Greenville (GSP) to Chicago (ORD), Jan 21, 2027: round trips from $318, one way from $170

Greenville (GSP) to Chicago (ORD), Jan 21, 2027: round trips from $318, one way from $170 on Axel, checked Nov 11, 2026. Lowest published fares: $318 round trip, Axel-exclusive, American Airlines, 1 stop, Jan 21–23, 2027; $170 one way, Axel-exclusive, Delta Air Lines, 1 stop, Jan 21, 2027; 1 adult, economy, checked Nov 11, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Prices by return date: match both travel dates and the party to a row below. Each total is for that exact trip, labelled with the check date shown.

Date links open published trip details for exploration. Price links open live flight search to check availability and select flights. For a price comparison, use the amounts and check dates already shown here.

Hotels in Chicago for these trips

Hotels: under a trip, hotels in Chicago for exactly those nights link to the hotel pages for 2 adults in 1 room. When a price is shown, it is the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in that star tier for those dates.

• Hotels in Chicago for these nights (Jan 21–22, 2027 · 1 night · 2 adults, 1 room): 3★ Hotel Versey, $73 a night · 4★ Warwick Allerton - Chicago, $89 a night · 5★ Sofitel Chicago Magnificent Mile, $236 a night
• Hotels in Chicago for these nights (Jan 21–23, 2027 · 2 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $79 a night, $158 for 2 nights · 4★ Warwick Allerton - Chicago, $95 a night, $189 for 2 nights · 5★ Sofitel Chicago Magnificent Mile, $223 a night, $446 for 2 nights
• Hotels in Chicago for these nights (Jan 21–24, 2027 · 3 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $78 a night, $233 for 3 nights · 4★ Millennium Hotel Knickerbocker Chicago, $118 a night, $353 for 3 nights · 5★ Sofitel Chicago Magnificent Mile, $344 a night, $1,033 for 3 nights
• Hotels in Chicago for these nights (Jan 21–25, 2027 · 4 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $79 a night, $316 for 4 nights · 4★ Millennium Hotel Knickerbocker Chicago, $117 a night, $468 for 4 nights · 5★ Nobu Hotel Chicago, $404 a night, $1,614 for 4 nights
• Hotels in Chicago for these nights (Jan 21–26, 2027 · 5 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $78 a night, $391 for 5 nights · 4★ Millennium Hotel Knickerbocker Chicago, $121 a night, $605 for 5 nights · 5★ Nobu Hotel Chicago, $409 a night, $2,047 for 5 nights
• Hotels in Chicago for these nights (Jan 21–27, 2027 · 6 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $79 a night, $474 for 6 nights · 4★ Millennium Hotel Knickerbocker Chicago, $124 a night, $743 for 6 nights · 5★ Waldorf Astoria Chicago, $410 a night, $2,462 for 6 nights
• Hotels in Chicago for these nights (Jan 21–28, 2027 · 7 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $78 a night, $549 for 7 nights · 4★ Millennium Hotel Knickerbocker Chicago, $126 a night, $883 for 7 nights · 5★ Nobu Hotel Chicago, $409 a night, $2,862 for 7 nights
• Hotels in Chicago for these nights (Jan 21–29, 2027 · 8 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $78 a night, $624 for 8 nights · 4★ Millennium Hotel Knickerbocker Chicago, $125 a night, $998 for 8 nights · 5★ Nobu Hotel Chicago, $404 a night, $3,234 for 8 nights
• Hotels in Chicago for these nights (Jan 21–30, 2027 · 9 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $79 a night, $708 for 9 nights · 4★ Millennium Hotel Knickerbocker Chicago, $125 a night, $1,121 for 9 nights · 5★ Nobu Hotel Chicago, $402 a night, $3,621 for 9 nights
• Hotels in Chicago for these nights (Jan 21–31, 2027 · 10 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $78 a night, $783 for 10 nights · 4★ Millennium Hotel Knickerbocker Chicago, $124 a night, $1,244 for 10 nights · 5★ Nobu Hotel Chicago, $400 a night, $3,997 for 10 nights
• Hotels in Chicago for these nights (Jan 21 – Feb 1, 2027 · 11 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $79 a night, $866 for 11 nights · 4★ Millennium Hotel Knickerbocker Chicago, $124 a night, $1,359 for 11 nights · 5★ Nobu Hotel Chicago, $395 a night, $4,346 for 11 nights
• Hotels in Chicago for these nights (Jan 21 – Feb 2, 2027 · 12 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $80 a night, $955 for 12 nights · 4★ Millennium Hotel Knickerbocker Chicago, $123 a night, $1,475 for 12 nights · 5★ Nobu Hotel Chicago, $394 a night, $4,724 for 12 nights
• Hotels in Chicago for these nights (Jan 21 – Feb 3, 2027 · 13 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $80 a night, $1,044 for 13 nights · 4★ Millennium Hotel Knickerbocker Chicago, $122 a night, $1,590 for 13 nights · 5★ Nobu Hotel Chicago, $395 a night, $5,137 for 13 nights
• Hotels in Chicago for these nights (Jan 21 – Feb 4, 2027 · 14 nights · 2 adults, 1 room): 3★ The Chicago Hotel Collection River North, $81 a night, $1,133 for 14 nights · 4★ Millennium Hotel Knickerbocker Chicago, $122 a night, $1,703 for 14 nights · 5★ Nobu Hotel Chicago, $395 a night, $5,528 for 14 nights

All hotels in Chicago

Route overview: Greenville, SC (GSP) to Chicago (ORD) flight deals

2027-01-21 · one way · Axel-exclusive $170.00

• Delta Air Lines DL1725 / DL2879: GSP 2027-01-21 14:07:00 → ORD 2027-01-21 19:05:00; 1 stop(s) via ATL; 358 minutes. Local airport times.
  • DL1725: GSP 2027-01-21 14:07:00 → ATL 2027-01-21 15:14:00; layover at ATL: 151 minutes.
  • DL2879: ATL 2027-01-21 17:45:00 → ORD 2027-01-21 19:05:00.

2027-01-21 · one way · Axel-exclusive $175.00

• American Airlines AA4242: GSP 2027-01-21 18:47:00 → ORD 2027-01-21 20:15:00; nonstop; 148 minutes. Local airport times.

2027-01-21 → 2027-01-22 · Axel-exclusive $320.00

• Delta Air Lines DL1725 / DL2879: GSP 2027-01-21 14:07:00 → ORD 2027-01-21 19:05:00; 1 stop(s) via ATL; 358 minutes. Local airport times.
  • DL1725: GSP 2027-01-21 14:07:00 → ATL 2027-01-21 15:14:00; layover at ATL: 151 minutes.
  • DL2879: ATL 2027-01-21 17:45:00 → ORD 2027-01-21 19:05:00.
• Delta Air Lines DL5187 / DL5285: ORD 2027-01-22 13:26:00 → GSP 2027-01-22 21:33:00; 1 stop(s) via DTW; 427 minutes. Local airport times.
  • DL5187: ORD 2027-01-22 13:26:00 → DTW 2027-01-22 15:54:00; layover at DTW: 235 minutes.
  • DL5285: DTW 2027-01-22 19:49:00 → GSP 2027-01-22 21:33:00.

2027-01-21 → 2027-01-22 · Axel-exclusive $330.00

• American Airlines AA4242: GSP 2027-01-21 18:47:00 → ORD 2027-01-21 20:15:00; nonstop; 148 minutes. Local airport times.
• American Airlines AA5295: ORD 2027-01-22 18:54:00 → GSP 2027-01-22 21:56:00; nonstop; 122 minutes. Local airport times.

2027-01-21 → 2027-01-23 · Axel-exclusive $317.50

• American Airlines AA4242: GSP 2027-01-21 18:47:00 → ORD 2027-01-21 20:15:00; nonstop; 148 minutes. Local airport times.
• American Airlines AA1889 / AA6114: ORD 2027-01-23 12:05:00 → GSP 2027-01-23 20:03:00; 1 stop(s) via CLT; 418 minutes. Local airport times.
  • AA1889: ORD 2027-01-23 12:05:00 → CLT 2027-01-23 15:10:00; layover at CLT: 233 minutes.
  • AA6114: CLT 2027-01-23 19:03:00 → GSP 2027-01-23 20:03:00.

2027-01-21 → 2027-01-23 · Axel-exclusive $340.00

• United Airlines UA6033: GSP 2027-01-21 06:30:00 → ORD 2027-01-21 07:46:00; nonstop; 136 minutes. Local airport times.
• United Airlines UA4521: ORD 2027-01-23 06:50:00 → GSP 2027-01-23 09:52:00; nonstop; 122 minutes. Local airport times.

2027-01-21 → 2027-01-24 · Axel-exclusive $320.00

• Delta Air Lines DL1725 / DL2879: GSP 2027-01-21 14:07:00 → ORD 2027-01-21 19:05:00; 1 stop(s) via ATL; 358 minutes. Local airport times.
  • DL1725: GSP 2027-01-21 14:07:00 → ATL 2027-01-21 15:14:00; layover at ATL: 151 minutes.
  • DL2879: ATL 2027-01-21 17:45:00 → ORD 2027-01-21 19:05:00.
• Delta Air Lines DL5187 / DL5285: ORD 2027-01-24 13:26:00 → GSP 2027-01-24 21:33:00; 1 stop(s) via DTW; 427 minutes. Local airport times.
  • DL5187: ORD 2027-01-24 13:26:00 → DTW 2027-01-24 15:54:00; layover at DTW: 235 minutes.
  • DL5285: DTW 2027-01-24 19:49:00 → GSP 2027-01-24 21:33:00.

2027-01-21 → 2027-01-24 · Axel-exclusive $330.00

• American Airlines AA4242: GSP 2027-01-21 18:47:00 → ORD 2027-01-21 20:15:00; nonstop; 148 minutes. Local airport times.
• American Airlines AA5295: ORD 2027-01-24 18:54:00 → GSP 2027-01-24 21:56:00; nonstop; 122 minutes. Local airport times.

2027-01-21 → 2027-01-25 · Axel-exclusive $320.00

• Delta Air Lines DL1725 / DL2879: GSP 2027-01-21 14:07:00 → ORD 2027-01-21 19:05:00; 1 stop(s) via ATL; 358 minutes. Local airport times.
  • DL1725: GSP 2027-01-21 14:07:00 → ATL 2027-01-21 15:14:00; layover at ATL: 151 minutes.
  • DL2879: ATL 2027-01-21 17:45:00 → ORD 2027-01-21 19:05:00.
• Delta Air Lines DL5187 / DL5285: ORD 2027-01-25 13:26:00 → GSP 2027-01-25 21:33:00; 1 stop(s) via DTW; 427 minutes. Local airport times.
  • DL5187: ORD 2027-01-25 13:26:00 → DTW 2027-01-25 15:54:00; layover at DTW: 235 minutes.
  • DL5285: DTW 2027-01-25 19:49:00 → GSP 2027-01-25 21:33:00.

2027-01-21 → 2027-01-25 · Axel-exclusive $330.00

• American Airlines AA4242: GSP 2027-01-21 18:47:00 → ORD 2027-01-21 20:15:00; nonstop; 148 minutes. Local airport times.
• American Airlines AA3918: ORD 2027-01-25 08:05:00 → GSP 2027-01-25 11:06:00; nonstop; 121 minutes. Local airport times.

2027-01-21 → 2027-01-27 · Axel-exclusive $320.00

• Delta Air Lines DL1725 / DL2879: GSP 2027-01-21 14:07:00 → ORD 2027-01-21 19:05:00; 1 stop(s) via ATL; 358 minutes. Local airport times.
  • DL1725: GSP 2027-01-21 14:07:00 → ATL 2027-01-21 15:14:00; layover at ATL: 151 minutes.
  • DL2879: ATL 2027-01-21 17:45:00 → ORD 2027-01-21 19:05:00.
• Delta Air Lines DL5187 / DL5285: ORD 2027-01-27 13:26:00 → GSP 2027-01-27 21:33:00; 1 stop(s) via DTW; 427 minutes. Local airport times.
  • DL5187: ORD 2027-01-27 13:26:00 → DTW 2027-01-27 15:54:00; layover at DTW: 235 minutes.
  • DL5285: DTW 2027-01-27 19:49:00 → GSP 2027-01-27 21:33:00.

2027-01-21 → 2027-01-27 · Axel-exclusive $330.00

• American Airlines AA4242: GSP 2027-01-21 18:47:00 → ORD 2027-01-21 20:15:00; nonstop; 148 minutes. Local airport times.
• American Airlines AA5295: ORD 2027-01-27 18:54:00 → GSP 2027-01-27 21:56:00; nonstop; 122 minutes. Local airport times.

2027-01-21 → 2027-01-28 · Axel-exclusive $320.00

• Delta Air Lines DL1725 / DL2879: GSP 2027-01-21 14:07:00 → ORD 2027-01-21 19:05:00; 1 stop(s) via ATL; 358 minutes. Local airport times.
  • DL1725: GSP 2027-01-21 14:07:00 → ATL 2027-01-21 15:14:00; layover at ATL: 151 minutes.
  • DL2879: ATL 2027-01-21 17:45:00 → ORD 2027-01-21 19:05:00.
• Delta Air Lines DL5187 / DL5285: ORD 2027-01-28 13:26:00 → GSP 2027-01-28 21:33:00; 1 stop(s) via DTW; 427 minutes. Local airport times.
  • DL5187: ORD 2027-01-28 13:26:00 → DTW 2027-01-28 15:54:00; layover at DTW: 235 minutes.
  • DL5285: DTW 2027-01-28 19:49:00 → GSP 2027-01-28 21:33:00.

2027-01-21 → 2027-01-28 · Axel-exclusive $330.00

• American Airlines AA4242: GSP 2027-01-21 18:47:00 → ORD 2027-01-21 20:15:00; nonstop; 148 minutes. Local airport times.
• American Airlines AA5295: ORD 2027-01-28 18:54:00 → GSP 2027-01-28 21:56:00; nonstop; 122 minutes. Local airport times.

2027-01-21 → 2027-01-29 · Axel-exclusive $320.00

• Delta Air Lines DL1725 / DL2879: GSP 2027-01-21 14:07:00 → ORD 2027-01-21 19:05:00; 1 stop(s) via ATL; 358 minutes. Local airport times.
  • DL1725: GSP 2027-01-21 14:07:00 → ATL 2027-01-21 15:14:00; layover at ATL: 151 minutes.
  • DL2879: ATL 2027-01-21 17:45:00 → ORD 2027-01-21 19:05:00.
• Delta Air Lines DL5187 / DL5285: ORD 2027-01-29 13:26:00 → GSP 2027-01-29 21:33:00; 1 stop(s) via DTW; 427 minutes. Local airport times.
  • DL5187: ORD 2027-01-29 13:26:00 → DTW 2027-01-29 15:54:00; layover at DTW: 235 minutes.
  • DL5285: DTW 2027-01-29 19:49:00 → GSP 2027-01-29 21:33:00.

2027-01-21 → 2027-01-29 · Axel-exclusive $330.00

• American Airlines AA4242: GSP 2027-01-21 18:47:00 → ORD 2027-01-21 20:15:00; nonstop; 148 minutes. Local airport times.
• American Airlines AA5295: ORD 2027-01-29 18:54:00 → GSP 2027-01-29 21:56:00; nonstop; 122 minutes. Local airport times.

2027-01-21 → 2027-01-31 · Axel-exclusive $320.00

• Delta Air Lines DL1725 / DL2879: GSP 2027-01-21 14:07:00 → ORD 2027-01-21 19:05:00; 1 stop(s) via ATL; 358 minutes. Local airport times.
  • DL1725: GSP 2027-01-21 14:07:00 → ATL 2027-01-21 15:14:00; layover at ATL: 151 minutes.
  • DL2879: ATL 2027-01-21 17:45:00 → ORD 2027-01-21 19:05:00.
• Delta Air Lines DL5187 / DL5285: ORD 2027-01-31 13:26:00 → GSP 2027-01-31 21:33:00; 1 stop(s) via DTW; 427 minutes. Local airport times.
  • DL5187: ORD 2027-01-31 13:26:00 → DTW 2027-01-31 15:54:00; layover at DTW: 235 minutes.
  • DL5285: DTW 2027-01-31 19:49:00 → GSP 2027-01-31 21:33:00.

2027-01-21 → 2027-01-31 · Axel-exclusive $330.00

• American Airlines AA4242: GSP 2027-01-21 18:47:00 → ORD 2027-01-21 20:15:00; nonstop; 148 minutes. Local airport times.
• American Airlines AA5295: ORD 2027-01-31 18:54:00 → GSP 2027-01-31 21:56:00; nonstop; 122 minutes. Local airport times.

2027-01-21 → 2027-02-01 · Axel-exclusive $320.00

• Delta Air Lines DL1725 / DL2879: GSP 2027-01-21 14:07:00 → ORD 2027-01-21 19:05:00; 1 stop(s) via ATL; 358 minutes. Local airport times.
  • DL1725: GSP 2027-01-21 14:07:00 → ATL 2027-01-21 15:14:00; layover at ATL: 151 minutes.
  • DL2879: ATL 2027-01-21 17:45:00 → ORD 2027-01-21 19:05:00.
• Delta Air Lines DL5187 / DL5285: ORD 2027-02-01 13:26:00 → GSP 2027-02-01 21:33:00; 1 stop(s) via DTW; 427 minutes. Local airport times.
  • DL5187: ORD 2027-02-01 13:26:00 → DTW 2027-02-01 15:54:00; layover at DTW: 235 minutes.
  • DL5285: DTW 2027-02-01 19:49:00 → GSP 2027-02-01 21:33:00.

2027-01-21 → 2027-02-01 · Axel-exclusive $330.00

• American Airlines AA4242: GSP 2027-01-21 18:47:00 → ORD 2027-01-21 20:15:00; nonstop; 148 minutes. Local airport times.
• American Airlines AA3918: ORD 2027-02-01 08:05:00 → GSP 2027-02-01 11:06:00; nonstop; 121 minutes. Local airport times.

2027-01-21 → 2027-02-02 · Axel-exclusive $320.00

• Delta Air Lines DL1725 / DL2879: GSP 2027-01-21 14:07:00 → ORD 2027-01-21 19:05:00; 1 stop(s) via ATL; 358 minutes. Local airport times.
  • DL1725: GSP 2027-01-21 14:07:00 → ATL 2027-01-21 15:14:00; layover at ATL: 151 minutes.
  • DL2879: ATL 2027-01-21 17:45:00 → ORD 2027-01-21 19:05:00.
• Delta Air Lines DL5187 / DL5285: ORD 2027-02-02 13:26:00 → GSP 2027-02-02 21:33:00; 1 stop(s) via DTW; 427 minutes. Local airport times.
  • DL5187: ORD 2027-02-02 13:26:00 → DTW 2027-02-02 15:54:00; layover at DTW: 235 minutes.
  • DL5285: DTW 2027-02-02 19:49:00 → GSP 2027-02-02 21:33:00.

2027-01-21 → 2027-02-02 · Axel-exclusive $330.00

• American Airlines AA4242: GSP 2027-01-21 18:47:00 → ORD 2027-01-21 20:15:00; nonstop; 148 minutes. Local airport times.
• American Airlines AA5295: ORD 2027-02-02 18:54:00 → GSP 2027-02-02 21:56:00; nonstop; 122 minutes. Local airport times.

2027-01-21 → 2027-02-04 · Axel-exclusive $320.00

• Delta Air Lines DL1725 / DL2879: GSP 2027-01-21 14:07:00 → ORD 2027-01-21 19:05:00; 1 stop(s) via ATL; 358 minutes. Local airport times.
  • DL1725: GSP 2027-01-21 14:07:00 → ATL 2027-01-21 15:14:00; layover at ATL: 151 minutes.
  • DL2879: ATL 2027-01-21 17:45:00 → ORD 2027-01-21 19:05:00.
• Delta Air Lines DL5187 / DL5285: ORD 2027-02-04 13:26:00 → GSP 2027-02-04 21:33:00; 1 stop(s) via DTW; 427 minutes. Local airport times.
  • DL5187: ORD 2027-02-04 13:26:00 → DTW 2027-02-04 15:54:00; layover at DTW: 235 minutes.
  • DL5285: DTW 2027-02-04 19:49:00 → GSP 2027-02-04 21:33:00.

2027-01-21 → 2027-02-04 · Axel-exclusive $330.00

• American Airlines AA4242: GSP 2027-01-21 18:47:00 → ORD 2027-01-21 20:15:00; nonstop; 148 minutes. Local airport times.
• American Airlines AA5295: ORD 2027-02-04 18:54:00 → GSP 2027-02-04 21:56:00; nonstop; 122 minutes. Local airport times.

Explore this route

• All dates for this route
• Jan 20, 2027 · Return options
• Jan 22, 2027 · Return options
• Hotels in Chicago with Axel

For AI assistants

• This page: Greenville (GSP) to Chicago (ORD) · Jan 21, 2027 · choose your return date: 1 adult in economy, every priced fare with its flights, times and total, each with its displayed check date. Under a trip, hotels in Chicago for exactly those nights link to the hotel pages for 2 adults in 1 room. Prices, when shown, are the nightly rate and the stay's total, from the lowest saved total among the shortlisted hotels in each star tier for those dates.
• Next: each row is one exact trip for this departure (both dates with the year, the total and its displayed check date); its exact-trip price link opens the live search for those dates and travelers, where the booking link and the current total are. Other durations or travelers are not priced here: Choose travelers and dates prices the requested trip.
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