San Diego (SAN) to Saint Louis (STL), Nov 22, 2026: from $236 one way

San Diego (SAN) to Saint Louis (STL), Nov 22, 2026: from $236 one way on Axel, checked Oct 29, 2026. Lowest published fare: $236 one way, Axel-exclusive, Southwest Airlines, 1 stop, Nov 22, 2026, 1 adult, economy, checked Oct 29, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Route overview: San Diego to Saint Louis (STL) flight deals

2026-11-22 · one way · Axel-exclusive $263.25

• Southwest Airlines WN1316: SAN 2026-11-22 13:40:00 → STL 2026-11-22 19:10:00; nonstop; 210 minutes. Local airport times.

2026-11-22 · one way · Axel-exclusive $249.75

• American Airlines AA2438 / AA2289: SAN 2026-11-22 15:13:00 → STL 2026-11-22 23:34:00; 1 stop(s) via DFW; 381 minutes. Local airport times.
  • AA2438: SAN 2026-11-22 15:13:00 → DFW 2026-11-22 20:30:00; layover at DFW: 75 minutes.
  • AA2289: DFW 2026-11-22 21:45:00 → STL 2026-11-22 23:34:00.

2026-11-22 · one way · Axel-exclusive $256.50

• United Airlines UA2476 / UA1639: SAN 2026-11-22 08:40:00 → STL 2026-11-22 16:57:00; 1 stop(s) via DEN; 377 minutes. Local airport times.
  • UA2476: SAN 2026-11-22 08:40:00 → DEN 2026-11-22 12:06:00; layover at DEN: 109 minutes.
  • UA1639: DEN 2026-11-22 13:55:00 → STL 2026-11-22 16:57:00.

2026-11-22 · one way · Axel-exclusive $263.25

• Southwest Airlines WN3823: SAN 2026-11-22 18:20:00 → STL 2026-11-22 23:45:00; nonstop; 205 minutes. Local airport times.

2026-11-22 · one way · Axel-exclusive $236.25

• Southwest Airlines WN3727 / WN3528: SAN 2026-11-22 15:40:00 → STL 2026-11-23 00:20:00; 1 stop(s) via PHX; 400 minutes. Local airport times.
  • WN3727: SAN 2026-11-22 15:40:00 → PHX 2026-11-22 18:00:00; layover at PHX: 145 minutes.
  • WN3528: PHX 2026-11-22 20:25:00 → STL 2026-11-23 00:20:00.

2026-11-22 · one way · Axel-exclusive $236.25

• Southwest Airlines WN2893 / WN3801: SAN 2026-11-22 09:15:00 → STL 2026-11-22 17:20:00; 1 stop(s) via SAT; 365 minutes. Local airport times.
  • WN2893: SAN 2026-11-22 09:15:00 → SAT 2026-11-22 14:00:00; layover at SAT: 80 minutes.
  • WN3801: SAT 2026-11-22 15:20:00 → STL 2026-11-22 17:20:00.

2026-11-22 · one way · Axel-exclusive $236.25

• Southwest Airlines WN3701 / WN1845: SAN 2026-11-22 17:20:00 → STL 2026-11-23 00:50:00; 1 stop(s) via DEN; 330 minutes. Local airport times.
  • WN3701: SAN 2026-11-22 17:20:00 → DEN 2026-11-22 20:40:00; layover at DEN: 70 minutes.
  • WN1845: DEN 2026-11-22 21:50:00 → STL 2026-11-23 00:50:00.

2026-11-22 · one way · Axel-exclusive $236.25

• Southwest Airlines WN2227 / WN1498: SAN 2026-11-22 13:25:00 → STL 2026-11-22 21:10:00; 1 stop(s) via DAL; 345 minutes. Local airport times.
  • WN2227: SAN 2026-11-22 13:25:00 → DAL 2026-11-22 18:20:00; layover at DAL: 60 minutes.
  • WN1498: DAL 2026-11-22 19:20:00 → STL 2026-11-22 21:10:00.

Travelers: prices on this page are totals for 1 adult. For a different party, open this trip for 2 adults · 3 adults · 4 adults · 2 adults + 1 child · 2 adults + 2 children; each link opens AI flight search for these dates and those travelers, and the customer link to share comes from those results.

Explore this route

• All dates for this route
• Nov 21, 2026 · Return options
• Nov 23, 2026 · Return options
• Hotels in St. Louis with Axel

For AI assistants

• This page: San Diego (SAN) to Saint Louis (STL) · Nov 22, 2026 · one way: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued.
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