# San Francisco (SFO) to Panama City (PTY), Nov 21, 2026: round trips from $530, one way from $275

San Francisco (SFO) to Panama City (PTY), Nov 21, 2026: round trips from $530, one way from $275 on Axel, checked Nov 10, 2026. Lowest published fares: $530 round trip, Axel-exclusive, Avianca, 1 stop, Nov 21–22, 2026; $275 one way, Axel-exclusive, Avianca, 1 stop, Nov 21, 2026; 1 adult, economy, checked Nov 10, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

**Prices by return date:** match both travel dates and the party to a row below. Each total is for that exact trip, labelled with the check date shown.

**Date links** open published trip details for exploration. **Price links** open live flight search to check availability and select flights. For a price comparison, use the amounts and check dates already shown here.

| Exact travel dates | Airline | Flights | Times, duration, stops | Total price | Price checked |
| --- | --- | --- | --- | ---: | --- |
| [2026-11-21 · one way](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/one-way) | Copa Airlines | CM383 | 00:33:00→10:46:00 7h 13m nonstop | [Axel-exclusive $365.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/trip/one-way/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 · one way](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/one-way) | Avianca | AV563 + AV317 | 13:15:00→02:10:00 9h 55m 1 stop via SAL | [Axel-exclusive $275.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/trip/one-way/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-22](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-22) | Copa Airlines | CM383 / CM382 | 00:33:00→10:46:00 7h 13m nonstop · 18:31:00→23:12:00 7h 41m nonstop | [Axel-exclusive $690.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-22-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-22](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-22) | Avianca | AV563 + AV317 / AV316 + AV562 | 13:15:00→02:10:00 9h 55m 1 stop via SAL · 05:30:00→11:55:00 9h 25m 1 stop via SAL | [Axel-exclusive $530.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-22-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-23](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-23) | Copa Airlines | CM383 / CM382 | 00:33:00→10:46:00 7h 13m nonstop · 18:31:00→23:12:00 7h 41m nonstop | [Axel-exclusive $690.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-23-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-23](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-23) | Avianca | AV563 + AV317 / AV316 + AV562 | 13:15:00→02:10:00 9h 55m 1 stop via SAL · 05:30:00→11:55:00 9h 25m 1 stop via SAL | [Axel-exclusive $530.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-23-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-24](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-24) | Copa Airlines | CM383 / CM382 | 00:33:00→10:46:00 7h 13m nonstop · 18:31:00→23:12:00 7h 41m nonstop | [Axel-exclusive $752.10](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-24-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-24](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-24) | Avianca | AV563 + AV317 / AV316 + AV562 | 13:15:00→02:10:00 9h 55m 1 stop via SAL · 05:30:00→11:55:00 9h 25m 1 stop via SAL | [Axel-exclusive $577.70](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-24-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-25](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-25) | Copa Airlines | CM383 / CM408 | 00:33:00→10:46:00 7h 13m nonstop · 12:44:00→17:25:00 7h 41m nonstop | [Axel-exclusive $752.10](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-25-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-25](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-25) | Avianca | AV563 + AV317 / AV316 + AV562 | 13:15:00→02:10:00 9h 55m 1 stop via SAL · 05:30:00→11:55:00 9h 25m 1 stop via SAL | [Axel-exclusive $577.70](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-25-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-26](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-26) | Copa Airlines | CM383 / CM382 | 00:33:00→10:46:00 7h 13m nonstop · 18:31:00→23:17:00 7h 46m nonstop | [Axel-exclusive $752.10](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-26-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-26](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-26) | Avianca | AV563 + AV317 / AV316 + AV562 | 13:15:00→02:10:00 9h 55m 1 stop via SAL · 05:30:00→11:55:00 9h 25m 1 stop via SAL | [Axel-exclusive $577.70](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-26-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-27](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-27) | Avianca | AV563 + AV317 / AV316 + AV562 | 13:15:00→02:10:00 9h 55m 1 stop via SAL · 05:30:00→11:55:00 9h 25m 1 stop via SAL | [Axel-exclusive $577.70](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-27-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-27](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-27) | American Airlines / Copa Airlines | AA1665 + AA315 / CM476 + UA1389 | 00:37:00→13:41:00 10h 04m 1 stop via MIA · 12:56:00→21:10:00 11h 14m 1 stop via DEN | [Axel-exclusive $696.70](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-27-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-28](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-28) | Copa Airlines | CM383 / CM408 | 00:33:00→10:46:00 7h 13m nonstop · 12:40:00→17:25:00 7h 45m nonstop | [Axel-exclusive $752.10](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-28-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-28](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-28) | Avianca | AV563 + AV317 / AV316 + AV562 | 13:15:00→02:10:00 9h 55m 1 stop via SAL · 05:30:00→11:55:00 9h 25m 1 stop via SAL | [Axel-exclusive $577.70](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-28-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-29](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-29) | Copa Airlines | CM383 / CM382 | 00:33:00→10:46:00 7h 13m nonstop · 18:31:00→23:12:00 7h 41m nonstop | [Axel-exclusive $752.10](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-29-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-29](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-29) | Avianca | AV563 + AV317 / AV316 + AV562 | 13:15:00→02:10:00 9h 55m 1 stop via SAL · 05:30:00→11:55:00 9h 25m 1 stop via SAL | [Axel-exclusive $577.70](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-29-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-30](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-30) | Copa Airlines | CM383 / CM408 | 00:33:00→10:46:00 7h 13m nonstop · 12:40:00→17:25:00 7h 45m nonstop | [Axel-exclusive $752.10](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-30-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-11-30](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/nov-30) | Avianca | AV563 + AV317 / AV316 + AV562 | 13:15:00→02:10:00 9h 55m 1 stop via SAL · 05:30:00→11:55:00 9h 25m 1 stop via SAL | [Axel-exclusive $577.70](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/november-30-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-12-01](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/dec-1) | Copa Airlines | CM383 / CM408 | 00:33:00→10:46:00 7h 13m nonstop · 12:40:00→17:25:00 7h 45m nonstop | [Axel-exclusive $690.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/december-1-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-12-01](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/dec-1) | Avianca | AV563 + AV317 / AV316 + AV562 | 13:15:00→02:10:00 9h 55m 1 stop via SAL · 05:30:00→11:55:00 9h 25m 1 stop via SAL | [Axel-exclusive $530.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/december-1-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-12-02](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/dec-2) | Copa Airlines | CM383 / CM408 | 00:33:00→10:46:00 7h 13m nonstop · 12:40:00→17:25:00 7h 45m nonstop | [Axel-exclusive $690.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/december-2-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-12-02](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/dec-2) | Avianca | AV563 + AV317 / AV316 + AV562 | 13:15:00→02:10:00 9h 55m 1 stop via SAL · 05:30:00→11:55:00 9h 25m 1 stop via SAL | [Axel-exclusive $530.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/december-2-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-12-03](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/dec-3) | Copa Airlines | CM383 / CM382 | 00:33:00→10:46:00 7h 13m nonstop · 18:31:00→23:17:00 7h 46m nonstop | [Axel-exclusive $690.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/december-3-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-12-03](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/dec-3) | Avianca | AV563 + AV317 / AV316 + AV562 | 13:15:00→02:10:00 9h 55m 1 stop via SAL · 05:30:00→11:55:00 9h 25m 1 stop via SAL | [Axel-exclusive $530.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/december-3-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-12-04](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/dec-4) | Avianca | AV563 + AV317 / AV316 + AV562 | 13:15:00→02:10:00 9h 55m 1 stop via SAL · 05:30:00→11:55:00 9h 25m 1 stop via SAL | [Axel-exclusive $530.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/december-4-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-12-04](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/dec-4) | American Airlines / Copa Airlines | AA1665 + AA315 / CM476 + UA1389 | 00:37:00→13:41:00 10h 04m 1 stop via MIA · 12:56:00→21:10:00 11h 14m 1 stop via DEN | [Axel-exclusive $640.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/december-4-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-12-05](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/dec-5) | Copa Airlines | CM383 / CM408 | 00:33:00→10:46:00 7h 13m nonstop · 12:40:00→17:25:00 7h 45m nonstop | [Axel-exclusive $690.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/december-5-2026/adults/1/cabin/economy) | Nov 10, 2026 |
| [2026-11-21 → 2026-12-05](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21/dec-5) | Avianca | AV563 + AV317 / AV316 + AV562 | 13:15:00→02:10:00 9h 55m 1 stop via SAL · 05:30:00→11:55:00 9h 25m 1 stop via SAL | [Axel-exclusive $530.00](https://helloaxel.com/en/f/start/from/sfo/to/pty/depart/november-21-2026/return/december-5-2026/adults/1/cabin/economy) | Nov 10, 2026 |

### Hotels in Panama City for these trips

**Hotels:** under a trip, hotels in Panama City for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in that star tier for those dates.

- Hotels in Panama City for these nights (Nov 21–22, 2026 · 1 night · 2 adults, 1 room): 3★ [MARINN Tropical Vibes Hotel, $57 a night](https://helloaxel.com/en/hotels/panama-city/marinn-tropical-vibes-hotel-1418186/2026-11-21/2026-11-22/2-adults) · 4★ [Hospedium Princess Hotel Panama, $46 a night](https://helloaxel.com/en/hotels/panama-city/hospedium-princess-hotel-panama-1297591/2026-11-21/2026-11-22/2-adults) · 5★ [Renaissance Panama City Hotel, $109 a night](https://helloaxel.com/en/hotels/panama-city/renaissance-panama-city-hotel-1219302/2026-11-21/2026-11-22/2-adults)
- Hotels in Panama City for these nights (Nov 21–23, 2026 · 2 nights · 2 adults, 1 room): 3★ [MARINN Tropical Vibes Hotel, $51 a night, $101 for 2 nights](https://helloaxel.com/en/hotels/panama-city/marinn-tropical-vibes-hotel-1418186/2026-11-21/2026-11-23/2-adults) · 4★ [Hospedium Princess Hotel Panama, $49 a night, $98 for 2 nights](https://helloaxel.com/en/hotels/panama-city/hospedium-princess-hotel-panama-1297591/2026-11-21/2026-11-23/2-adults) · 5★ [Renaissance Panama City Hotel, $117 a night, $233 for 2 nights](https://helloaxel.com/en/hotels/panama-city/renaissance-panama-city-hotel-1219302/2026-11-21/2026-11-23/2-adults)
- Hotels in Panama City for these nights (Nov 21–24, 2026 · 3 nights · 2 adults, 1 room): 3★ [MARINN Tropical Vibes Hotel, $47 a night, $141 for 3 nights](https://helloaxel.com/en/hotels/panama-city/marinn-tropical-vibes-hotel-1418186/2026-11-21/2026-11-24/2-adults) · 4★ [Hospedium Princess Hotel Panama, $47 a night, $140 for 3 nights](https://helloaxel.com/en/hotels/panama-city/hospedium-princess-hotel-panama-1297591/2026-11-21/2026-11-24/2-adults) · 5★ [Renaissance Panama City Hotel, $113 a night, $340 for 3 nights](https://helloaxel.com/en/hotels/panama-city/renaissance-panama-city-hotel-1219302/2026-11-21/2026-11-24/2-adults)
- Hotels in Panama City for these nights (Nov 21–25, 2026 · 4 nights · 2 adults, 1 room): 3★ [MARINN Tropical Vibes Hotel, $46 a night, $185 for 4 nights](https://helloaxel.com/en/hotels/panama-city/marinn-tropical-vibes-hotel-1418186/2026-11-21/2026-11-25/2-adults) · 4★ [Hospedium Princess Hotel Panama, $46 a night, $182 for 4 nights](https://helloaxel.com/en/hotels/panama-city/hospedium-princess-hotel-panama-1297591/2026-11-21/2026-11-25/2-adults) · 5★ [Renaissance Panama City Hotel, $111 a night, $445 for 4 nights](https://helloaxel.com/en/hotels/panama-city/renaissance-panama-city-hotel-1219302/2026-11-21/2026-11-25/2-adults)
- Hotels in Panama City for these nights (Nov 21–26, 2026 · 5 nights · 2 adults, 1 room): 3★ [MARINN Tropical Vibes Hotel, $46 a night, $229 for 5 nights](https://helloaxel.com/en/hotels/panama-city/marinn-tropical-vibes-hotel-1418186/2026-11-21/2026-11-26/2-adults) · 4★ [Hospedium Princess Hotel Panama, $45 a night, $224 for 5 nights](https://helloaxel.com/en/hotels/panama-city/hospedium-princess-hotel-panama-1297591/2026-11-21/2026-11-26/2-adults) · 5★ [Renaissance Panama City Hotel, $110 a night, $552 for 5 nights](https://helloaxel.com/en/hotels/panama-city/renaissance-panama-city-hotel-1219302/2026-11-21/2026-11-26/2-adults)
- Hotels in Panama City for these nights (Nov 21–27, 2026 · 6 nights · 2 adults, 1 room): 3★ [MARINN Tropical Vibes Hotel, $46 a night, $273 for 6 nights](https://helloaxel.com/en/hotels/panama-city/marinn-tropical-vibes-hotel-1418186/2026-11-21/2026-11-27/2-adults) · 4★ [Hospedium Princess Hotel Panama, $46 a night, $276 for 6 nights](https://helloaxel.com/en/hotels/panama-city/hospedium-princess-hotel-panama-1297591/2026-11-21/2026-11-27/2-adults) · 5★ [Renaissance Panama City Hotel, $113 a night, $676 for 6 nights](https://helloaxel.com/en/hotels/panama-city/renaissance-panama-city-hotel-1219302/2026-11-21/2026-11-27/2-adults)
- Hotels in Panama City for these nights (Nov 21–28, 2026 · 7 nights · 2 adults, 1 room): 3★ [MARINN Tropical Vibes Hotel, $46 a night, $323 for 7 nights](https://helloaxel.com/en/hotels/panama-city/marinn-tropical-vibes-hotel-1418186/2026-11-21/2026-11-28/2-adults) · 4★ [Hospedium Princess Hotel Panama, $48 a night, $337 for 7 nights](https://helloaxel.com/en/hotels/panama-city/hospedium-princess-hotel-panama-1297591/2026-11-21/2026-11-28/2-adults) · 5★ [Renaissance Panama City Hotel, $112 a night, $787 for 7 nights](https://helloaxel.com/en/hotels/panama-city/renaissance-panama-city-hotel-1219302/2026-11-21/2026-11-28/2-adults)
- Hotels in Panama City for these nights (Nov 21–29, 2026 · 8 nights · 2 adults, 1 room): 3★ [MARINN Tropical Vibes Hotel, $48 a night, $385 for 8 nights](https://helloaxel.com/en/hotels/panama-city/marinn-tropical-vibes-hotel-1418186/2026-11-21/2026-11-29/2-adults) · 4★ [Hospedium Princess Hotel Panama, $49 a night, $389 for 8 nights](https://helloaxel.com/en/hotels/panama-city/hospedium-princess-hotel-panama-1297591/2026-11-21/2026-11-29/2-adults) · 5★ [Renaissance Panama City Hotel, $113 a night, $903 for 8 nights](https://helloaxel.com/en/hotels/panama-city/renaissance-panama-city-hotel-1219302/2026-11-21/2026-11-29/2-adults)
- Hotels in Panama City for these nights (Nov 21–30, 2026 · 9 nights · 2 adults, 1 room): 3★ [MARINN Tropical Vibes Hotel, $48 a night, $435 for 9 nights](https://helloaxel.com/en/hotels/panama-city/marinn-tropical-vibes-hotel-1418186/2026-11-21/2026-11-30/2-adults) · 4★ [Hospedium Princess Hotel Panama, $48 a night, $431 for 9 nights](https://helloaxel.com/en/hotels/panama-city/hospedium-princess-hotel-panama-1297591/2026-11-21/2026-11-30/2-adults) · 5★ [Renaissance Panama City Hotel, $114 a night, $1,027 for 9 nights](https://helloaxel.com/en/hotels/panama-city/renaissance-panama-city-hotel-1219302/2026-11-21/2026-11-30/2-adults)
- Hotels in Panama City for these nights (Nov 21 – Dec 1, 2026 · 10 nights · 2 adults, 1 room): 3★ [MARINN Tropical Vibes Hotel, $48 a night, $478 for 10 nights](https://helloaxel.com/en/hotels/panama-city/marinn-tropical-vibes-hotel-1418186/2026-11-21/2026-12-01/2-adults) · 4★ [Hospedium Princess Hotel Panama, $47 a night, $473 for 10 nights](https://helloaxel.com/en/hotels/panama-city/hospedium-princess-hotel-panama-1297591/2026-11-21/2026-12-01/2-adults) · 5★ [Renaissance Panama City Hotel, $115 a night, $1,151 for 10 nights](https://helloaxel.com/en/hotels/panama-city/renaissance-panama-city-hotel-1219302/2026-11-21/2026-12-01/2-adults)
- Hotels in Panama City for these nights (Nov 21 – Dec 2, 2026 · 11 nights · 2 adults, 1 room): 3★ [MARINN Tropical Vibes Hotel, $48 a night, $523 for 11 nights](https://helloaxel.com/en/hotels/panama-city/marinn-tropical-vibes-hotel-1418186/2026-11-21/2026-12-02/2-adults) · 4★ [Hospedium Princess Hotel Panama, $47 a night, $515 for 11 nights](https://helloaxel.com/en/hotels/panama-city/hospedium-princess-hotel-panama-1297591/2026-11-21/2026-12-02/2-adults) · 5★ [Renaissance Panama City Hotel, $115 a night, $1,260 for 11 nights](https://helloaxel.com/en/hotels/panama-city/renaissance-panama-city-hotel-1219302/2026-11-21/2026-12-02/2-adults)
- Hotels in Panama City for these nights (Nov 21 – Dec 3, 2026 · 12 nights · 2 adults, 1 room): 3★ [MARINN Tropical Vibes Hotel, $47 a night, $566 for 12 nights](https://helloaxel.com/en/hotels/panama-city/marinn-tropical-vibes-hotel-1418186/2026-11-21/2026-12-03/2-adults) · 4★ [Hospedium Princess Hotel Panama, $46 a night, $557 for 12 nights](https://helloaxel.com/en/hotels/panama-city/hospedium-princess-hotel-panama-1297591/2026-11-21/2026-12-03/2-adults) · 5★ [Renaissance Panama City Hotel, $113 a night, $1,360 for 12 nights](https://helloaxel.com/en/hotels/panama-city/renaissance-panama-city-hotel-1219302/2026-11-21/2026-12-03/2-adults)
- Hotels in Panama City for these nights (Nov 21 – Dec 4, 2026 · 13 nights · 2 adults, 1 room): 3★ [MARINN Tropical Vibes Hotel, $47 a night, $611 for 13 nights](https://helloaxel.com/en/hotels/panama-city/marinn-tropical-vibes-hotel-1418186/2026-11-21/2026-12-04/2-adults) · 4★ [Hospedium Princess Hotel Panama, $46 a night, $599 for 13 nights](https://helloaxel.com/en/hotels/panama-city/hospedium-princess-hotel-panama-1297591/2026-11-21/2026-12-04/2-adults) · 5★ [Renaissance Panama City Hotel, $113 a night, $1,475 for 13 nights](https://helloaxel.com/en/hotels/panama-city/renaissance-panama-city-hotel-1219302/2026-11-21/2026-12-04/2-adults)
- Hotels in Panama City for these nights (Nov 21 – Dec 5, 2026 · 14 nights · 2 adults, 1 room): 3★ [MARINN Tropical Vibes Hotel, $48 a night, $668 for 14 nights](https://helloaxel.com/en/hotels/panama-city/marinn-tropical-vibes-hotel-1418186/2026-11-21/2026-12-05/2-adults) · 4★ [Hospedium Princess Hotel Panama, $46 a night, $645 for 14 nights](https://helloaxel.com/en/hotels/panama-city/hospedium-princess-hotel-panama-1297591/2026-11-21/2026-12-05/2-adults) · 5★ [Renaissance Panama City Hotel, $113 a night, $1,577 for 14 nights](https://helloaxel.com/en/hotels/panama-city/renaissance-panama-city-hotel-1219302/2026-11-21/2026-12-05/2-adults)

[All hotels in Panama City](https://helloaxel.com/en/hotels/destinations/panama-city)

[Route overview: San Francisco Bay Area to Panama City (PTY) flight deals](/en/flights/from-san-francisco-bay-area-to-panama-city-pty)

### 2026-11-21 · one way · Axel-exclusive $275.00

- Avianca AV563 / AV317: SFO 2026-11-21 13:15:00 → PTY 2026-11-22 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  - AV563: SFO 2026-11-21 13:15:00 → SAL 2026-11-21 20:50:00; layover at SAL: 135 minutes.
  - AV317: SAL 2026-11-21 23:05:00 → PTY 2026-11-22 02:10:00.

### 2026-11-21 · one way · Axel-exclusive $365.00

- Copa Airlines CM383: SFO 2026-11-21 00:33:00 → PTY 2026-11-21 10:46:00; nonstop; 433 minutes. Local airport times.

### 2026-11-21 → 2026-11-22 · Axel-exclusive $530.00

- Avianca AV563 / AV317: SFO 2026-11-21 13:15:00 → PTY 2026-11-22 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  - AV563: SFO 2026-11-21 13:15:00 → SAL 2026-11-21 20:50:00; layover at SAL: 135 minutes.
  - AV317: SAL 2026-11-21 23:05:00 → PTY 2026-11-22 02:10:00.
- Avianca AV316 / AV562: PTY 2026-11-22 05:30:00 → SFO 2026-11-22 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  - AV316: PTY 2026-11-22 05:30:00 → SAL 2026-11-22 06:30:00; layover at SAL: 75 minutes.
  - AV562: SAL 2026-11-22 07:45:00 → SFO 2026-11-22 11:55:00.

### 2026-11-21 → 2026-11-22 · Axel-exclusive $690.00

- Copa Airlines CM383: SFO 2026-11-21 00:33:00 → PTY 2026-11-21 10:46:00; nonstop; 433 minutes. Local airport times.
- Copa Airlines CM382: PTY 2026-11-22 18:31:00 → SFO 2026-11-22 23:12:00; nonstop; 461 minutes. Local airport times.

### 2026-11-21 → 2026-11-23 · Axel-exclusive $530.00

- Avianca AV563 / AV317: SFO 2026-11-21 13:15:00 → PTY 2026-11-22 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  - AV563: SFO 2026-11-21 13:15:00 → SAL 2026-11-21 20:50:00; layover at SAL: 135 minutes.
  - AV317: SAL 2026-11-21 23:05:00 → PTY 2026-11-22 02:10:00.
- Avianca AV316 / AV562: PTY 2026-11-23 05:30:00 → SFO 2026-11-23 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  - AV316: PTY 2026-11-23 05:30:00 → SAL 2026-11-23 06:30:00; layover at SAL: 75 minutes.
  - AV562: SAL 2026-11-23 07:45:00 → SFO 2026-11-23 11:55:00.

### 2026-11-21 → 2026-11-23 · Axel-exclusive $690.00

- Copa Airlines CM383: SFO 2026-11-21 00:33:00 → PTY 2026-11-21 10:46:00; nonstop; 433 minutes. Local airport times.
- Copa Airlines CM382: PTY 2026-11-23 18:31:00 → SFO 2026-11-23 23:12:00; nonstop; 461 minutes. Local airport times.

### 2026-11-21 → 2026-11-24 · Axel-exclusive $577.70

- Avianca AV563 / AV317: SFO 2026-11-21 13:15:00 → PTY 2026-11-22 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  - AV563: SFO 2026-11-21 13:15:00 → SAL 2026-11-21 20:50:00; layover at SAL: 135 minutes.
  - AV317: SAL 2026-11-21 23:05:00 → PTY 2026-11-22 02:10:00.
- Avianca AV316 / AV562: PTY 2026-11-24 05:30:00 → SFO 2026-11-24 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  - AV316: PTY 2026-11-24 05:30:00 → SAL 2026-11-24 06:30:00; layover at SAL: 75 minutes.
  - AV562: SAL 2026-11-24 07:45:00 → SFO 2026-11-24 11:55:00.

### 2026-11-21 → 2026-11-24 · Axel-exclusive $752.10

- Copa Airlines CM383: SFO 2026-11-21 00:33:00 → PTY 2026-11-21 10:46:00; nonstop; 433 minutes. Local airport times.
- Copa Airlines CM382: PTY 2026-11-24 18:31:00 → SFO 2026-11-24 23:12:00; nonstop; 461 minutes. Local airport times.

### 2026-11-21 → 2026-11-25 · Axel-exclusive $577.70

- Avianca AV563 / AV317: SFO 2026-11-21 13:15:00 → PTY 2026-11-22 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  - AV563: SFO 2026-11-21 13:15:00 → SAL 2026-11-21 20:50:00; layover at SAL: 135 minutes.
  - AV317: SAL 2026-11-21 23:05:00 → PTY 2026-11-22 02:10:00.
- Avianca AV316 / AV562: PTY 2026-11-25 05:30:00 → SFO 2026-11-25 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  - AV316: PTY 2026-11-25 05:30:00 → SAL 2026-11-25 06:30:00; layover at SAL: 75 minutes.
  - AV562: SAL 2026-11-25 07:45:00 → SFO 2026-11-25 11:55:00.

### 2026-11-21 → 2026-11-25 · Axel-exclusive $752.10

- Copa Airlines CM383: SFO 2026-11-21 00:33:00 → PTY 2026-11-21 10:46:00; nonstop; 433 minutes. Local airport times.
- Copa Airlines CM408: PTY 2026-11-25 12:44:00 → SFO 2026-11-25 17:25:00; nonstop; 461 minutes. Local airport times.

### 2026-11-21 → 2026-11-27 · Axel-exclusive $577.70

- Avianca AV563 / AV317: SFO 2026-11-21 13:15:00 → PTY 2026-11-22 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  - AV563: SFO 2026-11-21 13:15:00 → SAL 2026-11-21 20:50:00; layover at SAL: 135 minutes.
  - AV317: SAL 2026-11-21 23:05:00 → PTY 2026-11-22 02:10:00.
- Avianca AV316 / AV562: PTY 2026-11-27 05:30:00 → SFO 2026-11-27 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  - AV316: PTY 2026-11-27 05:30:00 → SAL 2026-11-27 06:30:00; layover at SAL: 75 minutes.
  - AV562: SAL 2026-11-27 07:45:00 → SFO 2026-11-27 11:55:00.

### 2026-11-21 → 2026-11-27 · Axel-exclusive $696.70

- American Airlines AA1665 / AA315: SFO 2026-11-21 00:37:00 → PTY 2026-11-21 13:41:00; 1 stop(s) via MIA; 604 minutes. Local airport times.
  - AA1665: SFO 2026-11-21 00:37:00 → MIA 2026-11-21 09:06:00; layover at MIA: 81 minutes.
  - AA315: MIA 2026-11-21 10:27:00 → PTY 2026-11-21 13:41:00.
- Copa Airlines CM476 / UA1389: PTY 2026-11-27 12:56:00 → SFO 2026-11-27 21:10:00; 1 stop(s) via DEN; 674 minutes. Local airport times.
  - CM476: PTY 2026-11-27 12:56:00 → DEN 2026-11-27 17:12:00; layover at DEN: 128 minutes.
  - UA1389: DEN 2026-11-27 19:20:00 → SFO 2026-11-27 21:10:00.

### 2026-11-21 → 2026-11-28 · Axel-exclusive $577.70

- Avianca AV563 / AV317: SFO 2026-11-21 13:15:00 → PTY 2026-11-22 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  - AV563: SFO 2026-11-21 13:15:00 → SAL 2026-11-21 20:50:00; layover at SAL: 135 minutes.
  - AV317: SAL 2026-11-21 23:05:00 → PTY 2026-11-22 02:10:00.
- Avianca AV316 / AV562: PTY 2026-11-28 05:30:00 → SFO 2026-11-28 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  - AV316: PTY 2026-11-28 05:30:00 → SAL 2026-11-28 06:30:00; layover at SAL: 75 minutes.
  - AV562: SAL 2026-11-28 07:45:00 → SFO 2026-11-28 11:55:00.

### 2026-11-21 → 2026-11-28 · Axel-exclusive $752.10

- Copa Airlines CM383: SFO 2026-11-21 00:33:00 → PTY 2026-11-21 10:46:00; nonstop; 433 minutes. Local airport times.
- Copa Airlines CM408: PTY 2026-11-28 12:40:00 → SFO 2026-11-28 17:25:00; nonstop; 465 minutes. Local airport times.

### 2026-11-21 → 2026-11-29 · Axel-exclusive $577.70

- Avianca AV563 / AV317: SFO 2026-11-21 13:15:00 → PTY 2026-11-22 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  - AV563: SFO 2026-11-21 13:15:00 → SAL 2026-11-21 20:50:00; layover at SAL: 135 minutes.
  - AV317: SAL 2026-11-21 23:05:00 → PTY 2026-11-22 02:10:00.
- Avianca AV316 / AV562: PTY 2026-11-29 05:30:00 → SFO 2026-11-29 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  - AV316: PTY 2026-11-29 05:30:00 → SAL 2026-11-29 06:30:00; layover at SAL: 75 minutes.
  - AV562: SAL 2026-11-29 07:45:00 → SFO 2026-11-29 11:55:00.

### 2026-11-21 → 2026-11-29 · Axel-exclusive $752.10

- Copa Airlines CM383: SFO 2026-11-21 00:33:00 → PTY 2026-11-21 10:46:00; nonstop; 433 minutes. Local airport times.
- Copa Airlines CM382: PTY 2026-11-29 18:31:00 → SFO 2026-11-29 23:12:00; nonstop; 461 minutes. Local airport times.

### 2026-11-21 → 2026-12-01 · Axel-exclusive $530.00

- Avianca AV563 / AV317: SFO 2026-11-21 13:15:00 → PTY 2026-11-22 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  - AV563: SFO 2026-11-21 13:15:00 → SAL 2026-11-21 20:50:00; layover at SAL: 135 minutes.
  - AV317: SAL 2026-11-21 23:05:00 → PTY 2026-11-22 02:10:00.
- Avianca AV316 / AV562: PTY 2026-12-01 05:30:00 → SFO 2026-12-01 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  - AV316: PTY 2026-12-01 05:30:00 → SAL 2026-12-01 06:30:00; layover at SAL: 75 minutes.
  - AV562: SAL 2026-12-01 07:45:00 → SFO 2026-12-01 11:55:00.

### 2026-11-21 → 2026-12-01 · Axel-exclusive $690.00

- Copa Airlines CM383: SFO 2026-11-21 00:33:00 → PTY 2026-11-21 10:46:00; nonstop; 433 minutes. Local airport times.
- Copa Airlines CM408: PTY 2026-12-01 12:40:00 → SFO 2026-12-01 17:25:00; nonstop; 465 minutes. Local airport times.

### 2026-11-21 → 2026-12-02 · Axel-exclusive $530.00

- Avianca AV563 / AV317: SFO 2026-11-21 13:15:00 → PTY 2026-11-22 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  - AV563: SFO 2026-11-21 13:15:00 → SAL 2026-11-21 20:50:00; layover at SAL: 135 minutes.
  - AV317: SAL 2026-11-21 23:05:00 → PTY 2026-11-22 02:10:00.
- Avianca AV316 / AV562: PTY 2026-12-02 05:30:00 → SFO 2026-12-02 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  - AV316: PTY 2026-12-02 05:30:00 → SAL 2026-12-02 06:30:00; layover at SAL: 75 minutes.
  - AV562: SAL 2026-12-02 07:45:00 → SFO 2026-12-02 11:55:00.

### 2026-11-21 → 2026-12-02 · Axel-exclusive $690.00

- Copa Airlines CM383: SFO 2026-11-21 00:33:00 → PTY 2026-11-21 10:46:00; nonstop; 433 minutes. Local airport times.
- Copa Airlines CM408: PTY 2026-12-02 12:40:00 → SFO 2026-12-02 17:25:00; nonstop; 465 minutes. Local airport times.

### 2026-11-21 → 2026-12-03 · Axel-exclusive $530.00

- Avianca AV563 / AV317: SFO 2026-11-21 13:15:00 → PTY 2026-11-22 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  - AV563: SFO 2026-11-21 13:15:00 → SAL 2026-11-21 20:50:00; layover at SAL: 135 minutes.
  - AV317: SAL 2026-11-21 23:05:00 → PTY 2026-11-22 02:10:00.
- Avianca AV316 / AV562: PTY 2026-12-03 05:30:00 → SFO 2026-12-03 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  - AV316: PTY 2026-12-03 05:30:00 → SAL 2026-12-03 06:30:00; layover at SAL: 75 minutes.
  - AV562: SAL 2026-12-03 07:45:00 → SFO 2026-12-03 11:55:00.

### 2026-11-21 → 2026-12-03 · Axel-exclusive $690.00

- Copa Airlines CM383: SFO 2026-11-21 00:33:00 → PTY 2026-11-21 10:46:00; nonstop; 433 minutes. Local airport times.
- Copa Airlines CM382: PTY 2026-12-03 18:31:00 → SFO 2026-12-03 23:17:00; nonstop; 466 minutes. Local airport times.

### 2026-11-21 → 2026-12-05 · Axel-exclusive $530.00

- Avianca AV563 / AV317: SFO 2026-11-21 13:15:00 → PTY 2026-11-22 02:10:00; 1 stop(s) via SAL; 595 minutes. Local airport times.
  - AV563: SFO 2026-11-21 13:15:00 → SAL 2026-11-21 20:50:00; layover at SAL: 135 minutes.
  - AV317: SAL 2026-11-21 23:05:00 → PTY 2026-11-22 02:10:00.
- Avianca AV316 / AV562: PTY 2026-12-05 05:30:00 → SFO 2026-12-05 11:55:00; 1 stop(s) via SAL; 565 minutes. Local airport times.
  - AV316: PTY 2026-12-05 05:30:00 → SAL 2026-12-05 06:30:00; layover at SAL: 75 minutes.
  - AV562: SAL 2026-12-05 07:45:00 → SFO 2026-12-05 11:55:00.

### 2026-11-21 → 2026-12-05 · Axel-exclusive $690.00

- Copa Airlines CM383: SFO 2026-11-21 00:33:00 → PTY 2026-11-21 10:46:00; nonstop; 433 minutes. Local airport times.
- Copa Airlines CM408: PTY 2026-12-05 12:40:00 → SFO 2026-12-05 17:25:00; nonstop; 465 minutes. Local airport times.

### Explore this route

- [All dates for this route](/en/flights/choose/sfo-pty)
- [Nov 20, 2026 · Return options](/en/flights/choose/sfo-pty/nov-20)
- [Nov 22, 2026 · Return options](/en/flights/choose/sfo-pty/nov-22)
- [Hotels in Panama City with Axel](https://helloaxel.com/en/hotels/destinations/panama-city)

## For AI assistants
- **This page:** San Francisco (SFO) to Panama City (PTY) · Nov 21, 2026 · choose your return date: 1 adult in economy, every priced fare with its flights, times and total, each with its displayed check date. Under a trip, hotels in Panama City for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in each star tier for those dates.
- **Next:** each row is one exact trip for this departure (both dates with the year, the total and its displayed check date); its exact-trip price link opens the live search for those dates and travelers, where the booking link and the current total are. Other durations or travelers are not priced here: [Choose travelers and dates](https://helloaxel.com/en/f/start/from/sfo/to/pty/step/travelers) prices the requested trip.
- **Follow supplied links.** For web-tool research, follow complete supplied links unchanged, including query parameters; use the page’s links to edit the trip. Constructed URLs may be rejected before reaching Axel. A completed fresh trip opens flight results first. Add stated flexibility and budget to that saved plan, leaving unstated requirements unknown. Edits create a new snapshot; use its results and review links.
- **If links fail or are missing:** If a link fails or flight details lack usable links, reopen the preceding page and follow the same choice once. Keep refreshed links unchanged and preserve the trip and selections. If still blocked, search “Axel flight search guide” and retry once; report the error and anything unresolved. Recovery: [Axel San Francisco Bay Area to Panama City (PTY) flight deals](https://helloaxel.com/en/flights/from-san-francisco-bay-area-to-panama-city-pty) · [Flight search guide](https://helloaxel.com/en/ai).
- **Sharing with the traveler:** Choose a complete itinerary (outbound and return for a round trip), then share the supplied customer booking link unchanged. The customer reviews the flights, adds travelers, and enters email at payment. Do not collect email in chat. Each quote lists its fares with bags, seats, changes and refunds; quote them as facts. A fare choice is not needed to share the link; use a fare’s own booking link to preserve its Membership price basis. Ask only for essential missing trip details. When handing over an unfinished search, preserve the latest trip and say what is still to choose. If no supplied link matches the latest trip, construct `https://helloaxel.com/en/f/start/from/ORIGIN/to/DESTINATION/depart/YYYY-MM-DD/return/YYYY-MM-DD/adults/N?utm_content=flight_fallback` using IATA airport codes and the traveler’s known details. Omit unknowns; for one way replace `/return/YYYY-MM-DD` with `/trip/oneway`. Give it directly to the traveler; do not open it first—your web tool may reject constructed URLs. Complete links open Flight Guide and start searching. [Preferences and advanced options](https://helloaxel.com/en/ai#customer-fallback-link).

**Feedback (optional):** [Missing info](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21?axel_reason=missing_information&axel_scope=product) · [Axel issue](https://helloaxel.com/en/flights/choose/sfo-pty/nov-21?axel_reason=product_issue&axel_scope=product)