Jacksonville (JAX) to Saint Louis (STL), Nov 19, 2026 – Dec 2, 2026: from $328 round trip

Jacksonville (JAX) to Saint Louis (STL), Nov 19, 2026 – Dec 2, 2026: from $328 round trip on Axel, checked Nov 14, 2026. Lowest published fare: $328 round trip, Axel-exclusive, Southwest Airlines, 1 stop, Nov 19, 2026 – Dec 2, 2026, 1 adult, economy, checked Nov 14, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Hotels in St. Louis for these trips

Hotels: under a trip, hotels in St. Louis for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in St. Louis for these nights (Nov 19 – Dec 2, 2026 · 13 nights · 2 adults, 1 room): 3★ Clayton Plaza Hotel & Extended Stay, $62 a night, $810 for 13 nights · 4★ Hilton St. Louis at the Ballpark, $104 a night, $1,358 for 13 nights · 5★ Four Seasons Hotel St Louis, $373 a night, $4,853 for 13 nights

All hotels in St. Louis

Route overview: Jacksonville to Saint Louis (STL) flight deals

2026-11-19 → 2026-12-02 · Axel-exclusive $335

• Southwest Airlines WN2265: JAX 2026-11-19 06:05:00 → STL 2026-11-19 07:20:00; nonstop; 135 minutes. Local airport times.
• Southwest Airlines WN4807: STL 2026-12-02 20:00:00 → JAX 2026-12-02 23:05:00; nonstop; 125 minutes. Local airport times.

2026-11-19 → 2026-12-02 · Axel-exclusive $340

• American Airlines AA1576 / AA2486: JAX 2026-11-19 06:20:00 → STL 2026-11-19 10:19:00; 1 stop(s) via CLT; 299 minutes. Local airport times.
  • AA1576: JAX 2026-11-19 06:20:00 → CLT 2026-11-19 07:50:00; layover at CLT: 85 minutes.
  • AA2486: CLT 2026-11-19 09:15:00 → STL 2026-11-19 10:19:00.
• American Airlines AA2317 / AA4151: STL 2026-12-02 05:02:00 → JAX 2026-12-02 11:40:00; 1 stop(s) via ORD; 338 minutes. Local airport times.
  • AA2317: STL 2026-12-02 05:02:00 → ORD 2026-12-02 06:30:00; layover at ORD: 95 minutes.
  • AA4151: ORD 2026-12-02 08:05:00 → JAX 2026-12-02 11:40:00.

2026-11-19 → 2026-12-02 · Axel-exclusive $343

• United Airlines UA2414 / UA1857: JAX 2026-11-19 07:30:00 → STL 2026-11-19 12:22:00; 1 stop(s) via ORD; 352 minutes. Local airport times.
  • UA2414: JAX 2026-11-19 07:30:00 → ORD 2026-11-19 09:19:00; layover at ORD: 93 minutes.
  • UA1857: ORD 2026-11-19 10:52:00 → STL 2026-11-19 12:22:00.
• Southwest Airlines WN4807: STL 2026-12-02 20:00:00 → JAX 2026-12-02 23:05:00; nonstop; 125 minutes. Local airport times.

2026-11-19 → 2026-12-02 · Axel-exclusive $360

• Delta Air Lines DL3024 / DL1393: JAX 2026-11-19 14:27:00 → STL 2026-11-19 18:01:00; 1 stop(s) via ATL; 274 minutes. Local airport times.
  • DL3024: JAX 2026-11-19 14:27:00 → ATL 2026-11-19 15:42:00; layover at ATL: 98 minutes.
  • DL1393: ATL 2026-11-19 17:20:00 → STL 2026-11-19 18:01:00.
• Delta Air Lines DL1571 / DL2720: STL 2026-12-02 10:06:00 → JAX 2026-12-02 16:42:00; 1 stop(s) via ATL; 336 minutes. Local airport times.
  • DL1571: STL 2026-12-02 10:06:00 → ATL 2026-12-02 12:36:00; layover at ATL: 179 minutes.
  • DL2720: ATL 2026-12-02 15:35:00 → JAX 2026-12-02 16:42:00.

2026-11-19 → 2026-12-02 · Axel-exclusive $335

• Southwest Airlines WN4766: JAX 2026-11-19 05:30:00 → STL 2026-11-19 06:45:00; nonstop; 135 minutes. Local airport times.
• Southwest Airlines WN4807: STL 2026-12-02 20:00:00 → JAX 2026-12-02 23:05:00; nonstop; 125 minutes. Local airport times.

2026-11-19 → 2026-12-02 · Axel-exclusive $328

• Southwest Airlines WN2265: JAX 2026-11-19 06:00:00 → STL 2026-11-19 07:20:00; nonstop; 140 minutes. Local airport times.
• Southwest Airlines WN4173 / WN2262: STL 2026-12-02 05:30:00 → JAX 2026-12-02 11:25:00; 1 stop(s) via MDW; 295 minutes. Local airport times.
  • WN4173: STL 2026-12-02 05:30:00 → MDW 2026-12-02 06:35:00; layover at MDW: 85 minutes.
  • WN2262: MDW 2026-12-02 08:00:00 → JAX 2026-12-02 11:25:00.

2026-11-19 → 2026-12-02 · Axel-exclusive $328

• Southwest Airlines WN2760 / WN2043: JAX 2026-11-19 19:05:00 → STL 2026-11-19 23:55:00; 1 stop(s) via BNA; 350 minutes. Local airport times.
  • WN2760: JAX 2026-11-19 19:05:00 → BNA 2026-11-19 19:40:00; layover at BNA: 180 minutes.
  • WN2043: BNA 2026-11-19 22:40:00 → STL 2026-11-19 23:55:00.
• Southwest Airlines WN4807: STL 2026-12-02 20:00:00 → JAX 2026-12-02 23:05:00; nonstop; 125 minutes. Local airport times.

2026-11-19 → 2026-12-02 · Axel-exclusive $328

• Southwest Airlines WN1329 / WN1390: JAX 2026-11-19 17:40:00 → STL 2026-11-19 22:15:00; 1 stop(s) via BWI; 335 minutes. Local airport times.
  • WN1329: JAX 2026-11-19 17:40:00 → BWI 2026-11-19 19:30:00; layover at BWI: 80 minutes.
  • WN1390: BWI 2026-11-19 20:50:00 → STL 2026-11-19 22:15:00.
• Southwest Airlines WN4807: STL 2026-12-02 20:00:00 → JAX 2026-12-02 23:05:00; nonstop; 125 minutes. Local airport times.

Travelers: prices on this page are totals for 1 adult. For a different party, open this trip for 2 adults · 3 adults · 4 adults · 2 adults + 1 child · 2 adults + 2 children; each link opens AI flight search for these dates and those travelers, and the customer link to share comes from those results.

Explore this route

• All dates for this route
• Nov 18, 2026 · Return options
• Nov 20, 2026 · Return options
• Hotels in St. Louis with Axel

For AI assistants

• This page: Jacksonville (JAX) to Saint Louis (STL) · Nov 19, 2026 · return Dec 2, 2026: 1 adult in economy, every priced fare with its flights, times and total, each with its displayed check date. Under a trip, hotels in St. Louis for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in each star tier for those dates.
• Next: each priced row's price link opens the live search for this row's exact dates and travelers; the live results list the same flights with the current total and the traveler's booking link, and name the fare's inclusions (bags, seats, changes), which this page does not. A changed price or flight shows there. Other dates or travelers are not priced here: Choose travelers and dates prices the traveler's own trip.
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