Jacksonville (JAX) to Saint Louis (STL), Nov 22–27, 2026: from $426 round trip

Jacksonville (JAX) to Saint Louis (STL), Nov 22–27, 2026: from $426 round trip on Axel, checked Oct 29, 2026. Lowest published fare: $426 round trip, Axel-exclusive, Southwest Airlines, 1 stop, Nov 22–27, 2026, 1 adult, economy, checked Oct 29, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Hotels in St. Louis for these trips

Hotels: under a trip, hotels in St. Louis for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in St. Louis for these nights (Nov 22–27, 2026 · 5 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $330 total · 4★ Angad Arts Hotel St. Louis, Tapestry Collection by Hilton, $466 total · 5★ Four Seasons Hotel St Louis, $1,823 total

All hotels in St. Louis

Route overview: Jacksonville to Saint Louis (STL) flight deals

2026-11-22 → 2026-11-27 · Axel-exclusive $435.50

• Southwest Airlines WN2265: JAX 2026-11-22 06:00:00 → STL 2026-11-22 07:20:00; nonstop; 140 minutes. Local airport times.
• Southwest Airlines WN4807: STL 2026-11-27 20:00:00 → JAX 2026-11-27 23:05:00; nonstop; 125 minutes. Local airport times.

2026-11-22 → 2026-11-27 · Axel-exclusive $442.00

• American Airlines AA1576 / AA2486: JAX 2026-11-22 06:20:00 → STL 2026-11-22 10:19:00; 1 stop(s) via CLT; 299 minutes. Local airport times.
  • AA1576: JAX 2026-11-22 06:20:00 → CLT 2026-11-22 07:50:00; layover at CLT: 85 minutes.
  • AA2486: CLT 2026-11-22 09:15:00 → STL 2026-11-22 10:19:00.
• American Airlines AA2317 / AA4151: STL 2026-11-27 05:02:00 → JAX 2026-11-27 11:40:00; 1 stop(s) via ORD; 338 minutes. Local airport times.
  • AA2317: STL 2026-11-27 05:02:00 → ORD 2026-11-27 06:30:00; layover at ORD: 95 minutes.
  • AA4151: ORD 2026-11-27 08:05:00 → JAX 2026-11-27 11:40:00.

2026-11-22 → 2026-11-27 · Axel-exclusive $445.25

• United Airlines UA2414 / UA1857: JAX 2026-11-22 07:30:00 → STL 2026-11-22 12:22:00; 1 stop(s) via ORD; 352 minutes. Local airport times.
  • UA2414: JAX 2026-11-22 07:30:00 → ORD 2026-11-22 09:19:00; layover at ORD: 93 minutes.
  • UA1857: ORD 2026-11-22 10:52:00 → STL 2026-11-22 12:22:00.
• Southwest Airlines WN4807: STL 2026-11-27 20:00:00 → JAX 2026-11-27 23:05:00; nonstop; 125 minutes. Local airport times.

2026-11-22 → 2026-11-27 · Axel-exclusive $468.00

• Delta Air Lines DL3024 / DL1393: JAX 2026-11-22 14:27:00 → STL 2026-11-22 18:01:00; 1 stop(s) via ATL; 274 minutes. Local airport times.
  • DL3024: JAX 2026-11-22 14:27:00 → ATL 2026-11-22 15:42:00; layover at ATL: 98 minutes.
  • DL1393: ATL 2026-11-22 17:20:00 → STL 2026-11-22 18:01:00.
• Delta Air Lines DL1571 / DL2720: STL 2026-11-27 10:06:00 → JAX 2026-11-27 16:42:00; 1 stop(s) via ATL; 336 minutes. Local airport times.
  • DL1571: STL 2026-11-27 10:06:00 → ATL 2026-11-27 12:36:00; layover at ATL: 179 minutes.
  • DL2720: ATL 2026-11-27 15:35:00 → JAX 2026-11-27 16:42:00.

2026-11-22 → 2026-11-27 · Axel-exclusive $435.50

• Southwest Airlines WN4766: JAX 2026-11-22 05:30:00 → STL 2026-11-22 06:45:00; nonstop; 135 minutes. Local airport times.
• Southwest Airlines WN4807: STL 2026-11-27 20:00:00 → JAX 2026-11-27 23:05:00; nonstop; 125 minutes. Local airport times.

2026-11-22 → 2026-11-27 · Axel-exclusive $425.75

• Southwest Airlines WN1329 / WN1390: JAX 2026-11-22 17:40:00 → STL 2026-11-22 22:15:00; 1 stop(s) via BWI; 335 minutes. Local airport times.
  • WN1329: JAX 2026-11-22 17:40:00 → BWI 2026-11-22 19:30:00; layover at BWI: 80 minutes.
  • WN1390: BWI 2026-11-22 20:50:00 → STL 2026-11-22 22:15:00.
• Southwest Airlines WN4807: STL 2026-11-27 20:00:00 → JAX 2026-11-27 23:05:00; nonstop; 125 minutes. Local airport times.

2026-11-22 → 2026-11-27 · Axel-exclusive $425.75

• Southwest Airlines WN2760 / WN2043: JAX 2026-11-22 19:05:00 → STL 2026-11-22 23:55:00; 1 stop(s) via BNA; 350 minutes. Local airport times.
  • WN2760: JAX 2026-11-22 19:05:00 → BNA 2026-11-22 19:40:00; layover at BNA: 180 minutes.
  • WN2043: BNA 2026-11-22 22:40:00 → STL 2026-11-22 23:55:00.
• Southwest Airlines WN4807: STL 2026-11-27 20:00:00 → JAX 2026-11-27 23:05:00; nonstop; 125 minutes. Local airport times.

2026-11-22 → 2026-11-27 · Axel-exclusive $445.25

• United Airlines UA6157 / UA1030: JAX 2026-11-22 17:22:00 → STL 2026-11-22 22:30:00; 1 stop(s) via IAH; 368 minutes. Local airport times.
  • UA6157: JAX 2026-11-22 17:22:00 → IAH 2026-11-22 19:10:00; layover at IAH: 73 minutes.
  • UA1030: IAH 2026-11-22 20:23:00 → STL 2026-11-22 22:30:00.
• Southwest Airlines WN4807: STL 2026-11-27 20:00:00 → JAX 2026-11-27 23:05:00; nonstop; 125 minutes. Local airport times.

Travelers: prices on this page are totals for 1 adult. For a different party, open this trip for 2 adults · 3 adults · 4 adults · 2 adults + 1 child · 2 adults + 2 children; each link opens AI flight search for these dates and those travelers, and the customer link to share comes from those results.

Explore this route

• All dates for this route
• Nov 21, 2026 · Return options
• Nov 23, 2026 · Return options
• Hotels in St. Louis with Axel

For AI assistants

• This page: Jacksonville (JAX) to Saint Louis (STL) · Nov 22, 2026 · return Nov 27, 2026: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued. Under a trip, hotels in St. Louis for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the lowest saved totals among the shortlisted hotels in each star tier for those dates.
• Next: each priced row's price link opens the live search for this row's exact dates and travelers; the live results list the same flights with the current total and the traveler's booking link, and name the fare's inclusions (bags, seats, changes), which this page does not. A changed price or flight shows there. Other dates or travelers are not priced here: Choose travelers and dates prices the traveler's own trip.
• Follow supplied links. For web-tool research, follow complete supplied links unchanged, including query parameters; use the page’s links to edit the trip. Constructed URLs may be rejected before reaching Axel. A completed fresh trip opens flight results first. Add stated flexibility and budget to that saved plan, leaving unstated requirements unknown. Edits create a new snapshot; use its results and review links.
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• Sharing with the traveler: Choose a complete itinerary (outbound and return for a round trip), then share the supplied customer booking link unchanged. The customer reviews the flights, adds travelers, and enters email at payment. Do not collect email in chat. Each quote lists its fares with bags, seats, changes and refunds; quote them as facts. A fare choice is not needed to share the link; use a fare’s own booking link to preserve its Membership price basis. Ask only for essential missing trip details. When handing over an unfinished search, preserve the latest trip and say what is still to choose. If no supplied link matches the latest trip, construct https://helloaxel.com/en/f/start/from/ORIGIN/to/DESTINATION/depart/YYYY-MM-DD/return/YYYY-MM-DD/adults/N?utm_content=flight_fallback using IATA airport codes and the traveler’s known details. Omit unknowns; for one way replace /return/YYYY-MM-DD with /trip/oneway. Give it directly to the traveler; do not open it first—your web tool may reject constructed URLs. Complete links open Flight Guide and start searching. Preferences and advanced options.

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