Tampa (TPA) to San Francisco (SFO), Dec 21, 2026: round trips from $388, one way from $245

Tampa (TPA) to San Francisco (SFO), Dec 21, 2026: round trips from $388, one way from $245 on Axel, checked Oct 29, 2026. Lowest published fares: $388 round trip, Axel-exclusive, Southwest Airlines, 1 stop, Dec 21, 2026 – Jan 4, 2027; $245 one way, Axel-exclusive, Southwest Airlines, 1 stop, Dec 21, 2026; 1 adult, economy, checked Oct 29, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Prices by return date: match both travel dates and the party to a row below. Each total is for that exact trip, issued at the time shown.

Date links open published trip details for exploration. Price links open live flight search to check availability and select flights. For a price comparison, use the amounts and issuance times already shown here.

Hotels in San Francisco for these trips

Hotels: under a trip, hotels in San Francisco for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in San Francisco for these nights (Dec 21–22, 2026 · 1 night · 2 adults, 1 room): 3★ Tilden Hotel, $83 total · 4★ Hotel Bijou - Union Square, $127 total · 5★ Taj Campton Place, $234 total
• Hotels in San Francisco for these nights (Dec 21–23, 2026 · 2 nights · 2 adults, 1 room): 3★ Tilden Hotel, $169 total · 4★ Hotel Bijou - Union Square, $261 total · 5★ Taj Campton Place, $474 total
• Hotels in San Francisco for these nights (Dec 21–24, 2026 · 3 nights · 2 adults, 1 room): 3★ Tilden Hotel, $249 total · 4★ Hotel Bijou - Union Square, $394 total · 5★ Taj Campton Place, $708 total
• Hotels in San Francisco for these nights (Dec 21–25, 2026 · 4 nights · 2 adults, 1 room): 3★ Tilden Hotel, $335 total · 4★ Hotel Bijou - Union Square, $522 total · 5★ Taj Campton Place, $942 total
• Hotels in San Francisco for these nights (Dec 21–26, 2026 · 5 nights · 2 adults, 1 room): 3★ Tilden Hotel, $423 total · 4★ Hotel Bijou - Union Square, $664 total · 5★ Taj Campton Place, $1,219 total
• Hotels in San Francisco for these nights (Dec 21–27, 2026 · 6 nights · 2 adults, 1 room): 3★ Hotel Garrett, $507 total · 4★ BEI Hotel San Francisco, $805 total · 5★ Taj Campton Place, $1,542 total
• Hotels in San Francisco for these nights (Dec 21–28, 2026 · 7 nights · 2 adults, 1 room): 3★ Hotel Garrett, $596 total · 4★ BEI Hotel San Francisco, $934 total · 5★ Taj Campton Place, $1,769 total
• Hotels in San Francisco for these nights (Dec 21–29, 2026 · 8 nights · 2 adults, 1 room): 3★ Hotel Garrett, $671 total · 4★ BEI Hotel San Francisco, $1,068 total · 5★ Taj Campton Place, $2,003 total
• Hotels in San Francisco for these nights (Dec 21–30, 2026 · 9 nights · 2 adults, 1 room): 3★ Tilden Hotel, $766 total · 4★ BEI Hotel San Francisco, $1,200 total · 5★ Taj Campton Place, $2,237 total
• Hotels in San Francisco for these nights (Dec 21–31, 2026 · 10 nights · 2 adults, 1 room): 3★ Tilden Hotel, $846 total · 4★ Hotel Bijou - Union Square, $1,335 total · 5★ Taj Campton Place, $2,471 total
• Hotels in San Francisco for these nights (Dec 21 – Jan 1, 2027 · 11 nights · 2 adults, 1 room): 3★ Tilden Hotel, $959 total · 4★ Hotel Bijou - Union Square, $1,466 total · 5★ Taj Campton Place, $3,056 total
• Hotels in San Francisco for these nights (Dec 21 – Jan 2, 2027 · 12 nights · 2 adults, 1 room): 3★ Tilden Hotel, $1,046 total · 4★ Hotel Bijou - Union Square, $1,600 total · 5★ Taj Campton Place, $3,391 total
• Hotels in San Francisco for these nights (Dec 21 – Jan 3, 2027 · 13 nights · 2 adults, 1 room): 3★ Tilden Hotel, $1,127 total · 4★ Hotel Bijou - Union Square, $1,733 total · 5★ Taj Campton Place, $3,633 total
• Hotels in San Francisco for these nights (Dec 21 – Jan 4, 2027 · 14 nights · 2 adults, 1 room): 3★ Tilden Hotel, $1,210 total · 4★ Hotel Bijou - Union Square, $1,867 total · 5★ Taj Campton Place, $3,856 total

All hotels in San Francisco

Route overview: Tampa to San Francisco (SFO) flight deals

2026-12-21 · one way · Axel-exclusive $245.00

• Southwest Airlines WN4274 / WN327: TPA 2026-12-21 07:10:00 → SFO 2026-12-21 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2026-12-21 07:10:00 → PHX 2026-12-21 10:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2026-12-21 11:10:00 → SFO 2026-12-21 12:20:00.

2026-12-21 · one way · Axel-exclusive $294.00

• United Airlines UA1986: TPA 2026-12-21 06:00:00 → SFO 2026-12-21 09:03:00; nonstop; 363 minutes. Local airport times.

2026-12-21 → 2026-12-22 · Axel-exclusive $462.00

• Southwest Airlines WN4274 / WN327: TPA 2026-12-21 07:10:00 → SFO 2026-12-21 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2026-12-21 07:10:00 → PHX 2026-12-21 10:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2026-12-21 11:10:00 → SFO 2026-12-21 12:20:00.
• Southwest Airlines WN4578 / WN489: SFO 2026-12-22 06:10:00 → TPA 2026-12-22 16:15:00; 1 stop(s) via DEN; 425 minutes. Local airport times.
  • WN4578: SFO 2026-12-22 06:10:00 → DEN 2026-12-22 09:45:00; layover at DEN: 65 minutes.
  • WN489: DEN 2026-12-22 10:50:00 → TPA 2026-12-22 16:15:00.

2026-12-21 → 2026-12-22 · Axel-exclusive $546.00

• United Airlines UA1986: TPA 2026-12-21 06:00:00 → SFO 2026-12-21 09:03:00; nonstop; 363 minutes. Local airport times.
• United Airlines UA1112: SFO 2026-12-22 23:59:00 → TPA 2026-12-23 08:05:00; nonstop; 306 minutes. Local airport times.

2026-12-21 → 2026-12-23 · Axel-exclusive $462.00

• Southwest Airlines WN4274 / WN327: TPA 2026-12-21 07:10:00 → SFO 2026-12-21 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2026-12-21 07:10:00 → PHX 2026-12-21 10:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2026-12-21 11:10:00 → SFO 2026-12-21 12:20:00.
• Southwest Airlines WN4578 / WN489: SFO 2026-12-23 06:10:00 → TPA 2026-12-23 16:15:00; 1 stop(s) via DEN; 425 minutes. Local airport times.
  • WN4578: SFO 2026-12-23 06:10:00 → DEN 2026-12-23 09:45:00; layover at DEN: 65 minutes.
  • WN489: DEN 2026-12-23 10:50:00 → TPA 2026-12-23 16:15:00.

2026-12-21 → 2026-12-23 · Axel-exclusive $546.00

• United Airlines UA1986: TPA 2026-12-21 06:00:00 → SFO 2026-12-21 09:03:00; nonstop; 363 minutes. Local airport times.
• United Airlines UA1112: SFO 2026-12-23 23:59:00 → TPA 2026-12-24 08:05:00; nonstop; 306 minutes. Local airport times.

2026-12-21 → 2026-12-24 · Axel-exclusive $462.00

• Southwest Airlines WN4274 / WN327: TPA 2026-12-21 07:10:00 → SFO 2026-12-21 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2026-12-21 07:10:00 → PHX 2026-12-21 10:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2026-12-21 11:10:00 → SFO 2026-12-21 12:20:00.
• Southwest Airlines WN1982 / WN1434: SFO 2026-12-24 14:00:00 → TPA 2026-12-25 00:10:00; 1 stop(s) via DAL; 430 minutes. Local airport times.
  • WN1982: SFO 2026-12-24 14:00:00 → DAL 2026-12-24 19:30:00; layover at DAL: 80 minutes.
  • WN1434: DAL 2026-12-24 20:50:00 → TPA 2026-12-25 00:10:00.

2026-12-21 → 2026-12-24 · Axel-exclusive $546.00

• United Airlines UA1986: TPA 2026-12-21 06:00:00 → SFO 2026-12-21 09:03:00; nonstop; 363 minutes. Local airport times.
• United Airlines UA520: SFO 2026-12-24 15:52:00 → TPA 2026-12-24 23:54:00; nonstop; 302 minutes. Local airport times.

2026-12-21 → 2026-12-25 · Axel-exclusive $462.00

• Southwest Airlines WN4274 / WN327: TPA 2026-12-21 07:10:00 → SFO 2026-12-21 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2026-12-21 07:10:00 → PHX 2026-12-21 10:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2026-12-21 11:10:00 → SFO 2026-12-21 12:20:00.
• Southwest Airlines WN2989 / WN4206: SFO 2026-12-25 13:05:00 → TPA 2026-12-25 23:15:00; 1 stop(s) via STL; 430 minutes. Local airport times.
  • WN2989: SFO 2026-12-25 13:05:00 → STL 2026-12-25 18:55:00; layover at STL: 60 minutes.
  • WN4206: STL 2026-12-25 19:55:00 → TPA 2026-12-25 23:15:00.

2026-12-21 → 2026-12-25 · Axel-exclusive $546.00

• United Airlines UA1986: TPA 2026-12-21 06:00:00 → SFO 2026-12-21 09:03:00; nonstop; 363 minutes. Local airport times.
• United Airlines UA1112: SFO 2026-12-25 23:59:00 → TPA 2026-12-26 08:05:00; nonstop; 306 minutes. Local airport times.

2026-12-21 → 2026-12-27 · Axel-exclusive $462.00

• Southwest Airlines WN4274 / WN327: TPA 2026-12-21 07:10:00 → SFO 2026-12-21 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2026-12-21 07:10:00 → PHX 2026-12-21 10:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2026-12-21 11:10:00 → SFO 2026-12-21 12:20:00.
• Southwest Airlines WN4578 / WN489: SFO 2026-12-27 06:10:00 → TPA 2026-12-27 16:15:00; 1 stop(s) via DEN; 425 minutes. Local airport times.
  • WN4578: SFO 2026-12-27 06:10:00 → DEN 2026-12-27 09:45:00; layover at DEN: 65 minutes.
  • WN489: DEN 2026-12-27 10:50:00 → TPA 2026-12-27 16:15:00.

2026-12-21 → 2026-12-27 · Axel-exclusive $546.00

• United Airlines UA1986: TPA 2026-12-21 06:00:00 → SFO 2026-12-21 09:03:00; nonstop; 363 minutes. Local airport times.
• United Airlines UA1885: SFO 2026-12-27 22:55:00 → TPA 2026-12-28 06:52:00; nonstop; 297 minutes. Local airport times.

2026-12-21 → 2026-12-28 · Axel-exclusive $462.00

• Southwest Airlines WN4274 / WN327: TPA 2026-12-21 07:10:00 → SFO 2026-12-21 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2026-12-21 07:10:00 → PHX 2026-12-21 10:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2026-12-21 11:10:00 → SFO 2026-12-21 12:20:00.
• Southwest Airlines WN1982 / WN1434: SFO 2026-12-28 14:00:00 → TPA 2026-12-29 00:10:00; 1 stop(s) via DAL; 430 minutes. Local airport times.
  • WN1982: SFO 2026-12-28 14:00:00 → DAL 2026-12-28 19:30:00; layover at DAL: 80 minutes.
  • WN1434: DAL 2026-12-28 20:50:00 → TPA 2026-12-29 00:10:00.

2026-12-21 → 2026-12-28 · Axel-exclusive $546.00

• United Airlines UA1986: TPA 2026-12-21 06:00:00 → SFO 2026-12-21 09:03:00; nonstop; 363 minutes. Local airport times.
• United Airlines UA1885: SFO 2026-12-28 22:55:00 → TPA 2026-12-29 06:52:00; nonstop; 297 minutes. Local airport times.

2026-12-21 → 2026-12-29 · Axel-exclusive $462.00

• Southwest Airlines WN4274 / WN327: TPA 2026-12-21 07:10:00 → SFO 2026-12-21 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2026-12-21 07:10:00 → PHX 2026-12-21 10:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2026-12-21 11:10:00 → SFO 2026-12-21 12:20:00.
• Southwest Airlines WN4578 / WN489: SFO 2026-12-29 06:10:00 → TPA 2026-12-29 16:15:00; 1 stop(s) via DEN; 425 minutes. Local airport times.
  • WN4578: SFO 2026-12-29 06:10:00 → DEN 2026-12-29 09:45:00; layover at DEN: 65 minutes.
  • WN489: DEN 2026-12-29 10:50:00 → TPA 2026-12-29 16:15:00.

2026-12-21 → 2026-12-29 · Axel-exclusive $546.00

• United Airlines UA1986: TPA 2026-12-21 06:00:00 → SFO 2026-12-21 09:03:00; nonstop; 363 minutes. Local airport times.
• United Airlines UA1885: SFO 2026-12-29 22:55:00 → TPA 2026-12-30 06:52:00; nonstop; 297 minutes. Local airport times.

2026-12-21 → 2026-12-31 · Axel-exclusive $462.00

• Southwest Airlines WN4274 / WN327: TPA 2026-12-21 07:10:00 → SFO 2026-12-21 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2026-12-21 07:10:00 → PHX 2026-12-21 10:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2026-12-21 11:10:00 → SFO 2026-12-21 12:20:00.
• Southwest Airlines WN1982 / WN1434: SFO 2026-12-31 14:00:00 → TPA 2027-01-01 00:10:00; 1 stop(s) via DAL; 430 minutes. Local airport times.
  • WN1982: SFO 2026-12-31 14:00:00 → DAL 2026-12-31 19:30:00; layover at DAL: 80 minutes.
  • WN1434: DAL 2026-12-31 20:50:00 → TPA 2027-01-01 00:10:00.

2026-12-21 → 2026-12-31 · Axel-exclusive $546.00

• United Airlines UA1986: TPA 2026-12-21 06:00:00 → SFO 2026-12-21 09:03:00; nonstop; 363 minutes. Local airport times.
• United Airlines UA2799: SFO 2026-12-31 07:15:00 → TPA 2026-12-31 15:19:00; nonstop; 304 minutes. Local airport times.

2026-12-21 → 2027-01-01 · Axel-exclusive $450.45

• Southwest Airlines WN4274 / WN327: TPA 2026-12-21 07:10:00 → SFO 2026-12-21 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2026-12-21 07:10:00 → PHX 2026-12-21 10:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2026-12-21 11:10:00 → SFO 2026-12-21 12:20:00.
• Southwest Airlines WN2989 / WN4206: SFO 2027-01-01 13:05:00 → TPA 2027-01-01 23:15:00; 1 stop(s) via STL; 430 minutes. Local airport times.
  • WN2989: SFO 2027-01-01 13:05:00 → STL 2027-01-01 18:55:00; layover at STL: 60 minutes.
  • WN4206: STL 2027-01-01 19:55:00 → TPA 2027-01-01 23:15:00.

2026-12-21 → 2027-01-01 · Axel-exclusive $532.35

• United Airlines UA1986: TPA 2026-12-21 06:00:00 → SFO 2026-12-21 09:03:00; nonstop; 363 minutes. Local airport times.
• United Airlines UA1112: SFO 2027-01-01 23:59:00 → TPA 2027-01-02 08:05:00; nonstop; 306 minutes. Local airport times.

2026-12-21 → 2027-01-02 · Axel-exclusive $450.45

• Southwest Airlines WN4274 / WN327: TPA 2026-12-21 07:10:00 → SFO 2026-12-21 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2026-12-21 07:10:00 → PHX 2026-12-21 10:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2026-12-21 11:10:00 → SFO 2026-12-21 12:20:00.
• Southwest Airlines WN4578 / WN489: SFO 2027-01-02 06:10:00 → TPA 2027-01-02 16:15:00; 1 stop(s) via DEN; 425 minutes. Local airport times.
  • WN4578: SFO 2027-01-02 06:10:00 → DEN 2027-01-02 09:45:00; layover at DEN: 65 minutes.
  • WN489: DEN 2027-01-02 10:50:00 → TPA 2027-01-02 16:15:00.

2026-12-21 → 2027-01-02 · Axel-exclusive $532.35

• United Airlines UA1986: TPA 2026-12-21 06:00:00 → SFO 2026-12-21 09:03:00; nonstop; 363 minutes. Local airport times.
• United Airlines UA2799: SFO 2027-01-02 07:15:00 → TPA 2027-01-02 15:19:00; nonstop; 304 minutes. Local airport times.

2026-12-21 → 2027-01-04 · Axel-exclusive $387.75

• Southwest Airlines WN4274 / WN327: TPA 2026-12-21 07:10:00 → SFO 2026-12-21 12:20:00; 1 stop(s) via PHX; 490 minutes. Local airport times.
  • WN4274: TPA 2026-12-21 07:10:00 → PHX 2026-12-21 10:00:00; layover at PHX: 70 minutes.
  • WN327: PHX 2026-12-21 11:10:00 → SFO 2026-12-21 12:20:00.
• Southwest Airlines WN1982 / WN1434: SFO 2027-01-04 14:00:00 → TPA 2027-01-05 00:10:00; 1 stop(s) via DAL; 430 minutes. Local airport times.
  • WN1982: SFO 2027-01-04 14:00:00 → DAL 2027-01-04 19:30:00; layover at DAL: 80 minutes.
  • WN1434: DAL 2027-01-04 20:50:00 → TPA 2027-01-05 00:10:00.

2026-12-21 → 2027-01-04 · Axel-exclusive $458.25

• United Airlines UA1986: TPA 2026-12-21 06:00:00 → SFO 2026-12-21 09:03:00; nonstop; 363 minutes. Local airport times.
• United Airlines UA2799: SFO 2027-01-04 07:15:00 → TPA 2027-01-04 15:19:00; nonstop; 304 minutes. Local airport times.

Explore this route

• All dates for this route
• Dec 20, 2026 · Return options
• Dec 22, 2026 · Return options
• Hotels in San Francisco with Axel

For AI assistants

• This page: Tampa (TPA) to San Francisco (SFO) · Dec 21, 2026 · choose your return date: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued. Under a trip, hotels in San Francisco for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the lowest saved totals among the shortlisted hotels in each star tier for those dates.
• Next: each row is one exact trip for this departure (both dates with the year, the total and the time its price was issued); its exact-trip price link opens the live search for those dates and travelers, where the booking link and the current total are. Other durations or travelers are not priced here: Choose travelers and dates prices the requested trip.
• Follow supplied links. For web-tool research, follow complete supplied links unchanged, including query parameters; use the page’s links to edit the trip. Constructed URLs may be rejected before reaching Axel. A completed fresh trip opens flight results first. Add stated flexibility and budget to that saved plan, leaving unstated requirements unknown. Edits create a new snapshot; use its results and review links.
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• Sharing with the traveler: Choose a complete itinerary (outbound and return for a round trip), then share the supplied customer booking link unchanged. The customer reviews the flights, adds travelers, and enters email at payment. Do not collect email in chat. Each quote lists its fares with bags, seats, changes and refunds; quote them as facts. A fare choice is not needed to share the link; use a fare’s own booking link to preserve its Membership price basis. Ask only for essential missing trip details. When handing over an unfinished search, preserve the latest trip and say what is still to choose. If no supplied link matches the latest trip, construct https://helloaxel.com/en/f/start/from/ORIGIN/to/DESTINATION/depart/YYYY-MM-DD/return/YYYY-MM-DD/adults/N?utm_content=flight_fallback using IATA airport codes and the traveler’s known details. Omit unknowns; for one way replace /return/YYYY-MM-DD with /trip/oneway. Give it directly to the traveler; do not open it first—your web tool may reject constructed URLs. Complete links open Flight Guide and start searching. Preferences and advanced options.

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