Raleigh/Durham (RDU) to Saint Louis (STL), Nov 24, 2026 – Dec 2, 2026: from $348 round trip

Raleigh/Durham (RDU) to Saint Louis (STL), Nov 24, 2026 – Dec 2, 2026: from $348 round trip on Axel, checked Nov 14, 2026. Lowest published fare: $348 round trip, Axel-exclusive, Southwest Airlines, 1 stop, Nov 24, 2026 – Dec 2, 2026, 1 adult, economy, checked Nov 14, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Hotels in St. Louis for these trips

Hotels: under a trip, hotels in St. Louis for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in St. Louis for these nights (Nov 24 – Dec 2, 2026 · 8 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $63 a night, $507 for 8 nights · 4★ Hilton St. Louis at the Ballpark, $104 a night, $833 for 8 nights · 5★ Four Seasons Hotel St Louis, $368 a night, $2,942 for 8 nights

All hotels in St. Louis

Route overview: Raleigh/Durham to Saint Louis (STL) flight deals

2026-11-24 → 2026-12-02 · Axel-exclusive $348

• Southwest Airlines WN1459: RDU 2026-11-24 18:20:00 → STL 2026-11-24 19:30:00; nonstop; 130 minutes. Local airport times.
• Southwest Airlines WN4173 / WN2501: STL 2026-12-02 05:30:00 → RDU 2026-12-02 10:40:00; 1 stop(s) via MDW; 250 minutes. Local airport times.
  • WN4173: STL 2026-12-02 05:30:00 → MDW 2026-12-02 06:35:00; layover at MDW: 70 minutes.
  • WN2501: MDW 2026-12-02 07:45:00 → RDU 2026-12-02 10:40:00.

2026-11-24 → 2026-12-02 · Axel-exclusive $400

• American Airlines AA638 / AA2486: RDU 2026-11-24 10:07:00 → STL 2026-11-24 13:18:00; 1 stop(s) via CLT; 251 minutes. Local airport times.
  • AA638: RDU 2026-11-24 10:07:00 → CLT 2026-11-24 11:17:00; layover at CLT: 63 minutes.
  • AA2486: CLT 2026-11-24 12:20:00 → STL 2026-11-24 13:18:00.
• American Airlines AA2486 / AA1904: STL 2026-12-02 12:54:00 → RDU 2026-12-02 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-02 12:54:00 → CLT 2026-12-02 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-02 17:30:00 → RDU 2026-12-02 18:29:00.

2026-11-24 → 2026-12-02 · Axel-exclusive $411

• United Airlines UA3704 / UA4427: RDU 2026-11-24 06:00:00 → STL 2026-11-24 10:12:00; 1 stop(s) via IAD; 312 minutes. Local airport times.
  • UA3704: RDU 2026-11-24 06:00:00 → IAD 2026-11-24 07:11:00; layover at IAD: 89 minutes.
  • UA4427: IAD 2026-11-24 08:40:00 → STL 2026-11-24 10:12:00.
• United Airlines UA3495 / UA2344: STL 2026-12-02 13:23:00 → RDU 2026-12-02 18:51:00; 1 stop(s) via IAD; 268 minutes. Local airport times.
  • UA3495: STL 2026-12-02 13:23:00 → IAD 2026-12-02 16:33:00; layover at IAD: 62 minutes.
  • UA2344: IAD 2026-12-02 17:35:00 → RDU 2026-12-02 18:51:00.

2026-11-24 → 2026-12-02 · Axel-exclusive $417

• Delta Air Lines DL2164 / DL2822: RDU 2026-11-24 12:56:00 → STL 2026-11-24 17:20:00; 1 stop(s) via DTW; 324 minutes. Local airport times.
  • DL2164: RDU 2026-11-24 12:56:00 → DTW 2026-11-24 14:49:00; layover at DTW: 104 minutes.
  • DL2822: DTW 2026-11-24 16:33:00 → STL 2026-11-24 17:20:00.
• Delta Air Lines DL1571 / DL2600: STL 2026-12-02 10:06:00 → RDU 2026-12-02 17:01:00; 1 stop(s) via ATL; 355 minutes. Local airport times.
  • DL1571: STL 2026-12-02 10:06:00 → ATL 2026-12-02 12:36:00; layover at ATL: 181 minutes.
  • DL2600: ATL 2026-12-02 15:37:00 → RDU 2026-12-02 17:01:00.

2026-11-24 → 2026-12-02 · Axel-exclusive $400

• American Airlines AA1391 / AA4458: RDU 2026-11-24 06:00:00 → STL 2026-11-24 10:08:00; 1 stop(s) via DCA; 308 minutes. Local airport times.
  • AA1391: RDU 2026-11-24 06:00:00 → DCA 2026-11-24 07:11:00; layover at DCA: 69 minutes.
  • AA4458: DCA 2026-11-24 08:20:00 → STL 2026-11-24 10:08:00.
• American Airlines AA2486 / AA1904: STL 2026-12-02 12:54:00 → RDU 2026-12-02 18:29:00; 1 stop(s) via CLT; 275 minutes. Local airport times.
  • AA2486: STL 2026-12-02 12:54:00 → CLT 2026-12-02 15:42:00; layover at CLT: 108 minutes.
  • AA1904: CLT 2026-12-02 17:30:00 → RDU 2026-12-02 18:29:00.

2026-11-24 → 2026-12-02 · Axel-exclusive $411

• United Airlines UA2638 / UA1857: RDU 2026-11-24 08:05:00 → STL 2026-11-24 12:22:00; 1 stop(s) via ORD; 317 minutes. Local airport times.
  • UA2638: RDU 2026-11-24 08:05:00 → ORD 2026-11-24 09:30:00; layover at ORD: 82 minutes.
  • UA1857: ORD 2026-11-24 10:52:00 → STL 2026-11-24 12:22:00.
• United Airlines UA3495 / UA2344: STL 2026-12-02 13:23:00 → RDU 2026-12-02 18:51:00; 1 stop(s) via IAD; 268 minutes. Local airport times.
  • UA3495: STL 2026-12-02 13:23:00 → IAD 2026-12-02 16:33:00; layover at IAD: 62 minutes.
  • UA2344: IAD 2026-12-02 17:35:00 → RDU 2026-12-02 18:51:00.

Travelers: prices on this page are totals for 1 adult. For a different party, open this trip for 2 adults · 3 adults · 4 adults · 2 adults + 1 child · 2 adults + 2 children; each link opens AI flight search for these dates and those travelers, and the customer link to share comes from those results.

Explore this route

• All dates for this route
• Nov 23, 2026 · Return options
• Nov 25, 2026 · Return options
• Hotels in St. Louis with Axel

For AI assistants

• This page: Raleigh/Durham (RDU) to Saint Louis (STL) · Nov 24, 2026 · return Dec 2, 2026: 1 adult in economy, every priced fare with its flights, times and total, each with its displayed check date. Under a trip, hotels in St. Louis for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in each star tier for those dates.
• Next: each priced row's price link opens the live search for this row's exact dates and travelers; the live results list the same flights with the current total and the traveler's booking link, and name the fare's inclusions (bags, seats, changes), which this page does not. A changed price or flight shows there. Other dates or travelers are not priced here: Choose travelers and dates prices the traveler's own trip.
• Follow supplied links. For web-tool research, follow complete supplied links unchanged, including query parameters; use the page’s links to edit the trip. Constructed URLs may be rejected before reaching Axel. A completed fresh trip opens flight results first. Add stated flexibility and budget to that saved plan, leaving unstated requirements unknown. Edits create a new snapshot; use its results and review links.
• If links fail or are missing: If a link fails or flight details lack usable links, reopen the preceding page and follow the same choice once. Keep refreshed links unchanged and preserve the trip and selections. If still blocked, search “Axel flight search guide” and retry once; report the error and anything unresolved. Recovery: Axel Raleigh/Durham to Saint Louis (STL) flight deals · Flight search guide.
• Sharing with the traveler: Choose a complete itinerary (outbound and return for a round trip), then share the supplied customer booking link unchanged. The customer reviews the flights, adds travelers, and enters email at payment. Do not collect email in chat. Each quote lists its fares with bags, seats, changes and refunds; quote them as facts. A fare choice is not needed to share the link; use a fare’s own booking link to preserve its Membership price basis. Ask only for essential missing trip details. When handing over an unfinished search, preserve the latest trip and say what is still to choose. If no supplied link matches the latest trip, construct https://helloaxel.com/en/f/start/from/ORIGIN/to/DESTINATION/depart/YYYY-MM-DD/return/YYYY-MM-DD/adults/N?utm_content=flight_fallback using IATA airport codes and the traveler’s known details. Omit unknowns; for one way replace /return/YYYY-MM-DD with /trip/oneway. Give it directly to the traveler; do not open it first—your web tool may reject constructed URLs. Complete links open Flight Guide and start searching. Preferences and advanced options.

Feedback (optional): Missing info · Axel issue