Tampa (TPA) to Knoxville (TYS) · Dec 5, 2026 · return Dec 12, 2026

Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Hotels in Knoxville for these trips

Hotels: under a trip, hotels in Knoxville for exactly those nights: the lowest 3★, 4★, 5★ stay totals among the city's featured hotels, Axel's price for 2 adults in 1 room, each opening that hotel's page for those dates with the rooms and the booking link.

• Hotels in Knoxville for these nights (Dec 5–12, 2026 · 7 nights · 2 adults, 1 room): 3★ Holiday Inn Knoxville N - Merchant Drive by IHG, $757 total · 4★ Marriott Knoxville Downtown, $1,341 total

All hotels in Knoxville

Route overview: Tampa to Knoxville (TYS) flight deals

2026-12-05 → 2026-12-12 · Axel-exclusive $315.00

• Southwest Airlines WN4205: TPA 2026-12-05 12:40:00 → TYS 2026-12-05 14:30:00; nonstop; 110 minutes. Local airport times.
• Southwest Airlines WN1745 / WN748: TYS 2026-12-12 19:15:00 → TPA 2026-12-13 01:05:00; 1 stop(s) via BNA; 350 minutes. Local airport times.
  • WN1745: TYS 2026-12-12 19:15:00 → BNA 2026-12-12 19:15:00; layover at BNA: 180 minutes.
  • WN748: BNA 2026-12-12 22:15:00 → TPA 2026-12-13 01:05:00.

2026-12-05 → 2026-12-12 · Axel-exclusive $345.00

• American Airlines AA1565 / AA6437: TPA 2026-12-05 12:38:00 → TYS 2026-12-05 16:43:00; 1 stop(s) via CLT; 245 minutes. Local airport times.
  • AA1565: TPA 2026-12-05 12:38:00 → CLT 2026-12-05 14:24:00; layover at CLT: 61 minutes.
  • AA6437: CLT 2026-12-05 15:25:00 → TYS 2026-12-05 16:43:00.
• American Airlines AA3721 / AA1970: TYS 2026-12-12 18:47:00 → TPA 2026-12-12 23:21:00; 1 stop(s) via MIA; 274 minutes. Local airport times.
  • AA3721: TYS 2026-12-12 18:47:00 → MIA 2026-12-12 21:00:00; layover at MIA: 65 minutes.
  • AA1970: MIA 2026-12-12 22:05:00 → TPA 2026-12-12 23:21:00.

2026-12-05 → 2026-12-12 · Axel-exclusive $365.00

• Delta Air Lines DL1099 / DL2571: TPA 2026-12-05 13:20:00 → TYS 2026-12-05 17:22:00; 1 stop(s) via ATL; 242 minutes. Local airport times.
  • DL1099: TPA 2026-12-05 13:20:00 → ATL 2026-12-05 14:55:00; layover at ATL: 90 minutes.
  • DL2571: ATL 2026-12-05 16:25:00 → TYS 2026-12-05 17:22:00.
• Delta Air Lines DL4666 / DL1167: TYS 2026-12-12 10:35:00 → TPA 2026-12-12 16:15:00; 1 stop(s) via ATL; 340 minutes. Local airport times.
  • DL4666: TYS 2026-12-12 10:35:00 → ATL 2026-12-12 11:36:00; layover at ATL: 189 minutes.
  • DL1167: ATL 2026-12-12 14:45:00 → TPA 2026-12-12 16:15:00.

2026-12-05 → 2026-12-12 · Axel-exclusive $325.00

• Southwest Airlines WN523 / WN1875: TPA 2026-12-05 08:05:00 → TYS 2026-12-05 12:20:00; 1 stop(s) via BNA; 255 minutes. Local airport times.
  • WN523: TPA 2026-12-05 08:05:00 → BNA 2026-12-05 09:00:00; layover at BNA: 80 minutes.
  • WN1875: BNA 2026-12-05 10:20:00 → TYS 2026-12-05 12:20:00.
• Southwest Airlines WN1745 / WN748: TYS 2026-12-12 19:15:00 → TPA 2026-12-13 01:05:00; 1 stop(s) via BNA; 350 minutes. Local airport times.
  • WN1745: TYS 2026-12-12 19:15:00 → BNA 2026-12-12 19:15:00; layover at BNA: 180 minutes.
  • WN748: BNA 2026-12-12 22:15:00 → TPA 2026-12-13 01:05:00.

2026-12-05 → 2026-12-12 · Axel-exclusive $345.00

• American Airlines AA3998 / AA4061: TPA 2026-12-05 13:11:00 → TYS 2026-12-05 20:14:00; 1 stop(s) via MIA; 423 minutes. Local airport times.
  • AA3998: TPA 2026-12-05 13:11:00 → MIA 2026-12-05 14:19:00; layover at MIA: 208 minutes.
  • AA4061: MIA 2026-12-05 17:47:00 → TYS 2026-12-05 20:14:00.
• American Airlines AA3721 / AA1970: TYS 2026-12-12 18:47:00 → TPA 2026-12-12 23:21:00; 1 stop(s) via MIA; 274 minutes. Local airport times.
  • AA3721: TYS 2026-12-12 18:47:00 → MIA 2026-12-12 21:00:00; layover at MIA: 65 minutes.
  • AA1970: MIA 2026-12-12 22:05:00 → TPA 2026-12-12 23:21:00.

Explore this route

• All dates for this route
• Dec 4, 2026 · Return options
• Dec 6, 2026 · Return options
• Hotels in Knoxville with Axel

For AI assistants

• This page: Tampa (TPA) to Knoxville (TYS) · Dec 5, 2026 · return Dec 12, 2026: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued. Under a trip, hotels in Knoxville for exactly those nights: the lowest 3★, 4★ and 5★ stay totals for 2 adults in 1 room, each linking to that hotel's page for those dates.
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