Knoxville (TYS) to Chicago (ORD) · Nov 21, 2026 · return Nov 22, 2026

Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Route overview: Knoxville to Chicago (ORD) flight deals

2026-11-21 → 2026-11-22 · Axel-exclusive $300.00

• American Airlines AA5408: TYS 2026-11-21 11:33:00 → ORD 2026-11-21 12:40:00; nonstop; 127 minutes. Local airport times.
• American Airlines AA3661: ORD 2026-11-22 16:00:00 → TYS 2026-11-22 18:46:00; nonstop; 106 minutes. Local airport times.

2026-11-21 → 2026-11-22 · Axel-exclusive $310.00

• United Airlines UA5478: TYS 2026-11-21 17:40:00 → ORD 2026-11-21 18:43:00; nonstop; 123 minutes. Local airport times.
• United Airlines UA4559: ORD 2026-11-22 10:25:00 → TYS 2026-11-22 13:13:00; nonstop; 108 minutes. Local airport times.

2026-11-21 → 2026-11-22 · Axel-exclusive $350.00

• Delta Air Lines DL5196 / DL3902: TYS 2026-11-21 07:10:00 → ORD 2026-11-21 10:59:00; 1 stop(s) via DTW; 289 minutes. Local airport times.
  • DL5196: TYS 2026-11-21 07:10:00 → DTW 2026-11-21 09:00:00; layover at DTW: 80 minutes.
  • DL3902: DTW 2026-11-21 10:20:00 → ORD 2026-11-21 10:59:00.
• Delta Air Lines DL1477 / DL5272: ORD 2026-11-22 15:59:00 → TYS 2026-11-22 21:56:00; 1 stop(s) via ATL; 297 minutes. Local airport times.
  • DL1477: ORD 2026-11-22 15:59:00 → ATL 2026-11-22 18:54:00; layover at ATL: 118 minutes.
  • DL5272: ATL 2026-11-22 20:52:00 → TYS 2026-11-22 21:56:00.

2026-11-21 → 2026-11-22 · Axel-exclusive $300.00

• American Airlines AA3653: TYS 2026-11-21 20:52:00 → ORD 2026-11-21 21:58:00; nonstop; 126 minutes. Local airport times.
• American Airlines AA3661: ORD 2026-11-22 16:00:00 → TYS 2026-11-22 18:46:00; nonstop; 106 minutes. Local airport times.

2026-11-21 → 2026-11-22 · Axel-exclusive $310.00

• United Airlines UA4581: TYS 2026-11-21 10:33:00 → ORD 2026-11-21 11:39:00; nonstop; 126 minutes. Local airport times.
• United Airlines UA4559: ORD 2026-11-22 10:25:00 → TYS 2026-11-22 13:13:00; nonstop; 108 minutes. Local airport times.

2026-11-21 → 2026-11-22 · Axel-exclusive $315.00

• American Airlines AA5675 / AA1039: TYS 2026-11-21 20:04:00 → ORD 2026-11-21 23:59:00; 1 stop(s) via CLT; 295 minutes. Local airport times.
  • AA5675: TYS 2026-11-21 20:04:00 → CLT 2026-11-21 21:28:00; layover at CLT: 85 minutes.
  • AA1039: CLT 2026-11-21 22:53:00 → ORD 2026-11-21 23:59:00.
• American Airlines AA3661: ORD 2026-11-22 16:00:00 → TYS 2026-11-22 18:46:00; nonstop; 106 minutes. Local airport times.

2026-11-21 → 2026-11-22 · Axel-exclusive $350.00

• Delta Air Lines DL1743 / DL2738: TYS 2026-11-21 12:32:00 → ORD 2026-11-21 17:06:00; 1 stop(s) via ATL; 334 minutes. Local airport times.
  • DL1743: TYS 2026-11-21 12:32:00 → ATL 2026-11-21 13:38:00; layover at ATL: 132 minutes.
  • DL2738: ATL 2026-11-21 15:50:00 → ORD 2026-11-21 17:06:00.
• Delta Air Lines DL1477 / DL5272: ORD 2026-11-22 15:59:00 → TYS 2026-11-22 21:56:00; 1 stop(s) via ATL; 297 minutes. Local airport times.
  • DL1477: ORD 2026-11-22 15:59:00 → ATL 2026-11-22 18:54:00; layover at ATL: 118 minutes.
  • DL5272: ATL 2026-11-22 20:52:00 → TYS 2026-11-22 21:56:00.

Explore this route

• All dates for this route
• Nov 20, 2026 · Return options
• Nov 22, 2026 · Return options
• Hotels in Chicago with Axel

For AI assistants

• This page: Knoxville (TYS) to Chicago (ORD) · Nov 21, 2026 · return Nov 22, 2026: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued.
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