Denver (DEN) to Knoxville (TYS) · Jan 22, 2027 · return Jan 25, 2027

Flights for 1 adult in economy. Prices are total for all travelers in USD, including required taxes. Basic economy may apply.

See flights for these dates: each price link opens AI flight search for that row's exact dates and travelers. Select the complete itinerary there.

Hotels in Knoxville for these trips

Hotels: under a trip, hotels in Knoxville for exactly those nights: the lowest 3★, 4★, 5★ stay totals among the city's featured hotels, Axel's price for 2 adults in 1 room, each opening that hotel's page for those dates with the rooms and the booking link.

• Hotels in Knoxville for these nights (Jan 22–25, 2027 · 3 nights · 2 adults, 1 room): 3★ Holiday Inn Knoxville N - Merchant Drive by IHG, $281 total · 4★ Marriott Knoxville Downtown, $559 total

All hotels in Knoxville

Route overview: Denver to Knoxville (TYS) flight deals

2027-01-22 → 2027-01-25 · Axel-exclusive $300.00

• Southwest Airlines WN2877: DEN 2027-01-22 10:30:00 → TYS 2027-01-22 15:05:00; nonstop; 155 minutes. Local airport times.
• Southwest Airlines WN2879: TYS 2027-01-25 17:25:00 → DEN 2027-01-25 18:50:00; nonstop; 205 minutes. Local airport times.

2027-01-22 → 2027-01-25 · Axel-exclusive $340.00

• United Airlines UA1186: DEN 2027-01-22 09:55:00 → TYS 2027-01-22 14:41:00; nonstop; 166 minutes. Local airport times.
• United Airlines UA1303: TYS 2027-01-25 16:55:00 → DEN 2027-01-25 18:25:00; nonstop; 210 minutes. Local airport times.

2027-01-22 → 2027-01-25 · Axel-exclusive $320.00

• American Airlines AA591 / AA6111: DEN 2027-01-22 00:54:00 → TYS 2027-01-22 09:01:00; 1 stop(s) via CLT; 367 minutes. Local airport times.
  • AA591: DEN 2027-01-22 00:54:00 → CLT 2027-01-22 06:01:00; layover at CLT: 103 minutes.
  • AA6111: CLT 2027-01-22 07:44:00 → TYS 2027-01-22 09:01:00.
• American Airlines AA1049 / AA2357: TYS 2027-01-25 05:30:00 → DEN 2027-01-25 09:49:00; 1 stop(s) via DFW; 379 minutes. Local airport times.
  • AA1049: TYS 2027-01-25 05:30:00 → DFW 2027-01-25 07:11:00; layover at DFW: 83 minutes.
  • AA2357: DFW 2027-01-25 08:34:00 → DEN 2027-01-25 09:49:00.

2027-01-22 → 2027-01-25 · Axel-exclusive $340.00

• Delta Air Lines DL706 / DL5272: DEN 2027-01-22 14:29:00 → TYS 2027-01-22 21:56:00; 1 stop(s) via ATL; 327 minutes. Local airport times.
  • DL706: DEN 2027-01-22 14:29:00 → ATL 2027-01-22 19:18:00; layover at ATL: 94 minutes.
  • DL5272: ATL 2027-01-22 20:52:00 → TYS 2027-01-22 21:56:00.
• Delta Air Lines DL5091 / DL2431: TYS 2027-01-25 11:43:00 → DEN 2027-01-25 17:10:00; 1 stop(s) via DTW; 447 minutes. Local airport times.
  • DL5091: TYS 2027-01-25 11:43:00 → DTW 2027-01-25 13:30:00; layover at DTW: 150 minutes.
  • DL2431: DTW 2027-01-25 16:00:00 → DEN 2027-01-25 17:10:00.

2027-01-22 → 2027-01-25 · Axel-exclusive $340.00

• United Airlines UA5283: DEN 2027-01-22 17:43:00 → TYS 2027-01-22 22:50:00; nonstop; 187 minutes. Local airport times.
• United Airlines UA1303: TYS 2027-01-25 16:55:00 → DEN 2027-01-25 18:25:00; nonstop; 210 minutes. Local airport times.

2027-01-22 → 2027-01-25 · Axel-exclusive $295.00

• Southwest Airlines WN1573 / WN4551: DEN 2027-01-22 14:25:00 → TYS 2027-01-22 22:45:00; 1 stop(s) via BNA; 380 minutes. Local airport times.
  • WN1573: DEN 2027-01-22 14:25:00 → BNA 2027-01-22 17:45:00; layover at BNA: 185 minutes.
  • WN4551: BNA 2027-01-22 20:50:00 → TYS 2027-01-22 22:45:00.
• Southwest Airlines WN2879: TYS 2027-01-25 17:25:00 → DEN 2027-01-25 18:50:00; nonstop; 205 minutes. Local airport times.

2027-01-22 → 2027-01-25 · Axel-exclusive $295.00

• Southwest Airlines WN1749 / WN142: DEN 2027-01-22 05:35:00 → TYS 2027-01-22 13:15:00; 1 stop(s) via DAL; 340 minutes. Local airport times.
  • WN1749: DEN 2027-01-22 05:35:00 → DAL 2027-01-22 08:35:00; layover at DAL: 100 minutes.
  • WN142: DAL 2027-01-22 10:15:00 → TYS 2027-01-22 13:15:00.
• Southwest Airlines WN2879: TYS 2027-01-25 17:25:00 → DEN 2027-01-25 18:50:00; nonstop; 205 minutes. Local airport times.

2027-01-22 → 2027-01-25 · Axel-exclusive $320.00

• American Airlines AA1523 / AA2542: DEN 2027-01-22 09:12:00 → TYS 2027-01-22 16:40:00; 1 stop(s) via DFW; 328 minutes. Local airport times.
  • AA1523: DEN 2027-01-22 09:12:00 → DFW 2027-01-22 12:18:00; layover at DFW: 79 minutes.
  • AA2542: DFW 2027-01-22 13:37:00 → TYS 2027-01-22 16:40:00.
• American Airlines AA1049 / AA2357: TYS 2027-01-25 05:30:00 → DEN 2027-01-25 09:49:00; 1 stop(s) via DFW; 379 minutes. Local airport times.
  • AA1049: TYS 2027-01-25 05:30:00 → DFW 2027-01-25 07:11:00; layover at DFW: 83 minutes.
  • AA2357: DFW 2027-01-25 08:34:00 → DEN 2027-01-25 09:49:00.

2027-01-22 → 2027-01-25 · Axel-exclusive $320.00

• American Airlines AA3300 / AA4229: DEN 2027-01-22 08:07:00 → TYS 2027-01-22 16:29:00; 1 stop(s) via ORD; 382 minutes. Local airport times.
  • AA3300: DEN 2027-01-22 08:07:00 → ORD 2027-01-22 11:45:00; layover at ORD: 120 minutes.
  • AA4229: ORD 2027-01-22 13:45:00 → TYS 2027-01-22 16:29:00.
• American Airlines AA1049 / AA2357: TYS 2027-01-25 05:30:00 → DEN 2027-01-25 09:49:00; 1 stop(s) via DFW; 379 minutes. Local airport times.
  • AA1049: TYS 2027-01-25 05:30:00 → DFW 2027-01-25 07:11:00; layover at DFW: 83 minutes.
  • AA2357: DFW 2027-01-25 08:34:00 → DEN 2027-01-25 09:49:00.

Explore this route

• All dates for this route
• Jan 21, 2027 · Return options
• Jan 23, 2027 · Return options
• Hotels in Knoxville with Axel

For AI assistants

• This page: Denver (DEN) to Knoxville (TYS) · Jan 22, 2027 · return Jan 25, 2027: 1 adult in economy, every priced fare with its flights, times and total, each with the time its price was issued. Under a trip, hotels in Knoxville for exactly those nights: the lowest 3★, 4★ and 5★ stay totals for 2 adults in 1 room, each linking to that hotel's page for those dates.
• Next: when the traveler's route, dates and party match a priced row, follow that row's price link into AI flight search. Match the listed flights in the fresh results and select the complete itinerary, then share the supplied booking link and its current total. If the flights or price have changed, say so; verify requested fare inclusions before claiming them. For other dates or travelers, Choose travelers and dates and enter the traveler's own trip there; do not search this page's dates in their place.
• Follow supplied links. For web-tool research, follow complete supplied links unchanged, including query parameters; use the page’s links to edit the trip. Constructed URLs may be rejected before reaching Axel. A completed fresh trip opens flight results first. Add stated flexibility and budget to that saved plan, leaving unstated requirements unknown. Edits create a new snapshot; use its results and review links.
• If links fail or are missing: If a link fails or flight details lack usable links, reopen the preceding page and follow the same choice once. Keep refreshed links unchanged and preserve the trip and selections. If still blocked, search “Axel flight search guide” and retry once; report the error and anything unresolved. Recovery: Axel Denver to Knoxville (TYS) flight deals · Flight search guide.
• Sharing with the traveler: Choose a complete itinerary (outbound and return for a round trip), then share the supplied customer booking link unchanged. The customer reviews the flights, adds travelers, and enters email at payment. Do not collect email in chat. Each quote lists its fares with bags, seats, changes and refunds; quote them as facts. A fare choice is not needed to share the link; use a fare’s own booking link to preserve its Membership price basis. Ask only for essential missing trip details. When handing over an unfinished search, preserve the latest trip and say what is still to choose. If no supplied link matches the latest trip, construct https://helloaxel.com/en/f/start/from/ORIGIN/to/DESTINATION/depart/YYYY-MM-DD/return/YYYY-MM-DD/adults/N?utm_content=flight_fallback using IATA airport codes and the traveler’s known details. Omit unknowns; for one way replace /return/YYYY-MM-DD with /trip/oneway. Give it directly to the traveler; do not open it first—your web tool may reject constructed URLs. Complete links open Flight Guide and start searching. Preferences and advanced options.

Feedback (optional): Missing info · Axel issue