Saint Louis (STL) to Raleigh/Durham (RDU), Dec 22, 2026: round trips from $326, one way from $194

Saint Louis (STL) to Raleigh/Durham (RDU), Dec 22, 2026: round trips from $326, one way from $194 on Axel, checked Oct 29, 2026. Lowest published fares: $326 round trip, Axel-exclusive, Southwest Airlines, nonstop, Dec 22, 2026 – Jan 4, 2027; $194 one way, Axel-exclusive, Southwest Airlines, nonstop, Dec 22, 2026; 1 adult, economy, checked Oct 29, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Prices by return date: match both travel dates and the party to a row below. Each total is for that exact trip, issued at the time shown.

Date links open published trip details for exploration. Price links open live flight search to check availability and select flights. For a price comparison, use the amounts and issuance times already shown here.

Hotels in Raleigh-Durham for these trips

Hotels: under a trip, hotels in Raleigh-Durham for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in Raleigh-Durham for these nights (Dec 22–23, 2026 · 1 night · 2 adults, 1 room): 3★ La Quinta Inn & Suites by Wyndham Raleigh Durham Intl AP, $76 total · 4★ Hilton Raleigh North Hills, $108 total
• Hotels in Raleigh-Durham for these nights (Dec 22–24, 2026 · 2 nights · 2 adults, 1 room): 3★ La Quinta Inn & Suites by Wyndham Raleigh Durham Intl AP, $150 total · 4★ Hilton Raleigh North Hills, $216 total
• Hotels in Raleigh-Durham for these nights (Dec 22–25, 2026 · 3 nights · 2 adults, 1 room): 3★ La Quinta Inn & Suites by Wyndham Raleigh Durham Intl AP, $224 total · 4★ Hilton Raleigh North Hills, $323 total
• Hotels in Raleigh-Durham for these nights (Dec 22–26, 2026 · 4 nights · 2 adults, 1 room): 3★ La Quinta Inn & Suites by Wyndham Raleigh Durham Intl AP, $302 total · 4★ Hilton Raleigh North Hills, $433 total
• Hotels in Raleigh-Durham for these nights (Dec 22–27, 2026 · 5 nights · 2 adults, 1 room): 3★ La Quinta Inn & Suites by Wyndham Raleigh Durham Intl AP, $382 total · 4★ Hilton Raleigh North Hills, $541 total
• Hotels in Raleigh-Durham for these nights (Dec 22–28, 2026 · 6 nights · 2 adults, 1 room): 3★ La Quinta Inn & Suites by Wyndham Raleigh Durham Intl AP, $456 total · 4★ Hilton Raleigh North Hills, $648 total
• Hotels in Raleigh-Durham for these nights (Dec 22–29, 2026 · 7 nights · 2 adults, 1 room): 3★ La Quinta Inn & Suites by Wyndham Raleigh Durham Intl AP, $532 total · 4★ Hilton Raleigh North Hills, $760 total
• Hotels in Raleigh-Durham for these nights (Dec 22–30, 2026 · 8 nights · 2 adults, 1 room): 3★ La Quinta Inn & Suites by Wyndham Raleigh Durham Intl AP, $603 total · 4★ Hilton Raleigh North Hills, $872 total
• Hotels in Raleigh-Durham for these nights (Dec 22–31, 2026 · 9 nights · 2 adults, 1 room): 3★ La Quinta Inn & Suites by Wyndham Raleigh Durham Intl AP, $679 total · 4★ Hilton Raleigh North Hills, $982 total
• Hotels in Raleigh-Durham for these nights (Dec 22 – Jan 1, 2027 · 10 nights · 2 adults, 1 room): 3★ La Quinta Inn & Suites by Wyndham Raleigh Durham Intl AP, $756 total · 4★ Hilton Raleigh North Hills, $1,198 total
• Hotels in Raleigh-Durham for these nights (Dec 22 – Jan 2, 2027 · 11 nights · 2 adults, 1 room): 3★ La Quinta Inn & Suites by Wyndham Raleigh Durham Intl AP, $836 total · 4★ Hilton Raleigh North Hills, $1,306 total
• Hotels in Raleigh-Durham for these nights (Dec 22 – Jan 3, 2027 · 12 nights · 2 adults, 1 room): 3★ La Quinta Inn & Suites by Wyndham Raleigh Durham Intl AP, $914 total · 4★ Hilton Raleigh North Hills, $1,414 total
• Hotels in Raleigh-Durham for these nights (Dec 22 – Jan 4, 2027 · 13 nights · 2 adults, 1 room): 3★ La Quinta Inn & Suites by Wyndham Raleigh Durham Intl AP, $988 total · 4★ Hilton Raleigh North Hills, $1,525 total
• Hotels in Raleigh-Durham for these nights (Dec 22 – Jan 5, 2027 · 14 nights · 2 adults, 1 room): 3★ La Quinta Inn & Suites by Wyndham Raleigh Durham Intl AP, $1,060 total · 4★ Hilton Raleigh North Hills, $1,638 total

All hotels in Raleigh-Durham

Route overview: Saint Louis to Raleigh/Durham (RDU) flight deals

2026-12-22 · one way · Axel-exclusive $193.75

• Southwest Airlines WN4192: STL 2026-12-22 10:15:00 → RDU 2026-12-22 13:05:00; nonstop; 110 minutes. Local airport times.

2026-12-22 · one way · Axel-exclusive $206.25

• American Airlines AA2486 / AA1904: STL 2026-12-22 12:54:00 → RDU 2026-12-22 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-22 12:54:00 → CLT 2026-12-22 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-22 17:30:00 → RDU 2026-12-22 18:29:00.

2026-12-22 → 2026-12-23 · Axel-exclusive $362.50

• Southwest Airlines WN4192: STL 2026-12-22 10:15:00 → RDU 2026-12-22 13:05:00; nonstop; 110 minutes. Local airport times.
• Southwest Airlines WN3622: RDU 2026-12-23 06:05:00 → STL 2026-12-23 07:20:00; nonstop; 135 minutes. Local airport times.

2026-12-22 → 2026-12-23 · Axel-exclusive $387.50

• American Airlines AA2486 / AA1904: STL 2026-12-22 12:54:00 → RDU 2026-12-22 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-22 12:54:00 → CLT 2026-12-22 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-22 17:30:00 → RDU 2026-12-22 18:29:00.
• American Airlines AA1391 / AA4458: RDU 2026-12-23 06:00:00 → STL 2026-12-23 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-12-23 06:00:00 → DCA 2026-12-23 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-12-23 08:20:00 → STL 2026-12-23 10:08:00.

2026-12-22 → 2026-12-24 · Axel-exclusive $362.50

• Southwest Airlines WN4192: STL 2026-12-22 10:15:00 → RDU 2026-12-22 13:05:00; nonstop; 110 minutes. Local airport times.
• Southwest Airlines WN3623: RDU 2026-12-24 19:50:00 → STL 2026-12-24 21:00:00; nonstop; 130 minutes. Local airport times.

2026-12-22 → 2026-12-24 · Axel-exclusive $387.50

• American Airlines AA2486 / AA1904: STL 2026-12-22 12:54:00 → RDU 2026-12-22 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-22 12:54:00 → CLT 2026-12-22 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-22 17:30:00 → RDU 2026-12-22 18:29:00.
• American Airlines AA1391 / AA4458: RDU 2026-12-24 06:00:00 → STL 2026-12-24 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-12-24 06:00:00 → DCA 2026-12-24 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-12-24 08:20:00 → STL 2026-12-24 10:08:00.

2026-12-22 → 2026-12-25 · Axel-exclusive $362.50

• Southwest Airlines WN4192: STL 2026-12-22 10:15:00 → RDU 2026-12-22 13:05:00; nonstop; 110 minutes. Local airport times.
• Southwest Airlines WN3623: RDU 2026-12-25 19:50:00 → STL 2026-12-25 21:00:00; nonstop; 130 minutes. Local airport times.

2026-12-22 → 2026-12-25 · Axel-exclusive $387.50

• American Airlines AA2486 / AA1904: STL 2026-12-22 12:54:00 → RDU 2026-12-22 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-22 12:54:00 → CLT 2026-12-22 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-22 17:30:00 → RDU 2026-12-22 18:29:00.
• American Airlines AA1391 / AA4458: RDU 2026-12-25 06:00:00 → STL 2026-12-25 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-12-25 06:00:00 → DCA 2026-12-25 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-12-25 08:20:00 → STL 2026-12-25 10:08:00.

2026-12-22 → 2026-12-26 · Axel-exclusive $362.50

• Southwest Airlines WN4192: STL 2026-12-22 10:15:00 → RDU 2026-12-22 13:05:00; nonstop; 110 minutes. Local airport times.
• Southwest Airlines WN3623: RDU 2026-12-26 19:50:00 → STL 2026-12-26 21:00:00; nonstop; 130 minutes. Local airport times.

2026-12-22 → 2026-12-26 · Axel-exclusive $387.50

• American Airlines AA2486 / AA1904: STL 2026-12-22 12:54:00 → RDU 2026-12-22 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-22 12:54:00 → CLT 2026-12-22 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-22 17:30:00 → RDU 2026-12-22 18:29:00.
• American Airlines AA1391 / AA4458: RDU 2026-12-26 06:00:00 → STL 2026-12-26 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-12-26 06:00:00 → DCA 2026-12-26 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-12-26 08:20:00 → STL 2026-12-26 10:08:00.

2026-12-22 → 2026-12-28 · Axel-exclusive $362.50

• Southwest Airlines WN4192: STL 2026-12-22 10:15:00 → RDU 2026-12-22 13:05:00; nonstop; 110 minutes. Local airport times.
• Southwest Airlines WN3623: RDU 2026-12-28 19:50:00 → STL 2026-12-28 21:00:00; nonstop; 130 minutes. Local airport times.

2026-12-22 → 2026-12-28 · Axel-exclusive $387.50

• American Airlines AA2486 / AA1904: STL 2026-12-22 12:54:00 → RDU 2026-12-22 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-22 12:54:00 → CLT 2026-12-22 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-22 17:30:00 → RDU 2026-12-22 18:29:00.
• American Airlines AA1391 / AA4458: RDU 2026-12-28 06:00:00 → STL 2026-12-28 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-12-28 06:00:00 → DCA 2026-12-28 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-12-28 08:20:00 → STL 2026-12-28 10:08:00.

2026-12-22 → 2026-12-29 · Axel-exclusive $362.50

• Southwest Airlines WN4192: STL 2026-12-22 10:15:00 → RDU 2026-12-22 13:05:00; nonstop; 110 minutes. Local airport times.
• Southwest Airlines WN3622: RDU 2026-12-29 06:05:00 → STL 2026-12-29 07:20:00; nonstop; 135 minutes. Local airport times.

2026-12-22 → 2026-12-29 · Axel-exclusive $387.50

• American Airlines AA2486 / AA1904: STL 2026-12-22 12:54:00 → RDU 2026-12-22 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-22 12:54:00 → CLT 2026-12-22 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-22 17:30:00 → RDU 2026-12-22 18:29:00.
• American Airlines AA638 / AA2486: RDU 2026-12-29 10:07:00 → STL 2026-12-29 13:18:00; 1 stop(s) via CLT; 251 minutes. Local airport times.
  • AA638: RDU 2026-12-29 10:07:00 → CLT 2026-12-29 11:17:00; layover at CLT: 63 minutes.
  • AA2486: CLT 2026-12-29 12:20:00 → STL 2026-12-29 13:18:00.

2026-12-22 → 2026-12-30 · Axel-exclusive $362.50

• Southwest Airlines WN4192: STL 2026-12-22 10:15:00 → RDU 2026-12-22 13:05:00; nonstop; 110 minutes. Local airport times.
• Southwest Airlines WN3622: RDU 2026-12-30 06:05:00 → STL 2026-12-30 07:20:00; nonstop; 135 minutes. Local airport times.

2026-12-22 → 2026-12-30 · Axel-exclusive $387.50

• American Airlines AA2486 / AA1904: STL 2026-12-22 12:54:00 → RDU 2026-12-22 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-22 12:54:00 → CLT 2026-12-22 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-22 17:30:00 → RDU 2026-12-22 18:29:00.
• American Airlines AA1391 / AA4458: RDU 2026-12-30 06:00:00 → STL 2026-12-30 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-12-30 06:00:00 → DCA 2026-12-30 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-12-30 08:20:00 → STL 2026-12-30 10:08:00.

2026-12-22 → 2027-01-01 · Axel-exclusive $362.50

• Southwest Airlines WN4192: STL 2026-12-22 10:15:00 → RDU 2026-12-22 13:05:00; nonstop; 110 minutes. Local airport times.
• Southwest Airlines WN3623: RDU 2027-01-01 19:50:00 → STL 2027-01-01 21:00:00; nonstop; 130 minutes. Local airport times.

2026-12-22 → 2027-01-01 · Axel-exclusive $387.50

• American Airlines AA2486 / AA1904: STL 2026-12-22 12:54:00 → RDU 2026-12-22 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-22 12:54:00 → CLT 2026-12-22 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-22 17:30:00 → RDU 2026-12-22 18:29:00.
• American Airlines AA1391 / AA4458: RDU 2027-01-01 06:00:00 → STL 2027-01-01 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2027-01-01 06:00:00 → DCA 2027-01-01 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2027-01-01 08:20:00 → STL 2027-01-01 10:08:00.

2026-12-22 → 2027-01-02 · Axel-exclusive $362.50

• Southwest Airlines WN4192: STL 2026-12-22 10:15:00 → RDU 2026-12-22 13:05:00; nonstop; 110 minutes. Local airport times.
• Southwest Airlines WN3623: RDU 2027-01-02 19:50:00 → STL 2027-01-02 21:00:00; nonstop; 130 minutes. Local airport times.

2026-12-22 → 2027-01-02 · Axel-exclusive $387.50

• American Airlines AA2486 / AA1904: STL 2026-12-22 12:54:00 → RDU 2026-12-22 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-22 12:54:00 → CLT 2026-12-22 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-22 17:30:00 → RDU 2026-12-22 18:29:00.
• American Airlines AA1391 / AA4458: RDU 2027-01-02 06:00:00 → STL 2027-01-02 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2027-01-02 06:00:00 → DCA 2027-01-02 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2027-01-02 08:20:00 → STL 2027-01-02 10:08:00.

2026-12-22 → 2027-01-03 · Axel-exclusive $362.50

• Southwest Airlines WN4192: STL 2026-12-22 10:15:00 → RDU 2026-12-22 13:05:00; nonstop; 110 minutes. Local airport times.
• Southwest Airlines WN3623: RDU 2027-01-03 20:50:00 → STL 2027-01-03 22:00:00; nonstop; 130 minutes. Local airport times.

2026-12-22 → 2027-01-03 · Axel-exclusive $387.50

• American Airlines AA2486 / AA1904: STL 2026-12-22 12:54:00 → RDU 2026-12-22 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-22 12:54:00 → CLT 2026-12-22 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-22 17:30:00 → RDU 2026-12-22 18:29:00.
• American Airlines AA1391 / AA4458: RDU 2027-01-03 06:00:00 → STL 2027-01-03 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2027-01-03 06:00:00 → DCA 2027-01-03 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2027-01-03 08:20:00 → STL 2027-01-03 10:08:00.

2026-12-22 → 2027-01-05 · Axel-exclusive $326.25

• Southwest Airlines WN4192: STL 2026-12-22 10:15:00 → RDU 2026-12-22 13:05:00; nonstop; 110 minutes. Local airport times.
• Southwest Airlines WN3622: RDU 2027-01-05 06:05:00 → STL 2027-01-05 07:20:00; nonstop; 135 minutes. Local airport times.

2026-12-22 → 2027-01-05 · Axel-exclusive $348.75

• American Airlines AA2486 / AA1904: STL 2026-12-22 12:54:00 → RDU 2026-12-22 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-22 12:54:00 → CLT 2026-12-22 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-22 17:30:00 → RDU 2026-12-22 18:29:00.
• American Airlines AA638 / AA2486: RDU 2027-01-05 10:07:00 → STL 2027-01-05 13:18:00; 1 stop(s) via CLT; 251 minutes. Local airport times.
  • AA638: RDU 2027-01-05 10:07:00 → CLT 2027-01-05 11:17:00; layover at CLT: 63 minutes.
  • AA2486: CLT 2027-01-05 12:20:00 → STL 2027-01-05 13:18:00.

Explore this route

• All dates for this route
• Dec 21, 2026 · Return options
• Dec 23, 2026 · Return options
• Hotels in Raleigh-Durham with Axel

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• This page: Saint Louis (STL) to Raleigh/Durham (RDU) · Dec 22, 2026 · choose your return date: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued. Under a trip, hotels in Raleigh-Durham for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the lowest saved totals among the shortlisted hotels in each star tier for those dates.
• Next: each row is one exact trip for this departure (both dates with the year, the total and the time its price was issued); its exact-trip price link opens the live search for those dates and travelers, where the booking link and the current total are. Other durations or travelers are not priced here: Choose travelers and dates prices the requested trip.
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