San Francisco (SFO) to Panama City (PTY), Nov 22, 2026: round trips from $530, one way from $275

San Francisco (SFO) to Panama City (PTY), Nov 22, 2026: round trips from $530, one way from $275 on Axel, checked Oct 29, 2026. Lowest published fares: $530 round trip, Axel-exclusive, Avianca, 1 stop, Nov 22–23, 2026; $275 one way, Axel-exclusive, Avianca, 1 stop, Nov 22, 2026; 1 adult, economy, checked Oct 29, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Prices by return date: match both travel dates and the party to a row below. Each total is for that exact trip, issued at the time shown.

Date links open published trip details for exploration. Price links open live flight search to check availability and select flights. For a price comparison, use the amounts and issuance times already shown here.

Hotels in Panama City for these trips

Hotels: under a trip, hotels in Panama City for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in Panama City for these nights (Nov 22–23, 2026 · 1 night · 2 adults, 1 room): 3★ MARINN Tropical Vibes Hotel, $44 total · 4★ Hospedium Princess Hotel Panama, $52 total · 5★ Renaissance Panama City Hotel, $124 total
• Hotels in Panama City for these nights (Nov 22–24, 2026 · 2 nights · 2 adults, 1 room): 3★ MARINN Tropical Vibes Hotel, $84 total · 4★ Hospedium Princess Hotel Panama, $94 total · 5★ Renaissance Panama City Hotel, $231 total
• Hotels in Panama City for these nights (Nov 22–25, 2026 · 3 nights · 2 adults, 1 room): 3★ MARINN Tropical Vibes Hotel, $128 total · 4★ Hospedium Princess Hotel Panama, $136 total · 5★ Renaissance Panama City Hotel, $336 total
• Hotels in Panama City for these nights (Nov 22–26, 2026 · 4 nights · 2 adults, 1 room): 3★ MARINN Tropical Vibes Hotel, $172 total · 4★ Hospedium Princess Hotel Panama, $178 total · 5★ Renaissance Panama City Hotel, $443 total
• Hotels in Panama City for these nights (Nov 22–27, 2026 · 5 nights · 2 adults, 1 room): 3★ MARINN Tropical Vibes Hotel, $216 total · 4★ Hospedium Princess Hotel Panama, $230 total · 5★ Renaissance Panama City Hotel, $567 total
• Hotels in Panama City for these nights (Nov 22–28, 2026 · 6 nights · 2 adults, 1 room): 3★ MARINN Tropical Vibes Hotel, $266 total · 4★ Hospedium Princess Hotel Panama, $291 total · 5★ Renaissance Panama City Hotel, $678 total
• Hotels in Panama City for these nights (Nov 22–29, 2026 · 7 nights · 2 adults, 1 room): 3★ MARINN Tropical Vibes Hotel, $328 total · 4★ Hospedium Princess Hotel Panama, $343 total · 5★ Renaissance Panama City Hotel, $794 total
• Hotels in Panama City for these nights (Nov 22–30, 2026 · 8 nights · 2 adults, 1 room): 3★ MARINN Tropical Vibes Hotel, $378 total · 4★ Hospedium Princess Hotel Panama, $385 total · 5★ Renaissance Panama City Hotel, $918 total
• Hotels in Panama City for these nights (Nov 22 – Dec 1, 2026 · 9 nights · 2 adults, 1 room): 3★ MARINN Tropical Vibes Hotel, $421 total · 4★ Hospedium Princess Hotel Panama, $427 total · 5★ Renaissance Panama City Hotel, $1,042 total
• Hotels in Panama City for these nights (Nov 22 – Dec 2, 2026 · 10 nights · 2 adults, 1 room): 3★ MARINN Tropical Vibes Hotel, $466 total · 4★ Hospedium Princess Hotel Panama, $469 total · 5★ Renaissance Panama City Hotel, $1,151 total
• Hotels in Panama City for these nights (Nov 22 – Dec 3, 2026 · 11 nights · 2 adults, 1 room): 3★ MARINN Tropical Vibes Hotel, $509 total · 4★ Hospedium Princess Hotel Panama, $511 total · 5★ Renaissance Panama City Hotel, $1,251 total
• Hotels in Panama City for these nights (Nov 22 – Dec 4, 2026 · 12 nights · 2 adults, 1 room): 3★ MARINN Tropical Vibes Hotel, $554 total · 4★ Hospedium Princess Hotel Panama, $553 total · 5★ Renaissance Panama City Hotel, $1,366 total
• Hotels in Panama City for these nights (Nov 22 – Dec 5, 2026 · 13 nights · 2 adults, 1 room): 3★ MARINN Tropical Vibes Hotel, $611 total · 4★ Hospedium Princess Hotel Panama, $599 total · 5★ Renaissance Panama City Hotel, $1,468 total
• Hotels in Panama City for these nights (Nov 22 – Dec 6, 2026 · 14 nights · 2 adults, 1 room): 3★ MARINN Tropical Vibes Hotel, $667 total · 4★ Hospedium Princess Hotel Panama, $645 total · 5★ Renaissance Panama City Hotel, $1,581 total

All hotels in Panama City

Route overview: San Francisco Bay Area to Panama City (PTY) flight deals

2026-11-22 · one way · Axel-exclusive $275.00

• Avianca AV563 / AV317: SFO 2026-11-22 13:15:00 → PTY 2026-11-23 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  • AV563: SFO 2026-11-22 13:15:00 → SAL 2026-11-22 20:50:00; layover at SAL: 135 minutes.
  • AV317: SAL 2026-11-22 23:05:00 → PTY 2026-11-23 02:10:00.

2026-11-22 · one way · Axel-exclusive $365.00

• Copa Airlines CM383: SFO 2026-11-22 00:33:00 → PTY 2026-11-22 10:46:00; nonstop; 433 minutes. Local airport times.

2026-11-22 → 2026-11-23 · Axel-exclusive $530.00

• Avianca AV563 / AV317: SFO 2026-11-22 13:15:00 → PTY 2026-11-23 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  • AV563: SFO 2026-11-22 13:15:00 → SAL 2026-11-22 20:50:00; layover at SAL: 135 minutes.
  • AV317: SAL 2026-11-22 23:05:00 → PTY 2026-11-23 02:10:00.
• Avianca AV316 / AV562: PTY 2026-11-23 05:30:00 → SFO 2026-11-23 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  • AV316: PTY 2026-11-23 05:30:00 → SAL 2026-11-23 06:30:00; layover at SAL: 75 minutes.
  • AV562: SAL 2026-11-23 07:45:00 → SFO 2026-11-23 11:55:00.

2026-11-22 → 2026-11-23 · Axel-exclusive $690.00

• Copa Airlines CM383: SFO 2026-11-22 00:33:00 → PTY 2026-11-22 10:46:00; nonstop; 433 minutes. Local airport times.
• Copa Airlines CM382: PTY 2026-11-23 18:31:00 → SFO 2026-11-23 23:12:00; nonstop; 461 minutes. Local airport times.

2026-11-22 → 2026-11-24 · Axel-exclusive $577.70

• Avianca AV563 / AV317: SFO 2026-11-22 13:15:00 → PTY 2026-11-23 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  • AV563: SFO 2026-11-22 13:15:00 → SAL 2026-11-22 20:50:00; layover at SAL: 135 minutes.
  • AV317: SAL 2026-11-22 23:05:00 → PTY 2026-11-23 02:10:00.
• Avianca AV316 / AV562: PTY 2026-11-24 05:30:00 → SFO 2026-11-24 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  • AV316: PTY 2026-11-24 05:30:00 → SAL 2026-11-24 06:30:00; layover at SAL: 75 minutes.
  • AV562: SAL 2026-11-24 07:45:00 → SFO 2026-11-24 11:55:00.

2026-11-22 → 2026-11-24 · Axel-exclusive $752.10

• Copa Airlines CM383: SFO 2026-11-22 00:33:00 → PTY 2026-11-22 10:46:00; nonstop; 433 minutes. Local airport times.
• Copa Airlines CM382: PTY 2026-11-24 18:31:00 → SFO 2026-11-24 23:12:00; nonstop; 461 minutes. Local airport times.

2026-11-22 → 2026-11-25 · Axel-exclusive $577.70

• Avianca AV563 / AV317: SFO 2026-11-22 13:15:00 → PTY 2026-11-23 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  • AV563: SFO 2026-11-22 13:15:00 → SAL 2026-11-22 20:50:00; layover at SAL: 135 minutes.
  • AV317: SAL 2026-11-22 23:05:00 → PTY 2026-11-23 02:10:00.
• Avianca AV316 / AV562: PTY 2026-11-25 05:30:00 → SFO 2026-11-25 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  • AV316: PTY 2026-11-25 05:30:00 → SAL 2026-11-25 06:30:00; layover at SAL: 75 minutes.
  • AV562: SAL 2026-11-25 07:45:00 → SFO 2026-11-25 11:55:00.

2026-11-22 → 2026-11-25 · Axel-exclusive $752.10

• Copa Airlines CM383: SFO 2026-11-22 00:33:00 → PTY 2026-11-22 10:46:00; nonstop; 433 minutes. Local airport times.
• Copa Airlines CM408: PTY 2026-11-25 12:44:00 → SFO 2026-11-25 17:25:00; nonstop; 461 minutes. Local airport times.

2026-11-22 → 2026-11-26 · Axel-exclusive $577.70

• Avianca AV563 / AV317: SFO 2026-11-22 13:15:00 → PTY 2026-11-23 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  • AV563: SFO 2026-11-22 13:15:00 → SAL 2026-11-22 20:50:00; layover at SAL: 135 minutes.
  • AV317: SAL 2026-11-22 23:05:00 → PTY 2026-11-23 02:10:00.
• Avianca AV316 / AV562: PTY 2026-11-26 05:30:00 → SFO 2026-11-26 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  • AV316: PTY 2026-11-26 05:30:00 → SAL 2026-11-26 06:30:00; layover at SAL: 75 minutes.
  • AV562: SAL 2026-11-26 07:45:00 → SFO 2026-11-26 11:55:00.

2026-11-22 → 2026-11-26 · Axel-exclusive $752.10

• Copa Airlines CM383: SFO 2026-11-22 00:33:00 → PTY 2026-11-22 10:46:00; nonstop; 433 minutes. Local airport times.
• Copa Airlines CM382: PTY 2026-11-26 18:31:00 → SFO 2026-11-26 23:17:00; nonstop; 466 minutes. Local airport times.

2026-11-22 → 2026-11-28 · Axel-exclusive $577.70

• Avianca AV563 / AV317: SFO 2026-11-22 13:15:00 → PTY 2026-11-23 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  • AV563: SFO 2026-11-22 13:15:00 → SAL 2026-11-22 20:50:00; layover at SAL: 135 minutes.
  • AV317: SAL 2026-11-22 23:05:00 → PTY 2026-11-23 02:10:00.
• Avianca AV316 / AV562: PTY 2026-11-28 05:30:00 → SFO 2026-11-28 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  • AV316: PTY 2026-11-28 05:30:00 → SAL 2026-11-28 06:30:00; layover at SAL: 75 minutes.
  • AV562: SAL 2026-11-28 07:45:00 → SFO 2026-11-28 11:55:00.

2026-11-22 → 2026-11-28 · Axel-exclusive $752.10

• Copa Airlines CM383: SFO 2026-11-22 00:33:00 → PTY 2026-11-22 10:46:00; nonstop; 433 minutes. Local airport times.
• Copa Airlines CM408: PTY 2026-11-28 12:40:00 → SFO 2026-11-28 17:25:00; nonstop; 465 minutes. Local airport times.

2026-11-22 → 2026-11-29 · Axel-exclusive $577.70

• Avianca AV563 / AV317: SFO 2026-11-22 13:15:00 → PTY 2026-11-23 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  • AV563: SFO 2026-11-22 13:15:00 → SAL 2026-11-22 20:50:00; layover at SAL: 135 minutes.
  • AV317: SAL 2026-11-22 23:05:00 → PTY 2026-11-23 02:10:00.
• Avianca AV316 / AV562: PTY 2026-11-29 05:30:00 → SFO 2026-11-29 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  • AV316: PTY 2026-11-29 05:30:00 → SAL 2026-11-29 06:30:00; layover at SAL: 75 minutes.
  • AV562: SAL 2026-11-29 07:45:00 → SFO 2026-11-29 11:55:00.

2026-11-22 → 2026-11-29 · Axel-exclusive $752.10

• Copa Airlines CM383: SFO 2026-11-22 00:33:00 → PTY 2026-11-22 10:46:00; nonstop; 433 minutes. Local airport times.
• Copa Airlines CM382: PTY 2026-11-29 18:31:00 → SFO 2026-11-29 23:12:00; nonstop; 461 minutes. Local airport times.

2026-11-22 → 2026-11-30 · Axel-exclusive $577.70

• Avianca AV563 / AV317: SFO 2026-11-22 13:15:00 → PTY 2026-11-23 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  • AV563: SFO 2026-11-22 13:15:00 → SAL 2026-11-22 20:50:00; layover at SAL: 135 minutes.
  • AV317: SAL 2026-11-22 23:05:00 → PTY 2026-11-23 02:10:00.
• Avianca AV316 / AV562: PTY 2026-11-30 05:30:00 → SFO 2026-11-30 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  • AV316: PTY 2026-11-30 05:30:00 → SAL 2026-11-30 06:30:00; layover at SAL: 75 minutes.
  • AV562: SAL 2026-11-30 07:45:00 → SFO 2026-11-30 11:55:00.

2026-11-22 → 2026-11-30 · Axel-exclusive $752.10

• Copa Airlines CM383: SFO 2026-11-22 00:33:00 → PTY 2026-11-22 10:46:00; nonstop; 433 minutes. Local airport times.
• Copa Airlines CM408: PTY 2026-11-30 12:40:00 → SFO 2026-11-30 17:25:00; nonstop; 465 minutes. Local airport times.

2026-11-22 → 2026-12-02 · Axel-exclusive $530.00

• Avianca AV563 / AV317: SFO 2026-11-22 13:15:00 → PTY 2026-11-23 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  • AV563: SFO 2026-11-22 13:15:00 → SAL 2026-11-22 20:50:00; layover at SAL: 135 minutes.
  • AV317: SAL 2026-11-22 23:05:00 → PTY 2026-11-23 02:10:00.
• Avianca AV316 / AV562: PTY 2026-12-02 05:30:00 → SFO 2026-12-02 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  • AV316: PTY 2026-12-02 05:30:00 → SAL 2026-12-02 06:30:00; layover at SAL: 75 minutes.
  • AV562: SAL 2026-12-02 07:45:00 → SFO 2026-12-02 11:55:00.

2026-11-22 → 2026-12-02 · Axel-exclusive $690.00

• Copa Airlines CM383: SFO 2026-11-22 00:33:00 → PTY 2026-11-22 10:46:00; nonstop; 433 minutes. Local airport times.
• Copa Airlines CM408: PTY 2026-12-02 12:40:00 → SFO 2026-12-02 17:25:00; nonstop; 465 minutes. Local airport times.

2026-11-22 → 2026-12-03 · Axel-exclusive $530.00

• Avianca AV563 / AV317: SFO 2026-11-22 13:15:00 → PTY 2026-11-23 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  • AV563: SFO 2026-11-22 13:15:00 → SAL 2026-11-22 20:50:00; layover at SAL: 135 minutes.
  • AV317: SAL 2026-11-22 23:05:00 → PTY 2026-11-23 02:10:00.
• Avianca AV316 / AV562: PTY 2026-12-03 05:30:00 → SFO 2026-12-03 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  • AV316: PTY 2026-12-03 05:30:00 → SAL 2026-12-03 06:30:00; layover at SAL: 75 minutes.
  • AV562: SAL 2026-12-03 07:45:00 → SFO 2026-12-03 11:55:00.

2026-11-22 → 2026-12-03 · Axel-exclusive $690.00

• Copa Airlines CM383: SFO 2026-11-22 00:33:00 → PTY 2026-11-22 10:46:00; nonstop; 433 minutes. Local airport times.
• Copa Airlines CM382: PTY 2026-12-03 18:31:00 → SFO 2026-12-03 23:17:00; nonstop; 466 minutes. Local airport times.

2026-11-22 → 2026-12-04 · Axel-exclusive $530.00

• Avianca AV563 / AV317: SFO 2026-11-22 13:15:00 → PTY 2026-11-23 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  • AV563: SFO 2026-11-22 13:15:00 → SAL 2026-11-22 20:50:00; layover at SAL: 135 minutes.
  • AV317: SAL 2026-11-22 23:05:00 → PTY 2026-11-23 02:10:00.
• Avianca AV316 / AV562: PTY 2026-12-04 05:30:00 → SFO 2026-12-04 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  • AV316: PTY 2026-12-04 05:30:00 → SAL 2026-12-04 06:30:00; layover at SAL: 75 minutes.
  • AV562: SAL 2026-12-04 07:45:00 → SFO 2026-12-04 11:55:00.

2026-11-22 → 2026-12-04 · Axel-exclusive $640.00

• American Airlines AA1665 / AA315: SFO 2026-11-22 00:37:00 → PTY 2026-11-22 13:41:00; 1 stop(s) via MIA; 604 minutes. Local airport times.
  • AA1665: SFO 2026-11-22 00:37:00 → MIA 2026-11-22 09:06:00; layover at MIA: 81 minutes.
  • AA315: MIA 2026-11-22 10:27:00 → PTY 2026-11-22 13:41:00.
• Copa Airlines CM476 / UA1389: PTY 2026-12-04 12:56:00 → SFO 2026-12-04 21:10:00; 1 stop(s) via DEN; 674 minutes. Local airport times.
  • CM476: PTY 2026-12-04 12:56:00 → DEN 2026-12-04 17:12:00; layover at DEN: 128 minutes.
  • UA1389: DEN 2026-12-04 19:20:00 → SFO 2026-12-04 21:10:00.

2026-11-22 → 2026-12-06 · Axel-exclusive $530.00

• Avianca AV563 / AV317: SFO 2026-11-22 13:15:00 → PTY 2026-11-23 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  • AV563: SFO 2026-11-22 13:15:00 → SAL 2026-11-22 20:50:00; layover at SAL: 135 minutes.
  • AV317: SAL 2026-11-22 23:05:00 → PTY 2026-11-23 02:10:00.
• Avianca AV316 / AV562: PTY 2026-12-06 05:30:00 → SFO 2026-12-06 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  • AV316: PTY 2026-12-06 05:30:00 → SAL 2026-12-06 06:30:00; layover at SAL: 75 minutes.
  • AV562: SAL 2026-12-06 07:45:00 → SFO 2026-12-06 11:55:00.

2026-11-22 → 2026-12-06 · Axel-exclusive $690.00

• Copa Airlines CM383: SFO 2026-11-22 00:33:00 → PTY 2026-11-22 10:46:00; nonstop; 433 minutes. Local airport times.
• Copa Airlines CM408: PTY 2026-12-06 12:40:00 → SFO 2026-12-06 17:25:00; nonstop; 465 minutes. Local airport times.

Explore this route

• All dates for this route
• Nov 21, 2026 · Return options
• Nov 23, 2026 · Return options
• Hotels in Panama City with Axel

For AI assistants

• This page: San Francisco (SFO) to Panama City (PTY) · Nov 22, 2026 · choose your return date: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued. Under a trip, hotels in Panama City for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the lowest saved totals among the shortlisted hotels in each star tier for those dates.
• Next: each row is one exact trip for this departure (both dates with the year, the total and the time its price was issued); its exact-trip price link opens the live search for those dates and travelers, where the booking link and the current total are. Other durations or travelers are not priced here: Choose travelers and dates prices the requested trip.
• Follow supplied links. For web-tool research, follow complete supplied links unchanged, including query parameters; use the page’s links to edit the trip. Constructed URLs may be rejected before reaching Axel. A completed fresh trip opens flight results first. Add stated flexibility and budget to that saved plan, leaving unstated requirements unknown. Edits create a new snapshot; use its results and review links.
• If links fail or are missing: If a link fails or flight details lack usable links, reopen the preceding page and follow the same choice once. Keep refreshed links unchanged and preserve the trip and selections. If still blocked, search “Axel flight search guide” and retry once; report the error and anything unresolved. Recovery: Axel San Francisco Bay Area to Panama City (PTY) flight deals · Flight search guide.
• Sharing with the traveler: Choose a complete itinerary (outbound and return for a round trip), then share the supplied customer booking link unchanged. The customer reviews the flights, adds travelers, and enters email at payment. Do not collect email in chat. Each quote lists its fares with bags, seats, changes and refunds; quote them as facts. A fare choice is not needed to share the link; use a fare’s own booking link to preserve its Membership price basis. Ask only for essential missing trip details. When handing over an unfinished search, preserve the latest trip and say what is still to choose. If no supplied link matches the latest trip, construct https://helloaxel.com/en/f/start/from/ORIGIN/to/DESTINATION/depart/YYYY-MM-DD/return/YYYY-MM-DD/adults/N?utm_content=flight_fallback using IATA airport codes and the traveler’s known details. Omit unknowns; for one way replace /return/YYYY-MM-DD with /trip/oneway. Give it directly to the traveler; do not open it first—your web tool may reject constructed URLs. Complete links open Flight Guide and start searching. Preferences and advanced options.

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