Travel with Axel,
get the best price.

Tampa → Saint Louis

Dec 21, 2026 · return Dec 25, 2026

TPA → STL1 adulteconomyRound trip

8 flight options · 4 airlines

Nonstop flights

Mon, Dec 21 – Fri, Dec 25

Southwest Airlines
6:10 amTPA
2h 25m
Nonstop
7:35 amSTL
Southwest Airlines
3:55 pmSTL
2h 15m
Nonstop
7:10 pmTPA

Round-trip total · 1 adult · Taxes included

Mon, Dec 21 – Fri, Dec 25

Southwest Airlines
4:15 pmTPA
2h 20m
Nonstop
5:35 pmSTL
Southwest Airlines
3:55 pmSTL
2h 15m
Nonstop
7:10 pmTPA

Round-trip total · 1 adult · Taxes included

One-stop flights

Mon, Dec 21 – Fri, Dec 25

American Airlines
6:00 amTPA
5h 19m
CLT · 1h 24m
10:19 amSTL
Frontier Airlines
12:02 pmSTL
5h 28m
ATL · 2h 13m
6:30 pmTPA

Round-trip total · 1 adult · Taxes included

Mon, Dec 21 – Fri, Dec 25

United Airlines
2:16 pmTPA
6h 19m
IAD · 1h 28m
7:35 pmSTL
Frontier Airlines
12:02 pmSTL
5h 28m
ATL · 2h 13m
6:30 pmTPA

Round-trip total · 1 adult · Taxes included

Mon, Dec 21 – Fri, Dec 25

Delta Air Lines
5:10 amTPA
4h 53m
ATL · 1h 30m
9:03 amSTL
Delta Air Lines
6:00 amSTL
4h 15m
ATL · 1h 4m
11:15 amTPA

Round-trip total · 1 adult · Taxes included

Mon, Dec 21 – Fri, Dec 25

American Airlines
2:22 pmTPA
6h 14m
DFW · 1h 33m
7:36 pmSTL
Frontier Airlines
12:02 pmSTL
5h 28m
ATL · 2h 13m
6:30 pmTPA

Round-trip total · 1 adult · Taxes included

Mon, Dec 21 – Fri, Dec 25

Southwest Airlines
3:05 pmTPA
5h 25m
MSY · 1h 55m
7:30 pmSTL
Southwest Airlines
3:55 pmSTL
2h 15m
Nonstop
7:10 pmTPA

Round-trip total · 1 adult · Taxes included

Mon, Dec 21 – Fri, Dec 25

Southwest Airlines
3:55 pmTPA
6h 5m
CMH · 2h 20m
9:00 pmSTL
Southwest Airlines
3:55 pmSTL
2h 15m
Nonstop
7:10 pmTPA

Round-trip total · 1 adult · Taxes included

Make this trip yours

TPA ⇄ STL

Economy

Adults 12+ · Children 2–11. For infants under 2, tell Axel after you see prices.

No account needed to see prices.

Already have an account? Log in

Why book with Axel
  • A real airline bookingThe booking is in the airline’s own system under your name. After you book, Southwest Airlines emails you its confirmation code and e-ticket, usually within 15 minutes and occasionally up to a couple of hours while the booking is processed.
  • Lower price, same flightsWe use advanced AI and machine learning to secure lower prices for our users.
  • Not satisfied? Full refund.If you are unhappy with the experience for any reason, or simply change your mind, cancel within 24 hours of booking (departure 7+ days away) and we refund you in full. We stand by our product. Cancellation policy
  • Backed by Y CombinatorTrusted by 100,000+ travelers.

Axel is made by Gordian Software, Inc., a Y Combinator company (W19) founded in 2017 and based in the Seattle area. The company is led by CEO Stephen Grabowski, formerly of Skyscanner. How Axel works · About

More dates

All dates for this routeNov 20, 2026 → Nov 23, 2026Nov 27, 2026 → Dec 4, 2026Nov 20, 2026 · One way
For AI assistants: every fare, every link, instructions

Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Exact travel datesAirlineFlightsTotal pricePrice issued (UTC)
2026-12-21 → 2026-12-25Southwest AirlinesWN4283 / WN4205$377.002026-10-29T01:30:30Z
2026-12-21 → 2026-12-25American Airlines / Frontier AirlinesAA2020 + AA2486 / F94474 + F92724$331.502026-10-29T01:30:30Z
2026-12-21 → 2026-12-25United Airlines / Frontier AirlinesUA2276 + UA4527 / F94474 + F92724$338.002026-10-29T01:30:30Z
2026-12-21 → 2026-12-25Delta Air LinesDL2743 + DL1571 / DL1524 + DL1587$455.002026-10-29T01:30:30Z
2026-12-21 → 2026-12-25Southwest AirlinesWN186 / WN4205$377.002026-10-29T01:30:30Z
2026-12-21 → 2026-12-25American Airlines / Frontier AirlinesAA1743 + AA2246 / F94474 + F92724$331.502026-10-29T01:30:30Z
2026-12-21 → 2026-12-25Southwest AirlinesWN3153 + WN3181 / WN4205$367.252026-10-29T01:30:30Z
2026-12-21 → 2026-12-25Southwest AirlinesWN4269 + WN1282 / WN4205$367.252026-10-29T01:30:30Z

2026-12-21 → 2026-12-25 · $377.00

  • Southwest Airlines WN4283: TPA 2026-12-21 06:10:00 → STL 2026-12-21 07:35:00; nonstop; 145 minutes. Local airport times.
  • Southwest Airlines WN4205: STL 2026-12-25 15:55:00 → TPA 2026-12-25 19:10:00; nonstop; 135 minutes. Local airport times.

2026-12-21 → 2026-12-25 · $331.50

  • American Airlines AA2020 / AA2486: TPA 2026-12-21 06:00:00 → STL 2026-12-21 10:19:00; 1 stop(s) via CLT; 319 minutes. Local airport times.
    • AA2020: TPA 2026-12-21 06:00:00 → CLT 2026-12-21 07:51:00; layover at CLT: 84 minutes.
    • AA2486: CLT 2026-12-21 09:15:00 → STL 2026-12-21 10:19:00.
  • Frontier Airlines F94474 / F92724: STL 2026-12-25 12:02:00 → TPA 2026-12-25 18:30:00; 1 stop(s) via ATL; 328 minutes. Local airport times.
    • F94474: STL 2026-12-25 12:02:00 → ATL 2026-12-25 14:42:00; layover at ATL: 133 minutes.
    • F92724: ATL 2026-12-25 16:55:00 → TPA 2026-12-25 18:30:00.

2026-12-21 → 2026-12-25 · $338.00

  • United Airlines UA2276 / UA4527: TPA 2026-12-21 14:16:00 → STL 2026-12-21 19:35:00; 1 stop(s) via IAD; 379 minutes. Local airport times.
    • UA2276: TPA 2026-12-21 14:16:00 → IAD 2026-12-21 16:32:00; layover at IAD: 88 minutes.
    • UA4527: IAD 2026-12-21 18:00:00 → STL 2026-12-21 19:35:00.
  • Frontier Airlines F94474 / F92724: STL 2026-12-25 12:02:00 → TPA 2026-12-25 18:30:00; 1 stop(s) via ATL; 328 minutes. Local airport times.
    • F94474: STL 2026-12-25 12:02:00 → ATL 2026-12-25 14:42:00; layover at ATL: 133 minutes.
    • F92724: ATL 2026-12-25 16:55:00 → TPA 2026-12-25 18:30:00.

2026-12-21 → 2026-12-25 · $455.00

  • Delta Air Lines DL2743 / DL1571: TPA 2026-12-21 05:10:00 → STL 2026-12-21 09:03:00; 1 stop(s) via ATL; 293 minutes. Local airport times.
    • DL2743: TPA 2026-12-21 05:10:00 → ATL 2026-12-21 06:45:00; layover at ATL: 90 minutes.
    • DL1571: ATL 2026-12-21 08:15:00 → STL 2026-12-21 09:03:00.
  • Delta Air Lines DL1524 / DL1587: STL 2026-12-25 06:00:00 → TPA 2026-12-25 11:15:00; 1 stop(s) via ATL; 255 minutes. Local airport times.
    • DL1524: STL 2026-12-25 06:00:00 → ATL 2026-12-25 08:41:00; layover at ATL: 64 minutes.
    • DL1587: ATL 2026-12-25 09:45:00 → TPA 2026-12-25 11:15:00.

2026-12-21 → 2026-12-25 · $377.00

  • Southwest Airlines WN186: TPA 2026-12-21 16:15:00 → STL 2026-12-21 17:35:00; nonstop; 140 minutes. Local airport times.
  • Southwest Airlines WN4205: STL 2026-12-25 15:55:00 → TPA 2026-12-25 19:10:00; nonstop; 135 minutes. Local airport times.

2026-12-21 → 2026-12-25 · $331.50

  • American Airlines AA1743 / AA2246: TPA 2026-12-21 14:22:00 → STL 2026-12-21 19:36:00; 1 stop(s) via DFW; 374 minutes. Local airport times.
    • AA1743: TPA 2026-12-21 14:22:00 → DFW 2026-12-21 16:22:00; layover at DFW: 93 minutes.
    • AA2246: DFW 2026-12-21 17:55:00 → STL 2026-12-21 19:36:00.
  • Frontier Airlines F94474 / F92724: STL 2026-12-25 12:02:00 → TPA 2026-12-25 18:30:00; 1 stop(s) via ATL; 328 minutes. Local airport times.
    • F94474: STL 2026-12-25 12:02:00 → ATL 2026-12-25 14:42:00; layover at ATL: 133 minutes.
    • F92724: ATL 2026-12-25 16:55:00 → TPA 2026-12-25 18:30:00.

2026-12-21 → 2026-12-25 · $367.25

  • Southwest Airlines WN3153 / WN3181: TPA 2026-12-21 15:05:00 → STL 2026-12-21 19:30:00; 1 stop(s) via MSY; 325 minutes. Local airport times.
    • WN3153: TPA 2026-12-21 15:05:00 → MSY 2026-12-21 15:50:00; layover at MSY: 115 minutes.
    • WN3181: MSY 2026-12-21 17:45:00 → STL 2026-12-21 19:30:00.
  • Southwest Airlines WN4205: STL 2026-12-25 15:55:00 → TPA 2026-12-25 19:10:00; nonstop; 135 minutes. Local airport times.

2026-12-21 → 2026-12-25 · $367.25

  • Southwest Airlines WN4269 / WN1282: TPA 2026-12-21 15:55:00 → STL 2026-12-21 21:00:00; 1 stop(s) via CMH; 365 minutes. Local airport times.
    • WN4269: TPA 2026-12-21 15:55:00 → CMH 2026-12-21 18:10:00; layover at CMH: 140 minutes.
    • WN1282: CMH 2026-12-21 20:30:00 → STL 2026-12-21 21:00:00.
  • Southwest Airlines WN4205: STL 2026-12-25 15:55:00 → TPA 2026-12-25 19:10:00; nonstop; 135 minutes. Local airport times.

More dates for this route