 14:53:00; layover at ORD: 172 minutes.
  • UA5232: ORD 2027-02-04 17:45:00 → DTW 2027-02-04 20:27:00.
• United Airlines UA5381 / UA551: DTW 2027-02-07 14:00:00 → DSM 2027-02-07 17:28:00; 1 stop(s) via ORD; 268 minutes. Local airport times.
  • UA5381: DTW 2027-02-07 14:00:00 → ORD 2027-02-07 14:39:00; layover at ORD: 81 minutes.
  • UA551: ORD 2027-02-07 16:00:00 → DSM 2027-02-07 17:28:00.

2027-02-04 → 2027-02-07 · Axel-exclusive $375.26

• Delta Air Lines DL5345: DSM 2027-02-04 17:29:00 → DTW 2027-02-04 20:22:00; nonstop; 113 minutes. Local airport times.
• Delta Air Lines DL5087: DTW 2027-02-07 19:45:00 → DSM 2027-02-07 20:43:00; nonstop; 118 minutes. Local airport times.

2027-03-19 → 2027-03-22 · Axel-exclusive $325.00

• Southwest Airlines WN700 / WN1711: DSM 2027-03-19 15:30:00 → DTW 2027-03-19 20:30:00; 1 stop(s) via MDW; 240 minutes. Local airport times.
  • WN700: DSM 2027-03-19 15:30:00 → MDW 2027-03-19 17:00:00; layover at MDW: 70 minutes.
  • WN1711: MDW 2027-03-19 18:10:00 → DTW 2027-03-19 20:30:00.
• Southwest Airlines WN955 / WN164: DTW 2027-03-22 19:35:00 → DSM 2027-03-22 23:00:00; 1 stop(s) via MDW; 265 minutes. Local airport times.
  • WN955: DTW 2027-03-22 19:35:00 → MDW 2027-03-22 19:55:00; layover at MDW: 95 minutes.
  • WN164: MDW 2027-03-22 21:30:00 → DSM 2027-03-22 23:00:00.

2027-03-19 → 2027-03-22 · Axel-exclusive $395.00

• Delta Air Lines DL5345: DSM 2027-03-19 17:29:00 → DTW 2027-03-19 20:22:00; nonstop; 113 minutes. Local airport times.
• Delta Air Lines DL5058: DTW 2027-03-22 08:40:00 → DSM 2027-03-22 09:44:00; nonstop; 124 minutes. Local airport times.

2027-05-15 → 2027-05-22 · Axel-exclusive $360.00

• Southwest Airlines WN700 / WN1711: DSM 2027-05-15 15:30:00 → DTW 2027-05-15 20:30:00; 1 stop(s) via MDW; 240 minutes. Local airport times.
  • WN700: DSM 2027-05-15 15:30:00 → MDW 2027-05-15 17:00:00; layover at MDW: 70 minutes.
  • WN1711: MDW 2027-05-15 18:10:00 → DTW 2027-05-15 20:30:00.
• Southwest Airlines WN955 / WN164: DTW 2027-05-22 19:35:00 → DSM 2027-05-22 23:00:00; 1 stop(s) via MDW; 265 minutes. Local airport times.
  • WN955: DTW 2027-05-22 19:35:00 → MDW 2027-05-22 19:55:00; layover at MDW: 95 minutes.
  • WN164: MDW 2027-05-22 21:30:00 → DSM 2027-05-22 23:00:00.

2027-05-15 → 2027-05-22 · Axel-exclusive $430.00

• Delta Air Lines DL5345: DSM 2027-05-15 17:29:00 → DTW 2027-05-15 20:19:00; nonstop; 110 minutes. Local airport times.
• Delta Air Lines DL5087: DTW 2027-05-22 19:45:00 → DSM 2027-05-22 20:43:00; nonstop; 118 minutes. Local airport times.

2027-07-10 → 2027-07-17 · Axel-exclusive $360.00

• Southwest Airlines WN700 / WN1711: DSM 2027-07-10 15:30:00 → DTW 2027-07-10 20:30:00; 1 stop(s) via MDW; 240 minutes. Local airport times.
  • WN700: DSM 2027-07-10 15:30:00 → MDW 2027-07-10 17:00:00; layover at MDW: 70 minutes.
  • WN1711: MDW 2027-07-10 18:10:00 → DTW 2027-07-10 20:30:00.
• Southwest Airlines WN955 / WN164: DTW 2027-07-17 19:35:00 → DSM 2027-07-17 23:00:00; 1 stop(s) via MDW; 265 minutes. Local airport times.
  • WN955: DTW 2027-07-17 19:35:00 → MDW 2027-07-17 19:55:00; layover at MDW: 95 minutes.
  • WN164: MDW 2027-07-17 21:30:00 → DSM 2027-07-17 23:00:00.

2027-07-10 → 2027-07-17 · Axel-exclusive $430.00

• Delta Air Lines DL5345: DSM 2027-07-10 17:29:00 → DTW 2027-07-10 20:19:00; nonstop; 110 minutes. Local airport times.
• Delta Air Lines DL5087: DTW 2027-07-17 19:45:00 → DSM 2027-07-17 20:43:00; nonstop; 118 minutes. Local airport times.

2027-09-25 → 2027-10-02 · Axel-exclusive $351.00

• Southwest Airlines WN700 / WN1711: DSM 2027-09-25 15:30:00 → DTW 2027-09-25 20:30:00; 1 stop(s) via MDW; 240 minutes. Local airport times.
  • WN700: DSM 2027-09-25 15:30:00 → MDW 2027-09-25 17:00:00; layover at MDW: 70 minutes.
  • WN1711: MDW 2027-09-25 18:10:00 → DTW 2027-09-25 20:30:00.
• Southwest Airlines WN955 / WN164: DTW 2027-10-02 19:35:00 → DSM 2027-10-02 23:00:00; 1 stop(s) via MDW; 265 minutes. Local airport times.
  • WN955: DTW 2027-10-02 19:35:00 → MDW 2027-10-02 19:55:00; layover at MDW: 95 minutes.
  • WN164: MDW 2027-10-02 21:30:00 → DSM 2027-10-02 23:00:00.

2027-09-25 → 2027-10-02 · Axel-exclusive $419.25

• Delta Air Lines DL5345: DSM 2027-09-25 17:29:00 → DTW 2027-09-25 20:19:00; nonstop; 110 minutes. Local airport times.
• Delta Air Lines DL5087: DTW 2027-10-02 19:45:00 → DSM 2027-10-02 20:43:00; nonstop; 118 minutes. Local airport times.

More dates for this route

• Nov 19, 2026 · Return options
• Nov 27, 2026 · Return options
• Dec 8, 2026 · Return options
• Dec 19, 2026 · Return options
• Dec 29, 2026 · Return options
• Jan 8, 2027 · Return options
• Jan 19, 2027 · Return options
• Jan 30, 2027 · Return options
• Feb 19, 2027 · Return options
• May 14, 2027 · Return options
• Jul 9, 2027 · Return options
• Sep 25, 2027 · Return options
• Hotels in Detroit with Axel

Flights from Des Moines · Des Moines to United States flight deals

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Detroit (DTW) · Minneapolis (MSP) · Chicago (ORD)

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Fares observed November 5, 2026. USD for the travelers shown.

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Hotels in Detroit with Axel

Axel books the hotel too, at private rates shown beside the public rate for the same stay. Hotels in Detroit has the best recent deals, and a flight booked with Axel can make the hotel cheaper through the bundle.

Where to stay: Where to stay in Detroit: the 6 best neighborhoods, ranked · Detroit hotels where a family of four can share one room

Hotel details in Detroit: Hotel David Whitney, Autograph Collection 4★ · Atheneum Suite Hotel 4★ · AC Hotel by Marriott Detroit at the Bonstelle 2★ · MotorCity Casino Hotel 4★ · Comfort Inn Detroit Downtown 2★ from $72 a night in the next 30 days · All 45 hotels in Detroit

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• This page: Des Moines to the Midwest flight deals. Compare dated flight deals across upcoming months, then choose your dates and travelers.
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