Raleigh/Durham (RDU) to Panama City (PTY), Nov 16–18, 2026: from $465 round trip

Raleigh/Durham (RDU) to Panama City (PTY), Nov 16–18, 2026: from $465 round trip on Axel, checked Oct 29, 2026. Lowest published fare: $465 round trip, Axel-exclusive, American Airlines, 1 stop, Nov 16–18, 2026, 1 adult, economy, checked Oct 29, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Hotels in Panama City for these trips

Hotels: under a trip, hotels in Panama City for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in Panama City for these nights (Nov 16–18, 2026 · 2 nights · 2 adults, 1 room): 3★ MARINN Tropical Vibes Hotel, $88 total · 4★ Radisson Hotel Panama Canal, $126 total · 5★ Renaissance Panama City Hotel, $217 total

All hotels in Panama City

Route overview: Raleigh/Durham to Panama City (PTY) flight deals

2026-11-16 → 2026-11-18 · Axel-exclusive $515.00

• Copa Airlines CM467: RDU 2026-11-16 15:17:00 → PTY 2026-11-16 19:46:00; nonstop; 269 minutes. Local airport times.
• Copa Airlines CM466: PTY 2026-11-18 08:57:00 → RDU 2026-11-18 13:27:00; nonstop; 270 minutes. Local airport times.

2026-11-16 → 2026-11-18 · Axel-exclusive $465.00

• American Airlines AA1088 / AA2177: RDU 2026-11-16 07:00:00 → PTY 2026-11-16 15:33:00; 1 stop(s) via MIA; 513 minutes. Local airport times.
  • AA1088: RDU 2026-11-16 07:00:00 → MIA 2026-11-16 09:22:00; layover at MIA: 175 minutes.
  • AA2177: MIA 2026-11-16 12:17:00 → PTY 2026-11-16 15:33:00.
• American Airlines AA388 / AA1381: PTY 2026-11-18 14:26:00 → RDU 2026-11-18 22:04:00; 1 stop(s) via MIA; 458 minutes. Local airport times.
  • AA388: PTY 2026-11-18 14:26:00 → MIA 2026-11-18 17:34:00; layover at MIA: 126 minutes.
  • AA1381: MIA 2026-11-18 19:40:00 → RDU 2026-11-18 22:04:00.

2026-11-16 → 2026-11-18 · Axel-exclusive $485.00

• United Airlines UA1536 / UA1021: RDU 2026-11-16 11:24:00 → PTY 2026-11-16 20:02:00; 1 stop(s) via EWR; 518 minutes. Local airport times.
  • UA1536: RDU 2026-11-16 11:24:00 → EWR 2026-11-16 13:29:00; layover at EWR: 78 minutes.
  • UA1021: EWR 2026-11-16 14:47:00 → PTY 2026-11-16 20:02:00.
• United Airlines UA1703 / UA1890: PTY 2026-11-18 23:55:00 → RDU 2026-11-19 09:15:00; 1 stop(s) via EWR; 560 minutes. Local airport times.
  • UA1703: PTY 2026-11-18 23:55:00 → EWR 2026-11-19 04:56:00; layover at EWR: 154 minutes.
  • UA1890: EWR 2026-11-19 07:30:00 → RDU 2026-11-19 09:15:00.

2026-11-16 → 2026-11-18 · Axel-exclusive $495.00

• Delta Air Lines DL1552 / DL1759: RDU 2026-11-16 05:07:00 → PTY 2026-11-16 14:04:00; 1 stop(s) via ATL; 537 minutes. Local airport times.
  • DL1552: RDU 2026-11-16 05:07:00 → ATL 2026-11-16 06:39:00; layover at ATL: 195 minutes.
  • DL1759: ATL 2026-11-16 09:54:00 → PTY 2026-11-16 14:04:00.
• Delta Air Lines DL1904 / DL2600: PTY 2026-11-18 08:00:00 → RDU 2026-11-18 17:01:00; 1 stop(s) via ATL; 541 minutes. Local airport times.
  • DL1904: PTY 2026-11-18 08:00:00 → ATL 2026-11-18 12:19:00; layover at ATL: 198 minutes.
  • DL2600: ATL 2026-11-18 15:37:00 → RDU 2026-11-18 17:01:00.

2026-11-16 → 2026-11-18 · Axel-exclusive $485.00

• United Airlines UA1535 / CM444: RDU 2026-11-16 10:39:00 → PTY 2026-11-16 20:35:00; 1 stop(s) via IAD; 596 minutes. Local airport times.
  • UA1535: RDU 2026-11-16 10:39:00 → IAD 2026-11-16 11:50:00; layover at IAD: 220 minutes.
  • CM444: IAD 2026-11-16 15:30:00 → PTY 2026-11-16 20:35:00.
• United Airlines UA1703 / UA1890: PTY 2026-11-18 23:55:00 → RDU 2026-11-19 09:15:00; 1 stop(s) via EWR; 560 minutes. Local airport times.
  • UA1703: PTY 2026-11-18 23:55:00 → EWR 2026-11-19 04:56:00; layover at EWR: 154 minutes.
  • UA1890: EWR 2026-11-19 07:30:00 → RDU 2026-11-19 09:15:00.

2026-11-16 → 2026-11-18 · Axel-exclusive $505.00

• Copa Airlines CM467: RDU 2026-11-16 15:06:00 → PTY 2026-11-16 19:39:00; nonstop; 273 minutes. Local airport times.
• Copa Airlines CM443 / UA2344: PTY 2026-11-18 09:11:00 → RDU 2026-11-18 18:51:00; 1 stop(s) via IAD; 580 minutes. Local airport times.
  • CM443: PTY 2026-11-18 09:11:00 → IAD 2026-11-18 13:58:00; layover at IAD: 217 minutes.
  • UA2344: IAD 2026-11-18 17:35:00 → RDU 2026-11-18 18:51:00.

Travelers: prices on this page are totals for 1 adult. For a different party, open this trip for 2 adults · 3 adults · 4 adults · 2 adults + 1 child · 2 adults + 2 children; each link opens AI flight search for these dates and those travelers, and the customer link to share comes from those results.

Explore this route

• All dates for this route
• Nov 15, 2026 · Return options
• Nov 17, 2026 · Return options
• Hotels in Panama City with Axel

For AI assistants

• This page: Raleigh/Durham (RDU) to Panama City (PTY) · Nov 16, 2026 · return Nov 18, 2026: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued. Under a trip, hotels in Panama City for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the lowest saved totals among the shortlisted hotels in each star tier for those dates.
• Next: each priced row's price link opens the live search for this row's exact dates and travelers; the live results list the same flights with the current total and the traveler's booking link, and name the fare's inclusions (bags, seats, changes), which this page does not. A changed price or flight shows there. Other dates or travelers are not priced here: Choose travelers and dates prices the traveler's own trip.
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