Knoxville (TYS) to Chicago (ORD), Nov 24–27, 2026: from $405 round trip

Knoxville (TYS) to Chicago (ORD), Nov 24–27, 2026: from $405 round trip on Axel, checked Oct 29, 2026. Lowest published fare: $405 round trip, Axel-exclusive, American Airlines, nonstop, Nov 24–27, 2026, 1 adult, economy, checked Oct 29, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Hotels in Chicago for these trips

Hotels: under a trip, hotels in Chicago for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in Chicago for these nights (Nov 24–27, 2026 · 3 nights · 2 adults, 1 room): 3★ Hyatt Place Chicago/Wicker Park · 4★ LondonHouse Chicago, Curio Collection by Hilton · 5★ The Langham, Chicago

All hotels in Chicago

Route overview: Knoxville to Chicago (ORD) flight deals

2026-11-24 → 2026-11-27 · Axel-exclusive $405.00

• American Airlines AA5408: TYS 2026-11-24 11:33:00 → ORD 2026-11-24 12:40:00; nonstop; 127 minutes. Local airport times.
• American Airlines AA3661: ORD 2026-11-27 16:00:00 → TYS 2026-11-27 18:46:00; nonstop; 106 minutes. Local airport times.

2026-11-24 → 2026-11-27 · Axel-exclusive $418.50

• United Airlines UA5478: TYS 2026-11-24 17:40:00 → ORD 2026-11-24 18:43:00; nonstop; 123 minutes. Local airport times.
• United Airlines UA5693: ORD 2026-11-27 14:10:00 → TYS 2026-11-27 17:00:00; nonstop; 110 minutes. Local airport times.

2026-11-24 → 2026-11-27 · Axel-exclusive $472.50

• Delta Air Lines DL1743 / DL2738: TYS 2026-11-24 12:32:00 → ORD 2026-11-24 17:06:00; 1 stop(s) via ATL; 334 minutes. Local airport times.
  • DL1743: TYS 2026-11-24 12:32:00 → ATL 2026-11-24 13:38:00; layover at ATL: 132 minutes.
  • DL2738: ATL 2026-11-24 15:50:00 → ORD 2026-11-24 17:06:00.
• Delta Air Lines DL1477 / DL5272: ORD 2026-11-27 15:59:00 → TYS 2026-11-27 21:56:00; 1 stop(s) via ATL; 297 minutes. Local airport times.
  • DL1477: ORD 2026-11-27 15:59:00 → ATL 2026-11-27 18:54:00; layover at ATL: 118 minutes.
  • DL5272: ATL 2026-11-27 20:52:00 → TYS 2026-11-27 21:56:00.

2026-11-24 → 2026-11-27 · Axel-exclusive $405.00

• American Airlines AA3653: TYS 2026-11-24 20:52:00 → ORD 2026-11-24 21:58:00; nonstop; 126 minutes. Local airport times.
• American Airlines AA3661: ORD 2026-11-27 16:00:00 → TYS 2026-11-27 18:46:00; nonstop; 106 minutes. Local airport times.

2026-11-24 → 2026-11-27 · Axel-exclusive $418.50

• United Airlines UA4581: TYS 2026-11-24 10:33:00 → ORD 2026-11-24 11:39:00; nonstop; 126 minutes. Local airport times.
• United Airlines UA5693: ORD 2026-11-27 14:10:00 → TYS 2026-11-27 17:00:00; nonstop; 110 minutes. Local airport times.

2026-11-24 → 2026-11-27 · Axel-exclusive $425.25

• American Airlines AA5675 / AA1039: TYS 2026-11-24 20:04:00 → ORD 2026-11-24 23:59:00; 1 stop(s) via CLT; 295 minutes. Local airport times.
  • AA5675: TYS 2026-11-24 20:04:00 → CLT 2026-11-24 21:28:00; layover at CLT: 85 minutes.
  • AA1039: CLT 2026-11-24 22:53:00 → ORD 2026-11-24 23:59:00.
• American Airlines AA3661: ORD 2026-11-27 16:00:00 → TYS 2026-11-27 18:46:00; nonstop; 106 minutes. Local airport times.

2026-11-24 → 2026-11-27 · Axel-exclusive $472.50

• Delta Air Lines DL5196 / DL3902: TYS 2026-11-24 07:10:00 → ORD 2026-11-24 10:59:00; 1 stop(s) via DTW; 289 minutes. Local airport times.
  • DL5196: TYS 2026-11-24 07:10:00 → DTW 2026-11-24 09:00:00; layover at DTW: 80 minutes.
  • DL3902: DTW 2026-11-24 10:20:00 → ORD 2026-11-24 10:59:00.
• Delta Air Lines DL1477 / DL5272: ORD 2026-11-27 15:59:00 → TYS 2026-11-27 21:56:00; 1 stop(s) via ATL; 297 minutes. Local airport times.
  • DL1477: ORD 2026-11-27 15:59:00 → ATL 2026-11-27 18:54:00; layover at ATL: 118 minutes.
  • DL5272: ATL 2026-11-27 20:52:00 → TYS 2026-11-27 21:56:00.

Travelers: prices on this page are totals for 1 adult. For a different party, open this trip for 2 adults · 3 adults · 4 adults · 2 adults + 1 child · 2 adults + 2 children; each link opens AI flight search for these dates and those travelers, and the customer link to share comes from those results.

Explore this route

• All dates for this route
• Nov 23, 2026 · Return options
• Nov 25, 2026 · Return options
• Hotels in Chicago with Axel

For AI assistants

• This page: Knoxville (TYS) to Chicago (ORD) · Nov 24, 2026 · return Nov 27, 2026: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued. Under a trip, hotels in Chicago for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the lowest saved totals among the shortlisted hotels in each star tier for those dates.
• Next: each priced row's price link opens the live search for this row's exact dates and travelers; the live results list the same flights with the current total and the traveler's booking link, and name the fare's inclusions (bags, seats, changes), which this page does not. A changed price or flight shows there. Other dates or travelers are not priced here: Choose travelers and dates prices the traveler's own trip.
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• Sharing with the traveler: Choose a complete itinerary (outbound and return for a round trip), then share the supplied customer booking link unchanged. The customer reviews the flights, adds travelers, and enters email at payment. Do not collect email in chat. Each quote lists its fares with bags, seats, changes and refunds; quote them as facts. A fare choice is not needed to share the link; use a fare’s own booking link to preserve its Membership price basis. Ask only for essential missing trip details. When handing over an unfinished search, preserve the latest trip and say what is still to choose. If no supplied link matches the latest trip, construct https://helloaxel.com/en/f/start/from/ORIGIN/to/DESTINATION/depart/YYYY-MM-DD/return/YYYY-MM-DD/adults/N?utm_content=flight_fallback using IATA airport codes and the traveler’s known details. Omit unknowns; for one way replace /return/YYYY-MM-DD with /trip/oneway. Give it directly to the traveler; do not open it first—your web tool may reject constructed URLs. Complete links open Flight Guide and start searching. Preferences and advanced options.

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