Chicago (MDW) to Lisbon (LIS), Apr 12, 2027: round trips from $1,080, one way from $720

Chicago (MDW) to Lisbon (LIS), Apr 12, 2027: round trips from $1,080, one way from $720 on Axel, checked Nov 13, 2026. Lowest published fares: $1,080 round trip, Axel-exclusive, Delta Air Lines / KLM Royal Dutch Airlines, 2 stops, Apr 12–14, 2027; $720 one way, Axel-exclusive, Delta Air Lines, 2 stops, Apr 12, 2027; 1 adult, economy, checked Nov 13, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Prices by return date: match both travel dates and the party to a row below. Each total is for that exact trip, labelled with the check date shown.

Date links open published trip details for exploration. Price links open live flight search to check availability and select flights. For a price comparison, use the amounts and check dates already shown here.

Hotels in Lisbon for these trips

Hotels: under a trip, hotels in Lisbon for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in Lisbon for these nights (Apr 12–14, 2027 · 2 nights · 2 adults, 1 room): 3★ Dorma Saldanha Hotel, $110 a night, $220 for 2 nights · 4★ Jupiter Lisboa Hotel – Rooftop & Spa, $129 a night, $257 for 2 nights · 5★ Myriad by SANA Hotels, $201 a night, $402 for 2 nights
• Hotels in Lisbon for these nights (Apr 12–15, 2027 · 3 nights · 2 adults, 1 room): 3★ Dorma Saldanha Hotel, $110 a night, $330 for 3 nights · 4★ Jupiter Lisboa Hotel – Rooftop & Spa, $126 a night, $378 for 3 nights · 5★ Myriad by SANA Hotels, $200 a night, $599 for 3 nights
• Hotels in Lisbon for these nights (Apr 12–16, 2027 · 4 nights · 2 adults, 1 room): 3★ Dorma Saldanha Hotel, $110 a night, $439 for 4 nights · 4★ Jupiter Lisboa Hotel – Rooftop & Spa, $125 a night, $499 for 4 nights · 5★ Myriad by SANA Hotels, $199 a night, $794 for 4 nights
• Hotels in Lisbon for these nights (Apr 12–17, 2027 · 5 nights · 2 adults, 1 room): 3★ Dorma Saldanha Hotel, $111 a night, $556 for 5 nights · 4★ Jupiter Lisboa Hotel – Rooftop & Spa, $126 a night, $629 for 5 nights · 5★ Myriad by SANA Hotels, $199 a night, $995 for 5 nights
• Hotels in Lisbon for these nights (Apr 12–18, 2027 · 6 nights · 2 adults, 1 room): 3★ Hotel Ikonik Lisboa, $112 a night, $672 for 6 nights · 4★ Jupiter Lisboa Hotel – Rooftop & Spa, $125 a night, $750 for 6 nights · 5★ Myriad by SANA Hotels, $200 a night, $1,200 for 6 nights
• Hotels in Lisbon for these nights (Apr 12–19, 2027 · 7 nights · 2 adults, 1 room): 3★ Hotel Ikonik Lisboa, $109 a night, $762 for 7 nights · 4★ Jupiter Lisboa Hotel – Rooftop & Spa, $126 a night, $880 for 7 nights · 5★ Myriad by SANA Hotels, $199 a night, $1,393 for 7 nights
• Hotels in Lisbon for these nights (Apr 12–20, 2027 · 8 nights · 2 adults, 1 room): 3★ Hotel Ikonik Lisboa, $107 a night, $852 for 8 nights · 4★ Jupiter Lisboa Hotel – Rooftop & Spa, $125 a night, $1,001 for 8 nights · 5★ Myriad by SANA Hotels, $201 a night, $1,609 for 8 nights
• Hotels in Lisbon for these nights (Apr 12–21, 2027 · 9 nights · 2 adults, 1 room): 3★ Hotel Ikonik Lisboa, $106 a night, $958 for 9 nights · 4★ Jupiter Lisboa Hotel – Rooftop & Spa, $125 a night, $1,122 for 9 nights · 5★ Myriad by SANA Hotels, $203 a night, $1,825 for 9 nights
• Hotels in Lisbon for these nights (Apr 12–22, 2027 · 10 nights · 2 adults, 1 room): 3★ Hotel Ikonik Lisboa, $106 a night, $1,064 for 10 nights · 4★ Jupiter Lisboa Hotel – Rooftop & Spa, $126 a night, $1,261 for 10 nights · 5★ Myriad by SANA Hotels, $203 a night, $2,026 for 10 nights
• Hotels in Lisbon for these nights (Apr 12–23, 2027 · 11 nights · 2 adults, 1 room): 3★ Hotel Ikonik Lisboa, $106 a night, $1,170 for 11 nights · 4★ Jupiter Lisboa Hotel – Rooftop & Spa, $126 a night, $1,382 for 11 nights · 5★ Myriad by SANA Hotels, $202 a night, $2,223 for 11 nights
• Hotels in Lisbon for these nights (Apr 12–24, 2027 · 12 nights · 2 adults, 1 room): 3★ Hotel Ikonik Lisboa, $106 a night, $1,276 for 12 nights · 4★ Jupiter Lisboa Hotel – Rooftop & Spa, $127 a night, $1,520 for 12 nights · 5★ Myriad by SANA Hotels, $202 a night, $2,424 for 12 nights
• Hotels in Lisbon for these nights (Apr 12–25, 2027 · 13 nights · 2 adults, 1 room): 3★ Hotel Ikonik Lisboa, $106 a night, $1,382 for 13 nights · 4★ Jupiter Lisboa Hotel – Rooftop & Spa, $128 a night, $1,658 for 13 nights · 5★ Myriad by SANA Hotels, $202 a night, $2,625 for 13 nights
• Hotels in Lisbon for these nights (Apr 12–26, 2027 · 14 nights · 2 adults, 1 room): 3★ Hotel Ikonik Lisboa, $106 a night, $1,488 for 14 nights · 4★ Jupiter Lisboa Hotel – Rooftop & Spa, $128 a night, $1,788 for 14 nights · 5★ Wine & Books Lisboa Hotel, $215 a night, $3,013 for 14 nights
• Hotels in Lisbon for these nights (Apr 12 – May 3, 2027 · 21 nights · 2 adults, 1 room): 3★ Blue Liberdade Hotel · 4★ The Emerald House Lisbon, Curio Collection By Hilton Hotel · 5★ Olissippo Lapa Palace
• Hotels in Lisbon for these nights (Apr 12 – May 10, 2027 · 28 nights · 2 adults, 1 room): 3★ Blue Liberdade Hotel · 4★ The Emerald House Lisbon, Curio Collection By Hilton Hotel · 5★ Olissippo Lapa Palace

All hotels in Lisbon

Route overview: Chicago to Lisbon (LIS) flight deals

2027-04-12 · one way · Axel-exclusive $720

• Delta Air Lines DL4901 / DL160 / KL1579: MDW 2027-04-12 12:30:00 → LIS 2027-04-13 10:30:00; 2 stop(s) via MSP, AMS; 960 minutes. Local airport times.
  • DL4901: MDW 2027-04-12 12:30:00 → MSP 2027-04-12 14:10:00; layover at MSP: 80 minutes.
  • DL160: MSP 2027-04-12 15:30:00 → AMS 2027-04-13 06:50:00; layover at AMS: 100 minutes.
  • KL1579: AMS 2027-04-13 08:30:00 → LIS 2027-04-13 10:30:00.

2027-04-12 → 2027-04-14 · Axel-exclusive $1,080

• Delta Air Lines DL4901 / DL160 / KL1579: MDW 2027-04-12 12:30:00 → LIS 2027-04-13 10:30:00; 2 stop(s) via MSP, AMS; 960 minutes. Local airport times.
  • DL4901: MDW 2027-04-12 12:30:00 → MSP 2027-04-12 14:10:00; layover at MSP: 80 minutes.
  • DL160: MSP 2027-04-12 15:30:00 → AMS 2027-04-13 06:50:00; layover at AMS: 100 minutes.
  • KL1579: AMS 2027-04-13 08:30:00 → LIS 2027-04-13 10:30:00.
• KLM Royal Dutch Airlines KL1578 / DL161 / DL4714: LIS 2027-04-14 05:00:00 → MDW 2027-04-14 16:39:00; 2 stop(s) via AMS, MSP; 1059 minutes. Local airport times.
  • KL1578: LIS 2027-04-14 05:00:00 → AMS 2027-04-14 09:00:00; layover at AMS: 85 minutes.
  • DL161: AMS 2027-04-14 10:25:00 → MSP 2027-04-14 12:42:00; layover at MSP: 138 minutes.
  • DL4714: MSP 2027-04-14 15:00:00 → MDW 2027-04-14 16:39:00.

2027-04-12 → 2027-04-15 · Axel-exclusive $1,080

• Delta Air Lines DL4901 / DL160 / KL1579: MDW 2027-04-12 12:30:00 → LIS 2027-04-13 10:30:00; 2 stop(s) via MSP, AMS; 960 minutes. Local airport times.
  • DL4901: MDW 2027-04-12 12:30:00 → MSP 2027-04-12 14:10:00; layover at MSP: 80 minutes.
  • DL160: MSP 2027-04-12 15:30:00 → AMS 2027-04-13 06:50:00; layover at AMS: 100 minutes.
  • KL1579: AMS 2027-04-13 08:30:00 → LIS 2027-04-13 10:30:00.
• KLM Royal Dutch Airlines KL1578 / DL161 / DL4714: LIS 2027-04-15 05:00:00 → MDW 2027-04-15 16:39:00; 2 stop(s) via AMS, MSP; 1059 minutes. Local airport times.
  • KL1578: LIS 2027-04-15 05:00:00 → AMS 2027-04-15 09:00:00; layover at AMS: 85 minutes.
  • DL161: AMS 2027-04-15 10:25:00 → MSP 2027-04-15 12:42:00; layover at MSP: 138 minutes.
  • DL4714: MSP 2027-04-15 15:00:00 → MDW 2027-04-15 16:39:00.

2027-04-12 → 2027-04-16 · Axel-exclusive $1,080

• Delta Air Lines DL4901 / DL160 / KL1579: MDW 2027-04-12 12:30:00 → LIS 2027-04-13 10:30:00; 2 stop(s) via MSP, AMS; 960 minutes. Local airport times.
  • DL4901: MDW 2027-04-12 12:30:00 → MSP 2027-04-12 14:10:00; layover at MSP: 80 minutes.
  • DL160: MSP 2027-04-12 15:30:00 → AMS 2027-04-13 06:50:00; layover at AMS: 100 minutes.
  • KL1579: AMS 2027-04-13 08:30:00 → LIS 2027-04-13 10:30:00.
• KLM Royal Dutch Airlines KL1578 / DL161 / DL4714: LIS 2027-04-16 05:00:00 → MDW 2027-04-16 16:39:00; 2 stop(s) via AMS, MSP; 1059 minutes. Local airport times.
  • KL1578: LIS 2027-04-16 05:00:00 → AMS 2027-04-16 09:00:00; layover at AMS: 85 minutes.
  • DL161: AMS 2027-04-16 10:25:00 → MSP 2027-04-16 12:42:00; layover at MSP: 138 minutes.
  • DL4714: MSP 2027-04-16 15:00:00 → MDW 2027-04-16 16:39:00.

2027-04-12 → 2027-04-18 · Axel-exclusive $1,080

• Delta Air Lines DL4901 / DL160 / KL1579: MDW 2027-04-12 12:30:00 → LIS 2027-04-13 10:30:00; 2 stop(s) via MSP, AMS; 960 minutes. Local airport times.
  • DL4901: MDW 2027-04-12 12:30:00 → MSP 2027-04-12 14:10:00; layover at MSP: 80 minutes.
  • DL160: MSP 2027-04-12 15:30:00 → AMS 2027-04-13 06:50:00; layover at AMS: 100 minutes.
  • KL1579: AMS 2027-04-13 08:30:00 → LIS 2027-04-13 10:30:00.
• KLM Royal Dutch Airlines KL1578 / DL161 / DL4714: LIS 2027-04-18 05:00:00 → MDW 2027-04-18 16:39:00; 2 stop(s) via AMS, MSP; 1059 minutes. Local airport times.
  • KL1578: LIS 2027-04-18 05:00:00 → AMS 2027-04-18 09:00:00; layover at AMS: 85 minutes.
  • DL161: AMS 2027-04-18 10:25:00 → MSP 2027-04-18 12:42:00; layover at MSP: 138 minutes.
  • DL4714: MSP 2027-04-18 15:00:00 → MDW 2027-04-18 16:39:00.

2027-04-12 → 2027-04-19 · Axel-exclusive $1,095

• Delta Air Lines DL4901 / DL160 / KL1579: MDW 2027-04-12 12:30:00 → LIS 2027-04-13 10:30:00; 2 stop(s) via MSP, AMS; 960 minutes. Local airport times.
  • DL4901: MDW 2027-04-12 12:30:00 → MSP 2027-04-12 14:10:00; layover at MSP: 80 minutes.
  • DL160: MSP 2027-04-12 15:30:00 → AMS 2027-04-13 06:50:00; layover at AMS: 100 minutes.
  • KL1579: AMS 2027-04-13 08:30:00 → LIS 2027-04-13 10:30:00.
• Air France AF1125 / DL229 / DL4677: LIS 2027-04-19 05:30:00 → MDW 2027-04-19 18:01:00; 2 stop(s) via CDG, DTW; 1111 minutes. Local airport times.
  • AF1125: LIS 2027-04-19 05:30:00 → CDG 2027-04-19 09:10:00; layover at CDG: 80 minutes.
  • DL229: CDG 2027-04-19 10:30:00 → DTW 2027-04-19 13:45:00; layover at DTW: 235 minutes.
  • DL4677: DTW 2027-04-19 17:40:00 → MDW 2027-04-19 18:01:00.

2027-04-12 → 2027-04-21 · Axel-exclusive $1,080

• Delta Air Lines DL4901 / DL160 / KL1579: MDW 2027-04-12 12:30:00 → LIS 2027-04-13 10:30:00; 2 stop(s) via MSP, AMS; 960 minutes. Local airport times.
  • DL4901: MDW 2027-04-12 12:30:00 → MSP 2027-04-12 14:10:00; layover at MSP: 80 minutes.
  • DL160: MSP 2027-04-12 15:30:00 → AMS 2027-04-13 06:50:00; layover at AMS: 100 minutes.
  • KL1579: AMS 2027-04-13 08:30:00 → LIS 2027-04-13 10:30:00.
• KLM Royal Dutch Airlines KL1578 / DL161 / DL4714: LIS 2027-04-21 05:00:00 → MDW 2027-04-21 16:39:00; 2 stop(s) via AMS, MSP; 1059 minutes. Local airport times.
  • KL1578: LIS 2027-04-21 05:00:00 → AMS 2027-04-21 09:00:00; layover at AMS: 85 minutes.
  • DL161: AMS 2027-04-21 10:25:00 → MSP 2027-04-21 12:42:00; layover at MSP: 138 minutes.
  • DL4714: MSP 2027-04-21 15:00:00 → MDW 2027-04-21 16:39:00.

2027-04-12 → 2027-04-22 · Axel-exclusive $1,080

• Delta Air Lines DL4901 / DL160 / KL1579: MDW 2027-04-12 12:30:00 → LIS 2027-04-13 10:30:00; 2 stop(s) via MSP, AMS; 960 minutes. Local airport times.
  • DL4901: MDW 2027-04-12 12:30:00 → MSP 2027-04-12 14:10:00; layover at MSP: 80 minutes.
  • DL160: MSP 2027-04-12 15:30:00 → AMS 2027-04-13 06:50:00; layover at AMS: 100 minutes.
  • KL1579: AMS 2027-04-13 08:30:00 → LIS 2027-04-13 10:30:00.
• KLM Royal Dutch Airlines KL1578 / DL161 / DL4714: LIS 2027-04-22 05:00:00 → MDW 2027-04-22 16:39:00; 2 stop(s) via AMS, MSP; 1059 minutes. Local airport times.
  • KL1578: LIS 2027-04-22 05:00:00 → AMS 2027-04-22 09:00:00; layover at AMS: 85 minutes.
  • DL161: AMS 2027-04-22 10:25:00 → MSP 2027-04-22 12:42:00; layover at MSP: 138 minutes.
  • DL4714: MSP 2027-04-22 15:00:00 → MDW 2027-04-22 16:39:00.

2027-04-12 → 2027-04-23 · Axel-exclusive $1,080

• Delta Air Lines DL4901 / DL160 / KL1579: MDW 2027-04-12 12:30:00 → LIS 2027-04-13 10:30:00; 2 stop(s) via MSP, AMS; 960 minutes. Local airport times.
  • DL4901: MDW 2027-04-12 12:30:00 → MSP 2027-04-12 14:10:00; layover at MSP: 80 minutes.
  • DL160: MSP 2027-04-12 15:30:00 → AMS 2027-04-13 06:50:00; layover at AMS: 100 minutes.
  • KL1579: AMS 2027-04-13 08:30:00 → LIS 2027-04-13 10:30:00.
• KLM Royal Dutch Airlines KL1578 / DL161 / DL4714: LIS 2027-04-23 05:00:00 → MDW 2027-04-23 16:39:00; 2 stop(s) via AMS, MSP; 1059 minutes. Local airport times.
  • KL1578: LIS 2027-04-23 05:00:00 → AMS 2027-04-23 09:00:00; layover at AMS: 85 minutes.
  • DL161: AMS 2027-04-23 10:25:00 → MSP 2027-04-23 12:42:00; layover at MSP: 138 minutes.
  • DL4714: MSP 2027-04-23 15:00:00 → MDW 2027-04-23 16:39:00.

2027-04-12 → 2027-04-25 · Axel-exclusive $1,080

• Delta Air Lines DL4901 / DL160 / KL1579: MDW 2027-04-12 12:30:00 → LIS 2027-04-13 10:30:00; 2 stop(s) via MSP, AMS; 960 minutes. Local airport times.
  • DL4901: MDW 2027-04-12 12:30:00 → MSP 2027-04-12 14:10:00; layover at MSP: 80 minutes.
  • DL160: MSP 2027-04-12 15:30:00 → AMS 2027-04-13 06:50:00; layover at AMS: 100 minutes.
  • KL1579: AMS 2027-04-13 08:30:00 → LIS 2027-04-13 10:30:00.
• KLM Royal Dutch Airlines KL1578 / DL161 / DL4714: LIS 2027-04-25 05:00:00 → MDW 2027-04-25 16:39:00; 2 stop(s) via AMS, MSP; 1059 minutes. Local airport times.
  • KL1578: LIS 2027-04-25 05:00:00 → AMS 2027-04-25 09:00:00; layover at AMS: 85 minutes.
  • DL161: AMS 2027-04-25 10:25:00 → MSP 2027-04-25 12:42:00; layover at MSP: 138 minutes.
  • DL4714: MSP 2027-04-25 15:00:00 → MDW 2027-04-25 16:39:00.

2027-04-12 → 2027-04-26 · Axel-exclusive $1,095

• Delta Air Lines DL4901 / DL160 / KL1579: MDW 2027-04-12 12:30:00 → LIS 2027-04-13 10:30:00; 2 stop(s) via MSP, AMS; 960 minutes. Local airport times.
  • DL4901: MDW 2027-04-12 12:30:00 → MSP 2027-04-12 14:10:00; layover at MSP: 80 minutes.
  • DL160: MSP 2027-04-12 15:30:00 → AMS 2027-04-13 06:50:00; layover at AMS: 100 minutes.
  • KL1579: AMS 2027-04-13 08:30:00 → LIS 2027-04-13 10:30:00.
• Air France AF1125 / DL229 / DL4677: LIS 2027-04-26 05:30:00 → MDW 2027-04-26 18:01:00; 2 stop(s) via CDG, DTW; 1111 minutes. Local airport times.
  • AF1125: LIS 2027-04-26 05:30:00 → CDG 2027-04-26 09:10:00; layover at CDG: 80 minutes.
  • DL229: CDG 2027-04-26 10:30:00 → DTW 2027-04-26 13:45:00; layover at DTW: 235 minutes.
  • DL4677: DTW 2027-04-26 17:40:00 → MDW 2027-04-26 18:01:00.

2027-04-12 → 2027-05-10 · Axel-exclusive $1,095

• Delta Air Lines DL4901 / DL160 / KL1579: MDW 2027-04-12 12:30:00 → LIS 2027-04-13 10:30:00; 2 stop(s) via MSP, AMS; 960 minutes. Local airport times.
  • DL4901: MDW 2027-04-12 12:30:00 → MSP 2027-04-12 14:10:00; layover at MSP: 80 minutes.
  • DL160: MSP 2027-04-12 15:30:00 → AMS 2027-04-13 06:50:00; layover at AMS: 100 minutes.
  • KL1579: AMS 2027-04-13 08:30:00 → LIS 2027-04-13 10:30:00.
• Air France AF1125 / DL229 / DL4677: LIS 2027-05-10 05:30:00 → MDW 2027-05-10 18:01:00; 2 stop(s) via CDG, DTW; 1111 minutes. Local airport times.
  • AF1125: LIS 2027-05-10 05:30:00 → CDG 2027-05-10 09:10:00; layover at CDG: 80 minutes.
  • DL229: CDG 2027-05-10 10:30:00 → DTW 2027-05-10 13:45:00; layover at DTW: 235 minutes.
  • DL4677: DTW 2027-05-10 17:40:00 → MDW 2027-05-10 18:01:00.

Explore this route

• All dates for this route
• Apr 11, 2027 · Return options
• Apr 13, 2027 · Return options
• Hotels in Lisbon with Axel

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• This page: Chicago (MDW) to Lisbon (LIS) · Apr 12, 2027 · choose your return date: 1 adult in economy, every priced fare with its flights, times and total, each with its displayed check date. Under a trip, hotels in Lisbon for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in each star tier for those dates.
• Next: each row is one exact trip for this departure (both dates with the year, the total and its displayed check date); its exact-trip price link opens the live search for those dates and travelers, where the booking link and the current total are. Other durations or travelers are not priced here: Choose travelers and dates prices the requested trip.
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