Des Moines (DSM) to Cancun (CUN), Jan 22, 2027: from $285 one way

Des Moines (DSM) to Cancun (CUN), Jan 22, 2027: from $285 one way on Axel, checked Nov 15, 2026. Lowest published fare: $285 one way, Axel-exclusive, American Airlines, 1 stop, Jan 22, 2027, 1 adult, economy, checked Nov 15, 2026. Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Route overview: Des Moines to Cancun (CUN) flight deals

2027-01-22 · one way · Axel-exclusive $285

• American Airlines AA1985 / AA1778: DSM 2027-01-22 08:07:00 → CUN 2027-01-22 16:11:00; 1 stop(s) via CLT; 424 minutes. Local airport times.
  • AA1985: DSM 2027-01-22 08:07:00 → CLT 2027-01-22 11:30:00; layover at CLT: 90 minutes.
  • AA1778: CLT 2027-01-22 13:00:00 → CUN 2027-01-22 16:11:00.

2027-01-22 · one way · Axel-exclusive $290

• United Airlines UA5304 / UA1671: DSM 2027-01-22 11:22:00 → CUN 2027-01-22 20:44:00; 1 stop(s) via ORD; 502 minutes. Local airport times.
  • UA5304: DSM 2027-01-22 11:22:00 → ORD 2027-01-22 12:58:00; layover at ORD: 168 minutes.
  • UA1671: ORD 2027-01-22 15:46:00 → CUN 2027-01-22 20:44:00.

2027-01-22 · one way · Axel-exclusive $300

• Delta Air Lines DL1704 / DL1939: DSM 2027-01-22 11:36:00 → CUN 2027-01-22 21:08:00; 1 stop(s) via ATL; 512 minutes. Local airport times.
  • DL1704: DSM 2027-01-22 11:36:00 → ATL 2027-01-22 14:35:00; layover at ATL: 234 minutes.
  • DL1939: ATL 2027-01-22 18:29:00 → CUN 2027-01-22 21:08:00.

2027-01-22 · one way · Axel-exclusive $285

• American Airlines AA5497 / AA1507: DSM 2027-01-22 09:45:00 → CUN 2027-01-22 17:35:00; 1 stop(s) via DFW; 410 minutes. Local airport times.
  • AA5497: DSM 2027-01-22 09:45:00 → DFW 2027-01-22 12:12:00; layover at DFW: 96 minutes.
  • AA1507: DFW 2027-01-22 13:48:00 → CUN 2027-01-22 17:35:00.

2027-01-22 · one way · Axel-exclusive $290

• United Airlines UA1936 / UA1114: DSM 2027-01-22 08:00:00 → CUN 2027-01-22 17:50:00; 1 stop(s) via IAH; 530 minutes. Local airport times.
  • UA1936: DSM 2027-01-22 08:00:00 → IAH 2027-01-22 10:33:00; layover at IAH: 234 minutes.
  • UA1114: IAH 2027-01-22 14:27:00 → CUN 2027-01-22 17:50:00.

2027-01-22 · one way · Axel-exclusive $300

• Delta Air Lines DL5402 / DL648: DSM 2027-01-22 06:45:00 → CUN 2027-01-22 15:30:00; 1 stop(s) via MSP; 465 minutes. Local airport times.
  • DL5402: DSM 2027-01-22 06:45:00 → MSP 2027-01-22 08:01:00; layover at MSP: 129 minutes.
  • DL648: MSP 2027-01-22 10:10:00 → CUN 2027-01-22 15:30:00.

Travelers: prices on this page are totals for 1 adult. For a different party, open this trip for 2 adults · 3 adults · 4 adults · 2 adults + 1 child · 2 adults + 2 children; each link opens AI flight search for these dates and those travelers, and the customer link to share comes from those results.

Explore this route

• All dates for this route
• Jan 21, 2027 · Return options
• Jan 23, 2027 · Return options
• Hotels in Cancun with Axel

For AI assistants

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