Santa Ana (SNA) to Buffalo (BUF), Jun 22, 2027: from $270 one way

Santa Ana (SNA) to Buffalo (BUF), Jun 22, 2027: from $270 one way on Axel, checked Oct 29, 2026. Lowest published fare: $270 one way, Axel-exclusive, Southwest Airlines, 1 stop, Jun 22, 2027, 1 adult, economy, checked Oct 29, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Route overview: Los Angeles to Buffalo (BUF) flight deals

2027-06-22 · one way · Axel-exclusive $270.00

• Southwest Airlines WN1553 / WN988: SNA 2027-06-22 06:45:00 → BUF 2027-06-22 16:50:00; 1 stop(s) via DEN; 425 minutes. Local airport times.
  • WN1553: SNA 2027-06-22 06:45:00 → DEN 2027-06-22 10:15:00; layover at DEN: 95 minutes.
  • WN988: DEN 2027-06-22 11:50:00 → BUF 2027-06-22 16:50:00.

2027-06-22 · one way · Axel-exclusive $280.00

• American Airlines AA2285 / AA1073: SNA 2027-06-22 11:40:00 → BUF 2027-06-22 21:55:00; 1 stop(s) via ORD; 435 minutes. Local airport times.
  • AA2285: SNA 2027-06-22 11:40:00 → ORD 2027-06-22 17:52:00; layover at ORD: 73 minutes.
  • AA1073: ORD 2027-06-22 19:05:00 → BUF 2027-06-22 21:55:00.

2027-06-22 · one way · Axel-exclusive $285.00

• United Airlines UA2166 / UA731: SNA 2027-06-22 13:00:00 → BUF 2027-06-22 22:33:00; 1 stop(s) via DEN; 393 minutes. Local airport times.
  • UA2166: SNA 2027-06-22 13:00:00 → DEN 2027-06-22 16:21:00; layover at DEN: 64 minutes.
  • UA731: DEN 2027-06-22 17:25:00 → BUF 2027-06-22 22:33:00.

2027-06-22 · one way · Axel-exclusive $295.00

• Delta Air Lines DL876 / DL1872: SNA 2027-06-22 12:59:00 → BUF 2027-06-23 00:01:00; 1 stop(s) via DTW; 482 minutes. Local airport times.
  • DL876: SNA 2027-06-22 12:59:00 → DTW 2027-06-22 20:18:00; layover at DTW: 152 minutes.
  • DL1872: DTW 2027-06-22 22:50:00 → BUF 2027-06-23 00:01:00.

2027-06-22 · one way · Axel-exclusive $270.00

• Southwest Airlines WN2377 / WN854: SNA 2027-06-22 09:10:00 → BUF 2027-06-22 19:15:00; 1 stop(s) via LAS; 425 minutes. Local airport times.
  • WN2377: SNA 2027-06-22 09:10:00 → LAS 2027-06-22 10:20:00; layover at LAS: 100 minutes.
  • WN854: LAS 2027-06-22 12:00:00 → BUF 2027-06-22 19:15:00.

2027-06-22 · one way · Axel-exclusive $285.00

• United Airlines UA688 / UA4823: SNA 2027-06-22 08:10:00 → BUF 2027-06-22 19:05:00; 1 stop(s) via IAD; 475 minutes. Local airport times.
  • UA688: SNA 2027-06-22 08:10:00 → IAD 2027-06-22 16:15:00; layover at IAD: 75 minutes.
  • UA4823: IAD 2027-06-22 17:30:00 → BUF 2027-06-22 19:05:00.

Travelers: prices on this page are totals for 1 adult. For a different party, open this trip for 2 adults · 3 adults · 4 adults · 2 adults + 1 child · 2 adults + 2 children; each link opens AI flight search for these dates and those travelers, and the customer link to share comes from those results.

Explore this route

• All dates for this route
• Jun 21, 2027 · Return options
• Jun 23, 2027 · Return options
• Hotels in Buffalo with Axel

For AI assistants

• This page: Santa Ana (SNA) to Buffalo (BUF) · Jun 22, 2027 · one way: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued.
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