Knoxville (TYS) to Chicago (ORD), Nov 29, 2026: from $223 one way

Knoxville (TYS) to Chicago (ORD), Nov 29, 2026: from $223 one way on Axel, checked Oct 29, 2026. Lowest published fare: $223 one way, Axel-exclusive, American Airlines, nonstop, Nov 29, 2026, 1 adult, economy, checked Oct 29, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Route overview: Knoxville to Chicago (ORD) flight deals

2026-11-29 · one way · Axel-exclusive $222.75

• American Airlines AA5408: TYS 2026-11-29 11:33:00 → ORD 2026-11-29 12:40:00; nonstop; 127 minutes. Local airport times.

2026-11-29 · one way · Axel-exclusive $229.50

• United Airlines UA5595: TYS 2026-11-29 17:35:00 → ORD 2026-11-29 18:36:00; nonstop; 121 minutes. Local airport times.

2026-11-29 · one way · Axel-exclusive $256.50

• Delta Air Lines DL5196 / DL3902: TYS 2026-11-29 07:10:00 → ORD 2026-11-29 10:59:00; 1 stop(s) via DTW; 289 minutes. Local airport times.
  • DL5196: TYS 2026-11-29 07:10:00 → DTW 2026-11-29 09:00:00; layover at DTW: 80 minutes.
  • DL3902: DTW 2026-11-29 10:20:00 → ORD 2026-11-29 10:59:00.

2026-11-29 · one way · Axel-exclusive $222.75

• American Airlines AA3653: TYS 2026-11-29 20:52:00 → ORD 2026-11-29 21:58:00; nonstop; 126 minutes. Local airport times.

2026-11-29 · one way · Axel-exclusive $229.50

• United Airlines UA5245: TYS 2026-11-29 06:00:00 → ORD 2026-11-29 07:06:00; nonstop; 126 minutes. Local airport times.

2026-11-29 · one way · Axel-exclusive $243.00

• American Airlines AA5675 / AA1039: TYS 2026-11-29 20:04:00 → ORD 2026-11-29 23:59:00; 1 stop(s) via CLT; 295 minutes. Local airport times.
  • AA5675: TYS 2026-11-29 20:04:00 → CLT 2026-11-29 21:28:00; layover at CLT: 85 minutes.
  • AA1039: CLT 2026-11-29 22:53:00 → ORD 2026-11-29 23:59:00.

2026-11-29 · one way · Axel-exclusive $256.50

• Delta Air Lines DL1743 / DL2738: TYS 2026-11-29 12:32:00 → ORD 2026-11-29 17:06:00; 1 stop(s) via ATL; 334 minutes. Local airport times.
  • DL1743: TYS 2026-11-29 12:32:00 → ATL 2026-11-29 13:38:00; layover at ATL: 132 minutes.
  • DL2738: ATL 2026-11-29 15:50:00 → ORD 2026-11-29 17:06:00.

Travelers: prices on this page are totals for 1 adult. For a different party, open this trip for 2 adults · 3 adults · 4 adults · 2 adults + 1 child · 2 adults + 2 children; each link opens AI flight search for these dates and those travelers, and the customer link to share comes from those results.

Explore this route

• All dates for this route
• Nov 28, 2026 · Return options
• Nov 30, 2026 · Return options
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For AI assistants

• This page: Knoxville (TYS) to Chicago (ORD) · Nov 29, 2026 · one way: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued.
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