Tampa (TPA) to San Francisco (SFO), Mar 25, 2027: round trips from $408, one way from $221

Tampa (TPA) to San Francisco (SFO), Mar 25, 2027: round trips from $408, one way from $221 on Axel, checked Nov 13, 2026. Lowest published fares: $408 round trip, Axel-exclusive, Southwest Airlines, 1 stop, Mar 25, 2027 – Apr 1, 2027; $221 one way, Axel-exclusive, Southwest Airlines, 1 stop, Mar 25, 2027; 1 adult, economy, checked Nov 13, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Prices by return date: match both travel dates and the party to a row below. Each total is for that exact trip, labelled with the check date shown.

Date links open published trip details for exploration. Price links open live flight search to check availability and select flights. For a price comparison, use the amounts and check dates already shown here.

Hotels in San Francisco for these trips

Hotels: under a trip, hotels in San Francisco for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in San Francisco for these nights (Mar 25–26, 2027 · 1 night · 2 adults, 1 room): 3★ Tilden Hotel, $111 a night · 4★ Hotel Bijou - Union Square, $134 a night · 5★ Taj Campton Place, $272 a night
• Hotels in San Francisco for these nights (Mar 25–27, 2027 · 2 nights · 2 adults, 1 room): 3★ Tilden Hotel, $118 a night, $235 for 2 nights · 4★ Hotel Bijou - Union Square, $133 a night, $266 for 2 nights · 5★ Taj Campton Place, $294 a night, $587 for 2 nights
• Hotels in San Francisco for these nights (Mar 25–28, 2027 · 3 nights · 2 adults, 1 room): 3★ Tilden Hotel, $119 a night, $358 for 3 nights · 4★ Hotel Bijou - Union Square, $133 a night, $399 for 3 nights · 5★ Taj Campton Place, $307 a night, $921 for 3 nights
• Hotels in San Francisco for these nights (Mar 25–29, 2027 · 4 nights · 2 adults, 1 room): 3★ Tilden Hotel, $119 a night, $475 for 4 nights · 4★ Hotel Bijou - Union Square, $134 a night, $535 for 4 nights · 5★ Taj Campton Place, $291 a night, $1,165 for 4 nights
• Hotels in San Francisco for these nights (Mar 25–30, 2027 · 5 nights · 2 adults, 1 room): 3★ Tilden Hotel, $118 a night, $591 for 5 nights · 4★ BEI Hotel San Francisco, $138 a night, $691 for 5 nights · 5★ Taj Campton Place, $283 a night, $1,413 for 5 nights
• Hotels in San Francisco for these nights (Mar 25–31, 2027 · 6 nights · 2 adults, 1 room): 3★ Tilden Hotel, $118 a night, $710 for 6 nights · 4★ BEI Hotel San Francisco, $139 a night, $836 for 6 nights · 5★ Taj Campton Place, $276 a night, $1,657 for 6 nights
• Hotels in San Francisco for these nights (Mar 25 – Apr 1, 2027 · 7 nights · 2 adults, 1 room): 3★ Tilden Hotel, $119 a night, $834 for 7 nights · 4★ BEI Hotel San Francisco, $141 a night, $989 for 7 nights · 5★ Taj Campton Place, $270 a night, $1,893 for 7 nights
• Hotels in San Francisco for these nights (Mar 25 – Apr 2, 2027 · 8 nights · 2 adults, 1 room): 3★ Tilden Hotel, $119 a night, $948 for 8 nights · 4★ BEI Hotel San Francisco, $143 a night, $1,140 for 8 nights · 5★ Taj Campton Place, $275 a night, $2,196 for 8 nights
• Hotels in San Francisco for these nights (Mar 25 – Apr 3, 2027 · 9 nights · 2 adults, 1 room): 3★ Tilden Hotel, $120 a night, $1,079 for 9 nights · 4★ BEI Hotel San Francisco, $142 a night, $1,282 for 9 nights · 5★ Taj Campton Place, $282 a night, $2,537 for 9 nights
• Hotels in San Francisco for these nights (Mar 25 – Apr 4, 2027 · 10 nights · 2 adults, 1 room): 3★ Tilden Hotel, $125 a night, $1,245 for 10 nights · 4★ BEI Hotel San Francisco, $143 a night, $1,430 for 10 nights · 5★ Taj Campton Place, $291 a night, $2,910 for 10 nights
• Hotels in San Francisco for these nights (Mar 25 – Apr 5, 2027 · 11 nights · 2 adults, 1 room): 3★ The Pickwick Hotel, $144 a night, $1,582 for 11 nights · 4★ Hotel Bijou - Union Square, $154 a night, $1,693 for 11 nights · 5★ Taj Campton Place, $301 a night, $3,306 for 11 nights
• Hotels in San Francisco for these nights (Mar 25 – Apr 6, 2027 · 12 nights · 2 adults, 1 room): 3★ The Pickwick Hotel, $191 a night, $2,296 for 12 nights · 4★ BEI Hotel San Francisco, $222 a night, $2,662 for 12 nights · 5★ Neighbourgood Sutter Mansion, $403 a night, $4,836 for 12 nights
• Hotels in San Francisco for these nights (Mar 25 – Apr 7, 2027 · 13 nights · 2 adults, 1 room): 3★ Tilden Hotel, $234 a night, $3,036 for 13 nights · 4★ BEI Hotel San Francisco, $255 a night, $3,311 for 13 nights · 5★ Neighbourgood Sutter Mansion, $439 a night, $5,708 for 13 nights
• Hotels in San Francisco for these nights (Mar 25 – Apr 8, 2027 · 14 nights · 2 adults, 1 room): 3★ Hotel Majestic, $247 a night, $3,463 for 14 nights · 4★ BEI Hotel San Francisco, $281 a night, $3,938 for 14 nights · 5★ Neighbourgood Sutter Mansion, $469 a night, $6,571 for 14 nights

All hotels in San Francisco

Route overview: Tampa to San Francisco (SFO) flight deals

2027-03-25 · one way · Axel-exclusive $221

• Southwest Airlines WN4274 / WN327: TPA 2027-03-25 07:10:00 → SFO 2027-03-25 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2027-03-25 07:10:00 → PHX 2027-03-25 09:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2027-03-25 10:10:00 → SFO 2027-03-25 12:20:00.

2027-03-25 · one way · Axel-exclusive $265

• United Airlines UA270: TPA 2027-03-25 08:00:00 → SFO 2027-03-25 11:02:00; nonstop; 362 minutes. Local airport times.

2027-03-25 → 2027-03-26 · Axel-exclusive $416

• Southwest Airlines WN4274 / WN327: TPA 2027-03-25 07:10:00 → SFO 2027-03-25 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2027-03-25 07:10:00 → PHX 2027-03-25 09:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2027-03-25 10:10:00 → SFO 2027-03-25 12:20:00.
• Southwest Airlines WN2989 / WN4206: SFO 2027-03-26 13:05:00 → TPA 2027-03-26 23:15:00; 1 stop(s) via STL; 430 minutes. Local airport times.
  • WN2989: SFO 2027-03-26 13:05:00 → STL 2027-03-26 18:55:00; layover at STL: 60 minutes.
  • WN4206: STL 2027-03-26 19:55:00 → TPA 2027-03-26 23:15:00.

2027-03-25 → 2027-03-26 · Axel-exclusive $491

• United Airlines UA270: TPA 2027-03-25 08:00:00 → SFO 2027-03-25 11:02:00; nonstop; 362 minutes. Local airport times.
• United Airlines UA1112: SFO 2027-03-26 23:59:00 → TPA 2027-03-27 08:05:00; nonstop; 306 minutes. Local airport times.

2027-03-25 → 2027-03-27 · Axel-exclusive $416

• Southwest Airlines WN4274 / WN327: TPA 2027-03-25 07:10:00 → SFO 2027-03-25 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2027-03-25 07:10:00 → PHX 2027-03-25 09:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2027-03-25 10:10:00 → SFO 2027-03-25 12:20:00.
• Southwest Airlines WN4578 / WN489: SFO 2027-03-27 06:10:00 → TPA 2027-03-27 16:15:00; 1 stop(s) via DEN; 425 minutes. Local airport times.
  • WN4578: SFO 2027-03-27 06:10:00 → DEN 2027-03-27 09:45:00; layover at DEN: 65 minutes.
  • WN489: DEN 2027-03-27 10:50:00 → TPA 2027-03-27 16:15:00.

2027-03-25 → 2027-03-27 · Axel-exclusive $491

• United Airlines UA270: TPA 2027-03-25 08:00:00 → SFO 2027-03-25 11:02:00; nonstop; 362 minutes. Local airport times.
• United Airlines UA1651: SFO 2027-03-27 08:15:00 → TPA 2027-03-27 16:21:00; nonstop; 306 minutes. Local airport times.

2027-03-25 → 2027-03-28 · Axel-exclusive $460

• Southwest Airlines WN4274 / WN327: TPA 2027-03-25 07:10:00 → SFO 2027-03-25 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2027-03-25 07:10:00 → PHX 2027-03-25 09:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2027-03-25 10:10:00 → SFO 2027-03-25 12:20:00.
• Southwest Airlines WN4578 / WN489: SFO 2027-03-28 06:10:00 → TPA 2027-03-28 16:15:00; 1 stop(s) via DEN; 425 minutes. Local airport times.
  • WN4578: SFO 2027-03-28 06:10:00 → DEN 2027-03-28 09:45:00; layover at DEN: 65 minutes.
  • WN489: DEN 2027-03-28 10:50:00 → TPA 2027-03-28 16:15:00.

2027-03-25 → 2027-03-28 · Axel-exclusive $542

• United Airlines UA270: TPA 2027-03-25 08:00:00 → SFO 2027-03-25 11:02:00; nonstop; 362 minutes. Local airport times.
• United Airlines UA1651: SFO 2027-03-28 07:25:00 → TPA 2027-03-28 15:31:00; nonstop; 306 minutes. Local airport times.

2027-03-25 → 2027-03-29 · Axel-exclusive $460

• Southwest Airlines WN4274 / WN327: TPA 2027-03-25 07:10:00 → SFO 2027-03-25 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2027-03-25 07:10:00 → PHX 2027-03-25 09:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2027-03-25 10:10:00 → SFO 2027-03-25 12:20:00.
• Southwest Airlines WN1982 / WN1434: SFO 2027-03-29 14:00:00 → TPA 2027-03-30 00:10:00; 1 stop(s) via DAL; 430 minutes. Local airport times.
  • WN1982: SFO 2027-03-29 14:00:00 → DAL 2027-03-29 19:30:00; layover at DAL: 80 minutes.
  • WN1434: DAL 2027-03-29 20:50:00 → TPA 2027-03-30 00:10:00.

2027-03-25 → 2027-03-29 · Axel-exclusive $542

• United Airlines UA270: TPA 2027-03-25 08:00:00 → SFO 2027-03-25 11:02:00; nonstop; 362 minutes. Local airport times.
• United Airlines UA2799: SFO 2027-03-29 07:15:00 → TPA 2027-03-29 15:19:00; nonstop; 304 minutes. Local airport times.

2027-03-25 → 2027-03-31 · Axel-exclusive $418

• Southwest Airlines WN4274 / WN327: TPA 2027-03-25 07:10:00 → SFO 2027-03-25 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2027-03-25 07:10:00 → PHX 2027-03-25 09:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2027-03-25 10:10:00 → SFO 2027-03-25 12:20:00.
• Southwest Airlines WN4578 / WN489: SFO 2027-03-31 06:10:00 → TPA 2027-03-31 16:15:00; 1 stop(s) via DEN; 425 minutes. Local airport times.
  • WN4578: SFO 2027-03-31 06:10:00 → DEN 2027-03-31 09:45:00; layover at DEN: 65 minutes.
  • WN489: DEN 2027-03-31 10:50:00 → TPA 2027-03-31 16:15:00.

2027-03-25 → 2027-03-31 · Axel-exclusive $492

• United Airlines UA270: TPA 2027-03-25 08:00:00 → SFO 2027-03-25 11:02:00; nonstop; 362 minutes. Local airport times.
• United Airlines UA448: SFO 2027-03-31 23:15:00 → TPA 2027-04-01 07:24:00; nonstop; 309 minutes. Local airport times.

2027-03-25 → 2027-04-01 · Axel-exclusive $408

• Southwest Airlines WN4274 / WN327: TPA 2027-03-25 07:10:00 → SFO 2027-03-25 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2027-03-25 07:10:00 → PHX 2027-03-25 09:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2027-03-25 10:10:00 → SFO 2027-03-25 12:20:00.
• Southwest Airlines WN1982 / WN1434: SFO 2027-04-01 14:00:00 → TPA 2027-04-02 00:10:00; 1 stop(s) via DAL; 430 minutes. Local airport times.
  • WN1982: SFO 2027-04-01 14:00:00 → DAL 2027-04-01 19:30:00; layover at DAL: 80 minutes.
  • WN1434: DAL 2027-04-01 20:50:00 → TPA 2027-04-02 00:10:00.

2027-03-25 → 2027-04-01 · Axel-exclusive $481

• United Airlines UA270: TPA 2027-03-25 08:00:00 → SFO 2027-03-25 11:02:00; nonstop; 362 minutes. Local airport times.
• United Airlines UA2799: SFO 2027-04-01 07:15:00 → TPA 2027-04-01 15:19:00; nonstop; 304 minutes. Local airport times.

2027-03-25 → 2027-04-02 · Axel-exclusive $408

• Southwest Airlines WN4274 / WN327: TPA 2027-03-25 07:10:00 → SFO 2027-03-25 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2027-03-25 07:10:00 → PHX 2027-03-25 09:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2027-03-25 10:10:00 → SFO 2027-03-25 12:20:00.
• Southwest Airlines WN2989 / WN4206: SFO 2027-04-02 13:05:00 → TPA 2027-04-02 23:15:00; 1 stop(s) via STL; 430 minutes. Local airport times.
  • WN2989: SFO 2027-04-02 13:05:00 → STL 2027-04-02 18:55:00; layover at STL: 60 minutes.
  • WN4206: STL 2027-04-02 19:55:00 → TPA 2027-04-02 23:15:00.

2027-03-25 → 2027-04-02 · Axel-exclusive $481

• United Airlines UA270: TPA 2027-03-25 08:00:00 → SFO 2027-03-25 11:02:00; nonstop; 362 minutes. Local airport times.
• United Airlines UA1112: SFO 2027-04-02 23:59:00 → TPA 2027-04-03 08:05:00; nonstop; 306 minutes. Local airport times.

2027-03-25 → 2027-04-04 · Axel-exclusive $408

• Southwest Airlines WN4274 / WN327: TPA 2027-03-25 07:10:00 → SFO 2027-03-25 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2027-03-25 07:10:00 → PHX 2027-03-25 09:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2027-03-25 10:10:00 → SFO 2027-03-25 12:20:00.
• Southwest Airlines WN4578 / WN489: SFO 2027-04-04 06:10:00 → TPA 2027-04-04 16:15:00; 1 stop(s) via DEN; 425 minutes. Local airport times.
  • WN4578: SFO 2027-04-04 06:10:00 → DEN 2027-04-04 09:45:00; layover at DEN: 65 minutes.
  • WN489: DEN 2027-04-04 10:50:00 → TPA 2027-04-04 16:15:00.

2027-03-25 → 2027-04-04 · Axel-exclusive $481

• United Airlines UA270: TPA 2027-03-25 08:00:00 → SFO 2027-03-25 11:02:00; nonstop; 362 minutes. Local airport times.
• United Airlines UA1651: SFO 2027-04-04 07:25:00 → TPA 2027-04-04 15:31:00; nonstop; 306 minutes. Local airport times.

2027-03-25 → 2027-04-05 · Axel-exclusive $408

• Southwest Airlines WN4274 / WN327: TPA 2027-03-25 07:10:00 → SFO 2027-03-25 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2027-03-25 07:10:00 → PHX 2027-03-25 09:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2027-03-25 10:10:00 → SFO 2027-03-25 12:20:00.
• Southwest Airlines WN1982 / WN1434: SFO 2027-04-05 14:00:00 → TPA 2027-04-06 00:10:00; 1 stop(s) via DAL; 430 minutes. Local airport times.
  • WN1982: SFO 2027-04-05 14:00:00 → DAL 2027-04-05 19:30:00; layover at DAL: 80 minutes.
  • WN1434: DAL 2027-04-05 20:50:00 → TPA 2027-04-06 00:10:00.

2027-03-25 → 2027-04-05 · Axel-exclusive $481

• United Airlines UA270: TPA 2027-03-25 08:00:00 → SFO 2027-03-25 11:02:00; nonstop; 362 minutes. Local airport times.
• United Airlines UA2799: SFO 2027-04-05 07:15:00 → TPA 2027-04-05 15:19:00; nonstop; 304 minutes. Local airport times.

2027-03-25 → 2027-04-06 · Axel-exclusive $408

• Southwest Airlines WN4274 / WN327: TPA 2027-03-25 07:10:00 → SFO 2027-03-25 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2027-03-25 07:10:00 → PHX 2027-03-25 09:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2027-03-25 10:10:00 → SFO 2027-03-25 12:20:00.
• Southwest Airlines WN4578 / WN489: SFO 2027-04-06 06:10:00 → TPA 2027-04-06 16:15:00; 1 stop(s) via DEN; 425 minutes. Local airport times.
  • WN4578: SFO 2027-04-06 06:10:00 → DEN 2027-04-06 09:45:00; layover at DEN: 65 minutes.
  • WN489: DEN 2027-04-06 10:50:00 → TPA 2027-04-06 16:15:00.

2027-03-25 → 2027-04-06 · Axel-exclusive $481

• United Airlines UA270: TPA 2027-03-25 08:00:00 → SFO 2027-03-25 11:02:00; nonstop; 362 minutes. Local airport times.
• United Airlines UA1885: SFO 2027-04-06 22:55:00 → TPA 2027-04-07 06:52:00; nonstop; 297 minutes. Local airport times.

2027-03-25 → 2027-04-08 · Axel-exclusive $408

• Southwest Airlines WN4274 / WN327: TPA 2027-03-25 07:10:00 → SFO 2027-03-25 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2027-03-25 07:10:00 → PHX 2027-03-25 09:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2027-03-25 10:10:00 → SFO 2027-03-25 12:20:00.
• Southwest Airlines WN1982 / WN1434: SFO 2027-04-08 14:00:00 → TPA 2027-04-09 00:10:00; 1 stop(s) via DAL; 430 minutes. Local airport times.
  • WN1982: SFO 2027-04-08 14:00:00 → DAL 2027-04-08 19:30:00; layover at DAL: 80 minutes.
  • WN1434: DAL 2027-04-08 20:50:00 → TPA 2027-04-09 00:10:00.

2027-03-25 → 2027-04-08 · Axel-exclusive $481

• United Airlines UA270: TPA 2027-03-25 08:00:00 → SFO 2027-03-25 11:02:00; nonstop; 362 minutes. Local airport times.
• United Airlines UA2799: SFO 2027-04-08 07:15:00 → TPA 2027-04-08 15:19:00; nonstop; 304 minutes. Local airport times.

Explore this route

• All dates for this route
• Mar 24, 2027 · Return options
• Mar 26, 2027 · Return options
• Hotels in San Francisco with Axel

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• This page: Tampa (TPA) to San Francisco (SFO) · Mar 25, 2027 · choose your return date: 1 adult in economy, every priced fare with its flights, times and total, each with its displayed check date. Under a trip, hotels in San Francisco for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in each star tier for those dates.
• Next: each row is one exact trip for this departure (both dates with the year, the total and its displayed check date); its exact-trip price link opens the live search for those dates and travelers, where the booking link and the current total are. Other durations or travelers are not priced here: Choose travelers and dates prices the requested trip.
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