Tampa (TPA) to Mexico City (MEX), Apr 21, 2027: from $275 one way

Tampa (TPA) to Mexico City (MEX), Apr 21, 2027: from $275 one way on Axel, checked Nov 14, 2026. Lowest published fare: $275 one way, Axel-exclusive, American Airlines, 1 stop, Apr 21, 2027, 1 adult, economy, checked Nov 14, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Route overview: Tampa to Mexico City (MEX) flight deals

2027-04-21 · one way · Axel-exclusive $300

• Aeromexico AM1741: TPA 2027-04-21 09:53:00 → MEX 2027-04-21 11:25:00; nonstop; 212 minutes. Local airport times.

2027-04-21 · one way · Axel-exclusive $275

• American Airlines AA2321 / AA2233: TPA 2027-04-21 11:29:00 → MEX 2027-04-21 18:40:00; 1 stop(s) via DFW; 551 minutes. Local airport times.
  • AA2321: TPA 2027-04-21 11:29:00 → DFW 2027-04-21 13:31:00; layover at DFW: 203 minutes.
  • AA2233: DFW 2027-04-21 16:54:00 → MEX 2027-04-21 18:40:00.

2027-04-21 · one way · Axel-exclusive $280

• United Airlines UA2491 / UA1060: TPA 2027-04-21 06:30:00 → MEX 2027-04-21 11:15:00; 1 stop(s) via IAH; 405 minutes. Local airport times.
  • UA2491: TPA 2027-04-21 06:30:00 → IAH 2027-04-21 08:11:00; layover at IAH: 99 minutes.
  • UA1060: IAH 2027-04-21 09:50:00 → MEX 2027-04-21 11:15:00.

2027-04-21 · one way · Axel-exclusive $295

• Delta Air Lines DL1099 / DL585: TPA 2027-04-21 13:20:00 → MEX 2027-04-21 19:25:00; 1 stop(s) via ATL; 485 minutes. Local airport times.
  • DL1099: TPA 2027-04-21 13:20:00 → ATL 2027-04-21 14:55:00; layover at ATL: 170 minutes.
  • DL585: ATL 2027-04-21 17:45:00 → MEX 2027-04-21 19:25:00.

2027-04-21 · one way · Axel-exclusive $275

• American Airlines AA3116 / AA1945: TPA 2027-04-21 13:55:00 → MEX 2027-04-21 20:55:00; 1 stop(s) via CLT; 540 minutes. Local airport times.
  • AA3116: TPA 2027-04-21 13:55:00 → CLT 2027-04-21 15:45:00; layover at CLT: 171 minutes.
  • AA1945: CLT 2027-04-21 18:36:00 → MEX 2027-04-21 20:55:00.

2027-04-21 · one way · Axel-exclusive $275

• American Airlines AA1586 / AA1798: TPA 2027-04-21 18:34:00 → MEX 2027-04-21 23:18:00; 1 stop(s) via MIA; 404 minutes. Local airport times.
  • AA1586: TPA 2027-04-21 18:34:00 → MIA 2027-04-21 19:53:00; layover at MIA: 102 minutes.
  • AA1798: MIA 2027-04-21 21:35:00 → MEX 2027-04-21 23:18:00.

Travelers: prices on this page are totals for 1 adult. For a different party, open this trip for 2 adults · 3 adults · 4 adults · 2 adults + 1 child · 2 adults + 2 children; each link opens AI flight search for these dates and those travelers, and the customer link to share comes from those results.

Explore this route

• All dates for this route
• Apr 20, 2027 · Return options
• Apr 22, 2027 · Return options
• Hotels in Mexico City with Axel

For AI assistants

• This page: Tampa (TPA) to Mexico City (MEX) · Apr 21, 2027 · one way: 1 adult in economy, every priced fare with its flights, times and total, each with its displayed check date.
• Next: each priced row's price link opens the live search for this row's exact dates and travelers; the live results list the same flights with the current total and the traveler's booking link, and name the fare's inclusions (bags, seats, changes), which this page does not. A changed price or flight shows there. Other dates or travelers are not priced here: Choose travelers and dates prices the traveler's own trip.
• Follow supplied links. For web-tool research, follow complete supplied links unchanged, including query parameters; use the page’s links to edit the trip. Constructed URLs may be rejected before reaching Axel. A completed fresh trip opens flight results first. Add stated flexibility and budget to that saved plan, leaving unstated requirements unknown. Edits create a new snapshot; use its results and review links.
• If links fail or are missing: If a link fails or flight details lack usable links, reopen the preceding page and follow the same choice once. Keep refreshed links unchanged and preserve the trip and selections. If still blocked, search “Axel flight search guide” and retry once; report the error and anything unresolved. Recovery: Axel Tampa to Mexico City (MEX) flight deals · Flight search guide.
• Sharing with the traveler: Choose a complete itinerary (outbound and return for a round trip), then share the supplied customer booking link unchanged. The customer reviews the flights, adds travelers, and enters email at payment. Do not collect email in chat. Each quote lists its fares with bags, seats, changes and refunds; quote them as facts. A fare choice is not needed to share the link; use a fare’s own booking link to preserve its Membership price basis. Ask only for essential missing trip details. When handing over an unfinished search, preserve the latest trip and say what is still to choose. If no supplied link matches the latest trip, construct https://helloaxel.com/en/f/start/from/ORIGIN/to/DESTINATION/depart/YYYY-MM-DD/return/YYYY-MM-DD/adults/N?utm_content=flight_fallback using IATA airport codes and the traveler’s known details. Omit unknowns; for one way replace /return/YYYY-MM-DD with /trip/oneway. Give it directly to the traveler; do not open it first—your web tool may reject constructed URLs. Complete links open Flight Guide and start searching. Preferences and advanced options.

Feedback (optional): Missing info · Axel issue