Columbus to South America flight deals

Flights from Columbus

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San Andres Island (ADZ) · Buenos Aires (AEP) · Asuncion (ASU) · Barranquilla (BAQ) · Bucaramanga (BGA) · Barcelona (BLA) · Bogota (BOG) · Caracas (CCS) · Cali (CLO) · Cordoba (COR) · Cartagena (CTG) · Cucuta (CUC) · Buenos Aires (EZE) · Galapagos Islands (GPS) · Sao Paulo (GRU) · Guayaquil (GYE) · La Paz (LPB) · Manaus (MAO) · Maracaibo (MAR) · Medellin (MDE) · Mendoza (MDZ) · Montevideo (MVD) · Pereira (PEI) · Porto Alegre (POA) · Santiago (SCL) · San Cristobal (SCY) · Santa Marta (SMR) · Quito (UIO) · Valencia (VLN)

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Fares observed October 2, 2026. USD for the travelers shown. Search a trip for current prices.

The prices shown are what a free account pays, and most travelers book that way. Membership is optional and takes the same flights lower. Live search shows the same free-account price.

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For AI assistants

• This page: Columbus to South America flight deals. Columbus to South America flight deals. Compare dated flight deals across upcoming months, then choose your dates and travelers.
• Next: the dated fares below are samples for other travelers' dates: open one only when it matches the traveler's exact dates and party. Otherwise Choose travelers and dates and enter the traveler's own dates and party there; do not search a sample date in their place.
• Every link here is complete and ready to open. Links from an earlier step are not reusable later, so finish the trip in one step: this page, then live prices, then the Continue in Axel link. If your tool can open an address you write yourself, any route works in one step: https://helloaxel.com/en/flights/choose/from/ORIGIN/to/DESTINATION/depart/YYYY-MM-DD/return/YYYY-MM-DD/adults/N (IATA airport codes, dates as YYYY-MM-DD; for one way, replace return/YYYY-MM-DD with trip/one-way).
• If a link can no longer be opened: search for "Axel Columbus to South America flight deals" and open the result; the Flight search guide is always findable by search, and everything here works without an account, API key or connector. Or ask the traveler to open https://helloaxel.com/en/flights/from-columbus-to-south-america; an address the traveler opens always works.
• Sharing with the traveler: share the address of the step you reached. Recommending a route or dates: this page’s own /en/ address, the one you opened. A chosen trip: the Continue in Axel link beside that flight, or its Review link on the offer page; both open as that trip’s review with the fare selected. Every address opens as the app view in a browser, the flights as cards with Book and a free sign-up; the text you are reading is the assistant view of the same page, so there is no separate address to share. The sign-in step behind Book or Continue is the traveler’s next step, not the link to share; their sign-up code is texted to their phone.