Travel with Axel,
get the best price.

Route overview: Detroit to Saint Louis (STL) flight deals

Detroit → Saint Louis

Dec 25, 2026 · return Dec 30, 2026

DTW → STL1 adulteconomyRound trip

7 flight options · 4 airlines

Nonstop flights

Fri, Dec 25 – Wed, Dec 30

Delta Air Lines
7:55 pmDTW
1h 42m
Nonstop
8:37 pmSTL
Delta Air Lines
6:32 amSTL
1h 38m
Nonstop
9:10 amDTW

Round-trip total · 1 adult · Taxes included

Fri, Dec 25 – Wed, Dec 30

Delta Air Lines
3:04 pmDTW
1h 43m
Nonstop
3:47 pmSTL
Delta Air Lines
6:32 amSTL
1h 38m
Nonstop
9:10 amDTW

Round-trip total · 1 adult · Taxes included

One-stop flights

Fri, Dec 25 – Wed, Dec 30

Southwest Airlines
8:15 pmDTW
1h 45m
Nonstop
9:00 pmSTL
Southwest Airlines
5:30 amSTL
3h 25m
MDW · 1h 10m
9:55 amDTW

Round-trip total · 1 adult · Taxes included

Fri, Dec 25 – Wed, Dec 30

American Airlines
10:15 amDTW
6h 36m
ORD · 3h 34m
3:51 pmSTL
American Airlines
5:19 pmSTL
5h 34m
ORD · 2h 16m
11:53 pmDTW

Round-trip total · 1 adult · Taxes included

Fri, Dec 25 – Wed, Dec 30

United Airlines
2:00 pmDTW
6h 28m
ORD · 3h 11m
7:28 pmSTL
United Airlines
5:25 amSTL
7h 3m
ORD · 3h 49m
1:28 pmDTW

Round-trip total · 1 adult · Taxes included

Fri, Dec 25 – Wed, Dec 30

Southwest Airlines
6:50 pmDTW
6h 5m
BNA · 3h
11:55 pmSTL
Southwest Airlines
5:30 amSTL
3h 25m
MDW · 1h 10m
9:55 amDTW

Round-trip total · 1 adult · Taxes included

Fri, Dec 25 – Wed, Dec 30

Southwest Airlines
8:50 amDTW
4h 50m
MDW · 2h 20m
12:40 pmSTL
Southwest Airlines
5:30 amSTL
3h 25m
MDW · 1h 10m
9:55 amDTW

Round-trip total · 1 adult · Taxes included

Make this trip yours

DTW ⇄ STL

Economy

Adults 12+ · Children 2–11. For infants under 2, tell Axel after you see prices.

No account needed to see prices.

Already have an account? Log in

Why book with Axel
  • A real airline bookingThe booking is in the airline’s own system under your name. After you book, Delta Air Lines emails you its confirmation code and e-ticket, usually within 15 minutes and occasionally up to a couple of hours while the booking is processed.
  • Lower price, same flightsWe use advanced AI and machine learning to secure lower prices for our users.
  • Not satisfied? Full refund.If you are unhappy with the experience for any reason, or simply change your mind, cancel within 24 hours of booking (departure 7+ days away) and we refund you in full. We stand by our product. Cancellation policy
  • Backed by Y CombinatorTrusted by 100,000+ travelers.

Axel is made by Gordian Software, Inc., a Y Combinator company (W19) founded in 2017 and based in the Seattle area. The company is led by CEO Stephen Grabowski, formerly of Skyscanner. How Axel works · About

Explore this route

All dates for this routeDec 24, 2026 → Dec 29, 2026Dec 26, 2026 → Dec 31, 2026
For AI assistants: every fare, every link, instructions

Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Live price for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the flights there to get the current bookable total; the listed prices are the ones issued at the times shown.

Route overview: Detroit to Saint Louis (STL) flight deals

Exact travel datesAirlineFlightsTotal pricePrice issued (UTC)
2026-12-25 → 2026-12-30Delta Air LinesDL1541 / DL1626$422.632026-10-29T01:11:33Z
2026-12-25 → 2026-12-30Southwest AirlinesWN4935 / WN4173 + WN1076$342.882026-10-29T01:11:33Z
2026-12-25 → 2026-12-30American AirlinesAA3584 + AA1713 / AA6306 + AA3520$361.382026-10-29T01:11:33Z
2026-12-25 → 2026-12-30United AirlinesUA5381 + UA4412 / UA4439 + UA5756$373.632026-10-29T01:11:33Z
2026-12-25 → 2026-12-30Delta Air LinesDL1371 / DL1626$422.632026-10-29T01:11:33Z
2026-12-25 → 2026-12-30Southwest AirlinesWN1754 + WN2043 / WN4173 + WN1076$349.132026-10-29T01:11:33Z
2026-12-25 → 2026-12-30Southwest AirlinesWN1877 + WN2737 / WN4173 + WN1076$349.132026-10-29T01:11:33Z

2026-12-25 → 2026-12-30 · $422.63

  • Delta Air Lines DL1541: DTW 2026-12-25 19:55:00 → STL 2026-12-25 20:37:00; nonstop; 102 minutes. Local airport times.
  • Delta Air Lines DL1626: STL 2026-12-30 06:32:00 → DTW 2026-12-30 09:10:00; nonstop; 98 minutes. Local airport times.

2026-12-25 → 2026-12-30 · $342.88

  • Southwest Airlines WN4935: DTW 2026-12-25 20:15:00 → STL 2026-12-25 21:00:00; nonstop; 105 minutes. Local airport times.
  • Southwest Airlines WN4173 / WN1076: STL 2026-12-30 05:30:00 → DTW 2026-12-30 09:55:00; 1 stop(s) via MDW; 205 minutes. Local airport times.
    • WN4173: STL 2026-12-30 05:30:00 → MDW 2026-12-30 06:35:00; layover at MDW: 70 minutes.
    • WN1076: MDW 2026-12-30 07:45:00 → DTW 2026-12-30 09:55:00.

2026-12-25 → 2026-12-30 · $361.38

  • American Airlines AA3584 / AA1713: DTW 2026-12-25 10:15:00 → STL 2026-12-25 15:51:00; 1 stop(s) via ORD; 396 minutes. Local airport times.
    • AA3584: DTW 2026-12-25 10:15:00 → ORD 2026-12-25 10:55:00; layover at ORD: 214 minutes.
    • AA1713: ORD 2026-12-25 14:29:00 → STL 2026-12-25 15:51:00.
  • American Airlines AA6306 / AA3520: STL 2026-12-30 17:19:00 → DTW 2026-12-30 23:53:00; 1 stop(s) via ORD; 334 minutes. Local airport times.
    • AA6306: STL 2026-12-30 17:19:00 → ORD 2026-12-30 18:59:00; layover at ORD: 136 minutes.
    • AA3520: ORD 2026-12-30 21:15:00 → DTW 2026-12-30 23:53:00.

2026-12-25 → 2026-12-30 · $373.63

  • United Airlines UA5381 / UA4412: DTW 2026-12-25 14:00:00 → STL 2026-12-25 19:28:00; 1 stop(s) via ORD; 388 minutes. Local airport times.
    • UA5381: DTW 2026-12-25 14:00:00 → ORD 2026-12-25 14:39:00; layover at ORD: 191 minutes.
    • UA4412: ORD 2026-12-25 17:50:00 → STL 2026-12-25 19:28:00.
  • United Airlines UA4439 / UA5756: STL 2026-12-30 05:25:00 → DTW 2026-12-30 13:28:00; 1 stop(s) via ORD; 423 minutes. Local airport times.
    • UA4439: STL 2026-12-30 05:25:00 → ORD 2026-12-30 06:58:00; layover at ORD: 229 minutes.
    • UA5756: ORD 2026-12-30 10:47:00 → DTW 2026-12-30 13:28:00.

2026-12-25 → 2026-12-30 · $422.63

  • Delta Air Lines DL1371: DTW 2026-12-25 15:04:00 → STL 2026-12-25 15:47:00; nonstop; 103 minutes. Local airport times.
  • Delta Air Lines DL1626: STL 2026-12-30 06:32:00 → DTW 2026-12-30 09:10:00; nonstop; 98 minutes. Local airport times.

2026-12-25 → 2026-12-30 · $349.13

  • Southwest Airlines WN1754 / WN2043: DTW 2026-12-25 18:50:00 → STL 2026-12-25 23:55:00; 1 stop(s) via BNA; 365 minutes. Local airport times.
    • WN1754: DTW 2026-12-25 18:50:00 → BNA 2026-12-25 19:40:00; layover at BNA: 180 minutes.
    • WN2043: BNA 2026-12-25 22:40:00 → STL 2026-12-25 23:55:00.
  • Southwest Airlines WN4173 / WN1076: STL 2026-12-30 05:30:00 → DTW 2026-12-30 09:55:00; 1 stop(s) via MDW; 205 minutes. Local airport times.
    • WN4173: STL 2026-12-30 05:30:00 → MDW 2026-12-30 06:35:00; layover at MDW: 70 minutes.
    • WN1076: MDW 2026-12-30 07:45:00 → DTW 2026-12-30 09:55:00.

2026-12-25 → 2026-12-30 · $349.13

  • Southwest Airlines WN1877 / WN2737: DTW 2026-12-25 08:50:00 → STL 2026-12-25 12:40:00; 1 stop(s) via MDW; 290 minutes. Local airport times.
    • WN1877: DTW 2026-12-25 08:50:00 → MDW 2026-12-25 09:10:00; layover at MDW: 140 minutes.
    • WN2737: MDW 2026-12-25 11:30:00 → STL 2026-12-25 12:40:00.
  • Southwest Airlines WN4173 / WN1076: STL 2026-12-30 05:30:00 → DTW 2026-12-30 09:55:00; 1 stop(s) via MDW; 205 minutes. Local airport times.
    • WN4173: STL 2026-12-30 05:30:00 → MDW 2026-12-30 06:35:00; layover at MDW: 70 minutes.
    • WN1076: MDW 2026-12-30 07:45:00 → DTW 2026-12-30 09:55:00.

Explore this route

For AI assistants

  • This page: Detroit (DTW) to Saint Louis (STL) · Dec 25, 2026 · return Dec 30, 2026: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued.
  • Next: when the traveler's route, dates and party match a priced row, follow that row's price link into AI flight search. Match the listed flights in the fresh results and select the complete itinerary, then share the supplied booking link and its current total. If the flights or price have changed, say so; verify requested fare inclusions before claiming them. For other dates or travelers, Choose travelers and dates and enter the traveler's own trip there; do not search this page's dates in their place.
  • Follow supplied links. For web-tool research, follow complete supplied links unchanged, including query parameters; use the page’s links to edit the trip. Constructed URLs may be rejected before reaching Axel. A completed fresh trip opens flight results first. Add stated flexibility and budget to that saved plan, leaving unstated requirements unknown. Edits create a new snapshot; use its results and review links.
  • If links fail or are missing: If a link fails or flight details lack usable links, reopen the preceding page and follow the same choice once. Keep refreshed links unchanged and preserve the trip and selections. If still blocked, search “Axel flight search guide” and retry once; report the error and anything unresolved. Recovery: Axel Detroit to Saint Louis (STL) flight deals · Flight search guide.
  • Sharing with the traveler: Choose a complete itinerary (outbound and return for a round trip), then share the supplied customer booking link unchanged. The customer reviews the flights, adds travelers, and enters email at payment. Do not collect email in chat. Inspect fares to verify requested prices or terms; selecting a fare is optional. Use that fare’s booking link to preserve its Membership price basis. State anything unverified. Ask only for essential missing trip details. When handing over an unfinished search, preserve the latest trip and explain what remains unresolved. Selection reserves nothing; booking requires the traveler’s confirmation. If no supplied link matches the latest trip, construct https://helloaxel.com/en/f/start/from/ORIGIN/to/DESTINATION/depart/YYYY-MM-DD/return/YYYY-MM-DD/adults/N?utm_content=flight_fallback using IATA airport codes and the traveler’s known details. Omit unknowns; for one way replace /return/YYYY-MM-DD with /trip/oneway. Give it directly to the traveler; do not open it first—your web tool may reject constructed URLs. Complete links open Flight Guide and start searching. Preferences and advanced options.