Raleigh/Durham (RDU) to Saint Louis (STL), Nov 25, 2026: from $209 one way

Raleigh/Durham (RDU) to Saint Louis (STL), Nov 25, 2026: from $209 one way on Axel, checked Oct 29, 2026. Lowest published fare: $209 one way, Axel-exclusive, Southwest Airlines, nonstop, Nov 25, 2026, 1 adult, economy, checked Oct 29, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Route overview: Raleigh/Durham to Saint Louis (STL) flight deals

2026-11-25 · one way · Axel-exclusive $209.25

• Southwest Airlines WN3623: RDU 2026-11-25 20:50:00 → STL 2026-11-25 22:00:00; nonstop; 130 minutes. Local airport times.

2026-11-25 · one way · Axel-exclusive $236.25

• American Airlines AA638 / AA2486: RDU 2026-11-25 10:07:00 → STL 2026-11-25 13:18:00; 1 stop(s) via CLT; 251 minutes. Local airport times.
  • AA638: RDU 2026-11-25 10:07:00 → CLT 2026-11-25 11:17:00; layover at CLT: 63 minutes.
  • AA2486: CLT 2026-11-25 12:20:00 → STL 2026-11-25 13:18:00.

2026-11-25 · one way · Axel-exclusive $243.00

• United Airlines UA3704 / UA4427: RDU 2026-11-25 06:00:00 → STL 2026-11-25 10:12:00; 1 stop(s) via IAD; 312 minutes. Local airport times.
  • UA3704: RDU 2026-11-25 06:00:00 → IAD 2026-11-25 07:11:00; layover at IAD: 89 minutes.
  • UA4427: IAD 2026-11-25 08:40:00 → STL 2026-11-25 10:12:00.

2026-11-25 · one way · Axel-exclusive $249.75

• Delta Air Lines DL2164 / DL2822: RDU 2026-11-25 12:56:00 → STL 2026-11-25 17:20:00; 1 stop(s) via DTW; 324 minutes. Local airport times.
  • DL2164: RDU 2026-11-25 12:56:00 → DTW 2026-11-25 14:49:00; layover at DTW: 104 minutes.
  • DL2822: DTW 2026-11-25 16:33:00 → STL 2026-11-25 17:20:00.

2026-11-25 · one way · Axel-exclusive $209.25

• Southwest Airlines WN3622: RDU 2026-11-25 06:05:00 → STL 2026-11-25 07:20:00; nonstop; 135 minutes. Local airport times.

2026-11-25 · one way · Axel-exclusive $236.25

• American Airlines AA1391 / AA4458: RDU 2026-11-25 06:00:00 → STL 2026-11-25 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-11-25 06:00:00 → DCA 2026-11-25 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-11-25 08:20:00 → STL 2026-11-25 10:08:00.

2026-11-25 · one way · Axel-exclusive $243.00

• United Airlines UA2638 / UA1857: RDU 2026-11-25 08:05:00 → STL 2026-11-25 12:22:00; 1 stop(s) via ORD; 317 minutes. Local airport times.
  • UA2638: RDU 2026-11-25 08:05:00 → ORD 2026-11-25 09:30:00; layover at ORD: 82 minutes.
  • UA1857: ORD 2026-11-25 10:52:00 → STL 2026-11-25 12:22:00.

2026-11-25 · one way · Axel-exclusive $249.75

• Delta Air Lines DL2478 / DL1400: RDU 2026-11-25 08:00:00 → STL 2026-11-25 11:29:00; 1 stop(s) via ATL; 269 minutes. Local airport times.
  • DL2478: RDU 2026-11-25 08:00:00 → ATL 2026-11-25 09:40:00; layover at ATL: 60 minutes.
  • DL1400: ATL 2026-11-25 10:40:00 → STL 2026-11-25 11:29:00.

Travelers: prices on this page are totals for 1 adult. For a different party, open this trip for 2 adults · 3 adults · 4 adults · 2 adults + 1 child · 2 adults + 2 children; each link opens AI flight search for these dates and those travelers, and the customer link to share comes from those results.

Explore this route

• All dates for this route
• Nov 24, 2026 · Return options
• Nov 26, 2026 · Return options
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