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San Francisco → Panama City

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SFO → PTY1 adulteconomy

22 flight options · 4 airlines

Round-trip flights

Fri, Nov 20 – Mon, Nov 23

Copa Airlines
7:36 pmSFO
7h 9m
Nonstop
5:45 am+1PTY
Copa Airlines
6:31 pmPTY
7h 41m
Nonstop
11:12 pmSFO

Round-trip total · 1 adult · Taxes included

Fri, Nov 20 – Mon, Nov 23

Avianca
1:15 pmSFO
9h 55m
SAL · 2h 15m
2:10 am+1PTY
Avianca
5:30 amPTY
9h 25m
SAL · 1h 15m
11:55 amSFO

Round-trip total · 1 adult · Taxes included

Fri, Nov 20 – Mon, Nov 23

United Airlines
7:15 amSFO
10h 4m
FLL · 1h 23m
8:19 pmPTY
United Airlines
8:55 amPTY
11h 12m
IAH · 2h 30m
5:07 pmSFO

Round-trip total · 1 adult · Taxes included

Fri, Nov 20 – Mon, Nov 23

American Airlines
12:37 amSFO
10h 4m
MIA · 1h 21m
1:41 pmPTY
Copa Airlines
6:31 pmPTY
7h 41m
Nonstop
11:12 pmSFO

Round-trip total · 1 adult · Taxes included

Fri, Nov 27 – Fri, Dec 4

Avianca
1:15 pmSFO
9h 55m
SAL · 2h 15m
2:10 am+1PTY
Avianca
5:30 amPTY
9h 25m
SAL · 1h 15m
11:55 amSFO

Round-trip total · 1 adult · Taxes included

Fri, Nov 20 – Mon, Nov 23

Copa Airlines
12:33 amSFO
7h 13m
Nonstop
10:46 amPTY
Copa Airlines
6:31 pmPTY
7h 41m
Nonstop
11:12 pmSFO

Round-trip total · 1 adult · Taxes included

Fri, Nov 20 – Mon, Nov 23

United Airlines
7:29 amSFO
9h 58m
MCO · 1h 16m
8:27 pmPTY
United Airlines
8:55 amPTY
11h 12m
IAH · 2h 30m
5:07 pmSFO

Round-trip total · 1 adult · Taxes included

Fri, Nov 20 – Mon, Nov 23

United Airlines
9:05 pmSFO
10h 9m
LAS · 2h 2m
10:14 am+1PTY
United Airlines
8:55 amPTY
11h 12m
IAH · 2h 30m
5:07 pmSFO

Round-trip total · 1 adult · Taxes included

Show 6 more flights

Fri, Nov 20 – Mon, Nov 23

United Airlines
9:22 pmSFO
9h 28m
LAX · 1h 23m
9:50 am+1PTY
United Airlines
8:55 amPTY
11h 12m
IAH · 2h 30m
5:07 pmSFO

Round-trip total · 1 adult · Taxes included

Fri, Nov 27 – Fri, Dec 4

American Airlines
12:37 amSFO
10h 4m
MIA · 1h 21m
1:41 pmPTY
Copa Airlines
12:56 pmPTY
11h 14m
DEN · 2h 8m
9:10 pmSFO

Round-trip total · 1 adult · Taxes included

Fri, Nov 27 – Fri, Dec 4

Copa Airlines
12:33 amSFO
7h 13m
Nonstop
10:46 amPTY
Copa Airlines
12:56 pmPTY
11h 14m
DEN · 2h 8m
9:10 pmSFO

Round-trip total · 1 adult · Taxes included

Fri, Nov 27 – Fri, Dec 4

United Airlines
9:22 pmSFO
9h 28m
LAX · 1h 23m
9:50 am+1PTY
United Airlines
8:55 amPTY
11h 12m
IAH · 2h 30m
5:07 pmSFO

Round-trip total · 1 adult · Taxes included

Fri, Nov 27 – Fri, Dec 4

United Airlines
7:29 amSFO
9h 58m
MCO · 1h 16m
8:27 pmPTY
United Airlines
8:55 amPTY
11h 12m
IAH · 2h 30m
5:07 pmSFO

Round-trip total · 1 adult · Taxes included

Fri, Nov 27 – Fri, Dec 4

United Airlines
7:15 amSFO
10h 4m
FLL · 1h 23m
8:19 pmPTY
United Airlines
8:55 amPTY
11h 12m
IAH · 2h 30m
5:07 pmSFO

Round-trip total · 1 adult · Taxes included

One-way flights

Fri, Nov 20 · One way

Copa Airlines
7:36 pmSFO
7h 9m
Nonstop
5:45 am+1PTY

One-way total · 1 adult · Taxes included

Fri, Nov 20 · One way

Avianca
1:15 pmSFO
9h 55m
SAL · 2h 15m
2:10 am+1PTY

One-way total · 1 adult · Taxes included

Fri, Nov 20 · One way

American Airlines
12:37 amSFO
10h 4m
MIA · 1h 21m
1:41 pmPTY

One-way total · 1 adult · Taxes included

Fri, Nov 20 · One way

United Airlines
9:22 pmSFO
9h 28m
LAX · 1h 23m
9:50 am+1PTY

One-way total · 1 adult · Taxes included

Fri, Nov 20 · One way

Copa Airlines
12:33 amSFO
7h 13m
Nonstop
10:46 amPTY

One-way total · 1 adult · Taxes included

Fri, Nov 20 · One way

United Airlines
7:29 amSFO
9h 58m
MCO · 1h 16m
8:27 pmPTY

One-way total · 1 adult · Taxes included

Fri, Nov 20 · One way

United Airlines
7:15 amSFO
10h 4m
FLL · 1h 23m
8:19 pmPTY

One-way total · 1 adult · Taxes included

Fri, Nov 20 · One way

United Airlines
9:05 pmSFO
10h 9m
LAS · 2h 2m
10:14 am+1PTY

One-way total · 1 adult · Taxes included

Make this trip yours

SFO ⇄ PTY

Economy

Adults 12+ · Children 2–11. For infants under 2, tell Axel after you see prices.

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Why book with Axel
  • A real airline bookingThe booking is in the airline’s own system under your name. After you book, Copa Airlines emails you its confirmation code and e-ticket, usually within 15 minutes and occasionally up to a couple of hours while the booking is processed.
  • Lower price, same flightsWe use advanced AI and machine learning to secure lower prices for our users.
  • 24-hour cancellationCancel within 24 hours of booking for a full refund when your departure is at least 7 days away. Closer to departure, the airline’s fare rules apply. Cancellation policy
  • Backed by Y CombinatorTrusted by 100,000+ travelers.

Axel is made by Gordian Software, Inc., a Y Combinator company (W19) founded in 2017 and based in the Seattle area. The company is led by CEO Stephen Grabowski, formerly of Skyscanner. How Axel works · About

More dates

Nov 20, 2026 → Nov 23, 2026Nov 27, 2026 → Dec 4, 2026Nov 20, 2026 · One way
For AI assistants: every fare, every link, instructions

Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Exact travel datesAirlineFlightsTotal pricePrice issued (UTC)
2026-11-20 · one wayCopa AirlinesCM409$365.002026-10-29T02:07:07Z
2026-11-20 → 2026-11-23Copa AirlinesCM409 / CM382$690.002026-10-29T02:07:07Z
2026-11-20 · one wayAviancaAV563 + AV317$275.002026-10-29T02:07:07Z
2026-11-20 · one wayAmerican AirlinesAA1665 + AA315$335.002026-10-29T02:07:07Z
2026-11-20 · one wayUnited AirlinesUA2862 + CM473$345.002026-10-29T02:07:07Z
2026-11-20 → 2026-11-23AviancaAV563 + AV317 / AV316 + AV562$530.002026-10-29T02:07:07Z
2026-11-20 → 2026-11-23United AirlinesUA2722 + CM266 / UA1249 + UA589$670.002026-10-29T02:07:07Z
2026-11-20 → 2026-11-23American Airlines / Copa AirlinesAA1665 + AA315 / CM382$670.002026-10-29T02:07:07Z
2026-11-27 → 2026-12-04AviancaAV563 + AV317 / AV316 + AV562$577.702026-10-29T02:07:07Z
2026-11-20 · one wayCopa AirlinesCM383$365.002026-10-29T02:07:07Z
2026-11-20 → 2026-11-23Copa AirlinesCM383 / CM382$690.002026-10-29T02:07:07Z
2026-11-20 · one wayUnited AirlinesUA1491 + CM445$345.002026-10-29T02:07:07Z
2026-11-20 · one wayUnited AirlinesUA2722 + CM266$345.002026-10-29T02:07:07Z
2026-11-20 · one wayUnited AirlinesUA406 + CM253$345.002026-10-29T02:07:07Z
2026-11-20 → 2026-11-23United AirlinesUA1491 + CM445 / UA1249 + UA589$670.002026-10-29T02:07:07Z
2026-11-20 → 2026-11-23United AirlinesUA406 + CM253 / UA1249 + UA589$670.002026-10-29T02:07:07Z
2026-11-20 → 2026-11-23United AirlinesUA2862 + CM473 / UA1249 + UA589$670.002026-10-29T02:07:07Z
2026-11-27 → 2026-12-04American Airlines / Copa AirlinesAA1665 + AA315 / CM476 + UA1389$698.502026-10-29T02:07:07Z
2026-11-27 → 2026-12-04Copa AirlinesCM383 / CM476 + UA1389$722.102026-10-29T02:07:07Z
2026-11-27 → 2026-12-04United AirlinesUA2862 + CM473 / UA1249 + UA589$730.302026-10-29T02:07:07Z
2026-11-27 → 2026-12-04United AirlinesUA1491 + CM445 / UA1249 + UA589$730.302026-10-29T02:07:07Z
2026-11-27 → 2026-12-04United AirlinesUA2722 + CM266 / UA1249 + UA589$730.302026-10-29T02:07:07Z

2026-11-20 · one way · $365.00

  • Copa Airlines CM409: SFO 2026-11-20 19:36:00 → PTY 2026-11-21 05:45:00; nonstop; 429 minutes. Local airport times.

2026-11-20 → 2026-11-23 · $690.00

  • Copa Airlines CM409: SFO 2026-11-20 19:36:00 → PTY 2026-11-21 05:45:00; nonstop; 429 minutes. Local airport times.
  • Copa Airlines CM382: PTY 2026-11-23 18:31:00 → SFO 2026-11-23 23:12:00; nonstop; 461 minutes. Local airport times.

2026-11-20 · one way · $275.00

  • Avianca AV563 / AV317: SFO 2026-11-20 13:15:00 → PTY 2026-11-21 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
    • AV563: SFO 2026-11-20 13:15:00 → SAL 2026-11-20 20:50:00; layover at SAL: 135 minutes.
    • AV317: SAL 2026-11-20 23:05:00 → PTY 2026-11-21 02:10:00.

2026-11-20 · one way · $335.00

  • American Airlines AA1665 / AA315: SFO 2026-11-20 00:37:00 → PTY 2026-11-20 13:41:00; 1 stop(s) via MIA; 604 minutes. Local airport times.
    • AA1665: SFO 2026-11-20 00:37:00 → MIA 2026-11-20 09:06:00; layover at MIA: 81 minutes.
    • AA315: MIA 2026-11-20 10:27:00 → PTY 2026-11-20 13:41:00.

2026-11-20 · one way · $345.00

  • United Airlines UA2862 / CM473: SFO 2026-11-20 21:22:00 → PTY 2026-11-21 09:50:00; 1 stop(s) via LAX; 568 minutes. Local airport times.
    • UA2862: SFO 2026-11-20 21:22:00 → LAX 2026-11-20 22:52:00; layover at LAX: 83 minutes.
    • CM473: LAX 2026-11-21 00:15:00 → PTY 2026-11-21 09:50:00.

2026-11-20 → 2026-11-23 · $530.00

  • Avianca AV563 / AV317: SFO 2026-11-20 13:15:00 → PTY 2026-11-21 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
    • AV563: SFO 2026-11-20 13:15:00 → SAL 2026-11-20 20:50:00; layover at SAL: 135 minutes.
    • AV317: SAL 2026-11-20 23:05:00 → PTY 2026-11-21 02:10:00.
  • Avianca AV316 / AV562: PTY 2026-11-23 05:30:00 → SFO 2026-11-23 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
    • AV316: PTY 2026-11-23 05:30:00 → SAL 2026-11-23 06:30:00; layover at SAL: 75 minutes.
    • AV562: SAL 2026-11-23 07:45:00 → SFO 2026-11-23 11:55:00.

2026-11-20 → 2026-11-23 · $670.00

  • United Airlines UA2722 / CM266: SFO 2026-11-20 07:15:00 → PTY 2026-11-20 20:19:00; 1 stop(s) via FLL; 604 minutes. Local airport times.
    • UA2722: SFO 2026-11-20 07:15:00 → FLL 2026-11-20 15:45:00; layover at FLL: 83 minutes.
    • CM266: FLL 2026-11-20 17:08:00 → PTY 2026-11-20 20:19:00.
  • United Airlines UA1249 / UA589: PTY 2026-11-23 08:55:00 → SFO 2026-11-23 17:07:00; 1 stop(s) via IAH; 672 minutes. Local airport times.
    • UA1249: PTY 2026-11-23 08:55:00 → IAH 2026-11-23 12:15:00; layover at IAH: 150 minutes.
    • UA589: IAH 2026-11-23 14:45:00 → SFO 2026-11-23 17:07:00.

2026-11-20 → 2026-11-23 · $670.00

  • American Airlines AA1665 / AA315: SFO 2026-11-20 00:37:00 → PTY 2026-11-20 13:41:00; 1 stop(s) via MIA; 604 minutes. Local airport times.
    • AA1665: SFO 2026-11-20 00:37:00 → MIA 2026-11-20 09:06:00; layover at MIA: 81 minutes.
    • AA315: MIA 2026-11-20 10:27:00 → PTY 2026-11-20 13:41:00.
  • Copa Airlines CM382: PTY 2026-11-23 18:31:00 → SFO 2026-11-23 23:12:00; nonstop; 461 minutes. Local airport times.

2026-11-27 → 2026-12-04 · $577.70

  • Avianca AV563 / AV317: SFO 2026-11-27 13:15:00 → PTY 2026-11-28 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
    • AV563: SFO 2026-11-27 13:15:00 → SAL 2026-11-27 20:50:00; layover at SAL: 135 minutes.
    • AV317: SAL 2026-11-27 23:05:00 → PTY 2026-11-28 02:10:00.
  • Avianca AV316 / AV562: PTY 2026-12-04 05:30:00 → SFO 2026-12-04 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
    • AV316: PTY 2026-12-04 05:30:00 → SAL 2026-12-04 06:30:00; layover at SAL: 75 minutes.
    • AV562: SAL 2026-12-04 07:45:00 → SFO 2026-12-04 11:55:00.

2026-11-20 · one way · $365.00

  • Copa Airlines CM383: SFO 2026-11-20 00:33:00 → PTY 2026-11-20 10:46:00; nonstop; 433 minutes. Local airport times.

2026-11-20 → 2026-11-23 · $690.00

  • Copa Airlines CM383: SFO 2026-11-20 00:33:00 → PTY 2026-11-20 10:46:00; nonstop; 433 minutes. Local airport times.
  • Copa Airlines CM382: PTY 2026-11-23 18:31:00 → SFO 2026-11-23 23:12:00; nonstop; 461 minutes. Local airport times.

2026-11-20 · one way · $345.00

  • United Airlines UA1491 / CM445: SFO 2026-11-20 07:29:00 → PTY 2026-11-20 20:27:00; 1 stop(s) via MCO; 598 minutes. Local airport times.
    • UA1491: SFO 2026-11-20 07:29:00 → MCO 2026-11-20 15:43:00; layover at MCO: 76 minutes.
    • CM445: MCO 2026-11-20 16:59:00 → PTY 2026-11-20 20:27:00.

2026-11-20 · one way · $345.00

  • United Airlines UA2722 / CM266: SFO 2026-11-20 07:15:00 → PTY 2026-11-20 20:19:00; 1 stop(s) via FLL; 604 minutes. Local airport times.
    • UA2722: SFO 2026-11-20 07:15:00 → FLL 2026-11-20 15:45:00; layover at FLL: 83 minutes.
    • CM266: FLL 2026-11-20 17:08:00 → PTY 2026-11-20 20:19:00.

2026-11-20 · one way · $345.00

  • United Airlines UA406 / CM253: SFO 2026-11-20 21:05:00 → PTY 2026-11-21 10:14:00; 1 stop(s) via LAS; 609 minutes. Local airport times.
    • UA406: SFO 2026-11-20 21:05:00 → LAS 2026-11-20 22:44:00; layover at LAS: 122 minutes.
    • CM253: LAS 2026-11-21 00:46:00 → PTY 2026-11-21 10:14:00.

2026-11-20 → 2026-11-23 · $670.00

  • United Airlines UA1491 / CM445: SFO 2026-11-20 07:29:00 → PTY 2026-11-20 20:27:00; 1 stop(s) via MCO; 598 minutes. Local airport times.
    • UA1491: SFO 2026-11-20 07:29:00 → MCO 2026-11-20 15:43:00; layover at MCO: 76 minutes.
    • CM445: MCO 2026-11-20 16:59:00 → PTY 2026-11-20 20:27:00.
  • United Airlines UA1249 / UA589: PTY 2026-11-23 08:55:00 → SFO 2026-11-23 17:07:00; 1 stop(s) via IAH; 672 minutes. Local airport times.
    • UA1249: PTY 2026-11-23 08:55:00 → IAH 2026-11-23 12:15:00; layover at IAH: 150 minutes.
    • UA589: IAH 2026-11-23 14:45:00 → SFO 2026-11-23 17:07:00.

2026-11-20 → 2026-11-23 · $670.00

  • United Airlines UA406 / CM253: SFO 2026-11-20 21:05:00 → PTY 2026-11-21 10:14:00; 1 stop(s) via LAS; 609 minutes. Local airport times.
    • UA406: SFO 2026-11-20 21:05:00 → LAS 2026-11-20 22:44:00; layover at LAS: 122 minutes.
    • CM253: LAS 2026-11-21 00:46:00 → PTY 2026-11-21 10:14:00.
  • United Airlines UA1249 / UA589: PTY 2026-11-23 08:55:00 → SFO 2026-11-23 17:07:00; 1 stop(s) via IAH; 672 minutes. Local airport times.
    • UA1249: PTY 2026-11-23 08:55:00 → IAH 2026-11-23 12:15:00; layover at IAH: 150 minutes.
    • UA589: IAH 2026-11-23 14:45:00 → SFO 2026-11-23 17:07:00.

2026-11-20 → 2026-11-23 · $670.00

  • United Airlines UA2862 / CM473: SFO 2026-11-20 21:22:00 → PTY 2026-11-21 09:50:00; 1 stop(s) via LAX; 568 minutes. Local airport times.
    • UA2862: SFO 2026-11-20 21:22:00 → LAX 2026-11-20 22:52:00; layover at LAX: 83 minutes.
    • CM473: LAX 2026-11-21 00:15:00 → PTY 2026-11-21 09:50:00.
  • United Airlines UA1249 / UA589: PTY 2026-11-23 08:55:00 → SFO 2026-11-23 17:07:00; 1 stop(s) via IAH; 672 minutes. Local airport times.
    • UA1249: PTY 2026-11-23 08:55:00 → IAH 2026-11-23 12:15:00; layover at IAH: 150 minutes.
    • UA589: IAH 2026-11-23 14:45:00 → SFO 2026-11-23 17:07:00.

2026-11-27 → 2026-12-04 · $698.50

  • American Airlines AA1665 / AA315: SFO 2026-11-27 00:37:00 → PTY 2026-11-27 13:41:00; 1 stop(s) via MIA; 604 minutes. Local airport times.
    • AA1665: SFO 2026-11-27 00:37:00 → MIA 2026-11-27 09:06:00; layover at MIA: 81 minutes.
    • AA315: MIA 2026-11-27 10:27:00 → PTY 2026-11-27 13:41:00.
  • Copa Airlines CM476 / UA1389: PTY 2026-12-04 12:56:00 → SFO 2026-12-04 21:10:00; 1 stop(s) via DEN; 674 minutes. Local airport times.
    • CM476: PTY 2026-12-04 12:56:00 → DEN 2026-12-04 17:12:00; layover at DEN: 128 minutes.
    • UA1389: DEN 2026-12-04 19:20:00 → SFO 2026-12-04 21:10:00.

2026-11-27 → 2026-12-04 · $722.10

  • Copa Airlines CM383: SFO 2026-11-27 00:33:00 → PTY 2026-11-27 10:46:00; nonstop; 433 minutes. Local airport times.
  • Copa Airlines CM476 / UA1389: PTY 2026-12-04 12:56:00 → SFO 2026-12-04 21:10:00; 1 stop(s) via DEN; 674 minutes. Local airport times.
    • CM476: PTY 2026-12-04 12:56:00 → DEN 2026-12-04 17:12:00; layover at DEN: 128 minutes.
    • UA1389: DEN 2026-12-04 19:20:00 → SFO 2026-12-04 21:10:00.

2026-11-27 → 2026-12-04 · $730.30

  • United Airlines UA2862 / CM473: SFO 2026-11-27 21:22:00 → PTY 2026-11-28 09:50:00; 1 stop(s) via LAX; 568 minutes. Local airport times.
    • UA2862: SFO 2026-11-27 21:22:00 → LAX 2026-11-27 22:52:00; layover at LAX: 83 minutes.
    • CM473: LAX 2026-11-28 00:15:00 → PTY 2026-11-28 09:50:00.
  • United Airlines UA1249 / UA589: PTY 2026-12-04 08:55:00 → SFO 2026-12-04 17:07:00; 1 stop(s) via IAH; 672 minutes. Local airport times.
    • UA1249: PTY 2026-12-04 08:55:00 → IAH 2026-12-04 12:15:00; layover at IAH: 150 minutes.
    • UA589: IAH 2026-12-04 14:45:00 → SFO 2026-12-04 17:07:00.

2026-11-27 → 2026-12-04 · $730.30

  • United Airlines UA1491 / CM445: SFO 2026-11-27 07:29:00 → PTY 2026-11-27 20:27:00; 1 stop(s) via MCO; 598 minutes. Local airport times.
    • UA1491: SFO 2026-11-27 07:29:00 → MCO 2026-11-27 15:43:00; layover at MCO: 76 minutes.
    • CM445: MCO 2026-11-27 16:59:00 → PTY 2026-11-27 20:27:00.
  • United Airlines UA1249 / UA589: PTY 2026-12-04 08:55:00 → SFO 2026-12-04 17:07:00; 1 stop(s) via IAH; 672 minutes. Local airport times.
    • UA1249: PTY 2026-12-04 08:55:00 → IAH 2026-12-04 12:15:00; layover at IAH: 150 minutes.
    • UA589: IAH 2026-12-04 14:45:00 → SFO 2026-12-04 17:07:00.

2026-11-27 → 2026-12-04 · $730.30

  • United Airlines UA2722 / CM266: SFO 2026-11-27 07:15:00 → PTY 2026-11-27 20:19:00; 1 stop(s) via FLL; 604 minutes. Local airport times.
    • UA2722: SFO 2026-11-27 07:15:00 → FLL 2026-11-27 15:45:00; layover at FLL: 83 minutes.
    • CM266: FLL 2026-11-27 17:08:00 → PTY 2026-11-27 20:19:00.
  • United Airlines UA1249 / UA589: PTY 2026-12-04 08:55:00 → SFO 2026-12-04 17:07:00; 1 stop(s) via IAH; 672 minutes. Local airport times.
    • UA1249: PTY 2026-12-04 08:55:00 → IAH 2026-12-04 12:15:00; layover at IAH: 150 minutes.
    • UA589: IAH 2026-12-04 14:45:00 → SFO 2026-12-04 17:07:00.

More dates for this route