Raleigh/Durham (RDU) to Saint Louis (STL), Nov 29, 2026: round trips from $348, one way from $209

Raleigh/Durham (RDU) to Saint Louis (STL), Nov 29, 2026: round trips from $348, one way from $209 on Axel, checked Oct 29, 2026. Lowest published fares: $348 round trip, Axel-exclusive, Southwest Airlines, 1 stop, Nov 29, 2026 – Dec 2, 2026; $209 one way, Axel-exclusive, Southwest Airlines, nonstop, Nov 29, 2026; 1 adult, economy, checked Oct 29, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Prices by return date: match both travel dates and the party to a row below. Each total is for that exact trip, issued at the time shown.

Date links open published trip details for exploration. Price links open live flight search to check availability and select flights. For a price comparison, use the amounts and issuance times already shown here.

Hotels in St. Louis for these trips

Hotels: under a trip, hotels in St. Louis for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in St. Louis for these nights (Nov 29–30, 2026 · 1 night · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $66 total · 4★ Hilton St. Louis at the Ballpark, $105 total · 5★ Four Seasons Hotel St Louis, $367 total
• Hotels in St. Louis for these nights (Nov 29 – Dec 1, 2026 · 2 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $120 total · 4★ Hilton St. Louis at the Ballpark, $209 total · 5★ Four Seasons Hotel St Louis, $733 total
• Hotels in St. Louis for these nights (Nov 29 – Dec 2, 2026 · 3 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $194 total · 4★ Hilton St. Louis at the Ballpark, $314 total · 5★ Four Seasons Hotel St Louis, $1,099 total
• Hotels in St. Louis for these nights (Nov 29 – Dec 3, 2026 · 4 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $255 total · 4★ Hilton St. Louis at the Ballpark, $419 total · 5★ Four Seasons Hotel St Louis, $1,465 total
• Hotels in St. Louis for these nights (Nov 29 – Dec 4, 2026 · 5 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $319 total · 4★ Hilton St. Louis at the Ballpark, $524 total · 5★ Four Seasons Hotel St Louis, $2,015 total
• Hotels in St. Louis for these nights (Nov 29 – Dec 5, 2026 · 6 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $392 total · 4★ CozySuites Central West End, $849 total · 5★ Four Seasons Hotel St Louis, $2,517 total
• Hotels in St. Louis for these nights (Nov 29 – Dec 6, 2026 · 7 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $467 total · 4★ CozySuites Central West End, $1,017 total · 5★ Four Seasons Hotel St Louis, $2,951 total
• Hotels in St. Louis for these nights (Nov 29 – Dec 7, 2026 · 8 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $529 total · 4★ CozySuites Central West End, $1,144 total · 5★ Four Seasons Hotel St Louis, $3,317 total
• Hotels in St. Louis for these nights (Nov 29 – Dec 8, 2026 · 9 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $603 total · 4★ CozySuites Central West End, $1,271 total · 5★ Four Seasons Hotel St Louis, $3,683 total
• Hotels in St. Louis for these nights (Nov 29 – Dec 9, 2026 · 10 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $667 total · 4★ CozySuites Central West End, $1,396 total · 5★ Four Seasons Hotel St Louis, $4,049 total
• Hotels in St. Louis for these nights (Nov 29 – Dec 10, 2026 · 11 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $741 total · 4★ CozySuites Central West End, $1,519 total · 5★ Four Seasons Hotel St Louis, $4,415 total
• Hotels in St. Louis for these nights (Nov 29 – Dec 11, 2026 · 12 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $806 total · 4★ CozySuites Central West End, $1,664 total · 5★ Four Seasons Hotel St Louis, $4,781 total
• Hotels in St. Louis for these nights (Nov 29 – Dec 12, 2026 · 13 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $880 total · 4★ The Westin St. Louis, $1,808.50 total · 5★ Four Seasons Hotel St Louis, $5,147 total
• Hotels in St. Louis for these nights (Nov 29 – Dec 13, 2026 · 14 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $954 total · 4★ The Westin St. Louis, $1,922.50 total · 5★ Four Seasons Hotel St Louis, $5,513 total

All hotels in St. Louis

Route overview: Raleigh/Durham to Saint Louis (STL) flight deals

2026-11-29 · one way · Axel-exclusive $209.25

• Southwest Airlines WN3623: RDU 2026-11-29 20:50:00 → STL 2026-11-29 22:00:00; nonstop; 130 minutes. Local airport times.

2026-11-29 · one way · Axel-exclusive $236.25

• American Airlines AA1391 / AA4458: RDU 2026-11-29 06:00:00 → STL 2026-11-29 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-11-29 06:00:00 → DCA 2026-11-29 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-11-29 08:20:00 → STL 2026-11-29 10:08:00.

2026-11-29 → 2026-11-30 · Axel-exclusive $398.25

• Southwest Airlines WN3623: RDU 2026-11-29 20:50:00 → STL 2026-11-29 22:00:00; nonstop; 130 minutes. Local airport times.
• Southwest Airlines WN665 / WN4766: STL 2026-11-30 10:35:00 → RDU 2026-11-30 16:35:00; 1 stop(s) via BNA; 300 minutes. Local airport times.
  • WN665: STL 2026-11-30 10:35:00 → BNA 2026-11-30 11:40:00; layover at BNA: 145 minutes.
  • WN4766: BNA 2026-11-30 14:05:00 → RDU 2026-11-30 16:35:00.

2026-11-29 → 2026-11-30 · Axel-exclusive $459.00

• American Airlines AA1391 / AA4458: RDU 2026-11-29 06:00:00 → STL 2026-11-29 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-11-29 06:00:00 → DCA 2026-11-29 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-11-29 08:20:00 → STL 2026-11-29 10:08:00.
• American Airlines AA2486 / AA1904: STL 2026-11-30 12:54:00 → RDU 2026-11-30 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-11-30 12:54:00 → CLT 2026-11-30 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-11-30 17:30:00 → RDU 2026-11-30 18:29:00.

2026-11-29 → 2026-12-01 · Axel-exclusive $352.50

• Southwest Airlines WN3623: RDU 2026-11-29 20:50:00 → STL 2026-11-29 22:00:00; nonstop; 130 minutes. Local airport times.
• Southwest Airlines WN4192: STL 2026-12-01 10:15:00 → RDU 2026-12-01 13:05:00; nonstop; 110 minutes. Local airport times.

2026-11-29 → 2026-12-01 · Axel-exclusive $399.50

• American Airlines AA1391 / AA4458: RDU 2026-11-29 06:00:00 → STL 2026-11-29 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-11-29 06:00:00 → DCA 2026-11-29 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-11-29 08:20:00 → STL 2026-11-29 10:08:00.
• American Airlines AA2486 / AA1904: STL 2026-12-01 12:54:00 → RDU 2026-12-01 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-01 12:54:00 → CLT 2026-12-01 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-01 17:30:00 → RDU 2026-12-01 18:29:00.

2026-11-29 → 2026-12-02 · Axel-exclusive $347.50

• Southwest Airlines WN3623: RDU 2026-11-29 20:50:00 → STL 2026-11-29 22:00:00; nonstop; 130 minutes. Local airport times.
• Southwest Airlines WN4173 / WN2501: STL 2026-12-02 05:30:00 → RDU 2026-12-02 10:40:00; 1 stop(s) via MDW; 250 minutes. Local airport times.
  • WN4173: STL 2026-12-02 05:30:00 → MDW 2026-12-02 06:35:00; layover at MDW: 70 minutes.
  • WN2501: MDW 2026-12-02 07:45:00 → RDU 2026-12-02 10:40:00.

2026-11-29 → 2026-12-02 · Axel-exclusive $399.50

• American Airlines AA1391 / AA4458: RDU 2026-11-29 06:00:00 → STL 2026-11-29 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-11-29 06:00:00 → DCA 2026-11-29 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-11-29 08:20:00 → STL 2026-11-29 10:08:00.
• American Airlines AA2486 / AA1904: STL 2026-12-02 12:54:00 → RDU 2026-12-02 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-02 12:54:00 → CLT 2026-12-02 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-02 17:30:00 → RDU 2026-12-02 18:29:00.

2026-11-29 → 2026-12-03 · Axel-exclusive $352.50

• Southwest Airlines WN3623: RDU 2026-11-29 20:50:00 → STL 2026-11-29 22:00:00; nonstop; 130 minutes. Local airport times.
• Southwest Airlines WN4192: STL 2026-12-03 10:15:00 → RDU 2026-12-03 13:05:00; nonstop; 110 minutes. Local airport times.

2026-11-29 → 2026-12-03 · Axel-exclusive $399.50

• American Airlines AA1391 / AA4458: RDU 2026-11-29 06:00:00 → STL 2026-11-29 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-11-29 06:00:00 → DCA 2026-11-29 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-11-29 08:20:00 → STL 2026-11-29 10:08:00.
• American Airlines AA2486 / AA1904: STL 2026-12-03 12:54:00 → RDU 2026-12-03 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-03 12:54:00 → CLT 2026-12-03 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-03 17:30:00 → RDU 2026-12-03 18:29:00.

2026-11-29 → 2026-12-05 · Axel-exclusive $352.50

• Southwest Airlines WN3623: RDU 2026-11-29 20:50:00 → STL 2026-11-29 22:00:00; nonstop; 130 minutes. Local airport times.
• Southwest Airlines WN4192: STL 2026-12-05 10:15:00 → RDU 2026-12-05 13:05:00; nonstop; 110 minutes. Local airport times.

2026-11-29 → 2026-12-05 · Axel-exclusive $399.50

• American Airlines AA1391 / AA4458: RDU 2026-11-29 06:00:00 → STL 2026-11-29 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-11-29 06:00:00 → DCA 2026-11-29 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-11-29 08:20:00 → STL 2026-11-29 10:08:00.
• American Airlines AA2486 / AA1904: STL 2026-12-05 12:54:00 → RDU 2026-12-05 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-05 12:54:00 → CLT 2026-12-05 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-05 17:30:00 → RDU 2026-12-05 18:29:00.

2026-11-29 → 2026-12-06 · Axel-exclusive $352.50

• Southwest Airlines WN3623: RDU 2026-11-29 20:50:00 → STL 2026-11-29 22:00:00; nonstop; 130 minutes. Local airport times.
• Southwest Airlines WN4192: STL 2026-12-06 10:15:00 → RDU 2026-12-06 13:05:00; nonstop; 110 minutes. Local airport times.

2026-11-29 → 2026-12-06 · Axel-exclusive $399.50

• American Airlines AA1391 / AA4458: RDU 2026-11-29 06:00:00 → STL 2026-11-29 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-11-29 06:00:00 → DCA 2026-11-29 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-11-29 08:20:00 → STL 2026-11-29 10:08:00.
• American Airlines AA2486 / AA1904: STL 2026-12-06 12:54:00 → RDU 2026-12-06 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-06 12:54:00 → CLT 2026-12-06 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-06 17:30:00 → RDU 2026-12-06 18:29:00.

2026-11-29 → 2026-12-07 · Axel-exclusive $347.50

• Southwest Airlines WN3623: RDU 2026-11-29 20:50:00 → STL 2026-11-29 22:00:00; nonstop; 130 minutes. Local airport times.
• Southwest Airlines WN665 / WN4766: STL 2026-12-07 10:35:00 → RDU 2026-12-07 16:35:00; 1 stop(s) via BNA; 300 minutes. Local airport times.
  • WN665: STL 2026-12-07 10:35:00 → BNA 2026-12-07 11:40:00; layover at BNA: 145 minutes.
  • WN4766: BNA 2026-12-07 14:05:00 → RDU 2026-12-07 16:35:00.

2026-11-29 → 2026-12-07 · Axel-exclusive $399.50

• American Airlines AA1391 / AA4458: RDU 2026-11-29 06:00:00 → STL 2026-11-29 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-11-29 06:00:00 → DCA 2026-11-29 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-11-29 08:20:00 → STL 2026-11-29 10:08:00.
• American Airlines AA2486 / AA1904: STL 2026-12-07 12:54:00 → RDU 2026-12-07 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-07 12:54:00 → CLT 2026-12-07 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-07 17:30:00 → RDU 2026-12-07 18:29:00.

2026-11-29 → 2026-12-09 · Axel-exclusive $347.50

• Southwest Airlines WN3623: RDU 2026-11-29 20:50:00 → STL 2026-11-29 22:00:00; nonstop; 130 minutes. Local airport times.
• Southwest Airlines WN4173 / WN2501: STL 2026-12-09 05:30:00 → RDU 2026-12-09 10:40:00; 1 stop(s) via MDW; 250 minutes. Local airport times.
  • WN4173: STL 2026-12-09 05:30:00 → MDW 2026-12-09 06:35:00; layover at MDW: 70 minutes.
  • WN2501: MDW 2026-12-09 07:45:00 → RDU 2026-12-09 10:40:00.

2026-11-29 → 2026-12-09 · Axel-exclusive $399.50

• American Airlines AA1391 / AA4458: RDU 2026-11-29 06:00:00 → STL 2026-11-29 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-11-29 06:00:00 → DCA 2026-11-29 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-11-29 08:20:00 → STL 2026-11-29 10:08:00.
• American Airlines AA2486 / AA1904: STL 2026-12-09 12:54:00 → RDU 2026-12-09 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-09 12:54:00 → CLT 2026-12-09 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-09 17:30:00 → RDU 2026-12-09 18:29:00.

2026-11-29 → 2026-12-10 · Axel-exclusive $352.50

• Southwest Airlines WN3623: RDU 2026-11-29 20:50:00 → STL 2026-11-29 22:00:00; nonstop; 130 minutes. Local airport times.
• Southwest Airlines WN4192: STL 2026-12-10 10:15:00 → RDU 2026-12-10 13:05:00; nonstop; 110 minutes. Local airport times.

2026-11-29 → 2026-12-10 · Axel-exclusive $399.50

• American Airlines AA1391 / AA4458: RDU 2026-11-29 06:00:00 → STL 2026-11-29 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-11-29 06:00:00 → DCA 2026-11-29 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-11-29 08:20:00 → STL 2026-11-29 10:08:00.
• American Airlines AA2486 / AA1904: STL 2026-12-10 12:54:00 → RDU 2026-12-10 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-10 12:54:00 → CLT 2026-12-10 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-10 17:30:00 → RDU 2026-12-10 18:29:00.

2026-11-29 → 2026-12-11 · Axel-exclusive $352.50

• Southwest Airlines WN3623: RDU 2026-11-29 20:50:00 → STL 2026-11-29 22:00:00; nonstop; 130 minutes. Local airport times.
• Southwest Airlines WN4192: STL 2026-12-11 10:15:00 → RDU 2026-12-11 13:05:00; nonstop; 110 minutes. Local airport times.

2026-11-29 → 2026-12-11 · Axel-exclusive $399.50

• American Airlines AA1391 / AA4458: RDU 2026-11-29 06:00:00 → STL 2026-11-29 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-11-29 06:00:00 → DCA 2026-11-29 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-11-29 08:20:00 → STL 2026-11-29 10:08:00.
• American Airlines AA2486 / AA1904: STL 2026-12-11 12:54:00 → RDU 2026-12-11 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-11 12:54:00 → CLT 2026-12-11 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-11 17:30:00 → RDU 2026-12-11 18:29:00.

2026-11-29 → 2026-12-13 · Axel-exclusive $352.50

• Southwest Airlines WN3623: RDU 2026-11-29 20:50:00 → STL 2026-11-29 22:00:00; nonstop; 130 minutes. Local airport times.
• Southwest Airlines WN4192: STL 2026-12-13 10:15:00 → RDU 2026-12-13 13:05:00; nonstop; 110 minutes. Local airport times.

2026-11-29 → 2026-12-13 · Axel-exclusive $399.50

• American Airlines AA1391 / AA4458: RDU 2026-11-29 06:00:00 → STL 2026-11-29 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-11-29 06:00:00 → DCA 2026-11-29 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-11-29 08:20:00 → STL 2026-11-29 10:08:00.
• American Airlines AA2486 / AA1904: STL 2026-12-13 12:54:00 → RDU 2026-12-13 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-13 12:54:00 → CLT 2026-12-13 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-13 17:30:00 → RDU 2026-12-13 18:29:00.

Explore this route

• All dates for this route
• Nov 28, 2026 · Return options
• Nov 30, 2026 · Return options
• Hotels in St. Louis with Axel

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• This page: Raleigh/Durham (RDU) to Saint Louis (STL) · Nov 29, 2026 · choose your return date: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued. Under a trip, hotels in St. Louis for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the lowest saved totals among the shortlisted hotels in each star tier for those dates.
• Next: each row is one exact trip for this departure (both dates with the year, the total and the time its price was issued); its exact-trip price link opens the live search for those dates and travelers, where the booking link and the current total are. Other durations or travelers are not priced here: Choose travelers and dates prices the requested trip.
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