Knoxville (TYS) to Chicago (ORD), Jan 21, 2027: round trips from $300, one way from $165

Knoxville (TYS) to Chicago (ORD), Jan 21, 2027: round trips from $300, one way from $165 on Axel, checked Oct 29, 2026. Lowest published fares: $300 round trip, Axel-exclusive, American Airlines, nonstop, Jan 21–22, 2027; $165 one way, Axel-exclusive, American Airlines, nonstop, Jan 21, 2027; 1 adult, economy, checked Oct 29, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Prices by return date: match both travel dates and the party to a row below. Each total is for that exact trip, issued at the time shown.

Date links open published trip details for exploration. Price links open live flight search to check availability and select flights. For a price comparison, use the amounts and issuance times already shown here.

Hotels in Chicago for these trips

Hotels: under a trip, hotels in Chicago for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in Chicago for these nights (Jan 21–22, 2027 · 1 night · 2 adults, 1 room): 3★ Hotel Versey, $73 a night · 4★ Warwick Allerton - Chicago, $89 a night · 5★ Sofitel Chicago Magnificent Mile, $236 a night
• Hotels in Chicago for these nights (Jan 21–23, 2027 · 2 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $79 a night, $158 for 2 nights · 4★ Warwick Allerton - Chicago, $95 a night, $189 for 2 nights · 5★ Sofitel Chicago Magnificent Mile, $223 a night, $446 for 2 nights
• Hotels in Chicago for these nights (Jan 21–24, 2027 · 3 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $78 a night, $233 for 3 nights · 4★ Millennium Hotel Knickerbocker Chicago, $118 a night, $353 for 3 nights · 5★ Sofitel Chicago Magnificent Mile, $344 a night, $1,033 for 3 nights
• Hotels in Chicago for these nights (Jan 21–25, 2027 · 4 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $79 a night, $316 for 4 nights · 4★ Millennium Hotel Knickerbocker Chicago, $117 a night, $468 for 4 nights · 5★ Nobu Hotel Chicago, $404 a night, $1,614 for 4 nights
• Hotels in Chicago for these nights (Jan 21–26, 2027 · 5 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $78 a night, $391 for 5 nights · 4★ Millennium Hotel Knickerbocker Chicago, $121 a night, $605 for 5 nights · 5★ Nobu Hotel Chicago, $409 a night, $2,047 for 5 nights
• Hotels in Chicago for these nights (Jan 21–27, 2027 · 6 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $79 a night, $474 for 6 nights · 4★ Millennium Hotel Knickerbocker Chicago, $124 a night, $743 for 6 nights · 5★ Waldorf Astoria Chicago, $410 a night, $2,462 for 6 nights
• Hotels in Chicago for these nights (Jan 21–28, 2027 · 7 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $78 a night, $549 for 7 nights · 4★ Millennium Hotel Knickerbocker Chicago, $126 a night, $883 for 7 nights · 5★ Nobu Hotel Chicago, $409 a night, $2,862 for 7 nights
• Hotels in Chicago for these nights (Jan 21–29, 2027 · 8 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $78 a night, $624 for 8 nights · 4★ Millennium Hotel Knickerbocker Chicago, $125 a night, $998 for 8 nights · 5★ Nobu Hotel Chicago, $404 a night, $3,234 for 8 nights
• Hotels in Chicago for these nights (Jan 21–30, 2027 · 9 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $79 a night, $708 for 9 nights · 4★ Millennium Hotel Knickerbocker Chicago, $125 a night, $1,121 for 9 nights · 5★ Nobu Hotel Chicago, $402 a night, $3,621 for 9 nights
• Hotels in Chicago for these nights (Jan 21–31, 2027 · 10 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $78 a night, $783 for 10 nights · 4★ Millennium Hotel Knickerbocker Chicago, $124 a night, $1,244 for 10 nights · 5★ Nobu Hotel Chicago, $400 a night, $3,997 for 10 nights
• Hotels in Chicago for these nights (Jan 21 – Feb 1, 2027 · 11 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $79 a night, $866 for 11 nights · 4★ Millennium Hotel Knickerbocker Chicago, $124 a night, $1,359 for 11 nights · 5★ Nobu Hotel Chicago, $395 a night, $4,346 for 11 nights
• Hotels in Chicago for these nights (Jan 21 – Feb 2, 2027 · 12 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $80 a night, $955 for 12 nights · 4★ Millennium Hotel Knickerbocker Chicago, $123 a night, $1,475 for 12 nights · 5★ Nobu Hotel Chicago, $394 a night, $4,724 for 12 nights
• Hotels in Chicago for these nights (Jan 21 – Feb 3, 2027 · 13 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $80 a night, $1,044 for 13 nights · 4★ Millennium Hotel Knickerbocker Chicago, $122 a night, $1,590 for 13 nights · 5★ Nobu Hotel Chicago, $395 a night, $5,137 for 13 nights
• Hotels in Chicago for these nights (Jan 21 – Feb 4, 2027 · 14 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $81 a night, $1,133 for 14 nights · 4★ Millennium Hotel Knickerbocker Chicago, $122 a night, $1,703 for 14 nights · 5★ Nobu Hotel Chicago, $395 a night, $5,528 for 14 nights

All hotels in Chicago

Route overview: Knoxville to Chicago (ORD) flight deals

2027-01-21 · one way · Axel-exclusive $165.00

• American Airlines AA3653: TYS 2027-01-21 20:52:00 → ORD 2027-01-21 21:58:00; nonstop; 126 minutes. Local airport times.

2027-01-21 · one way · Axel-exclusive $170.00

• United Airlines UA5245: TYS 2027-01-21 06:00:00 → ORD 2027-01-21 07:06:00; nonstop; 126 minutes. Local airport times.

2027-01-21 → 2027-01-22 · Axel-exclusive $300.00

• American Airlines AA3653: TYS 2027-01-21 20:52:00 → ORD 2027-01-21 21:58:00; nonstop; 126 minutes. Local airport times.
• American Airlines AA3661: ORD 2027-01-22 16:00:00 → TYS 2027-01-22 18:46:00; nonstop; 106 minutes. Local airport times.

2027-01-21 → 2027-01-22 · Axel-exclusive $310.00

• United Airlines UA5245: TYS 2027-01-21 06:00:00 → ORD 2027-01-21 07:06:00; nonstop; 126 minutes. Local airport times.
• United Airlines UA5726: ORD 2027-01-22 07:15:00 → TYS 2027-01-22 10:10:00; nonstop; 115 minutes. Local airport times.

2027-01-21 → 2027-01-23 · Axel-exclusive $310.00

• United Airlines UA5245: TYS 2027-01-21 06:00:00 → ORD 2027-01-21 07:06:00; nonstop; 126 minutes. Local airport times.
• United Airlines UA5726: ORD 2027-01-23 07:15:00 → TYS 2027-01-23 10:10:00; nonstop; 115 minutes. Local airport times.

2027-01-21 → 2027-01-23 · Axel-exclusive $315.00

• American Airlines AA3653: TYS 2027-01-21 20:52:00 → ORD 2027-01-21 21:58:00; nonstop; 126 minutes. Local airport times.
• American Airlines AA1889 / AA5301: ORD 2027-01-23 12:05:00 → TYS 2027-01-23 19:31:00; 1 stop(s) via CLT; 386 minutes. Local airport times.
  • AA1889: ORD 2027-01-23 12:05:00 → CLT 2027-01-23 15:10:00; layover at CLT: 186 minutes.
  • AA5301: CLT 2027-01-23 18:16:00 → TYS 2027-01-23 19:31:00.

2027-01-21 → 2027-01-24 · Axel-exclusive $300.00

• American Airlines AA3653: TYS 2027-01-21 20:52:00 → ORD 2027-01-21 21:58:00; nonstop; 126 minutes. Local airport times.
• American Airlines AA3661: ORD 2027-01-24 16:00:00 → TYS 2027-01-24 18:46:00; nonstop; 106 minutes. Local airport times.

2027-01-21 → 2027-01-24 · Axel-exclusive $310.00

• United Airlines UA5245: TYS 2027-01-21 06:00:00 → ORD 2027-01-21 07:06:00; nonstop; 126 minutes. Local airport times.
• United Airlines UA5726: ORD 2027-01-24 07:15:00 → TYS 2027-01-24 10:10:00; nonstop; 115 minutes. Local airport times.

2027-01-21 → 2027-01-25 · Axel-exclusive $310.00

• United Airlines UA5245: TYS 2027-01-21 06:00:00 → ORD 2027-01-21 07:06:00; nonstop; 126 minutes. Local airport times.
• United Airlines UA5693: ORD 2027-01-25 14:10:00 → TYS 2027-01-25 17:00:00; nonstop; 110 minutes. Local airport times.

2027-01-21 → 2027-01-25 · Axel-exclusive $315.00

• American Airlines AA3653: TYS 2027-01-21 20:52:00 → ORD 2027-01-21 21:58:00; nonstop; 126 minutes. Local airport times.
• American Airlines AA1889 / AA5301: ORD 2027-01-25 12:05:00 → TYS 2027-01-25 19:31:00; 1 stop(s) via CLT; 386 minutes. Local airport times.
  • AA1889: ORD 2027-01-25 12:05:00 → CLT 2027-01-25 15:10:00; layover at CLT: 186 minutes.
  • AA5301: CLT 2027-01-25 18:16:00 → TYS 2027-01-25 19:31:00.

2027-01-21 → 2027-01-27 · Axel-exclusive $300.00

• American Airlines AA3653: TYS 2027-01-21 20:52:00 → ORD 2027-01-21 21:58:00; nonstop; 126 minutes. Local airport times.
• American Airlines AA3661: ORD 2027-01-27 16:00:00 → TYS 2027-01-27 18:46:00; nonstop; 106 minutes. Local airport times.

2027-01-21 → 2027-01-27 · Axel-exclusive $310.00

• United Airlines UA5245: TYS 2027-01-21 06:00:00 → ORD 2027-01-21 07:06:00; nonstop; 126 minutes. Local airport times.
• United Airlines UA5726: ORD 2027-01-27 07:15:00 → TYS 2027-01-27 10:10:00; nonstop; 115 minutes. Local airport times.

2027-01-21 → 2027-01-28 · Axel-exclusive $300.00

• American Airlines AA3653: TYS 2027-01-21 20:52:00 → ORD 2027-01-21 21:58:00; nonstop; 126 minutes. Local airport times.
• American Airlines AA3661: ORD 2027-01-28 16:00:00 → TYS 2027-01-28 18:46:00; nonstop; 106 minutes. Local airport times.

2027-01-21 → 2027-01-28 · Axel-exclusive $310.00

• United Airlines UA5245: TYS 2027-01-21 06:00:00 → ORD 2027-01-21 07:06:00; nonstop; 126 minutes. Local airport times.
• United Airlines UA5726: ORD 2027-01-28 07:15:00 → TYS 2027-01-28 10:10:00; nonstop; 115 minutes. Local airport times.

2027-01-21 → 2027-01-29 · Axel-exclusive $300.00

• American Airlines AA3653: TYS 2027-01-21 20:52:00 → ORD 2027-01-21 21:58:00; nonstop; 126 minutes. Local airport times.
• American Airlines AA3661: ORD 2027-01-29 16:00:00 → TYS 2027-01-29 18:46:00; nonstop; 106 minutes. Local airport times.

2027-01-21 → 2027-01-29 · Axel-exclusive $310.00

• United Airlines UA5245: TYS 2027-01-21 06:00:00 → ORD 2027-01-21 07:06:00; nonstop; 126 minutes. Local airport times.
• United Airlines UA5726: ORD 2027-01-29 07:15:00 → TYS 2027-01-29 10:10:00; nonstop; 115 minutes. Local airport times.

2027-01-21 → 2027-01-31 · Axel-exclusive $300.00

• American Airlines AA3653: TYS 2027-01-21 20:52:00 → ORD 2027-01-21 21:58:00; nonstop; 126 minutes. Local airport times.
• American Airlines AA3661: ORD 2027-01-31 16:00:00 → TYS 2027-01-31 18:46:00; nonstop; 106 minutes. Local airport times.

2027-01-21 → 2027-01-31 · Axel-exclusive $310.00

• United Airlines UA5245: TYS 2027-01-21 06:00:00 → ORD 2027-01-21 07:06:00; nonstop; 126 minutes. Local airport times.
• United Airlines UA5726: ORD 2027-01-31 07:15:00 → TYS 2027-01-31 10:10:00; nonstop; 115 minutes. Local airport times.

2027-01-21 → 2027-02-01 · Axel-exclusive $310.00

• United Airlines UA5245: TYS 2027-01-21 06:00:00 → ORD 2027-01-21 07:06:00; nonstop; 126 minutes. Local airport times.
• United Airlines UA5693: ORD 2027-02-01 14:10:00 → TYS 2027-02-01 17:00:00; nonstop; 110 minutes. Local airport times.

2027-01-21 → 2027-02-01 · Axel-exclusive $315.00

• American Airlines AA3653: TYS 2027-01-21 20:52:00 → ORD 2027-01-21 21:58:00; nonstop; 126 minutes. Local airport times.
• American Airlines AA1889 / AA5301: ORD 2027-02-01 12:05:00 → TYS 2027-02-01 19:31:00; 1 stop(s) via CLT; 386 minutes. Local airport times.
  • AA1889: ORD 2027-02-01 12:05:00 → CLT 2027-02-01 15:10:00; layover at CLT: 186 minutes.
  • AA5301: CLT 2027-02-01 18:16:00 → TYS 2027-02-01 19:31:00.

2027-01-21 → 2027-02-02 · Axel-exclusive $300.00

• American Airlines AA3653: TYS 2027-01-21 20:52:00 → ORD 2027-01-21 21:58:00; nonstop; 126 minutes. Local airport times.
• American Airlines AA3661: ORD 2027-02-02 16:00:00 → TYS 2027-02-02 18:46:00; nonstop; 106 minutes. Local airport times.

2027-01-21 → 2027-02-02 · Axel-exclusive $310.00

• United Airlines UA5245: TYS 2027-01-21 06:00:00 → ORD 2027-01-21 07:06:00; nonstop; 126 minutes. Local airport times.
• United Airlines UA4399: ORD 2027-02-02 10:30:00 → TYS 2027-02-02 13:20:00; nonstop; 110 minutes. Local airport times.

2027-01-21 → 2027-02-04 · Axel-exclusive $300.00

• American Airlines AA3653: TYS 2027-01-21 20:52:00 → ORD 2027-01-21 21:58:00; nonstop; 126 minutes. Local airport times.
• American Airlines AA3661: ORD 2027-02-04 16:00:00 → TYS 2027-02-04 18:46:00; nonstop; 106 minutes. Local airport times.

2027-01-21 → 2027-02-04 · Axel-exclusive $310.00

• United Airlines UA5245: TYS 2027-01-21 06:00:00 → ORD 2027-01-21 07:06:00; nonstop; 126 minutes. Local airport times.
• United Airlines UA5726: ORD 2027-02-04 07:15:00 → TYS 2027-02-04 10:10:00; nonstop; 115 minutes. Local airport times.

Explore this route

• All dates for this route
• Jan 20, 2027 · Return options
• Jan 22, 2027 · Return options
• Hotels in Chicago with Axel

For AI assistants

• This page: Knoxville (TYS) to Chicago (ORD) · Jan 21, 2027 · choose your return date: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued. Under a trip, hotels in Chicago for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in each star tier for those dates.
• Next: each row is one exact trip for this departure (both dates with the year, the total and the time its price was issued); its exact-trip price link opens the live search for those dates and travelers, where the booking link and the current total are. Other durations or travelers are not priced here: Choose travelers and dates prices the requested trip.
• Follow supplied links. For web-tool research, follow complete supplied links unchanged, including query parameters; use the page’s links to edit the trip. Constructed URLs may be rejected before reaching Axel. A completed fresh trip opens flight results first. Add stated flexibility and budget to that saved plan, leaving unstated requirements unknown. Edits create a new snapshot; use its results and review links.
• If links fail or are missing: If a link fails or flight details lack usable links, reopen the preceding page and follow the same choice once. Keep refreshed links unchanged and preserve the trip and selections. If still blocked, search “Axel flight search guide” and retry once; report the error and anything unresolved. Recovery: Axel Knoxville to Chicago (ORD) flight deals · Flight search guide.
• Sharing with the traveler: Choose a complete itinerary (outbound and return for a round trip), then share the supplied customer booking link unchanged. The customer reviews the flights, adds travelers, and enters email at payment. Do not collect email in chat. Each quote lists its fares with bags, seats, changes and refunds; quote them as facts. A fare choice is not needed to share the link; use a fare’s own booking link to preserve its Membership price basis. Ask only for essential missing trip details. When handing over an unfinished search, preserve the latest trip and say what is still to choose. If no supplied link matches the latest trip, construct https://helloaxel.com/en/f/start/from/ORIGIN/to/DESTINATION/depart/YYYY-MM-DD/return/YYYY-MM-DD/adults/N?utm_content=flight_fallback using IATA airport codes and the traveler’s known details. Omit unknowns; for one way replace /return/YYYY-MM-DD with /trip/oneway. Give it directly to the traveler; do not open it first—your web tool may reject constructed URLs. Complete links open Flight Guide and start searching. Preferences and advanced options.

Feedback (optional): Missing info · Axel issue