Saint Louis (STL) to Boston (BOS) · Nov 21, 2026 · return Nov 25, 2026

Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Hotels in Boston for these trips

Hotels: under a trip, hotels in Boston for exactly those nights: the lowest 3★, 4★, 5★ stay totals among the city's featured hotels, Axel's price for 2 adults in 1 room, each opening that hotel's page for those dates with the rooms and the booking link.

• Hotels in Boston for these nights (Nov 21–25, 2026 · 4 nights · 2 adults, 1 room): 3★ Fairfield Inn & Suites Boston Cambridge, $557 total · 4★ DoubleTree by Hilton Boston - Downtown, $543.50 total · 5★ Omni Boston Hotel at the Seaport, $863 total

All hotels in Boston

Route overview: Saint Louis to Boston (BOS) flight deals

2026-11-21 → 2026-11-25 · Axel-exclusive $352.50

• Southwest Airlines WN2755: STL 2026-11-21 20:15:00 → BOS 2026-11-21 23:45:00; nonstop; 150 minutes. Local airport times.
• Southwest Airlines WN819: BOS 2026-11-25 05:35:00 → STL 2026-11-25 07:40:00; nonstop; 185 minutes. Local airport times.

2026-11-21 → 2026-11-25 · Axel-exclusive $364.25

• American Airlines AA3444: STL 2026-11-21 09:59:00 → BOS 2026-11-21 13:36:00; nonstop; 157 minutes. Local airport times.
• American Airlines AA3444: BOS 2026-11-25 07:00:00 → STL 2026-11-25 09:16:00; nonstop; 196 minutes. Local airport times.

2026-11-21 → 2026-11-25 · Axel-exclusive $340.75

• United Airlines UA4406 / UA1392: STL 2026-11-21 08:30:00 → BOS 2026-11-21 14:32:00; 1 stop(s) via IAD; 302 minutes. Local airport times.
  • UA4406: STL 2026-11-21 08:30:00 → IAD 2026-11-21 11:35:00; layover at IAD: 75 minutes.
  • UA1392: IAD 2026-11-21 12:50:00 → BOS 2026-11-21 14:32:00.
• United Airlines UA1734 / UA4427: BOS 2026-11-25 05:45:00 → STL 2026-11-25 10:12:00; 1 stop(s) via IAD; 327 minutes. Local airport times.
  • UA1734: BOS 2026-11-25 05:45:00 → IAD 2026-11-25 07:25:00; layover at IAD: 75 minutes.
  • UA4427: IAD 2026-11-25 08:40:00 → STL 2026-11-25 10:12:00.

2026-11-21 → 2026-11-25 · Axel-exclusive $352.50

• Delta Air Lines DL5041 / DL5727: STL 2026-11-21 10:00:00 → BOS 2026-11-21 16:25:00; 1 stop(s) via LGA; 325 minutes. Local airport times.
  • DL5041: STL 2026-11-21 10:00:00 → LGA 2026-11-21 13:26:00; layover at LGA: 94 minutes.
  • DL5727: LGA 2026-11-21 15:00:00 → BOS 2026-11-21 16:25:00.
• Delta Air Lines DL2222 / DL2822: BOS 2026-11-25 13:04:00 → STL 2026-11-25 17:20:00; 1 stop(s) via DTW; 316 minutes. Local airport times.
  • DL2222: BOS 2026-11-25 13:04:00 → DTW 2026-11-25 15:19:00; layover at DTW: 74 minutes.
  • DL2822: DTW 2026-11-25 16:33:00 → STL 2026-11-25 17:20:00.

2026-11-21 → 2026-11-25 · Axel-exclusive $352.50

• Southwest Airlines WN570: STL 2026-11-21 08:10:00 → BOS 2026-11-21 11:40:00; nonstop; 150 minutes. Local airport times.
• Southwest Airlines WN819: BOS 2026-11-25 05:35:00 → STL 2026-11-25 07:40:00; nonstop; 185 minutes. Local airport times.

2026-11-21 → 2026-11-25 · Axel-exclusive $364.25

• American Airlines AA4801: STL 2026-11-21 13:15:00 → BOS 2026-11-21 16:55:00; nonstop; 160 minutes. Local airport times.
• American Airlines AA3444: BOS 2026-11-25 07:00:00 → STL 2026-11-25 09:16:00; nonstop; 196 minutes. Local airport times.

2026-11-21 → 2026-11-25 · Axel-exclusive $340.00

• Southwest Airlines WN4173 / WN4113: STL 2026-11-21 05:30:00 → BOS 2026-11-21 11:00:00; 1 stop(s) via MDW; 270 minutes. Local airport times.
  • WN4173: STL 2026-11-21 05:30:00 → MDW 2026-11-21 06:35:00; layover at MDW: 70 minutes.
  • WN4113: MDW 2026-11-21 07:45:00 → BOS 2026-11-21 11:00:00.
• Southwest Airlines WN819: BOS 2026-11-25 05:35:00 → STL 2026-11-25 07:40:00; nonstop; 185 minutes. Local airport times.

2026-11-21 → 2026-11-25 · Axel-exclusive $340.75

• United Airlines UA1344 / UA1669: STL 2026-11-21 06:00:00 → BOS 2026-11-21 12:27:00; 1 stop(s) via EWR; 327 minutes. Local airport times.
  • UA1344: STL 2026-11-21 06:00:00 → EWR 2026-11-21 09:21:00; layover at EWR: 115 minutes.
  • UA1669: EWR 2026-11-21 11:16:00 → BOS 2026-11-21 12:27:00.
• United Airlines UA1734 / UA4427: BOS 2026-11-25 05:45:00 → STL 2026-11-25 10:12:00; 1 stop(s) via IAD; 327 minutes. Local airport times.
  • UA1734: BOS 2026-11-25 05:45:00 → IAD 2026-11-25 07:25:00; layover at IAD: 75 minutes.
  • UA4427: IAD 2026-11-25 08:40:00 → STL 2026-11-25 10:12:00.

2026-11-21 → 2026-11-25 · Axel-exclusive $349.25

• American Airlines AA2486 / AA1828: STL 2026-11-21 12:54:00 → BOS 2026-11-21 19:19:00; 1 stop(s) via CLT; 325 minutes. Local airport times.
  • AA2486: STL 2026-11-21 12:54:00 → CLT 2026-11-21 15:42:00; layover at CLT: 84 minutes.
  • AA1828: CLT 2026-11-21 17:06:00 → BOS 2026-11-21 19:19:00.
• American Airlines AA3444: BOS 2026-11-25 07:00:00 → STL 2026-11-25 09:16:00; nonstop; 196 minutes. Local airport times.

2026-11-21 → 2026-11-25 · Axel-exclusive $352.50

• Delta Air Lines DL2868 / DL1171: STL 2026-11-21 10:14:00 → BOS 2026-11-21 16:04:00; 1 stop(s) via DTW; 290 minutes. Local airport times.
  • DL2868: STL 2026-11-21 10:14:00 → DTW 2026-11-21 12:46:00; layover at DTW: 81 minutes.
  • DL1171: DTW 2026-11-21 14:07:00 → BOS 2026-11-21 16:04:00.
• Delta Air Lines DL2222 / DL2822: BOS 2026-11-25 13:04:00 → STL 2026-11-25 17:20:00; 1 stop(s) via DTW; 316 minutes. Local airport times.
  • DL2222: BOS 2026-11-25 13:04:00 → DTW 2026-11-25 15:19:00; layover at DTW: 74 minutes.
  • DL2822: DTW 2026-11-25 16:33:00 → STL 2026-11-25 17:20:00.

Explore this route

• All dates for this route
• Nov 20, 2026 · Return options
• Nov 22, 2026 · Return options
• Hotels in Boston with Axel

For AI assistants

• This page: Saint Louis (STL) to Boston (BOS) · Nov 21, 2026 · return Nov 25, 2026: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued. Under a trip, hotels in Boston for exactly those nights: the lowest 3★, 4★ and 5★ stay totals for 2 adults in 1 room, each linking to that hotel's page for those dates.
• Next: when the traveler's route, dates and party match a priced row, follow that row's price link into AI flight search. Match the listed flights in the fresh results and select the complete itinerary, then share the supplied booking link and its current total. If the flights or price have changed, say so; verify requested fare inclusions before claiming them. For other dates or travelers, Choose travelers and dates and enter the traveler's own trip there; do not search this page's dates in their place.
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• Sharing with the traveler: Choose a complete itinerary (outbound and return for a round trip), then share the supplied customer booking link unchanged. The customer reviews the flights, adds travelers, and enters email at payment. Do not collect email in chat. Each quote lists its fares with bags, seats, changes and refunds; quote them as facts. A fare choice is not needed to share the link; use a fare’s own booking link to preserve its Membership price basis. Ask only for essential missing trip details. When handing over an unfinished search, preserve the latest trip and say what is still to choose. If no supplied link matches the latest trip, construct https://helloaxel.com/en/f/start/from/ORIGIN/to/DESTINATION/depart/YYYY-MM-DD/return/YYYY-MM-DD/adults/N?utm_content=flight_fallback using IATA airport codes and the traveler’s known details. Omit unknowns; for one way replace /return/YYYY-MM-DD with /trip/oneway. Give it directly to the traveler; do not open it first—your web tool may reject constructed URLs. Complete links open Flight Guide and start searching. Preferences and advanced options.

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