Saint Louis (STL) to Fort Myers (RSW), May 21, 2027: round trips from $275, one way from $150

Saint Louis (STL) to Fort Myers (RSW), May 21, 2027: round trips from $275, one way from $150 on Axel, checked Nov 14, 2026. Lowest published fares: $275 round trip, Axel-exclusive, Southwest Airlines, nonstop, May 21–22, 2027; $150 one way, Axel-exclusive, Southwest Airlines, nonstop, May 21, 2027; 1 adult, economy, checked Nov 14, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Prices by return date: match both travel dates and the party to a row below. Each total is for that exact trip, labelled with the check date shown.

Date links open published trip details for exploration. Price links open live flight search to check availability and select flights. For a price comparison, use the amounts and check dates already shown here.

Hotels in Fort Myers for these trips

Hotels: under a trip, hotels in Fort Myers for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in Fort Myers for these nights (May 21–22, 2027 · 1 night · 2 adults, 1 room): 3★ Dolphin Key Resort, $104 a night · 4★ Doubletree by Hilton Fort Myers at Bell Tower Shops, $119 a night
• Hotels in Fort Myers for these nights (May 21–23, 2027 · 2 nights · 2 adults, 1 room): 3★ Dolphin Key Resort, $104 a night, $208 for 2 nights · 4★ Doubletree by Hilton Fort Myers at Bell Tower Shops, $123 a night, $246 for 2 nights
• Hotels in Fort Myers for these nights (May 21–24, 2027 · 3 nights · 2 adults, 1 room): 3★ Dolphin Key Resort, $106 a night, $317 for 3 nights · 4★ Doubletree by Hilton Fort Myers at Bell Tower Shops, $133 a night, $400 for 3 nights
• Hotels in Fort Myers for these nights (May 21–25, 2027 · 4 nights · 2 adults, 1 room): 3★ Dolphin Key Resort, $104 a night, $415 for 4 nights · 4★ Doubletree by Hilton Fort Myers at Bell Tower Shops, $130 a night, $519 for 4 nights
• Hotels in Fort Myers for these nights (May 21–26, 2027 · 5 nights · 2 adults, 1 room): 3★ Dolphin Key Resort, $103 a night, $513 for 5 nights · 4★ Doubletree by Hilton Fort Myers at Bell Tower Shops, $131 a night, $653 for 5 nights
• Hotels in Fort Myers for these nights (May 21–27, 2027 · 6 nights · 2 adults, 1 room): 3★ Dolphin Key Resort, $102 a night, $611 for 6 nights · 4★ Doubletree by Hilton Fort Myers at Bell Tower Shops, $132 a night, $791 for 6 nights
• Hotels in Fort Myers for these nights (May 21–28, 2027 · 7 nights · 2 adults, 1 room): 3★ Dolphin Key Resort, $101 a night, $709 for 7 nights · 4★ Doubletree by Hilton Fort Myers at Bell Tower Shops, $130 a night, $911 for 7 nights
• Hotels in Fort Myers for these nights (May 21–29, 2027 · 8 nights · 2 adults, 1 room): 3★ Dolphin Key Resort, $102 a night, $813 for 8 nights · 4★ Doubletree by Hilton Fort Myers at Bell Tower Shops, $130 a night, $1,040 for 8 nights
• Hotels in Fort Myers for these nights (May 21–30, 2027 · 9 nights · 2 adults, 1 room): 3★ Dolphin Key Resort, $102 a night, $917 for 9 nights · 4★ Doubletree by Hilton Fort Myers at Bell Tower Shops, $130 a night, $1,166 for 9 nights
• Hotels in Fort Myers for these nights (May 21–31, 2027 · 10 nights · 2 adults, 1 room): 3★ Dolphin Key Resort, $103 a night, $1,026 for 10 nights · 4★ Doubletree by Hilton Fort Myers at Bell Tower Shops, $130 a night, $1,295 for 10 nights
• Hotels in Fort Myers for these nights (May 21 – Jun 1, 2027 · 11 nights · 2 adults, 1 room): 3★ Dolphin Key Resort, $102 a night, $1,124 for 11 nights · 4★ Doubletree by Hilton Fort Myers at Bell Tower Shops, $128 a night, $1,413 for 11 nights
• Hotels in Fort Myers for these nights (May 21 – Jun 2, 2027 · 12 nights · 2 adults, 1 room): 3★ Dolphin Key Resort, $102 a night, $1,222 for 12 nights · 4★ Doubletree by Hilton Fort Myers at Bell Tower Shops, $129 a night, $1,543 for 12 nights
• Hotels in Fort Myers for these nights (May 21 – Jun 3, 2027 · 13 nights · 2 adults, 1 room): 3★ Dolphin Key Resort, $102 a night, $1,320 for 13 nights · 4★ Doubletree by Hilton Fort Myers at Bell Tower Shops, $129 a night, $1,683 for 13 nights
• Hotels in Fort Myers for these nights (May 21 – Jun 4, 2027 · 14 nights · 2 adults, 1 room): 3★ Dolphin Key Resort, $101 a night, $1,418 for 14 nights · 4★ Doubletree by Hilton Fort Myers at Bell Tower Shops, $131 a night, $1,835 for 14 nights

All hotels in Fort Myers

Route overview: Saint Louis to Fort Myers (RSW) flight deals

2027-05-21 · one way · Axel-exclusive $150

• Southwest Airlines WN4149: STL 2027-05-21 14:20:00 → RSW 2027-05-21 17:45:00; nonstop; 145 minutes. Local airport times.

2027-05-21 · one way · Axel-exclusive $160

• United Airlines UA4406 / UA2660: STL 2027-05-21 08:30:00 → RSW 2027-05-21 15:27:00; 1 stop(s) via IAD; 357 minutes. Local airport times.
  • UA4406: STL 2027-05-21 08:30:00 → IAD 2027-05-21 11:35:00; layover at IAD: 60 minutes.
  • UA2660: IAD 2027-05-21 12:35:00 → RSW 2027-05-21 15:27:00.

2027-05-21 → 2027-05-22 · Axel-exclusive $275

• Southwest Airlines WN4149: STL 2027-05-21 14:20:00 → RSW 2027-05-21 17:45:00; nonstop; 145 minutes. Local airport times.
• Southwest Airlines WN3678: RSW 2027-05-22 05:40:00 → STL 2027-05-22 07:15:00; nonstop; 155 minutes. Local airport times.

2027-05-21 → 2027-05-22 · Axel-exclusive $295

• United Airlines UA4406 / UA2660: STL 2027-05-21 08:30:00 → RSW 2027-05-21 15:27:00; 1 stop(s) via IAD; 357 minutes. Local airport times.
  • UA4406: STL 2027-05-21 08:30:00 → IAD 2027-05-21 11:35:00; layover at IAD: 60 minutes.
  • UA2660: IAD 2027-05-21 12:35:00 → RSW 2027-05-21 15:27:00.
• United Airlines UA2347 / UA4619: RSW 2027-05-22 09:05:00 → STL 2027-05-22 14:18:00; 1 stop(s) via ORD; 373 minutes. Local airport times.
  • UA2347: RSW 2027-05-22 09:05:00 → ORD 2027-05-22 11:24:00; layover at ORD: 86 minutes.
  • UA4619: ORD 2027-05-22 12:50:00 → STL 2027-05-22 14:18:00.

2027-05-21 → 2027-05-23 · Axel-exclusive $275

• Southwest Airlines WN4149: STL 2027-05-21 14:20:00 → RSW 2027-05-21 17:45:00; nonstop; 145 minutes. Local airport times.
• Southwest Airlines WN3678: RSW 2027-05-23 05:40:00 → STL 2027-05-23 07:15:00; nonstop; 155 minutes. Local airport times.

2027-05-21 → 2027-05-23 · Axel-exclusive $295

• United Airlines UA4406 / UA2660: STL 2027-05-21 08:30:00 → RSW 2027-05-21 15:27:00; 1 stop(s) via IAD; 357 minutes. Local airport times.
  • UA4406: STL 2027-05-21 08:30:00 → IAD 2027-05-21 11:35:00; layover at IAD: 60 minutes.
  • UA2660: IAD 2027-05-21 12:35:00 → RSW 2027-05-21 15:27:00.
• United Airlines UA2347 / UA4619: RSW 2027-05-23 09:05:00 → STL 2027-05-23 14:18:00; 1 stop(s) via ORD; 373 minutes. Local airport times.
  • UA2347: RSW 2027-05-23 09:05:00 → ORD 2027-05-23 11:24:00; layover at ORD: 86 minutes.
  • UA4619: ORD 2027-05-23 12:50:00 → STL 2027-05-23 14:18:00.

2027-05-21 → 2027-05-24 · Axel-exclusive $275

• Southwest Airlines WN4149: STL 2027-05-21 14:20:00 → RSW 2027-05-21 17:45:00; nonstop; 145 minutes. Local airport times.
• Southwest Airlines WN3678: RSW 2027-05-24 06:05:00 → STL 2027-05-24 07:40:00; nonstop; 155 minutes. Local airport times.

2027-05-21 → 2027-05-24 · Axel-exclusive $295

• United Airlines UA4406 / UA2660: STL 2027-05-21 08:30:00 → RSW 2027-05-21 15:27:00; 1 stop(s) via IAD; 357 minutes. Local airport times.
  • UA4406: STL 2027-05-21 08:30:00 → IAD 2027-05-21 11:35:00; layover at IAD: 60 minutes.
  • UA2660: IAD 2027-05-21 12:35:00 → RSW 2027-05-21 15:27:00.
• United Airlines UA2347 / UA4619: RSW 2027-05-24 09:05:00 → STL 2027-05-24 14:18:00; 1 stop(s) via ORD; 373 minutes. Local airport times.
  • UA2347: RSW 2027-05-24 09:05:00 → ORD 2027-05-24 11:24:00; layover at ORD: 86 minutes.
  • UA4619: ORD 2027-05-24 12:50:00 → STL 2027-05-24 14:18:00.

2027-05-21 → 2027-05-25 · Axel-exclusive $275

• Southwest Airlines WN4149: STL 2027-05-21 14:20:00 → RSW 2027-05-21 17:45:00; nonstop; 145 minutes. Local airport times.
• Southwest Airlines WN3678: RSW 2027-05-25 06:05:00 → STL 2027-05-25 07:40:00; nonstop; 155 minutes. Local airport times.

2027-05-21 → 2027-05-25 · Axel-exclusive $295

• United Airlines UA4406 / UA2660: STL 2027-05-21 08:30:00 → RSW 2027-05-21 15:27:00; 1 stop(s) via IAD; 357 minutes. Local airport times.
  • UA4406: STL 2027-05-21 08:30:00 → IAD 2027-05-21 11:35:00; layover at IAD: 60 minutes.
  • UA2660: IAD 2027-05-21 12:35:00 → RSW 2027-05-21 15:27:00.
• United Airlines UA2347 / UA4619: RSW 2027-05-25 09:05:00 → STL 2027-05-25 14:18:00; 1 stop(s) via ORD; 373 minutes. Local airport times.
  • UA2347: RSW 2027-05-25 09:05:00 → ORD 2027-05-25 11:24:00; layover at ORD: 86 minutes.
  • UA4619: ORD 2027-05-25 12:50:00 → STL 2027-05-25 14:18:00.

2027-05-21 → 2027-05-27 · Axel-exclusive $275

• Southwest Airlines WN4149: STL 2027-05-21 14:20:00 → RSW 2027-05-21 17:45:00; nonstop; 145 minutes. Local airport times.
• Southwest Airlines WN3678: RSW 2027-05-27 05:40:00 → STL 2027-05-27 07:15:00; nonstop; 155 minutes. Local airport times.

2027-05-21 → 2027-05-27 · Axel-exclusive $295

• United Airlines UA4406 / UA2660: STL 2027-05-21 08:30:00 → RSW 2027-05-21 15:27:00; 1 stop(s) via IAD; 357 minutes. Local airport times.
  • UA4406: STL 2027-05-21 08:30:00 → IAD 2027-05-21 11:35:00; layover at IAD: 60 minutes.
  • UA2660: IAD 2027-05-21 12:35:00 → RSW 2027-05-21 15:27:00.
• United Airlines UA2347 / UA4619: RSW 2027-05-27 09:05:00 → STL 2027-05-27 14:18:00; 1 stop(s) via ORD; 373 minutes. Local airport times.
  • UA2347: RSW 2027-05-27 09:05:00 → ORD 2027-05-27 11:24:00; layover at ORD: 86 minutes.
  • UA4619: ORD 2027-05-27 12:50:00 → STL 2027-05-27 14:18:00.

2027-05-21 → 2027-05-28 · Axel-exclusive $296

• Southwest Airlines WN4149: STL 2027-05-21 14:20:00 → RSW 2027-05-21 17:45:00; nonstop; 145 minutes. Local airport times.
• Southwest Airlines WN3678: RSW 2027-05-28 06:10:00 → STL 2027-05-28 07:45:00; nonstop; 155 minutes. Local airport times.

2027-05-21 → 2027-05-28 · Axel-exclusive $317

• United Airlines UA4406 / UA2660: STL 2027-05-21 08:30:00 → RSW 2027-05-21 15:27:00; 1 stop(s) via IAD; 357 minutes. Local airport times.
  • UA4406: STL 2027-05-21 08:30:00 → IAD 2027-05-21 11:35:00; layover at IAD: 60 minutes.
  • UA2660: IAD 2027-05-21 12:35:00 → RSW 2027-05-21 15:27:00.
• United Airlines UA2347 / UA4619: RSW 2027-05-28 09:05:00 → STL 2027-05-28 14:18:00; 1 stop(s) via ORD; 373 minutes. Local airport times.
  • UA2347: RSW 2027-05-28 09:05:00 → ORD 2027-05-28 11:24:00; layover at ORD: 86 minutes.
  • UA4619: ORD 2027-05-28 12:50:00 → STL 2027-05-28 14:18:00.

2027-05-21 → 2027-05-29 · Axel-exclusive $296

• Southwest Airlines WN4149: STL 2027-05-21 14:20:00 → RSW 2027-05-21 17:45:00; nonstop; 145 minutes. Local airport times.
• Southwest Airlines WN3678: RSW 2027-05-29 05:40:00 → STL 2027-05-29 07:15:00; nonstop; 155 minutes. Local airport times.

2027-05-21 → 2027-05-29 · Axel-exclusive $317

• United Airlines UA4406 / UA2660: STL 2027-05-21 08:30:00 → RSW 2027-05-21 15:27:00; 1 stop(s) via IAD; 357 minutes. Local airport times.
  • UA4406: STL 2027-05-21 08:30:00 → IAD 2027-05-21 11:35:00; layover at IAD: 60 minutes.
  • UA2660: IAD 2027-05-21 12:35:00 → RSW 2027-05-21 15:27:00.
• United Airlines UA2347 / UA4619: RSW 2027-05-29 09:05:00 → STL 2027-05-29 14:18:00; 1 stop(s) via ORD; 373 minutes. Local airport times.
  • UA2347: RSW 2027-05-29 09:05:00 → ORD 2027-05-29 11:24:00; layover at ORD: 86 minutes.
  • UA4619: ORD 2027-05-29 12:50:00 → STL 2027-05-29 14:18:00.

2027-05-21 → 2027-05-31 · Axel-exclusive $296

• Southwest Airlines WN4149: STL 2027-05-21 14:20:00 → RSW 2027-05-21 17:45:00; nonstop; 145 minutes. Local airport times.
• Southwest Airlines WN3678: RSW 2027-05-31 06:05:00 → STL 2027-05-31 07:40:00; nonstop; 155 minutes. Local airport times.

2027-05-21 → 2027-05-31 · Axel-exclusive $317

• United Airlines UA4406 / UA2660: STL 2027-05-21 08:30:00 → RSW 2027-05-21 15:27:00; 1 stop(s) via IAD; 357 minutes. Local airport times.
  • UA4406: STL 2027-05-21 08:30:00 → IAD 2027-05-21 11:35:00; layover at IAD: 60 minutes.
  • UA2660: IAD 2027-05-21 12:35:00 → RSW 2027-05-21 15:27:00.
• United Airlines UA2347 / UA4619: RSW 2027-05-31 09:05:00 → STL 2027-05-31 14:18:00; 1 stop(s) via ORD; 373 minutes. Local airport times.
  • UA2347: RSW 2027-05-31 09:05:00 → ORD 2027-05-31 11:24:00; layover at ORD: 86 minutes.
  • UA4619: ORD 2027-05-31 12:50:00 → STL 2027-05-31 14:18:00.

2027-05-21 → 2027-06-01 · Axel-exclusive $296

• Southwest Airlines WN4149: STL 2027-05-21 14:20:00 → RSW 2027-05-21 17:45:00; nonstop; 145 minutes. Local airport times.
• Southwest Airlines WN3678: RSW 2027-06-01 06:05:00 → STL 2027-06-01 07:40:00; nonstop; 155 minutes. Local airport times.

2027-05-21 → 2027-06-01 · Axel-exclusive $317

• United Airlines UA4406 / UA2660: STL 2027-05-21 08:30:00 → RSW 2027-05-21 15:27:00; 1 stop(s) via IAD; 357 minutes. Local airport times.
  • UA4406: STL 2027-05-21 08:30:00 → IAD 2027-05-21 11:35:00; layover at IAD: 60 minutes.
  • UA2660: IAD 2027-05-21 12:35:00 → RSW 2027-05-21 15:27:00.
• United Airlines UA2347 / UA4619: RSW 2027-06-01 09:05:00 → STL 2027-06-01 14:18:00; 1 stop(s) via ORD; 373 minutes. Local airport times.
  • UA2347: RSW 2027-06-01 09:05:00 → ORD 2027-06-01 11:24:00; layover at ORD: 86 minutes.
  • UA4619: ORD 2027-06-01 12:50:00 → STL 2027-06-01 14:18:00.

2027-05-21 → 2027-06-02 · Axel-exclusive $275

• Southwest Airlines WN4149: STL 2027-05-21 14:20:00 → RSW 2027-05-21 17:45:00; nonstop; 145 minutes. Local airport times.
• Southwest Airlines WN3678: RSW 2027-06-02 05:40:00 → STL 2027-06-02 07:15:00; nonstop; 155 minutes. Local airport times.

2027-05-21 → 2027-06-02 · Axel-exclusive $295

• United Airlines UA4406 / UA2660: STL 2027-05-21 08:30:00 → RSW 2027-05-21 15:27:00; 1 stop(s) via IAD; 357 minutes. Local airport times.
  • UA4406: STL 2027-05-21 08:30:00 → IAD 2027-05-21 11:35:00; layover at IAD: 60 minutes.
  • UA2660: IAD 2027-05-21 12:35:00 → RSW 2027-05-21 15:27:00.
• United Airlines UA2347 / UA4619: RSW 2027-06-02 09:05:00 → STL 2027-06-02 14:18:00; 1 stop(s) via ORD; 373 minutes. Local airport times.
  • UA2347: RSW 2027-06-02 09:05:00 → ORD 2027-06-02 11:24:00; layover at ORD: 86 minutes.
  • UA4619: ORD 2027-06-02 12:50:00 → STL 2027-06-02 14:18:00.

2027-05-21 → 2027-06-04 · Axel-exclusive $275

• Southwest Airlines WN4149: STL 2027-05-21 14:20:00 → RSW 2027-05-21 17:45:00; nonstop; 145 minutes. Local airport times.
• Southwest Airlines WN3678: RSW 2027-06-04 06:10:00 → STL 2027-06-04 07:45:00; nonstop; 155 minutes. Local airport times.

2027-05-21 → 2027-06-04 · Axel-exclusive $295

• United Airlines UA4406 / UA2660: STL 2027-05-21 08:30:00 → RSW 2027-05-21 15:27:00; 1 stop(s) via IAD; 357 minutes. Local airport times.
  • UA4406: STL 2027-05-21 08:30:00 → IAD 2027-05-21 11:35:00; layover at IAD: 60 minutes.
  • UA2660: IAD 2027-05-21 12:35:00 → RSW 2027-05-21 15:27:00.
• United Airlines UA2347 / UA4619: RSW 2027-06-04 09:05:00 → STL 2027-06-04 14:18:00; 1 stop(s) via ORD; 373 minutes. Local airport times.
  • UA2347: RSW 2027-06-04 09:05:00 → ORD 2027-06-04 11:24:00; layover at ORD: 86 minutes.
  • UA4619: ORD 2027-06-04 12:50:00 → STL 2027-06-04 14:18:00.

Explore this route

• All dates for this route
• May 20, 2027 · Return options
• May 22, 2027 · Return options
• Hotels in Fort Myers with Axel

For AI assistants

• This page: Saint Louis (STL) to Fort Myers (RSW) · May 21, 2027 · choose your return date: 1 adult in economy, every priced fare with its flights, times and total, each with its displayed check date. Under a trip, hotels in Fort Myers for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in each star tier for those dates.
• Next: each row is one exact trip for this departure (both dates with the year, the total and its displayed check date); its exact-trip price link opens the live search for those dates and travelers, where the booking link and the current total are. Other durations or travelers are not priced here: Choose travelers and dates prices the requested trip.
• Follow supplied links. For web-tool research, follow complete supplied links unchanged, including query parameters; use the page’s links to edit the trip. Constructed URLs may be rejected before reaching Axel. A completed fresh trip opens flight results first. Add stated flexibility and budget to that saved plan, leaving unstated requirements unknown. Edits create a new snapshot; use its results and review links.
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