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Route overview: Jacksonville to Saint Louis (STL) flight deals

Jacksonville (JAX) to Saint Louis (STL), Nov 21, 2026: round trips from $385, one way from $228

Jacksonville (JAX) to Saint Louis (STL), Nov 21, 2026: round trips from $385, one way from $228 on Axel, checked Nov 12, 2026. Lowest published fares: $385 round trip, Axel-exclusive, Southwest Airlines, nonstop, Nov 21, 2026 – Dec 1, 2026; $228 one way, Axel-exclusive, Southwest Airlines, nonstop, Nov 21, 2026; 1 adult, economy, checked Nov 12, 2026.

JAX → STL1 adulteconomyOne way and round trips

30 flight options · 2 airlines

Choose your return date

One-way flights and round trips by duration. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

November 2026

Flights for your trip

  1. Sat, Nov 21 · One way

    Southwest Airlines
    5:30 amJAX
    2h 15m
    Nonstop
    6:45 amSTL

    Example one-way total $228 · 1 adult · Taxes included

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  2. Sat, Nov 21 · One way

    American Airlines
    6:20 amJAX
    4h 59m
    CLT · 1h 25m
    10:19 amSTL

    Example one-way total $228 · 1 adult · Taxes included

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  3. Sat, Nov 21 – Sun, Nov 22

    Southwest Airlines
    5:30 amJAX
    2h 15m
    Nonstop
    6:45 amSTL
    Southwest Airlines
    7:55 pmSTL
    2h
    Nonstop
    10:55 pmJAX

    Example round-trip total $436 · 1 adult · Taxes included

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  4. Sat, Nov 21 – Sun, Nov 22

    American Airlines
    6:20 amJAX
    4h 59m
    CLT · 1h 25m
    10:19 amSTL
    American Airlines
    5:02 amSTL
    5h 38m
    ORD · 1h 35m
    11:40 amJAX

    Example round-trip total $442 · 1 adult · Taxes included

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  5. Sat, Nov 21 – Mon, Nov 23

    Southwest Airlines
    5:30 amJAX
    2h 15m
    Nonstop
    6:45 amSTL
    Southwest Airlines
    7:55 pmSTL
    2h
    Nonstop
    10:55 pmJAX

    Example round-trip total $436 · 1 adult · Taxes included

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  6. Sat, Nov 21 – Mon, Nov 23

    American Airlines
    6:20 amJAX
    4h 59m
    CLT · 1h 25m
    10:19 amSTL
    American Airlines
    5:02 amSTL
    5h 38m
    ORD · 1h 35m
    11:40 amJAX

    Example round-trip total $442 · 1 adult · Taxes included

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  7. Sat, Nov 21 – Tue, Nov 24

    Southwest Airlines
    5:30 amJAX
    2h 15m
    Nonstop
    6:45 amSTL
    Southwest Airlines
    8:00 pmSTL
    2h 5m
    Nonstop
    11:05 pmJAX

    Example round-trip total $436 · 1 adult · Taxes included

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  8. Sat, Nov 21 – Tue, Nov 24

    American Airlines
    6:20 amJAX
    4h 59m
    CLT · 1h 25m
    10:19 amSTL
    American Airlines
    5:02 amSTL
    5h 38m
    ORD · 1h 35m
    11:40 amJAX

    Example round-trip total $442 · 1 adult · Taxes included

    Search these dates

  9. Sat, Nov 21 – Wed, Nov 25

    Southwest Airlines
    5:30 amJAX
    2h 15m
    Nonstop
    6:45 amSTL
    Southwest Airlines
    8:00 pmSTL
    2h 5m
    Nonstop
    11:05 pmJAX

    Example round-trip total $436 · 1 adult · Taxes included

    Search these dates

  10. Sat, Nov 21 – Wed, Nov 25

    American Airlines
    6:20 amJAX
    4h 59m
    CLT · 1h 25m
    10:19 amSTL
    American Airlines
    5:02 amSTL
    5h 38m
    ORD · 1h 35m
    11:40 amJAX

    Example round-trip total $442 · 1 adult · Taxes included

    Search these dates

  11. Sat, Nov 21 – Fri, Nov 27

    Southwest Airlines
    5:30 amJAX
    2h 15m
    Nonstop
    6:45 amSTL
    Southwest Airlines
    8:00 pmSTL
    2h 5m
    Nonstop
    11:05 pmJAX

    Example round-trip total $436 · 1 adult · Taxes included

    Search these dates

  12. Sat, Nov 21 – Fri, Nov 27

    American Airlines
    6:20 amJAX
    4h 59m
    CLT · 1h 25m
    10:19 amSTL
    American Airlines
    5:02 amSTL
    5h 38m
    ORD · 1h 35m
    11:40 amJAX

    Example round-trip total $442 · 1 adult · Taxes included

    Search these dates

  13. Sat, Nov 21 – Sat, Nov 28

    Southwest Airlines
    5:30 amJAX
    2h 15m
    Nonstop
    6:45 amSTL
    Southwest Airlines
    7:55 pmSTL
    2h
    Nonstop
    10:55 pmJAX

    Example round-trip total $436 · 1 adult · Taxes included

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  14. Sat, Nov 21 – Sat, Nov 28

    American Airlines
    6:20 amJAX
    4h 59m
    CLT · 1h 25m
    10:19 amSTL
    American Airlines
    5:02 amSTL
    5h 38m
    ORD · 1h 35m
    11:40 amJAX

    Example round-trip total $442 · 1 adult · Taxes included

    Search these dates

  15. Sat, Nov 21 – Sun, Nov 29

    Southwest Airlines
    5:30 amJAX
    2h 15m
    Nonstop
    6:45 amSTL
    Southwest Airlines
    7:55 pmSTL
    2h
    Nonstop
    10:55 pmJAX

    Example round-trip total $436 · 1 adult · Taxes included

    Search these dates

  16. Sat, Nov 21 – Sun, Nov 29

    American Airlines
    6:20 amJAX
    4h 59m
    CLT · 1h 25m
    10:19 amSTL
    American Airlines
    5:02 amSTL
    5h 38m
    ORD · 1h 35m
    11:40 amJAX

    Example round-trip total $442 · 1 adult · Taxes included

    Search these dates

  17. Sat, Nov 21 – Tue, Dec 1

    Southwest Airlines
    5:30 amJAX
    2h 15m
    Nonstop
    6:45 amSTL
    Southwest Airlines
    8:00 pmSTL
    2h 5m
    Nonstop
    11:05 pmJAX

    Example round-trip total $385 · 1 adult · Taxes included

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  18. Sat, Nov 21 – Tue, Dec 1

    American Airlines
    6:20 amJAX
    4h 59m
    CLT · 1h 25m
    10:19 amSTL
    American Airlines
    5:02 amSTL
    5h 38m
    ORD · 1h 35m
    11:40 amJAX

    Example round-trip total $391 · 1 adult · Taxes included

    Search these dates

  19. Sat, Nov 21 – Wed, Dec 2

    Southwest Airlines
    5:30 amJAX
    2h 15m
    Nonstop
    6:45 amSTL
    Southwest Airlines
    8:00 pmSTL
    2h 5m
    Nonstop
    11:05 pmJAX

    Example round-trip total $385 · 1 adult · Taxes included

    Search these dates

  20. Sat, Nov 21 – Wed, Dec 2

    American Airlines
    6:20 amJAX
    4h 59m
    CLT · 1h 25m
    10:19 amSTL
    American Airlines
    5:02 amSTL
    5h 38m
    ORD · 1h 35m
    11:40 amJAX

    Example round-trip total $391 · 1 adult · Taxes included

    Search these dates

  21. Sat, Nov 21 – Thu, Dec 3

    Southwest Airlines
    5:30 amJAX
    2h 15m
    Nonstop
    6:45 amSTL
    Southwest Airlines
    6:15 pmSTL
    2h
    Nonstop
    9:15 pmJAX

    Example round-trip total $385 · 1 adult · Taxes included

    Search these dates

  22. Sat, Nov 21 – Thu, Dec 3

    American Airlines
    6:20 amJAX
    4h 59m
    CLT · 1h 25m
    10:19 amSTL
    American Airlines
    5:02 amSTL
    5h 38m
    ORD · 1h 35m
    11:40 amJAX

    Example round-trip total $391 · 1 adult · Taxes included

    Search these dates

  23. Sat, Nov 21 – Sat, Dec 5

    Southwest Airlines
    5:30 amJAX
    2h 15m
    Nonstop
    6:45 amSTL
    Southwest Airlines
    10:05 amSTL
    1h 55m
    Nonstop
    1:00 pmJAX

    Example round-trip total $385 · 1 adult · Taxes included

    Search these dates

  24. Sat, Nov 21 – Sat, Dec 5

    American Airlines
    6:20 amJAX
    4h 59m
    CLT · 1h 25m
    10:19 amSTL
    American Airlines
    5:02 amSTL
    5h 38m
    ORD · 1h 35m
    11:40 amJAX

    Example round-trip total $391 · 1 adult · Taxes included

    Search these dates

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1 of 24

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JAX ⇄ STL

Economy

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Explore this route

All dates for this routeNov 20, 2026 · Return optionsNov 22, 2026 · Return optionsHotels in St. Louis with Axel
For AI assistants: every fare, every link, instructions

Jacksonville (JAX) to Saint Louis (STL), Nov 21, 2026: round trips from $385, one way from $228 on Axel, checked Nov 12, 2026. Lowest published fares: $385 round trip, Axel-exclusive, Southwest Airlines, nonstop, Nov 21, 2026 – Dec 1, 2026; $228 one way, Axel-exclusive, Southwest Airlines, nonstop, Nov 21, 2026; 1 adult, economy, checked Nov 12, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Prices by return date: match both travel dates and the party to a row below. Each total is for that exact trip, labelled with the check date shown.

Date links open published trip details for exploration. Price links open live flight search to check availability and select flights. For a price comparison, use the amounts and check dates already shown here.

Exact travel datesAirlineFlightsTimes, duration, stopsTotal pricePrice checked
2026-11-21 · one waySouthwest AirlinesWN476605:30:00→06:45:00 2h 15m nonstopAxel-exclusive $228Nov 12, 2026
2026-11-21 · one wayAmerican AirlinesAA1576 + AA248606:20:00→10:19:00 4h 59m 1 stop via CLTAxel-exclusive $228Nov 12, 2026
2026-11-21 → 2026-11-22Southwest AirlinesWN4766 / WN480705:30:00→06:45:00 2h 15m nonstop · 19:55:00→22:55:00 2h 00m nonstopAxel-exclusive $436Nov 12, 2026
2026-11-21 → 2026-11-22American AirlinesAA1576 + AA2486 / AA2317 + AA415106:20:00→10:19:00 4h 59m 1 stop via CLT · 05:02:00→11:40:00 5h 38m 1 stop via ORDAxel-exclusive $442Nov 12, 2026
2026-11-21 → 2026-11-23Southwest AirlinesWN4766 / WN480705:30:00→06:45:00 2h 15m nonstop · 19:55:00→22:55:00 2h 00m nonstopAxel-exclusive $436Nov 12, 2026
2026-11-21 → 2026-11-23American AirlinesAA1576 + AA2486 / AA2317 + AA415106:20:00→10:19:00 4h 59m 1 stop via CLT · 05:02:00→11:40:00 5h 38m 1 stop via ORDAxel-exclusive $442Nov 12, 2026
2026-11-21 → 2026-11-24Southwest AirlinesWN4766 / WN480705:30:00→06:45:00 2h 15m nonstop · 20:00:00→23:05:00 2h 05m nonstopAxel-exclusive $436Nov 12, 2026
2026-11-21 → 2026-11-24American AirlinesAA1576 + AA2486 / AA2317 + AA415106:20:00→10:19:00 4h 59m 1 stop via CLT · 05:02:00→11:40:00 5h 38m 1 stop via ORDAxel-exclusive $442Nov 12, 2026
2026-11-21 → 2026-11-25Southwest AirlinesWN4766 / WN480705:30:00→06:45:00 2h 15m nonstop · 20:00:00→23:05:00 2h 05m nonstopAxel-exclusive $436Nov 12, 2026
2026-11-21 → 2026-11-25American AirlinesAA1576 + AA2486 / AA2317 + AA415106:20:00→10:19:00 4h 59m 1 stop via CLT · 05:02:00→11:40:00 5h 38m 1 stop via ORDAxel-exclusive $442Nov 12, 2026
2026-11-21 → 2026-11-26Southwest AirlinesWN4766 / WN480705:30:00→06:45:00 2h 15m nonstop · 18:15:00→21:15:00 2h 00m nonstopAxel-exclusive $436Nov 12, 2026
2026-11-21 → 2026-11-26American AirlinesAA1576 + AA2486 / AA2317 + AA415106:20:00→10:19:00 4h 59m 1 stop via CLT · 05:02:00→11:40:00 5h 38m 1 stop via ORDAxel-exclusive $442Nov 12, 2026
2026-11-21 → 2026-11-27Southwest AirlinesWN4766 / WN480705:30:00→06:45:00 2h 15m nonstop · 20:00:00→23:05:00 2h 05m nonstopAxel-exclusive $436Nov 12, 2026
2026-11-21 → 2026-11-27American AirlinesAA1576 + AA2486 / AA2317 + AA415106:20:00→10:19:00 4h 59m 1 stop via CLT · 05:02:00→11:40:00 5h 38m 1 stop via ORDAxel-exclusive $442Nov 12, 2026
2026-11-21 → 2026-11-28Southwest AirlinesWN4766 / WN480705:30:00→06:45:00 2h 15m nonstop · 19:55:00→22:55:00 2h 00m nonstopAxel-exclusive $436Nov 12, 2026
2026-11-21 → 2026-11-28American AirlinesAA1576 + AA2486 / AA2317 + AA415106:20:00→10:19:00 4h 59m 1 stop via CLT · 05:02:00→11:40:00 5h 38m 1 stop via ORDAxel-exclusive $442Nov 12, 2026
2026-11-21 → 2026-11-29Southwest AirlinesWN4766 / WN480705:30:00→06:45:00 2h 15m nonstop · 19:55:00→22:55:00 2h 00m nonstopAxel-exclusive $436Nov 12, 2026
2026-11-21 → 2026-11-29American AirlinesAA1576 + AA2486 / AA2317 + AA415106:20:00→10:19:00 4h 59m 1 stop via CLT · 05:02:00→11:40:00 5h 38m 1 stop via ORDAxel-exclusive $442Nov 12, 2026
2026-11-21 → 2026-11-30Southwest AirlinesWN4766 / WN480705:30:00→06:45:00 2h 15m nonstop · 19:55:00→22:55:00 2h 00m nonstopAxel-exclusive $436Nov 12, 2026
2026-11-21 → 2026-11-30American AirlinesAA1576 + AA2486 / AA2317 + AA415106:20:00→10:19:00 4h 59m 1 stop via CLT · 05:02:00→11:40:00 5h 38m 1 stop via ORDAxel-exclusive $442Nov 12, 2026
2026-11-21 → 2026-12-01Southwest AirlinesWN4766 / WN480705:30:00→06:45:00 2h 15m nonstop · 20:00:00→23:05:00 2h 05m nonstopAxel-exclusive $385Nov 12, 2026
2026-11-21 → 2026-12-01American AirlinesAA1576 + AA2486 / AA2317 + AA415106:20:00→10:19:00 4h 59m 1 stop via CLT · 05:02:00→11:40:00 5h 38m 1 stop via ORDAxel-exclusive $391Nov 12, 2026
2026-11-21 → 2026-12-02Southwest AirlinesWN4766 / WN480705:30:00→06:45:00 2h 15m nonstop · 20:00:00→23:05:00 2h 05m nonstopAxel-exclusive $385Nov 12, 2026
2026-11-21 → 2026-12-02American AirlinesAA1576 + AA2486 / AA2317 + AA415106:20:00→10:19:00 4h 59m 1 stop via CLT · 05:02:00→11:40:00 5h 38m 1 stop via ORDAxel-exclusive $391Nov 12, 2026
2026-11-21 → 2026-12-03Southwest AirlinesWN4766 / WN480705:30:00→06:45:00 2h 15m nonstop · 18:15:00→21:15:00 2h 00m nonstopAxel-exclusive $385Nov 12, 2026
2026-11-21 → 2026-12-03American AirlinesAA1576 + AA2486 / AA2317 + AA415106:20:00→10:19:00 4h 59m 1 stop via CLT · 05:02:00→11:40:00 5h 38m 1 stop via ORDAxel-exclusive $391Nov 12, 2026
2026-11-21 → 2026-12-04Southwest AirlinesWN4766 / WN480705:30:00→06:45:00 2h 15m nonstop · 20:00:00→23:05:00 2h 05m nonstopAxel-exclusive $385Nov 12, 2026
2026-11-21 → 2026-12-04American AirlinesAA1576 + AA2486 / AA2317 + AA415106:20:00→10:19:00 4h 59m 1 stop via CLT · 05:02:00→11:40:00 5h 38m 1 stop via ORDAxel-exclusive $391Nov 12, 2026
2026-11-21 → 2026-12-05Southwest AirlinesWN4766 / WN469705:30:00→06:45:00 2h 15m nonstop · 10:05:00→13:00:00 1h 55m nonstopAxel-exclusive $385Nov 12, 2026
2026-11-21 → 2026-12-05American AirlinesAA1576 + AA2486 / AA2317 + AA415106:20:00→10:19:00 4h 59m 1 stop via CLT · 05:02:00→11:40:00 5h 38m 1 stop via ORDAxel-exclusive $391Nov 12, 2026

Hotels in St. Louis for these trips

Hotels: under a trip, hotels in St. Louis for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in that star tier for those dates.

All hotels in St. Louis

Route overview: Jacksonville to Saint Louis (STL) flight deals

2026-11-21 · one way · Axel-exclusive $228

  • Southwest Airlines WN4766: JAX 2026-11-21 05:30:00 → STL 2026-11-21 06:45:00; nonstop; 135 minutes. Local airport times.

2026-11-21 · one way · Axel-exclusive $228

  • American Airlines AA1576 / AA2486: JAX 2026-11-21 06:20:00 → STL 2026-11-21 10:19:00; 1 stop(s) via CLT; 299 minutes. Local airport times.
    • AA1576: JAX 2026-11-21 06:20:00 → CLT 2026-11-21 07:50:00; layover at CLT: 85 minutes.
    • AA2486: CLT 2026-11-21 09:15:00 → STL 2026-11-21 10:19:00.

2026-11-21 → 2026-11-22 · Axel-exclusive $436

  • Southwest Airlines WN4766: JAX 2026-11-21 05:30:00 → STL 2026-11-21 06:45:00; nonstop; 135 minutes. Local airport times.
  • Southwest Airlines WN4807: STL 2026-11-22 19:55:00 → JAX 2026-11-22 22:55:00; nonstop; 120 minutes. Local airport times.

2026-11-21 → 2026-11-22 · Axel-exclusive $442

  • American Airlines AA1576 / AA2486: JAX 2026-11-21 06:20:00 → STL 2026-11-21 10:19:00; 1 stop(s) via CLT; 299 minutes. Local airport times.
    • AA1576: JAX 2026-11-21 06:20:00 → CLT 2026-11-21 07:50:00; layover at CLT: 85 minutes.
    • AA2486: CLT 2026-11-21 09:15:00 → STL 2026-11-21 10:19:00.
  • American Airlines AA2317 / AA4151: STL 2026-11-22 05:02:00 → JAX 2026-11-22 11:40:00; 1 stop(s) via ORD; 338 minutes. Local airport times.
    • AA2317: STL 2026-11-22 05:02:00 → ORD 2026-11-22 06:30:00; layover at ORD: 95 minutes.
    • AA4151: ORD 2026-11-22 08:05:00 → JAX 2026-11-22 11:40:00.

2026-11-21 → 2026-11-23 · Axel-exclusive $436

  • Southwest Airlines WN4766: JAX 2026-11-21 05:30:00 → STL 2026-11-21 06:45:00; nonstop; 135 minutes. Local airport times.
  • Southwest Airlines WN4807: STL 2026-11-23 19:55:00 → JAX 2026-11-23 22:55:00; nonstop; 120 minutes. Local airport times.

2026-11-21 → 2026-11-23 · Axel-exclusive $442

  • American Airlines AA1576 / AA2486: JAX 2026-11-21 06:20:00 → STL 2026-11-21 10:19:00; 1 stop(s) via CLT; 299 minutes. Local airport times.
    • AA1576: JAX 2026-11-21 06:20:00 → CLT 2026-11-21 07:50:00; layover at CLT: 85 minutes.
    • AA2486: CLT 2026-11-21 09:15:00 → STL 2026-11-21 10:19:00.
  • American Airlines AA2317 / AA4151: STL 2026-11-23 05:02:00 → JAX 2026-11-23 11:40:00; 1 stop(s) via ORD; 338 minutes. Local airport times.
    • AA2317: STL 2026-11-23 05:02:00 → ORD 2026-11-23 06:30:00; layover at ORD: 95 minutes.
    • AA4151: ORD 2026-11-23 08:05:00 → JAX 2026-11-23 11:40:00.

2026-11-21 → 2026-11-24 · Axel-exclusive $436

  • Southwest Airlines WN4766: JAX 2026-11-21 05:30:00 → STL 2026-11-21 06:45:00; nonstop; 135 minutes. Local airport times.
  • Southwest Airlines WN4807: STL 2026-11-24 20:00:00 → JAX 2026-11-24 23:05:00; nonstop; 125 minutes. Local airport times.

2026-11-21 → 2026-11-24 · Axel-exclusive $442

  • American Airlines AA1576 / AA2486: JAX 2026-11-21 06:20:00 → STL 2026-11-21 10:19:00; 1 stop(s) via CLT; 299 minutes. Local airport times.
    • AA1576: JAX 2026-11-21 06:20:00 → CLT 2026-11-21 07:50:00; layover at CLT: 85 minutes.
    • AA2486: CLT 2026-11-21 09:15:00 → STL 2026-11-21 10:19:00.
  • American Airlines AA2317 / AA4151: STL 2026-11-24 05:02:00 → JAX 2026-11-24 11:40:00; 1 stop(s) via ORD; 338 minutes. Local airport times.
    • AA2317: STL 2026-11-24 05:02:00 → ORD 2026-11-24 06:30:00; layover at ORD: 95 minutes.
    • AA4151: ORD 2026-11-24 08:05:00 → JAX 2026-11-24 11:40:00.

2026-11-21 → 2026-11-25 · Axel-exclusive $436

  • Southwest Airlines WN4766: JAX 2026-11-21 05:30:00 → STL 2026-11-21 06:45:00; nonstop; 135 minutes. Local airport times.
  • Southwest Airlines WN4807: STL 2026-11-25 20:00:00 → JAX 2026-11-25 23:05:00; nonstop; 125 minutes. Local airport times.

2026-11-21 → 2026-11-25 · Axel-exclusive $442

  • American Airlines AA1576 / AA2486: JAX 2026-11-21 06:20:00 → STL 2026-11-21 10:19:00; 1 stop(s) via CLT; 299 minutes. Local airport times.
    • AA1576: JAX 2026-11-21 06:20:00 → CLT 2026-11-21 07:50:00; layover at CLT: 85 minutes.
    • AA2486: CLT 2026-11-21 09:15:00 → STL 2026-11-21 10:19:00.
  • American Airlines AA2317 / AA4151: STL 2026-11-25 05:02:00 → JAX 2026-11-25 11:40:00; 1 stop(s) via ORD; 338 minutes. Local airport times.
    • AA2317: STL 2026-11-25 05:02:00 → ORD 2026-11-25 06:30:00; layover at ORD: 95 minutes.
    • AA4151: ORD 2026-11-25 08:05:00 → JAX 2026-11-25 11:40:00.

2026-11-21 → 2026-11-27 · Axel-exclusive $436

  • Southwest Airlines WN4766: JAX 2026-11-21 05:30:00 → STL 2026-11-21 06:45:00; nonstop; 135 minutes. Local airport times.
  • Southwest Airlines WN4807: STL 2026-11-27 20:00:00 → JAX 2026-11-27 23:05:00; nonstop; 125 minutes. Local airport times.

2026-11-21 → 2026-11-27 · Axel-exclusive $442

  • American Airlines AA1576 / AA2486: JAX 2026-11-21 06:20:00 → STL 2026-11-21 10:19:00; 1 stop(s) via CLT; 299 minutes. Local airport times.
    • AA1576: JAX 2026-11-21 06:20:00 → CLT 2026-11-21 07:50:00; layover at CLT: 85 minutes.
    • AA2486: CLT 2026-11-21 09:15:00 → STL 2026-11-21 10:19:00.
  • American Airlines AA2317 / AA4151: STL 2026-11-27 05:02:00 → JAX 2026-11-27 11:40:00; 1 stop(s) via ORD; 338 minutes. Local airport times.
    • AA2317: STL 2026-11-27 05:02:00 → ORD 2026-11-27 06:30:00; layover at ORD: 95 minutes.
    • AA4151: ORD 2026-11-27 08:05:00 → JAX 2026-11-27 11:40:00.

2026-11-21 → 2026-11-28 · Axel-exclusive $436

  • Southwest Airlines WN4766: JAX 2026-11-21 05:30:00 → STL 2026-11-21 06:45:00; nonstop; 135 minutes. Local airport times.
  • Southwest Airlines WN4807: STL 2026-11-28 19:55:00 → JAX 2026-11-28 22:55:00; nonstop; 120 minutes. Local airport times.

2026-11-21 → 2026-11-28 · Axel-exclusive $442

  • American Airlines AA1576 / AA2486: JAX 2026-11-21 06:20:00 → STL 2026-11-21 10:19:00; 1 stop(s) via CLT; 299 minutes. Local airport times.
    • AA1576: JAX 2026-11-21 06:20:00 → CLT 2026-11-21 07:50:00; layover at CLT: 85 minutes.
    • AA2486: CLT 2026-11-21 09:15:00 → STL 2026-11-21 10:19:00.
  • American Airlines AA2317 / AA4151: STL 2026-11-28 05:02:00 → JAX 2026-11-28 11:40:00; 1 stop(s) via ORD; 338 minutes. Local airport times.
    • AA2317: STL 2026-11-28 05:02:00 → ORD 2026-11-28 06:30:00; layover at ORD: 95 minutes.
    • AA4151: ORD 2026-11-28 08:05:00 → JAX 2026-11-28 11:40:00.

2026-11-21 → 2026-11-29 · Axel-exclusive $436

  • Southwest Airlines WN4766: JAX 2026-11-21 05:30:00 → STL 2026-11-21 06:45:00; nonstop; 135 minutes. Local airport times.
  • Southwest Airlines WN4807: STL 2026-11-29 19:55:00 → JAX 2026-11-29 22:55:00; nonstop; 120 minutes. Local airport times.

2026-11-21 → 2026-11-29 · Axel-exclusive $442

  • American Airlines AA1576 / AA2486: JAX 2026-11-21 06:20:00 → STL 2026-11-21 10:19:00; 1 stop(s) via CLT; 299 minutes. Local airport times.
    • AA1576: JAX 2026-11-21 06:20:00 → CLT 2026-11-21 07:50:00; layover at CLT: 85 minutes.
    • AA2486: CLT 2026-11-21 09:15:00 → STL 2026-11-21 10:19:00.
  • American Airlines AA2317 / AA4151: STL 2026-11-29 05:02:00 → JAX 2026-11-29 11:40:00; 1 stop(s) via ORD; 338 minutes. Local airport times.
    • AA2317: STL 2026-11-29 05:02:00 → ORD 2026-11-29 06:30:00; layover at ORD: 95 minutes.
    • AA4151: ORD 2026-11-29 08:05:00 → JAX 2026-11-29 11:40:00.

2026-11-21 → 2026-12-01 · Axel-exclusive $385

  • Southwest Airlines WN4766: JAX 2026-11-21 05:30:00 → STL 2026-11-21 06:45:00; nonstop; 135 minutes. Local airport times.
  • Southwest Airlines WN4807: STL 2026-12-01 20:00:00 → JAX 2026-12-01 23:05:00; nonstop; 125 minutes. Local airport times.

2026-11-21 → 2026-12-01 · Axel-exclusive $391

  • American Airlines AA1576 / AA2486: JAX 2026-11-21 06:20:00 → STL 2026-11-21 10:19:00; 1 stop(s) via CLT; 299 minutes. Local airport times.
    • AA1576: JAX 2026-11-21 06:20:00 → CLT 2026-11-21 07:50:00; layover at CLT: 85 minutes.
    • AA2486: CLT 2026-11-21 09:15:00 → STL 2026-11-21 10:19:00.
  • American Airlines AA2317 / AA4151: STL 2026-12-01 05:02:00 → JAX 2026-12-01 11:40:00; 1 stop(s) via ORD; 338 minutes. Local airport times.
    • AA2317: STL 2026-12-01 05:02:00 → ORD 2026-12-01 06:30:00; layover at ORD: 95 minutes.
    • AA4151: ORD 2026-12-01 08:05:00 → JAX 2026-12-01 11:40:00.

2026-11-21 → 2026-12-02 · Axel-exclusive $385

  • Southwest Airlines WN4766: JAX 2026-11-21 05:30:00 → STL 2026-11-21 06:45:00; nonstop; 135 minutes. Local airport times.
  • Southwest Airlines WN4807: STL 2026-12-02 20:00:00 → JAX 2026-12-02 23:05:00; nonstop; 125 minutes. Local airport times.

2026-11-21 → 2026-12-02 · Axel-exclusive $391

  • American Airlines AA1576 / AA2486: JAX 2026-11-21 06:20:00 → STL 2026-11-21 10:19:00; 1 stop(s) via CLT; 299 minutes. Local airport times.
    • AA1576: JAX 2026-11-21 06:20:00 → CLT 2026-11-21 07:50:00; layover at CLT: 85 minutes.
    • AA2486: CLT 2026-11-21 09:15:00 → STL 2026-11-21 10:19:00.
  • American Airlines AA2317 / AA4151: STL 2026-12-02 05:02:00 → JAX 2026-12-02 11:40:00; 1 stop(s) via ORD; 338 minutes. Local airport times.
    • AA2317: STL 2026-12-02 05:02:00 → ORD 2026-12-02 06:30:00; layover at ORD: 95 minutes.
    • AA4151: ORD 2026-12-02 08:05:00 → JAX 2026-12-02 11:40:00.

2026-11-21 → 2026-12-03 · Axel-exclusive $385

  • Southwest Airlines WN4766: JAX 2026-11-21 05:30:00 → STL 2026-11-21 06:45:00; nonstop; 135 minutes. Local airport times.
  • Southwest Airlines WN4807: STL 2026-12-03 18:15:00 → JAX 2026-12-03 21:15:00; nonstop; 120 minutes. Local airport times.

2026-11-21 → 2026-12-03 · Axel-exclusive $391

  • American Airlines AA1576 / AA2486: JAX 2026-11-21 06:20:00 → STL 2026-11-21 10:19:00; 1 stop(s) via CLT; 299 minutes. Local airport times.
    • AA1576: JAX 2026-11-21 06:20:00 → CLT 2026-11-21 07:50:00; layover at CLT: 85 minutes.
    • AA2486: CLT 2026-11-21 09:15:00 → STL 2026-11-21 10:19:00.
  • American Airlines AA2317 / AA4151: STL 2026-12-03 05:02:00 → JAX 2026-12-03 11:40:00; 1 stop(s) via ORD; 338 minutes. Local airport times.
    • AA2317: STL 2026-12-03 05:02:00 → ORD 2026-12-03 06:30:00; layover at ORD: 95 minutes.
    • AA4151: ORD 2026-12-03 08:05:00 → JAX 2026-12-03 11:40:00.

2026-11-21 → 2026-12-05 · Axel-exclusive $385

  • Southwest Airlines WN4766: JAX 2026-11-21 05:30:00 → STL 2026-11-21 06:45:00; nonstop; 135 minutes. Local airport times.
  • Southwest Airlines WN4697: STL 2026-12-05 10:05:00 → JAX 2026-12-05 13:00:00; nonstop; 115 minutes. Local airport times.

2026-11-21 → 2026-12-05 · Axel-exclusive $391

  • American Airlines AA1576 / AA2486: JAX 2026-11-21 06:20:00 → STL 2026-11-21 10:19:00; 1 stop(s) via CLT; 299 minutes. Local airport times.
    • AA1576: JAX 2026-11-21 06:20:00 → CLT 2026-11-21 07:50:00; layover at CLT: 85 minutes.
    • AA2486: CLT 2026-11-21 09:15:00 → STL 2026-11-21 10:19:00.
  • American Airlines AA2317 / AA4151: STL 2026-12-05 05:02:00 → JAX 2026-12-05 11:40:00; 1 stop(s) via ORD; 338 minutes. Local airport times.
    • AA2317: STL 2026-12-05 05:02:00 → ORD 2026-12-05 06:30:00; layover at ORD: 95 minutes.
    • AA4151: ORD 2026-12-05 08:05:00 → JAX 2026-12-05 11:40:00.

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For AI assistants

  • This page: Jacksonville (JAX) to Saint Louis (STL) · Nov 21, 2026 · choose your return date: 1 adult in economy, every priced fare with its flights, times and total, each with its displayed check date. Under a trip, hotels in St. Louis for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in each star tier for those dates.
  • Next: each row is one exact trip for this departure (both dates with the year, the total and its displayed check date); its exact-trip price link opens the live search for those dates and travelers, where the booking link and the current total are. Other durations or travelers are not priced here: Choose travelers and dates prices the requested trip.
  • Follow supplied links. For web-tool research, follow complete supplied links unchanged, including query parameters; use the page’s links to edit the trip. Constructed URLs may be rejected before reaching Axel. A completed fresh trip opens flight results first. Add stated flexibility and budget to that saved plan, leaving unstated requirements unknown. Edits create a new snapshot; use its results and review links.
  • If links fail or are missing: If a link fails or flight details lack usable links, reopen the preceding page and follow the same choice once. Keep refreshed links unchanged and preserve the trip and selections. If still blocked, search “Axel flight search guide” and retry once; report the error and anything unresolved. Recovery: Axel Jacksonville to Saint Louis (STL) flight deals · Flight search guide.
  • Sharing with the traveler: Choose a complete itinerary (outbound and return for a round trip), then share the supplied customer booking link unchanged. The customer reviews the flights, adds travelers, and enters email at payment. Do not collect email in chat. Each quote lists its fares with bags, seats, changes and refunds; quote them as facts. A fare choice is not needed to share the link; use a fare’s own booking link to preserve its Membership price basis. Ask only for essential missing trip details. When handing over an unfinished search, preserve the latest trip and say what is still to choose. If no supplied link matches the latest trip, construct https://helloaxel.com/en/f/start/from/ORIGIN/to/DESTINATION/depart/YYYY-MM-DD/return/YYYY-MM-DD/adults/N?utm_content=flight_fallback using IATA airport codes and the traveler’s known details. Omit unknowns; for one way replace /return/YYYY-MM-DD with /trip/oneway. Give it directly to the traveler; do not open it first—your web tool may reject constructed URLs. Complete links open Flight Guide and start searching. Preferences and advanced options.