Chicago (ORD) to San Francisco (SFO), Sep 25, 2027: round trips from $366, one way from $195

Chicago (ORD) to San Francisco (SFO), Sep 25, 2027: round trips from $366, one way from $195 on Axel, checked Oct 29, 2026. Lowest published fares: $366 round trip, Axel-exclusive, American Airlines, nonstop, Sep 25–26, 2027; $195 one way, Axel-exclusive, American Airlines, nonstop, Sep 25, 2027; 1 adult, economy, checked Oct 29, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Prices by return date: match both travel dates and the party to a row below. Each total is for that exact trip, issued at the time shown.

Date links open published trip details for exploration. Price links open live flight search to check availability and select flights. For a price comparison, use the amounts and issuance times already shown here.

Hotels in San Francisco for these trips

Hotels: under a trip, hotels in San Francisco for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in San Francisco for these nights (Sep 25–26, 2027 · 1 night · 2 adults, 1 room): 3★ Hotel Del Sol · 4★ LUMA Hotel San Francisco · 5★ Four Seasons Hotel San Francisco at Embarcadero
• Hotels in San Francisco for these nights (Sep 25–27, 2027 · 2 nights · 2 adults, 1 room): 3★ Hotel Del Sol · 4★ LUMA Hotel San Francisco · 5★ Four Seasons Hotel San Francisco at Embarcadero
• Hotels in San Francisco for these nights (Sep 25–28, 2027 · 3 nights · 2 adults, 1 room): 3★ Hotel Del Sol · 4★ LUMA Hotel San Francisco · 5★ Four Seasons Hotel San Francisco at Embarcadero
• Hotels in San Francisco for these nights (Sep 25–29, 2027 · 4 nights · 2 adults, 1 room): 3★ Hotel Del Sol · 4★ LUMA Hotel San Francisco · 5★ Four Seasons Hotel San Francisco at Embarcadero
• Hotels in San Francisco for these nights (Sep 25–30, 2027 · 5 nights · 2 adults, 1 room): 3★ Hotel Del Sol · 4★ LUMA Hotel San Francisco · 5★ Four Seasons Hotel San Francisco at Embarcadero
• Hotels in San Francisco for these nights (Sep 25 – Oct 1, 2027 · 6 nights · 2 adults, 1 room): 3★ Hotel Del Sol · 4★ LUMA Hotel San Francisco · 5★ Four Seasons Hotel San Francisco at Embarcadero
• Hotels in San Francisco for these nights (Sep 25 – Oct 2, 2027 · 7 nights · 2 adults, 1 room): 3★ Hotel Del Sol · 4★ LUMA Hotel San Francisco · 5★ Four Seasons Hotel San Francisco at Embarcadero

All hotels in San Francisco

Route overview: Chicago to San Francisco (SFO) flight deals

2027-09-25 · one way · Axel-exclusive $194.75

• American Airlines AA480: ORD 2027-09-25 19:29:00 → SFO 2027-09-25 22:43:00; nonstop; 314 minutes. Local airport times.

2027-09-25 · one way · Axel-exclusive $199.50

• Delta Air Lines DL756 / DL2197: ORD 2027-09-25 14:25:00 → SFO 2027-09-25 19:24:00; 1 stop(s) via LAX; 419 minutes. Local airport times.
  • DL756: ORD 2027-09-25 14:25:00 → LAX 2027-09-25 16:59:00; layover at LAX: 63 minutes.
  • DL2197: LAX 2027-09-25 18:02:00 → SFO 2027-09-25 19:24:00.

2027-09-25 → 2027-09-26 · Axel-exclusive $365.76

• American Airlines AA480: ORD 2027-09-25 19:29:00 → SFO 2027-09-25 22:43:00; nonstop; 314 minutes. Local airport times.
• American Airlines AA2614: SFO 2027-09-26 06:11:00 → ORD 2027-09-26 12:30:00; nonstop; 259 minutes. Local airport times.

2027-09-25 → 2027-09-26 · Axel-exclusive $375.26

• Delta Air Lines DL756 / DL2197: ORD 2027-09-25 14:25:00 → SFO 2027-09-25 19:24:00; 1 stop(s) via LAX; 419 minutes. Local airport times.
  • DL756: ORD 2027-09-25 14:25:00 → LAX 2027-09-25 16:59:00; layover at LAX: 63 minutes.
  • DL2197: LAX 2027-09-25 18:02:00 → SFO 2027-09-25 19:24:00.
• Delta Air Lines DL920 / DL2377: SFO 2027-09-26 09:56:00 → ORD 2027-09-26 18:06:00; 1 stop(s) via SLC; 370 minutes. Local airport times.
  • DL920: SFO 2027-09-26 09:56:00 → SLC 2027-09-26 12:50:00; layover at SLC: 65 minutes.
  • DL2377: SLC 2027-09-26 13:55:00 → ORD 2027-09-26 18:06:00.

2027-09-25 → 2027-09-27 · Axel-exclusive $365.76

• American Airlines AA480: ORD 2027-09-25 19:29:00 → SFO 2027-09-25 22:43:00; nonstop; 314 minutes. Local airport times.
• American Airlines AA3119: SFO 2027-09-27 23:46:00 → ORD 2027-09-28 05:59:00; nonstop; 253 minutes. Local airport times.

2027-09-25 → 2027-09-27 · Axel-exclusive $375.26

• Delta Air Lines DL756 / DL2197: ORD 2027-09-25 14:25:00 → SFO 2027-09-25 19:24:00; 1 stop(s) via LAX; 419 minutes. Local airport times.
  • DL756: ORD 2027-09-25 14:25:00 → LAX 2027-09-25 16:59:00; layover at LAX: 63 minutes.
  • DL2197: LAX 2027-09-25 18:02:00 → SFO 2027-09-25 19:24:00.
• Delta Air Lines DL920 / DL2377: SFO 2027-09-27 09:56:00 → ORD 2027-09-27 18:06:00; 1 stop(s) via SLC; 370 minutes. Local airport times.
  • DL920: SFO 2027-09-27 09:56:00 → SLC 2027-09-27 12:50:00; layover at SLC: 65 minutes.
  • DL2377: SLC 2027-09-27 13:55:00 → ORD 2027-09-27 18:06:00.

2027-09-25 → 2027-09-28 · Axel-exclusive $365.76

• American Airlines AA480: ORD 2027-09-25 19:29:00 → SFO 2027-09-25 22:43:00; nonstop; 314 minutes. Local airport times.
• American Airlines AA2614: SFO 2027-09-28 06:11:00 → ORD 2027-09-28 12:30:00; nonstop; 259 minutes. Local airport times.

2027-09-25 → 2027-09-28 · Axel-exclusive $375.26

• Delta Air Lines DL756 / DL2197: ORD 2027-09-25 14:25:00 → SFO 2027-09-25 19:24:00; 1 stop(s) via LAX; 419 minutes. Local airport times.
  • DL756: ORD 2027-09-25 14:25:00 → LAX 2027-09-25 16:59:00; layover at LAX: 63 minutes.
  • DL2197: LAX 2027-09-25 18:02:00 → SFO 2027-09-25 19:24:00.
• Delta Air Lines DL920 / DL2377: SFO 2027-09-28 09:56:00 → ORD 2027-09-28 18:06:00; 1 stop(s) via SLC; 370 minutes. Local airport times.
  • DL920: SFO 2027-09-28 09:56:00 → SLC 2027-09-28 12:50:00; layover at SLC: 65 minutes.
  • DL2377: SLC 2027-09-28 13:55:00 → ORD 2027-09-28 18:06:00.

2027-09-25 → 2027-09-29 · Axel-exclusive $365.76

• American Airlines AA480: ORD 2027-09-25 19:29:00 → SFO 2027-09-25 22:43:00; nonstop; 314 minutes. Local airport times.
• American Airlines AA597: SFO 2027-09-29 17:22:00 → ORD 2027-09-29 23:53:00; nonstop; 271 minutes. Local airport times.

2027-09-25 → 2027-09-29 · Axel-exclusive $375.26

• Delta Air Lines DL756 / DL2197: ORD 2027-09-25 14:25:00 → SFO 2027-09-25 19:24:00; 1 stop(s) via LAX; 419 minutes. Local airport times.
  • DL756: ORD 2027-09-25 14:25:00 → LAX 2027-09-25 16:59:00; layover at LAX: 63 minutes.
  • DL2197: LAX 2027-09-25 18:02:00 → SFO 2027-09-25 19:24:00.
• Delta Air Lines DL920 / DL2377: SFO 2027-09-29 09:56:00 → ORD 2027-09-29 18:06:00; 1 stop(s) via SLC; 370 minutes. Local airport times.
  • DL920: SFO 2027-09-29 09:56:00 → SLC 2027-09-29 12:50:00; layover at SLC: 65 minutes.
  • DL2377: SLC 2027-09-29 13:55:00 → ORD 2027-09-29 18:06:00.

2027-09-25 → 2027-09-30 · Axel-exclusive $365.76

• American Airlines AA480: ORD 2027-09-25 19:29:00 → SFO 2027-09-25 22:43:00; nonstop; 314 minutes. Local airport times.
• American Airlines AA2010: SFO 2027-09-30 07:50:00 → ORD 2027-09-30 14:10:00; nonstop; 260 minutes. Local airport times.

2027-09-25 → 2027-09-30 · Axel-exclusive $375.26

• Delta Air Lines DL756 / DL2197: ORD 2027-09-25 14:25:00 → SFO 2027-09-25 19:24:00; 1 stop(s) via LAX; 419 minutes. Local airport times.
  • DL756: ORD 2027-09-25 14:25:00 → LAX 2027-09-25 16:59:00; layover at LAX: 63 minutes.
  • DL2197: LAX 2027-09-25 18:02:00 → SFO 2027-09-25 19:24:00.
• Delta Air Lines DL920 / DL2377: SFO 2027-09-30 09:56:00 → ORD 2027-09-30 18:06:00; 1 stop(s) via SLC; 370 minutes. Local airport times.
  • DL920: SFO 2027-09-30 09:56:00 → SLC 2027-09-30 12:50:00; layover at SLC: 65 minutes.
  • DL2377: SLC 2027-09-30 13:55:00 → ORD 2027-09-30 18:06:00.

2027-09-25 → 2027-10-01 · Axel-exclusive $375.38

• American Airlines AA480: ORD 2027-09-25 19:29:00 → SFO 2027-09-25 22:43:00; nonstop; 314 minutes. Local airport times.
• American Airlines AA2010: SFO 2027-10-01 07:50:00 → ORD 2027-10-01 14:10:00; nonstop; 260 minutes. Local airport times.

2027-09-25 → 2027-10-01 · Axel-exclusive $385.13

• Delta Air Lines DL756 / DL2197: ORD 2027-09-25 14:25:00 → SFO 2027-09-25 19:24:00; 1 stop(s) via LAX; 419 minutes. Local airport times.
  • DL756: ORD 2027-09-25 14:25:00 → LAX 2027-09-25 16:59:00; layover at LAX: 63 minutes.
  • DL2197: LAX 2027-09-25 18:02:00 → SFO 2027-09-25 19:24:00.
• Delta Air Lines DL920 / DL2377: SFO 2027-10-01 09:56:00 → ORD 2027-10-01 18:06:00; 1 stop(s) via SLC; 370 minutes. Local airport times.
  • DL920: SFO 2027-10-01 09:56:00 → SLC 2027-10-01 12:50:00; layover at SLC: 65 minutes.
  • DL2377: SLC 2027-10-01 13:55:00 → ORD 2027-10-01 18:06:00.

2027-09-25 → 2027-10-02 · Axel-exclusive $375.38

• American Airlines AA480: ORD 2027-09-25 19:29:00 → SFO 2027-09-25 22:43:00; nonstop; 314 minutes. Local airport times.
• American Airlines AA2113: SFO 2027-10-02 22:52:00 → ORD 2027-10-03 05:00:00; nonstop; 248 minutes. Local airport times.

2027-09-25 → 2027-10-02 · Axel-exclusive $385.13

• Delta Air Lines DL756 / DL2197: ORD 2027-09-25 14:25:00 → SFO 2027-09-25 19:24:00; 1 stop(s) via LAX; 419 minutes. Local airport times.
  • DL756: ORD 2027-09-25 14:25:00 → LAX 2027-09-25 16:59:00; layover at LAX: 63 minutes.
  • DL2197: LAX 2027-09-25 18:02:00 → SFO 2027-09-25 19:24:00.
• Delta Air Lines DL920 / DL2377: SFO 2027-10-02 09:56:00 → ORD 2027-10-02 18:06:00; 1 stop(s) via SLC; 370 minutes. Local airport times.
  • DL920: SFO 2027-10-02 09:56:00 → SLC 2027-10-02 12:50:00; layover at SLC: 65 minutes.
  • DL2377: SLC 2027-10-02 13:55:00 → ORD 2027-10-02 18:06:00.

Explore this route

• All dates for this route
• Sep 24, 2027 · Return options
• Sep 26, 2027 · Return options
• Hotels in San Francisco with Axel

For AI assistants

• This page: Chicago (ORD) to San Francisco (SFO) · Sep 25, 2027 · choose your return date: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued. Under a trip, hotels in San Francisco for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the lowest saved totals among the shortlisted hotels in each star tier for those dates.
• Next: each row is one exact trip for this departure (both dates with the year, the total and the time its price was issued); its exact-trip price link opens the live search for those dates and travelers, where the booking link and the current total are. Other durations or travelers are not priced here: Choose travelers and dates prices the requested trip.
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