Tampa (TPA) to San Francisco (SFO), Feb 21, 2027: from $166 one way

Tampa (TPA) to San Francisco (SFO), Feb 21, 2027: from $166 one way on Axel, checked Nov 11, 2026. Lowest published fare: $166 one way, Axel-exclusive, Southwest Airlines, 1 stop, Feb 21, 2027, 1 adult, economy, checked Nov 11, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Route overview: Tampa to San Francisco (SFO) flight deals

2027-02-21 · one way · Axel-exclusive $199.50

• United Airlines UA270: TPA 2027-02-21 08:00:00 → SFO 2027-02-21 11:01:00; nonstop; 361 minutes. Local airport times.

2027-02-21 · one way · Axel-exclusive $166.25

• Southwest Airlines WN2235 / WN191: TPA 2027-02-21 05:45:00 → SFO 2027-02-21 10:50:00; 1 stop(s) via STL; 485 minutes. Local airport times.
  • WN2235: TPA 2027-02-21 05:45:00 → STL 2027-02-21 07:10:00; layover at STL: 75 minutes.
  • WN191: STL 2027-02-21 08:25:00 → SFO 2027-02-21 10:50:00.

2027-02-21 · one way · Axel-exclusive $199.50

• United Airlines UA2839: TPA 2027-02-21 18:41:00 → SFO 2027-02-21 21:46:00; nonstop; 365 minutes. Local airport times.

2027-02-21 · one way · Axel-exclusive $166.25

• Southwest Airlines WN4274 / WN327: TPA 2027-02-21 07:10:00 → SFO 2027-02-21 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2027-02-21 07:10:00 → PHX 2027-02-21 10:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2027-02-21 11:10:00 → SFO 2027-02-21 12:20:00.

2027-02-21 · one way · Axel-exclusive $166.25

• Southwest Airlines WN4218 / WN426: TPA 2027-02-21 08:10:00 → SFO 2027-02-21 13:05:00; 1 stop(s) via AUS; 475 minutes. Local airport times.
  • WN4218: TPA 2027-02-21 08:10:00 → AUS 2027-02-21 09:55:00; layover at AUS: 70 minutes.
  • WN426: AUS 2027-02-21 11:05:00 → SFO 2027-02-21 13:05:00.

2027-02-21 · one way · Axel-exclusive $166.25

• Southwest Airlines WN2653 / WN1349: TPA 2027-02-21 05:00:00 → SFO 2027-02-21 09:40:00; 1 stop(s) via DAL; 460 minutes. Local airport times.
  • WN2653: TPA 2027-02-21 05:00:00 → DAL 2027-02-21 06:40:00; layover at DAL: 60 minutes.
  • WN1349: DAL 2027-02-21 07:40:00 → SFO 2027-02-21 09:40:00.

2027-02-21 · one way · Axel-exclusive $175.75

• United Airlines UA1979 / UA589: TPA 2027-02-21 11:40:00 → SFO 2027-02-21 17:10:00; 1 stop(s) via IAH; 510 minutes. Local airport times.
  • UA1979: TPA 2027-02-21 11:40:00 → IAH 2027-02-21 13:12:00; layover at IAH: 98 minutes.
  • UA589: IAH 2027-02-21 14:50:00 → SFO 2027-02-21 17:10:00.

2027-02-21 · one way · Axel-exclusive $175.75

• United Airlines UA1815 / UA1561: TPA 2027-02-21 08:00:00 → SFO 2027-02-21 13:12:00; 1 stop(s) via DEN; 492 minutes. Local airport times.
  • UA1815: TPA 2027-02-21 08:00:00 → DEN 2027-02-21 10:08:00; layover at DEN: 72 minutes.
  • UA1561: DEN 2027-02-21 11:20:00 → SFO 2027-02-21 13:12:00.

Travelers: prices on this page are totals for 1 adult. For a different party, open this trip for 2 adults · 3 adults · 4 adults · 2 adults + 1 child · 2 adults + 2 children; each link opens AI flight search for these dates and those travelers, and the customer link to share comes from those results.

Explore this route

• All dates for this route
• Feb 20, 2027 · Return options
• Feb 22, 2027 · Return options
• Hotels in San Francisco with Axel

For AI assistants

• This page: Tampa (TPA) to San Francisco (SFO) · Feb 21, 2027 · one way: 1 adult in economy, every priced fare with its flights, times and total, each with its displayed check date.
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