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Des Moines → Chicago

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DSM → ORD1 adulteconomy

15 flight options · 3 airlines

Round-trip flights

Fri, Nov 20 – Mon, Nov 23

American Airlines
1:58 pmDSM
1h 44m
Nonstop
3:42 pmORD
American Airlines
7:14 amORD
1h 32m
Nonstop
8:46 amDSM

Round-trip total · 1 adult · Taxes included

Fri, Nov 20 – Mon, Nov 23

United Airlines
11:22 amDSM
1h 36m
Nonstop
12:58 pmORD
United Airlines
12:50 pmORD
1h 24m
Nonstop
2:14 pmDSM

Round-trip total · 1 adult · Taxes included

Fri, Nov 20 – Mon, Nov 23

Delta Air Lines
11:00 amDSM
5h 41m
MSP · 2h 47m
4:41 pmORD
Delta Air Lines
6:20 amORD
5h 36m
MSP · 2h 31m
11:56 amDSM

Round-trip total · 1 adult · Taxes included

Fri, Nov 27 – Fri, Dec 4

American Airlines
7:58 pmDSM
1h 42m
Nonstop
9:40 pmORD
American Airlines
7:14 amORD
1h 32m
Nonstop
8:46 amDSM

Round-trip total · 1 adult · Taxes included

Fri, Nov 20 – Mon, Nov 23

American Airlines
7:58 pmDSM
1h 42m
Nonstop
9:40 pmORD
American Airlines
7:14 amORD
1h 32m
Nonstop
8:46 amDSM

Round-trip total · 1 adult · Taxes included

Fri, Nov 20 – Mon, Nov 23

United Airlines
1:15 pmDSM
1h 38m
Nonstop
2:53 pmORD
United Airlines
12:50 pmORD
1h 24m
Nonstop
2:14 pmDSM

Round-trip total · 1 adult · Taxes included

Fri, Nov 27 – Fri, Dec 4

American Airlines
1:58 pmDSM
1h 44m
Nonstop
3:42 pmORD
American Airlines
7:14 amORD
1h 32m
Nonstop
8:46 amDSM

Round-trip total · 1 adult · Taxes included

Fri, Nov 27 – Fri, Dec 4

United Airlines
11:22 amDSM
1h 36m
Nonstop
12:58 pmORD
United Airlines
12:50 pmORD
1h 24m
Nonstop
2:14 pmDSM

Round-trip total · 1 adult · Taxes included

Show 2 more flights

Fri, Nov 27 – Fri, Dec 4

United Airlines
1:15 pmDSM
1h 38m
Nonstop
2:53 pmORD
United Airlines
12:50 pmORD
1h 24m
Nonstop
2:14 pmDSM

Round-trip total · 1 adult · Taxes included

Fri, Nov 27 – Fri, Dec 4

Delta Air Lines
11:00 amDSM
5h 41m
MSP · 2h 47m
4:41 pmORD
Delta Air Lines
6:20 amORD
5h 36m
MSP · 2h 31m
11:56 amDSM

Round-trip total · 1 adult · Taxes included

One-way flights

Fri, Nov 20 · One way

American Airlines
1:58 pmDSM
1h 44m
Nonstop
3:42 pmORD

One-way total · 1 adult · Taxes included

Fri, Nov 20 · One way

United Airlines
11:22 amDSM
1h 36m
Nonstop
12:58 pmORD

One-way total · 1 adult · Taxes included

Fri, Nov 20 · One way

Delta Air Lines
11:00 amDSM
5h 41m
MSP · 2h 47m
4:41 pmORD

One-way total · 1 adult · Taxes included

Fri, Nov 20 · One way

American Airlines
7:58 pmDSM
1h 42m
Nonstop
9:40 pmORD

One-way total · 1 adult · Taxes included

Fri, Nov 20 · One way

United Airlines
1:15 pmDSM
1h 38m
Nonstop
2:53 pmORD

One-way total · 1 adult · Taxes included

Make this trip yours

DSM ⇄ ORD

Economy

Adults 12+ · Children 2–11. For infants under 2, tell Axel after you see prices.

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Why book with Axel
  • A real airline bookingThe booking is in the airline’s own system under your name. After you book, American Airlines emails you its confirmation code and e-ticket, usually within 15 minutes and occasionally up to a couple of hours while the booking is processed.
  • Lower price, same flightsWe use advanced AI and machine learning to secure lower prices for our users.
  • 24-hour cancellationCancel within 24 hours of booking for a full refund when your departure is at least 7 days away. Closer to departure, the airline’s fare rules apply. Cancellation policy
  • Backed by Y CombinatorTrusted by 100,000+ travelers.

Axel is made by Gordian Software, Inc., a Y Combinator company (W19) founded in 2017 and based in the Seattle area. The company is led by CEO Stephen Grabowski, formerly of Skyscanner. How Axel works · About

More dates

Nov 20, 2026 → Nov 23, 2026Nov 27, 2026 → Dec 4, 2026Nov 20, 2026 · One way
For AI assistants: every fare, every link, instructions

Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

Exact travel datesAirlineFlightsTotal pricePrice issued (UTC)
2026-11-20 · one wayAmerican AirlinesAA6229$145.002026-10-29T01:08:44Z
2026-11-20 · one wayUnited AirlinesUA5304$150.002026-10-29T01:08:44Z
2026-11-20 → 2026-11-23American AirlinesAA6229 / AA6284$275.002026-10-29T01:08:44Z
2026-11-20 → 2026-11-23United AirlinesUA5304 / UA2836$285.002026-10-29T01:08:44Z
2026-11-20 · one wayDelta Air LinesDL4998 + DL1471$180.002026-10-29T01:08:44Z
2026-11-20 → 2026-11-23Delta Air LinesDL4998 + DL1471 / DL1717 + DL4998$340.002026-10-29T01:08:44Z
2026-11-27 → 2026-12-04American AirlinesAA3571 / AA6284$323.132026-10-29T01:08:44Z
2026-11-20 · one wayAmerican AirlinesAA3571$145.002026-10-29T01:08:44Z
2026-11-20 · one wayUnited AirlinesUA6040$150.002026-10-29T01:08:44Z
2026-11-20 → 2026-11-23American AirlinesAA3571 / AA6284$275.002026-10-29T01:08:44Z
2026-11-20 → 2026-11-23United AirlinesUA6040 / UA2836$285.002026-10-29T01:08:44Z
2026-11-27 → 2026-12-04American AirlinesAA6229 / AA6284$323.132026-10-29T01:08:44Z
2026-11-27 → 2026-12-04United AirlinesUA5304 / UA2836$334.882026-10-29T01:08:44Z
2026-11-27 → 2026-12-04United AirlinesUA6040 / UA2836$334.882026-10-29T01:08:44Z
2026-11-27 → 2026-12-04Delta Air LinesDL4998 + DL1471 / DL1717 + DL4998$399.502026-10-29T01:08:44Z

2026-11-20 · one way · $145.00

  • American Airlines AA6229: DSM 2026-11-20 13:58:00 → ORD 2026-11-20 15:42:00; nonstop; 104 minutes. Local airport times.

2026-11-20 · one way · $150.00

  • United Airlines UA5304: DSM 2026-11-20 11:22:00 → ORD 2026-11-20 12:58:00; nonstop; 96 minutes. Local airport times.

2026-11-20 → 2026-11-23 · $275.00

  • American Airlines AA6229: DSM 2026-11-20 13:58:00 → ORD 2026-11-20 15:42:00; nonstop; 104 minutes. Local airport times.
  • American Airlines AA6284: ORD 2026-11-23 07:14:00 → DSM 2026-11-23 08:46:00; nonstop; 92 minutes. Local airport times.

2026-11-20 → 2026-11-23 · $285.00

  • United Airlines UA5304: DSM 2026-11-20 11:22:00 → ORD 2026-11-20 12:58:00; nonstop; 96 minutes. Local airport times.
  • United Airlines UA2836: ORD 2026-11-23 12:50:00 → DSM 2026-11-23 14:14:00; nonstop; 84 minutes. Local airport times.

2026-11-20 · one way · $180.00

  • Delta Air Lines DL4998 / DL1471: DSM 2026-11-20 11:00:00 → ORD 2026-11-20 16:41:00; 1 stop(s) via MSP; 341 minutes. Local airport times.
    • DL4998: DSM 2026-11-20 11:00:00 → MSP 2026-11-20 12:14:00; layover at MSP: 167 minutes.
    • DL1471: MSP 2026-11-20 15:01:00 → ORD 2026-11-20 16:41:00.

2026-11-20 → 2026-11-23 · $340.00

  • Delta Air Lines DL4998 / DL1471: DSM 2026-11-20 11:00:00 → ORD 2026-11-20 16:41:00; 1 stop(s) via MSP; 341 minutes. Local airport times.
    • DL4998: DSM 2026-11-20 11:00:00 → MSP 2026-11-20 12:14:00; layover at MSP: 167 minutes.
    • DL1471: MSP 2026-11-20 15:01:00 → ORD 2026-11-20 16:41:00.
  • Delta Air Lines DL1717 / DL4998: ORD 2026-11-23 06:20:00 → DSM 2026-11-23 11:56:00; 1 stop(s) via MSP; 336 minutes. Local airport times.
    • DL1717: ORD 2026-11-23 06:20:00 → MSP 2026-11-23 07:54:00; layover at MSP: 151 minutes.
    • DL4998: MSP 2026-11-23 10:25:00 → DSM 2026-11-23 11:56:00.

2026-11-27 → 2026-12-04 · $323.13

  • American Airlines AA3571: DSM 2026-11-27 19:58:00 → ORD 2026-11-27 21:40:00; nonstop; 102 minutes. Local airport times.
  • American Airlines AA6284: ORD 2026-12-04 07:14:00 → DSM 2026-12-04 08:46:00; nonstop; 92 minutes. Local airport times.

2026-11-20 · one way · $145.00

  • American Airlines AA3571: DSM 2026-11-20 19:58:00 → ORD 2026-11-20 21:40:00; nonstop; 102 minutes. Local airport times.

2026-11-20 · one way · $150.00

  • United Airlines UA6040: DSM 2026-11-20 13:15:00 → ORD 2026-11-20 14:53:00; nonstop; 98 minutes. Local airport times.

2026-11-20 → 2026-11-23 · $275.00

  • American Airlines AA3571: DSM 2026-11-20 19:58:00 → ORD 2026-11-20 21:40:00; nonstop; 102 minutes. Local airport times.
  • American Airlines AA6284: ORD 2026-11-23 07:14:00 → DSM 2026-11-23 08:46:00; nonstop; 92 minutes. Local airport times.

2026-11-20 → 2026-11-23 · $285.00

  • United Airlines UA6040: DSM 2026-11-20 13:15:00 → ORD 2026-11-20 14:53:00; nonstop; 98 minutes. Local airport times.
  • United Airlines UA2836: ORD 2026-11-23 12:50:00 → DSM 2026-11-23 14:14:00; nonstop; 84 minutes. Local airport times.

2026-11-27 → 2026-12-04 · $323.13

  • American Airlines AA6229: DSM 2026-11-27 13:58:00 → ORD 2026-11-27 15:42:00; nonstop; 104 minutes. Local airport times.
  • American Airlines AA6284: ORD 2026-12-04 07:14:00 → DSM 2026-12-04 08:46:00; nonstop; 92 minutes. Local airport times.

2026-11-27 → 2026-12-04 · $334.88

  • United Airlines UA5304: DSM 2026-11-27 11:22:00 → ORD 2026-11-27 12:58:00; nonstop; 96 minutes. Local airport times.
  • United Airlines UA2836: ORD 2026-12-04 12:50:00 → DSM 2026-12-04 14:14:00; nonstop; 84 minutes. Local airport times.

2026-11-27 → 2026-12-04 · $334.88

  • United Airlines UA6040: DSM 2026-11-27 13:15:00 → ORD 2026-11-27 14:53:00; nonstop; 98 minutes. Local airport times.
  • United Airlines UA2836: ORD 2026-12-04 12:50:00 → DSM 2026-12-04 14:14:00; nonstop; 84 minutes. Local airport times.

2026-11-27 → 2026-12-04 · $399.50

  • Delta Air Lines DL4998 / DL1471: DSM 2026-11-27 11:00:00 → ORD 2026-11-27 16:41:00; 1 stop(s) via MSP; 341 minutes. Local airport times.
    • DL4998: DSM 2026-11-27 11:00:00 → MSP 2026-11-27 12:14:00; layover at MSP: 167 minutes.
    • DL1471: MSP 2026-11-27 15:01:00 → ORD 2026-11-27 16:41:00.
  • Delta Air Lines DL1717 / DL4998: ORD 2026-12-04 06:20:00 → DSM 2026-12-04 11:56:00; 1 stop(s) via MSP; 336 minutes. Local airport times.
    • DL1717: ORD 2026-12-04 06:20:00 → MSP 2026-12-04 07:54:00; layover at MSP: 151 minutes.
    • DL4998: MSP 2026-12-04 10:25:00 → DSM 2026-12-04 11:56:00.

More dates for this route